Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome? by Lohith, Talakad G., Osterweil, Emily, Fujita, Masahiro, Jenko, Kimberly J., Bear, Mark, Innis, Robert B.

“…Recent animal studies suggest that upregulated downstream signaling by metabotropic glutamate receptor 5 (mGluR5) might be an important mechanism for cognitive and behavioral abnormalities associated with FXS. …”
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Plasma endocannabinoids in cocaine dependence and their relation to cerebral metabotropic glutamate receptor 5 density by Sara L. Kroll, Lea M. Hulka, Ann-Kathrin Kexel, Matthias Vonmoos, Katrin H. Preller, Valerie Treyer, Simon M. Ametamey, Markus R. Baumgartner, Carola Boost, Franziska Pahlisch, Cathrin Rohleder, F. Markus Leweke, Boris B. Quednow

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Anti‐metabotropic glutamate receptor 5 encephalitis: Five case reports and literature review by Sixian Chen, Haitao Ren, Fuhong Lin, Siyuan Fan, Yuze Cao, Weili Zhao, Hongzhi Guan, the Encephalitis Collaborative Group

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Nicotine Use and Metabotropic Glutamate Receptor 5 in Individuals With Major Depressive and Posttraumatic Stress Disorders by Stephen R. Baldassarri, Ruth H. Asch, Ansel T. Hillmer, Robert H. Pietrzak, Nicole DellaGioia, Irina Esterlis, Margaret T. Davis

“…Metabotropic glutamate receptor 5 (mGluR5) dysregulation has been implicated in the pathophysiology of many psychiatric disorders, as well as nicotine use and dependence. …”
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Metabotropic glutamate receptor 5 (mGluR5) regulates white adipocyte browning by LUO Xie, ZENG Li, YUAN Lei

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Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5). by Christopher M Olsen, Daniel S Childs, Gregg D Stanwood, Danny G Winder

“…Pharmacological and genetic studies have suggested that the metabotropic glutamate receptor 5 (mGluR5) is critically involved in mediating the reinforcing effects of drugs of abuse, but not food. …”
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Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function by Uematsu, Ken, Heiman, Myriam, Zelenina, Marina, Padovan, Julio, Chait, Brian T., Aperia, Anita, Nishi, Akinori, Greengard, Paul

“…Metabotropic glutamate receptor 5 (mGluR5) regulates excitatory post-synaptic signaling in the central nervous system (CNS) and is implicated in various CNS disorders. …”
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Metabotropic Glutamate Receptor 5 in the Dysgranular Zone of Primary Somatosensory Cortex Mediates Neuropathic Pain in Rats by Geehoon Chung, Yeong-Chan Yun, Chae Young Kim, Sun Kwang Kim, Sang Jeong Kim

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THE ROLE OF METABOTROPIC GLUTAMATE RECEPTOR 5 IN THE NUCLEUS ACCUMBENS SHELL ON EXTINCTION AND REINSTATEMENT OF MORPHINE PLACE PREFERENCE IN RATS by Roghayeh Mozafari, Fariba Khodagholi, Mohammad Esmaeil Zibaei, Abbas Haghparast, Peter Kalivas

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Metabotropic glutamate receptor 5 : a therapeutic target in Fragile X and a regulator of plasticity in visual cortex by Sidorov, Michael S. (Michael Samuel)

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Preliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders by Siyan Fan, Ruth H. Asch, Margaret T. Davis, Nicole DellaGioia, Ryan Cool, Hilary P. Blumberg, Irina Esterlis

“…Prior work also showed differentiation in metabotropic glutamate receptor 5 (mGlu5) abnormalities in BD versus MDD, which could be a mechanism affected in the frontotemporal system. …”
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The novel peptide LCGM-10 attenuates metabotropic glutamate receptor 5 activity and demonstrates behavioral effects in animal models by Anton V. Malyshev, Vsevolod V. Pavshintcev, Nikita A. Mitkin, Iuliia A. Sukhanova, Vasilina R. Gedzun, Alexander S. Zlobin, Igor I. Doronin, Gennady A. Babkin, Tomi K. Sawyer

“…We employed a structural bioinformatics approach to develop novel peptides with predicted affinity to the binding site for negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGluR5). Primary screening in zebrafish (Danio rerio) revealed a stimulatory effect of two peptides, LCGM-10 and LCGM-15. …”
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The change of metabotropic glutamate receptor 5 expression level in rats with late-stage traumatic brain injury and the therapeutic effect of taurine by Ying CAI, Hui-ling HUANG, Wei-jia FAN, Qiao-li WU

“…<p><strong>Objective </strong> To investigate the change of metabotropic glutamate receptor 5 (mGluR5) expression level in rats with late-stage (the 7th day) traumatic brain injury (TBI) and the role of taurine.…”
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β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X by Laura J. Stoppel, Benjamin D. Auerbach, Rebecca K. Senter, Anthony R. Preza, Robert J. Lefkowitz, Mark F. Bear

“…Neural activity directs local protein synthesis via activation of metabotropic glutamate receptor 5 (mGlu5), yet how mGlu5 couples to the intracellular signaling pathways that regulate mRNA translation is poorly understood. …”
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Prevention of L-Dopa-Induced Dyskinesias by MPEP Blockade of Metabotropic Glutamate Receptor 5 Is Associated with Reduced Inflammation in the Brain of Parkinsonian Monkeys by Marc Morissette, Mélanie Bourque, Marie-Ève Tremblay, Thérèse Di Paolo

“…We previously reported that MPEP (a metabotropic glutamate receptor 5 antagonist) reduced the development of LID in de novo MPTP-lesioned monkeys. …”
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ß-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X by Auerbach, Benjamin D., Lefkowitz, Robert J., Stoppel, Laura Jane, Senter, Rebecca K, Preza, Anthony R., Bear, Mark

“…Neural activity directs local protein synthesis via activation of metabotropic glutamate receptor 5 (mGlu[subscript 5]), yet how mGlu[subscript 5] couples to the intracellular signaling pathways that regulate mRNA translation is poorly understood. …”
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β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X by Auerbach, Benjamin D., Lefkowitz, Robert J., Stoppel, Laura Jane, Senter, Rebecca K, Preza, Anthony R., Bear, Mark

“…Neural activity directs local protein synthesis via activation of metabotropic glutamate receptor 5 (mGlu 5 ), yet how mGlu 5 couples to the intracellular signaling pathways that regulate mRNA translation is poorly understood. …”
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Effects of the Positive Allosteric Modulator of Metabotropic Glutamate Receptor 5, VU-29, on Maintenance Association between Environmental Cues and Rewarding Properties of Ethanol in Rats by Marta Marszalek-Grabska, Kinga Gawel, Dariusz Matosiuk, Ewa Gibula-Tarlowska, Joanna Listos, Jolanta H. Kotlinska

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Case report: Orthostatic leg tremor as the initial manifestation in a patient with metabotropic glutamate receptor-5 encephalitis without cortical dysfunction: complexities in identification and treatment by Xia Yang, Qiong Liu, Ming-feng Lai, Xiao-hong Ma, Xiao-hong Ma, Xiao-ting Hao, Jia-jun Xu, Wan-jun Guo

“…ObjectiveMetabotropic glutamate receptor 5 (mGluR5) encephalitis is such a rare type of autoimmune encephalitis that its diagnosis remains a challenge.Case reportA 19-year-old female patient initially presented with anxiety and orthostatic leg tremors without cortical dysfunction. …”
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Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer’s disease: A [18F]PSS232 PET/MRI study by Jie Wang, Yingfang He, Xing Chen, Lin Huang, Junpeng Li, Zhiwen You, Qi Huang, Shuhua Ren, Kun He, Roger Schibli, Linjing Mu, Yihui Guan, Qihao Guo, Jun Zhao, Fang Xie

Subjects: “…Metabotropic glutamate receptor 5…”
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