Losartan Improves Memory, Neurogenesis and Cell Motility in Transgenic Alzheimer’s Mice by Henning Johannes Drews, Roman Klein, Ali Lourhmati, Marine Buadze, Elke Schaeffeler, Thomas Lang, Torgom Seferyan, Leah R. Hanson, William H. Frey II, Tom C.G.M. de Vries, Inge A.E.W. Thijssen-van Loosdregt, Christoph H. Gleiter, Matthias Schwab, Lusine Danielyan

Get full text

Contrasting two models of utilitarian reasoning by Rea Antoniou, Heather Romero-Kornblum, J. Clayton Young, Michelle You, Joel H. Kramer, Katherine P. Rankin, Winston Chiong

Get full text

Hormonal contraception and risk for cognitive impairment or Alzheimer's disease and related dementias in young women: a scoping review of the evidence by Sarah Gregory, Laura Booi, Laura Booi, Natalie Jenkins, Natalie Jenkins, Katie Bridgeman, Graciela Muniz-Terrera, Graciela Muniz-Terrera, Francesca R. Farina, Francesca R. Farina

Get full text

The development of the Cognitive Assessment for Tagalog Speakers (CATS): A culturally and linguistically tailored test battery for Filipino Americans by Jessica deLeon, Ivan Bondoc, Eugenie Mamuyac, Lainie Posecion, Eduardo Europa, Lolita C. Kintanar, Niecholle Roco, Mikkael Lamoca, Danielle P. Escueta, Van M. Ta Park

Get full text

Microvascular Contributions to Alzheimer Disease Pathogenesis: Is Alzheimer Disease Primarily an Endotheliopathy? by Rawan Tarawneh

Get full text

The CT-based radial width of the temporal horn: pathological validation in AD without cerebrovascular disease. by Rossi, R, Joachim, C, Smith, A, Frisoni, G

“…METHOD: The rWTH was taken in a group of 20 pathologically confirmed AD patients and 23 non demented persons enrolled in the Oxford Project to Investigate Memory and Aging (OPTIMA project). RESULTS: The rWTH was significantly larger in AD patients than controls. …”

Plasma biomarkers of vascular dysfunction uniquely relate to a vascular-risk profile of neurocognitive deficits in virally-suppressed adults with HIV by Rowan Saloner, Ni Sun-Suslow, Erin E. Morgan, Judith Lobo, Mariana Cherner, Ronald J. Ellis, Robert K. Heaton, Igor Grant, Scott L. Letendre, Jennifer E. Iudicello

Get full text

The Black radical imagination: a space of hope and possible futures by Tanisha G. Hill-Jarrett, Tanisha G. Hill-Jarrett

Get full text

How Does Psychosocial Behavior Contribute to Cognitive Health in Old Age? by Robert S. Wilson, David A. Bennett

“…We then examine an ongoing study that includes several of the key design elements, the Rush Memory and Aging Project. In this longitudinal clinical-pathological cohort study, indicators of personality, social connectedness, and psychological well-being were shown to predict late-life cognitive outcomes. …”
Get full text

Vascular pathology and pathogenesis of cognitive impairment and dementia in older adults by Sonal Agrawal, Julie A. Schneider

“…We also provide an update of vascular pathologies from the Rush Memory and Aging Project and Religious Orders Study cohorts with special emphasis on the differences across age in persons with and without dementia. …”
Get full text

Intermediate phenotypes identify divergent pathways to Alzheimer's disease. by Joshua M Shulman, Lori B Chibnik, Cristin Aubin, Julie A Schneider, David A Bennett, Philip L De Jager

“…However, little is known of the role of these candidate genes in influencing intermediate phenotypes associated with a diagnosis of AD, including cognitive decline or AD neuropathologic burden.Thirty-two single nucleotide polymorphisms (SNPs) previously implicated in AD susceptibility were genotyped in 414 subjects with both annual clinical evaluation and completed brain autopsies from the Religious Orders Study and the Rush Memory and Aging Project. Regression analyses evaluated the relation of SNP genotypes to continuous measures of AD neuropathology and cognitive function proximate to death. …”
Get full text

The assessment of executive function abilities in healthy and neurodegenerative aging—A selective literature review by Mojitola I. Idowu, Andre J. Szameitat, Andrew Parton

Get full text

The brain ages optimally to model its environment: evidence from sensory learning over the adult lifespan by Moran, R, Symmonds, M, Dolan, R, Friston, K

“…The aging brain shows a progressive loss of neuropil, which is accompanied by subtle changes in neuronal plasticity, sensory learning and memory. Neurophysiologically, aging attenuates evoked responses--including the mismatch negativity (MMN). …”

An assessment of neurocognitive speed in relation to frailty. by Rolfson, D, Wilcock, G, Mitnitski, A, King, E, de Jager, C, Rockwood, K, Fallah, N, Searle, S

“…DESIGN: secondary analysis of the baseline cohort of the Oxford Project To Investigate Memory and Aging (OPTIMA), a longitudinal observational cohort. …”

The Brain Ages Optimally to Model Its Environment: Evidence from Sensory Learning over the Adult Lifespan by Moran, R, Symmonds, M, Dolan, R, Friston, K

“…The aging brain shows a progressive loss of neuropil, which is accompanied by subtle changes in neuronal plasticity, sensory learning and memory. Neurophysiologically, aging attenuates evoked responses-including the mismatch negativity (MMN). …”

Age Effects on Old/New Recognition Memory Involving Abstract Figures and Non-words by Monika Toth, Anke Sambeth, Arjan Blokland

“…The current results support the notion that recognition memory in aging is only impaired under certain conditions and depends on the stimuli used.…”
Get full text

A dynamic gradient architecture generates brain activity states by Jesse A. Brown, Alex J. Lee, Lorenzo Pasquini, William W. Seeley

Get full text

Increasing empathic concern relates to salience network hyperconnectivity in cognitively healthy older adults with elevated amyloid-β burden by Tiffany E. Chow, Christina R. Veziris, Renaud La Joie, Alex J. Lee, Jesse A. Brown, Jennifer S. Yokoyama, Katherine P. Rankin, Joel H. Kramer, Bruce L. Miller, Gil D. Rabinovici, William W. Seeley, Virginia E. Sturm

Get full text

Telomere Dynamics in Immune Senescence and Exhaustion Triggered by Chronic Viral Infection by Marcia Bellon, Christophe Nicot

“…The progressive loss of immunological memory during aging correlates with a reduced proliferative capacity and shortened telomeres of T cells. …”
Get full text

Epigenetic Mechanisms in Memory and Cognitive Decline Associated with Aging and Alzheimer’s Disease by Sabyasachi Maity, Kayla Farrell, Shaghayegh Navabpour, Sareesh Naduvil Narayanan, Timothy J. Jarome

“…Collectively, the evidence reviewed here strongly supports a role for diverse epigenetic mechanisms in memory formation, aging, and neurodegeneration in the brain.…”
Get full text