Impact of Sr2+ and hypoxia on 3D triple cultures of primary human osteoblasts, osteocytes and osteoclasts by Katharina Wirsig, David Kilian, Max von Witzleben, Michael Gelinsky, Anne Bernhardt

“…Osteocyte gene marker expression of PDPN, MEPE, RANKL, OPG, osteocalcin and likewise the amount of secreted osteocalcin was reduced in the presence of Sr2+. …”
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Effects of different training modalities on phosphate homeostasis and local vitamin D metabolism in rat bone by Joost Buskermolen, Karen van der Meijden, Regula Furrer, Dirk-Jan Mons, Huib W. van Essen, Annemieke C. Heijboer, Paul Lips, Richard T. Jaspers, Nathalie Bravenboer

“…In cortical bone, mRNA expression levels of sclerostin (SOST), dental matrix protein 1 (DMP1), phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) and matrix extracellular phosphoglycoprotein (MEPE) were lower after PT compared to ET and PET. …”
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Genomic selection signatures in sheep from the Western Pyrenees by Otsanda Ruiz-Larrañaga, Jorge Langa, Fernando Rendo, Carmen Manzano, Mikel Iriondo, Andone Estonba

“…The major genomic difference between Sasi Ardi and Latxa sheep was on OAR6, which is known to affect milk production, with highly selected regions around the ABCG2, SPP1, LAP3, NCAPG, LCORL, and MEPE genes in Latxa sheep. The effect of the modern genetic improvement program on Latxa sheep was also evident on OAR15, on which several olfactory genes are located. …”
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PHEX^L222P Mutation Increases <i>Phex</i> Expression in a New ENU Mouse Model for XLH Disease by Carole El Hakam, Alexis Parenté, Fabienne Baraige, Laetitia Magnol, Lionel Forestier, Florent Di Meo, Véronique Blanquet

“…Actually, <i>Phex^L222P</i> mice show an increase in <i>Fgf23</i>, <i>Dmp1</i>, and <i>Mepe</i> and <i>Slc34a1 (Na-Pi IIa cotransporter)</i> mRNA expression similar to those observed in <i>Hyp</i> mice. …”
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Influence of Hydrogen Peroxide on Mineralization in Dental Pulp Cells: A Systematic Review by Alexandre Henrique dos Reis-Prado, Isadora Rodrigues Grossi, Hebertt Gonzaga dos Santos Chaves, Carolina Bosso André, Luís Fernando dos Santos Alves Morgan, André Luiz Fraga Briso, Luciano Tavares Angelo Cintra, Francine Benetti

“…Of those three studies that investigated other mineralization markers, two found a reduction in the expression of dentin matrix acidic phosphoprotein (DMP)-1, dentin sialophosphoprotein (DSPP), and matrix extracellular phosphoglycoprotein (MEPE) among some bleaching gel concentrations. In contrast, one study showed a greater expression of osteopontin (OPN) and osteocalcin (OCN) in 100 μmol/L HP after 5 or 10 min of exposure, and another study showed significant induction of DSPP in concentrations of up to 0.5 mmol/L HP.Conclusion: Especially, high concentrations of bleaching gel reduce the potential of mineralization in pulp cells in in vitro studies; however, different HP concentrations, bleaching protocols, and analysis periods can influence this outcome.…”
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Single-cell RNA sequencing identifies Fgf23-expressing osteocytes in response to 1,25-dihydroxyvitamin D3 treatment by Ayako Hanai, Ayako Hanai, Ayako Kawabata, Kenta Nakajima, Kazuhiro Masuda, Itaru Urakawa, Masahiro Abe, Yuji Yamazaki, Seiji Fukumoto

“…We first detected Dmp1, Mepe, and Phex expression in murine osteocytes by in situ hybridization and used these as marker genes of osteocytes. …”
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A Delphinidin-Enriched Maqui Berry Extract Improves Bone Metabolism and Protects against Bone Loss in Osteopenic Mouse Models by Masahiro Nagaoka, Toyonobu Maeda, Masahiro Chatani, Kazuaki Handa, Tomoyuki Yamakawa, Shuichi Kiyohara, Takako Negishi-Koga, Yasumasa Kato, Masamichi Takami, Shumpei Niida, Stefanie C. Lang, Marlena C. Kruger, Keiko Suzuki

“…MBE stimulated the osteoblastic differentiation of MC3T3-E1 cells, as indicated by enhanced mineralized nodule formation, and increased alkaline phosphatase activity, through the upregulation of bone morphogenetic protein 2 (<i>Bmp2</i>), runt-related transcription factor 2 (<i>Runx2</i>), Osterix (<i>Osx</i>), osteocalcin (<i>Ocn</i>), and matrix extracellular phosphoglycoprotein (<i>Mepe</i>) mRNA expression. Immunostaining and immunoprecipitation assays demonstrated that MBE suppressed NF-κB transnucleation through acting as a superoxide anion/peroxynitrite scavenger in MC3T3-E1 cells. …”
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Kappa-carrageenan-Functionalization of octacalcium phosphate-coated titanium Discs enhances pre-osteoblast behavior and osteogenic differentiation by Wei Cao, Wei Cao, Jianfeng Jin, Gang Wu, Nathalie Bravenboer, Marco N. Helder, Engelbert A. J. M. Schulten, Rommel G. Bacabac, Janak L. Pathak, Jenneke Klein-Nulend

“…However, κ-carrageenan (2 mg/ml) increased (1.26-fold) MC3T3-E1 pre-osteoblast spreading at 1 h i.e., κ-Carrageenan in the OCP-coating increased pre-osteoblast proliferation (max. 1.92-fold at 2 mg/ml, day 1), metabolic activity (max. 1.50-fold at 2 mg/ml, day 3), and alkaline phosphatase protein (max. 4.21-fold at 2 mg/ml, day 3), as well as matrix mineralization (max. 5.45-fold at 2 mg/ml, day 21). κ-Carrageenan (2 mg/ml) in the OCP-coating increased gene expression of Mepe (4.93-fold) at day 14, and Runx2 (2.94-fold), Opn (3.59-fold), Fgf2 (3.47-fold), Ocn (3.88-fold), and Dmp1 (4.59-fold) at day 21 in pre-osteoblasts. …”
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K-Carrageenan Stimulates Pre-Osteoblast Proliferation and Osteogenic Differentiation: A Potential Factor for the Promotion of Bone Regeneration? by Wei Cao, Jianfeng Jin, Gang Wu, Nathalie Bravenboer, Marco N. Helder, Janak L. Pathak, Behrouz Zandieh-Doulabi, Jolanda M. A. Hogervorst, Shingo Matsukawa, Lester C. Geonzon, Rommel G. Bacabac, Engelbert A. J. M. Schulten, Jenneke Klein-Nulend

“…K-carrageenan enhanced osteogenic gene expression (<i>Opn</i>, <i>Dmp1</i>, and <i>Mepe</i>) at day 14 and 21. In conclusion, κ-carrageenan promoted MC3T3-E1 pre-osteoblast adhesion and spreading, metabolic activity, proliferation, and osteogenic differentiation, suggesting that κ-carrageenan is a potential osteogenic inductive factor for clinical application to enhance bone regeneration.…”
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The Predictive Capabilities of the Auroral Electrojet Index for Medium Energy Electron Precipitation by H. Nesse Tyssøy, N. Partamies, N. Partamies, E. M. Babu, C. Smith-Johnsen, J. A. Salice

“…To explore the energy dependent time scales, each of the MEPED energy channels, &gt; 43, &gt;114, and &gt;292 keV are evaluated independently. …”
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Search for Electron Bursts in the Inner Van Allen Belts with the CSES and NOAA POES Satellites by Coralie Neubüser, Roberto Battiston, William Jerome Burger, Francesco Maria Follega, Vincenzo Vitale

“…This article presents the studied datasets of the low-energy HEPP instrument onboard the CSES-01 satellite and the electron telescopes of the MEPED detector onboard the NOAA POES-19 satellite, introduces the method for the background estimation, and discusses the first correlation studies of particle bursts with geomagnetic indices obtained within this framework.…”
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Energetic particle counterparts for geomagnetic pulsations of Pc1 and IPDP types by T. A. Yahnina, A. G. Yahnin, J. Kangas, J. Manninen, D. S. Evans, A. G. Demekhov, V. Yu. Trakhtengerts, M. F. Thomsen, G. D. Reeves, B. B. Gvozdevsky

“…These flux variation types have a common feature, i.e. the presence of precipitating protons measured by the MEPED instrument at energies more than 30 keV, but they are distinguished by the fact of the presence or absence of the lower-energy component as measured by the TED detector on board the NOAA satellite. …”
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A educação do campo no estado do Espírito Santo: os movimentos sociais e a materialização das lutas = The education field in the State of Espírito Santo: the social movements and t... by Bicalho, Ramofly

“…Dentre as iniciativas pesquisadas, destacamos: o Movimento de Educação Promocional do Espírito Santo (Mepes), as Escolas Comunitárias Rurais (Ecors), a Regional das Associações dos Centros Familiares de Formação em Alternância do Espírito Santo (Raceffaes), a Federação dos Trabalhadores na Agricultura no Espírito Santo (Fetaes), o Movimento dos Pequenos Agricultores (MPA), a Educação Indígena, Educação Quilombola e o Movimento dos Trabalhadores Rurais Sem Terra (MST). …”
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The high-energy tail of energetic electron precipitation: solar wind drivers and geomagnetic responses by Josephine Salice, Hilde Nesse, Noora Partamies, Emilia Kilpua, Andrew Kavanagh, Margot Decotte, Eldho Babu, Christine Smith-Johnsen

“…This study utilizes EEP flux data from MEPED aboard the POES/Metop satellites from 2004–2014. …”
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