Perimenopausal Bone Loss Is Associated with Ovulatory Activity—Results of the PeKnO Study (Perimenopausal Bone Density and Ovulation) by Teresa Starrach, Anita Santl, Vanadin Regina Seifert-Klauss

“…Background: During the menopausal transition, around 25% of women experience a particularly accelerated loss of bone mineral density. …”
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Breast Cancer in Turkey: Clinical and Histopathological Characteristics (Analysis of 13.240 Patients) by Vahit Özmen

“…Parameters examined in patients included age, menopausal status, distribution of clinical and pathological stage, histological type, tumor diameter, histological grades, regional lymphatic stage, estrogen (ER), progesterone (PR), HER-2 receptors and molecular subtypes. …”
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Association between CNS-active drugs and risk of Alzheimer’s and age-related neurodegenerative diseases by Helena Cortes-Flores, Helena Cortes-Flores, Georgina Torrandell-Haro, Georgina Torrandell-Haro, Roberta Diaz Brinton, Roberta Diaz Brinton, Roberta Diaz Brinton

“…Furthermore, responders to these therapeutics were characterized by diagnosed obesity and higher prescriptions of anti-inflammatory drugs and menopausal hormonal therapy, compared to patients with a diagnosis of AD (non-responders). …”
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The Development of Gonadotropins for Clinical Use in the Treatment of Infertility by Bruno Lunenfeld, Wilma Bilger, Salvatore Longobardi, Veronica Alam, Veronica Alam, Thomas D'Hooghe, Thomas D'Hooghe, Thomas D'Hooghe, Sesh K. Sunkara

“…This prompted the development of human pituitary gonadotropins; however, supply problems, the risk for Creutzfeld–Jakob disease, and the advent of recombinant technology eventually led to the withdrawal of human pituitary gonadotropin from the market. Urinary human menopausal gonadotropin (hMG) preparations were also produced, with subsequent improvements in purification techniques enabling development of products with standardized proportions of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity. …”
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Effects of Female Reproductive Hormone Levels on Inadvertent Intraoperative Hypothermia during Laparoscopic Gynecologic Surgery: A Retrospective Study by Cheol Lee, SeongNam Park, ByoungRyun Kim, Hyeonbin Yim, Myeongjong Lee, Juhwan Lee, Hyungtae Kim

“…<i>Materials and Methods:</i> This retrospective study included 660 menstruating and menopausal female patients aged 19–65 years. The patients were divided into two groups according to the occurrence of inadvertent intraoperative hypothermia: non-hypothermia group (<i>N</i> = 472) and hypothermia group (<i>N</i> = 188). …”
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Adherence to the Dietary Approaches to Stop Hypertension diet reduces the risk of breast cancer: A systematic review and meta-analysis by Long Shu, Yi-Qian Huang, Xiao-Yan Zhang, Pei-Fen Zheng, Pei-Fen Zheng, Qin Zhu, Qin Zhu, Jian-Ying Zhou

“…Similarly, when we conducted analyses separately by menopausal status, we found a significant inverse association between DASH diet and breast cancer risk in postmenopausal women (RR = 0.58; 95% CI: 0.39–0.87, P = 0.008).ConclusionThe results of this systematic review and meta-analysis indicate a significant inverse association between adherence to the DASH diet and risk of breast cancer. …”
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The cumulative live birth rate of recombinant follicle-stimulating hormone alfa verse urinary human follicle-stimulating hormone for ovarian stimulation in assisted reproductive te... by Chunxia Yang, Naijun Dong, Feng Li, Yurong Ji, Yu Pan, Hong She

“…An issue with controlled ovarian stimulation (COS) is the selection of an exogenous gonadotropin (Gn) regimen, which is mainly based on urinary follicle-stimulating hormone (uFSH), recombinant follicle-stimulating hormone alfa (rFSH-alfa), and human menopausal gonadotropin (HMG). In addition, most previous studies focused on the clinical pregnancy rates or live birth rates (LBR) per transfer cycle, but not on the cumulative live birth rate (CLBR) per started cycle. …”
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Long-Term Survival, Prognostic Factors, and Quality of Life of Patients Undergoing Pelvic Exenteration for Cervical Cancer by Mihai Stanca, Dan Mihai Căpîlna, Mihai Emil Căpîlna

“…The cost of favorable survival has been translated into poor overall QoL, unsatisfactory functional, social, and symptom scores, a high prevalence of cervical cancer-specific symptoms such as lymphedema, peripheral neuropathy, severe menopausal symptoms, distorted body image, and lack of sexual desire. …”
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Personalized comprehensive rehabilitation program after surgical treatment of endometrial cancer: results of a prospective randomized comparative study by L. N. Sandzhieva, A. G. Solopova, D. V. Blinov, E. A. Son, V. N. Galkin, A. B. Alekseev

“…Quality of life (QоL) was determined using the following questionnaires: Functional Assessment of Cancer Therapy for Patients with Endometrial Cancer (FACT-En), Kupperman-Uvarova Modified Menopausal Index (MMI), The Female Sexual Function Index (FSFI), Hospital Anxiety and Depression Scale (HADS). …”
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Effects of Royal Jelly Supplementation on Dry Mouth Sensation in Patients with Normal Saliva Function: A Randomised Clinical Study by Yumi Mochizuki, Fumihiko Tushima, Yuji Kabasawa, Hiroyuki Harada

“…Based on recent studies, daily oral royal jelly supplementation (1000 mg) for eight weeks has beneficial effects on menopausal symptoms such as anxiety. However, there are no studies on the effects of royal jelly supplementation on dry mouth sensation in patients with normal salivary function. …”
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WITHDRAWN: Ovarian ablation for early breast cancer. by Clarke, M

“…Data were obtained for 12 of the 13 studies that assessed ovarian ablation by irradiation or surgery, all of which began before 1980, but not for the four studies that assessed ovarian suppression by drugs, all of which began after 1985. Menopausal status was not consistently defined across trials; therefore, the main analyses are limited to women aged under 50 (rather than "premenopausal") when randomised. …”

Serum hormone levels in women with chronic pain by Buck, L

“…</p> <p><b>Methods:</b></p> <p>Local ethical approval was obtained (Oxford REC 15/SC/0077). </p> <p>Pre-menopausal women (aged 18 – 50) with chronic (&gt;6 months) pelvic or musculoskeletal pain were recruited by advertisement. …”

Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease. by Cancer, C

“…Risk ratios for breast cancer were calculated by conditional logistic regression, stratified by study, age, menopausal status, number of sisters, parity, and age when the first child was born. …”

Effects of Morinda citrifolia L. leaf aqueous extract on fatigue and bone health by Mohamad Shalan, Nor Aijratul Asikin

“…M. citrifolia leaf extract also protected bone from deterioration under condition of estrogen deficiency, indicating benefits for the aged and menopausal women.…”
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Computational approaches for discovering significant microRNAs, microRNA-mRNA regulatory pathways, and therapeutic protein targets in endometrial cancer by Ghada Ajabnoor, Fai Alsubhi, Thoraia Shinawi, Wisam Habhab, Wisam Habhab, Walaa F. Albaqami, Hussain S. Alqahtani, Hisham Nasief, Nabeel Bondagji, Nabeel Bondagji, Ramu Elango, Ramu Elango, Noor Ahmad Shaik, Noor Ahmad Shaik, Babajan Banaganapalli, Babajan Banaganapalli

“…Endometrial cancer (EC) is a urogenital cancer affecting millions of post-menopausal women, globally. This study aims to identify key miRNAs, target genes, and drug targets associated with EC metastasis. …”
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Guidance for the gastrointestinal evaluation and management of iron deficiency in Sub-Saharan Africa by W M Simmonds, Y Awuku, C Barrett, M Brand, K Davidson, D Epstein, E Fredericks, S Gabriel, S Grobler, C Gounden, L Katsidzira, V J Louw, V Naidoo, C Noel, E Ogutu, N Ramonate, N Seabi, M Setshedi, J Van Zyl, G Watermeyer, C Kassianides

“…As iron deficiency (ID) anaemia in men and post-menopausal women is mostly caused by gastrointestinal blood loss or malabsorption, the initial evaluation of a patient with ID anaemia involves referral to a gastroenterologist. …”
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Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors. by Stefan Nickels, Thérèse Truong, Rebecca Hein, Kristen Stevens, Katharina Buck, Sabine Behrens, Ursula Eilber, Martina Schmidt, Lothar Häberle, Alina Vrieling, Mia Gaudet, Jonine Figueroa, Nils Schoof, Amanda B Spurdle, Anja Rudolph, Peter A Fasching, John L Hopper, Enes Makalic, Daniel F Schmidt, Melissa C Southey, Matthias W Beckmann, Arif B Ekici, Olivia Fletcher, Lorna Gibson, Isabel dos Santos Silva, Julian Peto, Manjeet K Humphreys, Jean Wang, Emilie Cordina-Duverger, Florence Menegaux, Børge G Nordestgaard, Stig E Bojesen, Charlotte Lanng, Hoda Anton-Culver, Argyrios Ziogas, Leslie Bernstein, Christina A Clarke, Hermann Brenner, Heiko Müller, Volker Arndt, Christa Stegmaier, Hiltrud Brauch, Thomas Brüning, Volker Harth, Genica Network, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M Hartikainen, kConFab, AOCS Management Group, Diether Lambrechts, Dominiek Smeets, Patrick Neven, Robert Paridaens, Dieter Flesch-Janys, Nadia Obi, Shan Wang-Gohrke, Fergus J Couch, Janet E Olson, Celine M Vachon, Graham G Giles, Gianluca Severi, Laura Baglietto, Kenneth Offit, Esther M John, Alexander Miron, Irene L Andrulis, Julia A Knight, Gord Glendon, Anna Marie Mulligan, Stephen J Chanock, Jolanta Lissowska, Jianjun Liu, Angela Cox, Helen Cramp, Dan Connley, Sabapathy Balasubramanian, Alison M Dunning, Mitul Shah, Amy Trentham-Dietz, Polly Newcomb, Linda Titus, Kathleen Egan, Elizabeth K Cahoon, Preetha Rajaraman, Alice J Sigurdson, Michele M Doody, Pascal Guénel, Paul D P Pharoah, Marjanka K Schmidt, Per Hall, Doug F Easton, Montserrat Garcia-Closas, Roger L Milne, Jenny Chang-Claude

“…Using up to 34,793 invasive breast cancers and 41,099 controls, we examined whether the relative risks associated with 23 single nucleotide polymorphisms were modified by 10 established environmental risk factors (age at menarche, parity, breastfeeding, body mass index, height, oral contraceptive use, menopausal hormone therapy use, alcohol consumption, cigarette smoking, physical activity) in women of European ancestry. …”
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Protective Effect of Long-Term Fermented Soybeans with Abundant <i>Bacillus subtilis</i> on Glucose and Bone Metabolism and Memory Function in Ovariectomized Rats: Modulation of th... by Hee-Jong Yang, Ting Zhang, Yu Yue, Su-Ji Jeong, Myeong-Seon Ryu, Xuangao Wu, Chen Li, Do-Yeon Jeong, Sunmin Park

“…Further research is needed to make specific recommendations for <i>B. subtilis</i>-rich TMD for menopausal women.…”
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Comparison of dyslipidemia incidence in Chinese early-stage breast cancer patients following different endocrine therapies: A population-based cohort study by Junren Wang, Junren Wang, Jin Yin, Jin Yin, Jin Yin, Jiajun Qiu, Jiajun Qiu, Jingwen Jiang, Jingwen Jiang, Yao Hu, Yao Hu, Kunrui Zhu, Kunrui Zhu, Hong Zheng, Hong Zheng, Ting Luo, Ting Luo, Xiaorong Zhong, Xiaorong Zhong

“…In postmenopausal patients, the risk of abnormal TC or LDL-C levels showed a similar trend in the AI and SERM groups.ConclusionsIn addition to postmenopausal patients, dyslipidemia is also common in premenopausal Chinese patients with EBC who received endocrine therapy. Irrespective of menopausal status, AI treatment increases the risk of TC/LDL-C dyslipidemia than SERM treatment.…”
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Ovulation induction regimens are associated with a higher rate of livebirth after frozen single-blastocyst transfer among women with polycystic ovary syndrome by Yue Niu, Yue Niu, Yue Niu, Dingying Zhao, Dingying Zhao, Dingying Zhao, Yuhuan Wang, Yuhuan Wang, Yuhuan Wang, Lu Suo, Lu Suo, Lu Suo, Jialin Zou, Jialin Zou, Jialin Zou, Daimin Wei, Daimin Wei, Daimin Wei

“…We retrospectively compared the pregnancy and neonatal outcomes after frozen single-blastocyst transfer with endometrial preparation by HRT regimen (n = 3540), ovulation induction by human menopausal gonadotropin (hMG) regimen (n = 226), and ovulation induction by letrozole regimen (n = 175).ResultsAfter adjustment for confounders with multivariable logistic regression, the hMG regimen group [(58.4% vs. 49.6%; adjusted odds ratio (aOR): 1.43; 95% confidence interval (CI): 1.09-1.89)] and letrozole regimen group (58.9% vs. 49.6%; aOR: 1.42; 95% CI: 1.04-1.93) were associated with a higher rate of livebirth (primary outcome), compared with the group with HRT regimen. …”
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