Comparison of the Efficacies of Direct-Acting Antiviral Treatment for HCV Infection in People Who Inject Drugs and Non-Drug Users by Jui-Ting Hsu, Ping-I Hsu, Chang-Bih Shie, Seng-Kee Chuah, I-Ting Wu, Wen-Wei Huang, Sheng-Yeh Tang, Kun-Feng Tsai, Li-Fu Kuo, Supratip Ghose, Jui-Che Hsu, Chih-An Shih

“…<i>Materials and Methods</i>: In this retrospective cohort study, we included 53 PWIDs with HCV infections treated on site in a methadone program and 106 age- and sex-matched patients with HCV infections who had no history of opioid injection (ratio of 1:2). …”
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Project CHARIOT: study protocol for a hybrid type 1 effectiveness-implementation study of comprehensive tele-harm reduction for engagement of people who inject drugs in HIV prevent... by Tyler S. Bartholomew, Marina Plesons, David P. Serota, Elizabeth Alonso, Lisa R. Metsch, Daniel J. Feaster, Jessica Ucha, Edward Suarez, David W. Forrest, Teresa A. Chueng, Katrina Ciraldo, Jimmie Brooks, Justin D. Smith, Joshua A. Barocas, Hansel E. Tookes

“…For MOUD, engagement is defined as screening positive for norbuprenorphine or methadone on urine drug screen; or naltrexone or buprenorphine injection within the previous 4 weeks. …”
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Development of a decision support tool for primary care management of patients with abnormal liver function tests without clinically apparent liver disease: a record-linkage popula... by PT Donnan, D McLernon, JF Dillon, S Ryder, P Roderick, F Sullivan, W Rosenberg

“…All LFTs were predictive of liver disease, and high probability of liver disease was associated with being female, methadone use, alcohol dependency and deprivation. …”
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A Novel UHPLC-MS/MS Method for the Quantification of Seven Opioids in Different Human Tissues by Alessandra Manca, Amedeo De Nicolò, Elisa Delia De Vivo, Micol Ferrara, Sharon Oh, Sahar Khalili, Niamh Higgins, Robert G. Deiss, Stefano Bonora, Jessica Cusato, Alice Palermiti, Jacopo Mula, Sara Gianella, Antonio D’Avolio

“…Methods: We describe an ultra-high-performance liquid chromatography coupled with tandem mass spectrometry method for the simultaneous quantification of methadone, morphine, oxycodone, hydrocodone, oxymorphone, hydromorphone and fentanyl in several tissues: liver, brain, kidney, abdominal adipose tissue, lung and blood plasma. …”
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First-line opioid agonist treatment as prevention against assisting others in initiating injection drug use: A longitudinal cohort study of people who inject drugs in Vancouver, Ca... by Zachary Bouck, Andrea C. Tricco, Laura C. Rosella, Hailey R. Banack, Matthew P. Fox, Robert W. Platt, M-J Milloy, Kora DeBeck, Kanna Hayashi, Dan Werb

“…As these factors may reflect an underlying substance use disorder, we investigated whether first-line oral opioid agonist treatment (OAT; methadone or buprenorphine/naloxone) reduces the likelihood that people who inject drugs help others initiate injecting. …”
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A cohort study examining emergency department visits and hospital admissions among people who use drugs in Ottawa, Canada by Claire E. Kendall, Lisa M. Boucher, Amy E. Mark, Alana Martin, Zack Marshall, Rob Boyd, Pam Oickle, Nicola Diliso, Dave Pineau, Brad Renaud, Tiffany Rose, Sean LeBlanc, Mark Tyndall, Olivia M. Lee, Ahmed M. Bayoumi

“…After adjustment, factors predicting more ED visits were receiving disability (adjusted odds ratio [AOR] 3.0; 95% CI 1.7–5.5) or income assistance (AOR 2.7; 95% CI 1.5–5.0), injection drug use (AOR 2.1; 95% CI 1.3–3.4), incarceration within 12 months (AOR 1.6; 95% CI 1.1–2.4), mental health comorbidity (AOR 2.1; 95% CI 1.4–3.1), and a suicide attempt within 12 months (AOR 2.1; 95% CI 1.1–3.4). Receiving methadone (AOR 0.5; 95% CI 0.3–0.9) and having a regular family physician (AOR 0.5; 95% CI 0.2–0.9) were associated with lower odds of having more ED visits. …”
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Temporal trend of drug overdose-related deaths and excess deaths during the COVID-19 pandemic: a population-based study in the United States from 2012 to 2022Research in context by Yunyu Zhao, Yi Liu, Fan Lv, Xinyuan He, Wee Han Ng, Sikai Qiu, Lanting Zhang, Zixuan Xing, Yuxin Guo, Jian Zu, Yee Hui Yeo, Fanpu Ji

“…All drug types except heroin experienced varying degrees of excess ASMRs, with prescription opioid pain relievers (23.5%–55.1%), benzodiazepines (27.4%–40.9%) and antidepressants (10.4%–17.8%) exhibiting consistent increases from 2020 to 2022, while the excess ASMRs for illicit fentanyl and synthetics (25.3%–10.0%), psychostimulants (32.8%–14.6%) and methadone (35.0%–33.3%) decreased between 2021 and 2022. …”
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Aprazamento seguro da terapia analgésica com opioides no paciente queimado: um estudo transversal [Safe opioid analgesic therapy dose scheduling for burn patients: a cross-sectiona... by Danielle de Mendonça Henrique, Lolita Dopico da Silva, Flavia Giron Camerini, Karla Biancha Silva Andrade, Sandra Regina Maciqueira Pereira, Cintia Silva Fassarella

“…Results: analgesia was predominantly with the opioids: tramadol (45.49%) and methadone (18.45%). Predominant administration times were 10pm and 6pm. …”
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HIV testing among incarcerated people with a history of HIV-related high-risk behaviours in Iran: Findings from three consecutive national bio-behavioural surveys by Fatemeh Tavakoli, Najmeh Parhizgari, Mostafa Shokoohi, Mehrdad Khezri, Ali Akbar Haghdoost, Iman Ghasemzadeh, Ivana Bozicevic, Armita Shahesmaeili, Naser Nasiri, Ahmad Danesh, Mohammad Karamouzian, Hamid Sharifi

“…Our multivariable multinomial regression model showed older age (Relative-risk ratio [RRR]: 1.24, 95% Confidence Intervals [CI]: 1.05, 1.47), history of the previous incarceration (RRR: 1.46, 95% CI: 1.24, 1.71), currently receiving methadone maintenance therapy inside prison (RRR: 2.09, 95% CI: 1.81, 2.43), having access to condoms inside prison (RRR: 1.42, 95% CI: 1.20, 1.68) and sufficient HIV knowledge (RRR: 1.74, 95% CI: 1.47, 2.05) were significantly associated with an increased probability of having an HIV test in the last 12 months inside prison. …”
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Design, Synthesis, and In Vivo Evaluation of C1-Linked 4,5-Epoxymorphinan Haptens for Heroin Vaccines by Agnieszka Sulima, Fuying Li, Jeffrey Brian Morgan, Phong Truong, Joshua F. G. Antoline, Therese Oertel, Rodell C. Barrientos, Oscar B. Torres, Zoltan Beck, Gregory H. Imler, Jeffrey R. Deschamps, Gary R. Matyas, Arthur E. Jacobson, Kenner C. Rice

“…None of the TT–hapten conjugates induced antibodies that cross-reacted with morphine, methadone, naloxone, or naltrexone, and only TT-<b>3</b> interacted weakly with buprenorphine, and that subtle structural difference, especially at the C6 position, can vastly alter the specificity of the induced antibodies. …”
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Comparing clonidine and dexmedetomidine effects in the treatment of opiate withdrawal syndrome in poisoned patients by Azadeh Memarian, Mahdiye Abiyarghamsari, Shahin Shadnia, Babak Mostafazadeh, Peyman Erfan Talab Evini, Mahdiye Golestani Fard, Mitra Rahimi

“…Fifty-two patients, matched based on the type of drug use (methadone, opiate, heroin), were included and divided into 2 groups. …”
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A community-based intervention to decrease the prevalence of HIV viremia among people who inject drugs in Vietnam by Huong Thi Duong, Jean-Pierre Moles, Khue Minh Pham, Roselyne Vallo, Giang Thi Hoang, Vinh Hai Vu, Oanh Thi Hai Khuat, Thanh Tuyet Thi Nham, Duc Quang Nguyen, Catherine Quillet, Delphine Rapoud, Philippe Van de Perre, Joëlle Castellani, Jonathan Feelemyer, Laurent Michel, Didier Laureillard, Don Des Jarlais, Nicolas Nagot

“…Methods: Between 2016 and 2020, we implemented an intervention consisting of mass HIV screening of PWID using three annual respondent-driven sampling surveys (RDSS) and a post-intervention evaluation RDSS in community-based organisation (CBO) sites, coupled with peer support to facilitate/improve access to antiretroviral and methadone therapy in Haiphong, Vietnam. The primary outcome was the proportion of identified uncontrolled HIV-positive PWID who achieved viral control. …”
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Using a pragmatically adapted, low-cost contingency management intervention to promote heroin abstinence in individuals undergoing treatment for heroin use disorder in UK drug serv... by Julian Mutz, Andrew Pickles, Sarah Byford, John Dunn, Kimberley Goldsmith, Franziska Mosler, Tim Weaver, James Shearer, Emily Finch, John Strang, Clare Davey, Stephen Pilling, Anthony Glasper, Nicola Metrebian, Jennifer Hellier, Luke Mitcheson, Prun Bijral, Nadine Bogdan, Owen Bowden-Jones, Edward Day, Sam Forshall, Shabana Akhtar, Jalpa Bajaria, Carmel Bennett, Elizabeth Bishop, Vikki Charles, Roopal Desai, Claire Goodfellow, Farjana Haque, Nicholas Little, Hortencia McKechnie, Jo Morris, Ruth Pauli, Dilkushi Poovendran, Elizabeth Phillips

“…Introduction Most individuals treated for heroin use disorder receive opioid agonist treatment (OAT)(methadone or buprenorphine). However, OAT is associated with high attrition and persistent, occasional heroin use. …”
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A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary... by Irene García García, Miguel Rodriguez-Rubio, Amelia Rodríguez Mariblanca, Lucía Martínez de Soto, Lucía Díaz García, Jaime Monserrat Villatoro, Javier Queiruga Parada, Enrique Seco Meseguer, María J. Rosales, Juan González, José R. Arribas, Antonio J. Carcas, Pedro de la Oliva, Alberto M. Borobia

“…Treatment with drugs that may prolong QT in the last month before randomization for more than 7 days including: azithromycin, chlorpromazine, cisapride, clarithromycin, domperidone, droperidol, erythromycin, halofantrine, haloperidol, lumefantrine, mefloquine, methadone, pentamidine, procainamide, quinidine, quinine, sotalol, sparfloxacin, thioridazine, amiodarone. …”
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Rapid and Accurate Diagnosis of Substance Abuse: A Narrative Review by Fatemeh Heidarzadeh, MohammadHossein Shahrabadi, Shahideh Rostami, Majid Pazoki, Hessan Abbasi, Seyed Morteza Hosseiniara, SeyedReza Hosseiniara

“…The finding that amphetamines, methadone, and tetrahydrocannabinol are readily detectable after inhalation has led to further development of this matrix for the detection of substance abuse [43]. ... …”
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Policies Affecting Pregnant Women with Substance Use Disorder by Colburn Yu

“…Rather than family medicine, OB/GYN, or emergency medicine healthcare workers having to refer their patients to an addiction specialist, they could treat patients with methadone for maintenance or detoxification where they would deliver their baby. …”
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Homeward by Julia K. Nguyen

“…The involuntary jerking had stopped and he only had some pain when turning. Methadone, lorazepam, and haloperidol were held. For the next nine days, we titrated the KFM. …”
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13th National Congress of the South African Society of Psychiatrists, 20-23 September 2004 by Eugene Allers, Christer Allgulander, Sean Exner Baumann, Charles L Bowden, P Buckley, David J Castle, Beatrix J Coetzee, Franco Colin, A M Dikobe, Charl Els, Robin Emsley, Senathi Fisha, A E Gangat, T Goba, Gerhard Grundling, Jürgen Harms, S M Hawkridge, Erick Hollander, M L Janet, A B R Janse van Rensburg, Shabeer Ahmed Jeeva, J A Joska, Andre Joubert, Sean Z Kaliski, V N Khanyile, Fred Kigozi, B Levinson, Marilyn Lucas, E N Madela-Mntla, M Y H Moosa, Piet Oosthuizen, Ted Parran, A Pauw, Willie Pienaar, Felix Potocnik, Ramovha Rachel, J. L Roos, Steven P Roose, Martin Scholtz, Soraya Seedat, M Spitzer, Dan J Stein, Ugash Subramaney, Dave Swingler, Christopher Paul Szabo, Godfrey B Tangwa, Michael Trimble, H van der Bijl, L M van der Merwe, Vasi van Deventer, C W van Staden, W J C Verbeeck, G C Verster, Merryll Vorster, Bruce Lydiard

“…Integration of Pharmacotherapy for Opioid dependence into general psychiatric practice: Naltrexone, Methadone and Buprenorphine/ Naloxone Ted Parran 47. …”
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Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017); Venice (Italy); October 31-November 4, 2017; Session "Neurology and Follow-up" by --- Various Authors

“…ATYPICAL BRAIN DEVELOPMENT ASSOCIATED WITH PRENATAL METHADONE EXPOSURE • V. Monnelly, D. Anblagan, A. Quigley, E. …”
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The Effect of Corona Anxiety and Death Anxiety on Maternal-Child Conflict in Home Quarantine related to :COVID-19 by Sahar Ehsani, Abbas Shahverdi, Manijeh Firouzi, Fatemeh Soltani

“…Comparison of the effectiveness of two cognitive-behavioral and mother-child interactive therapies on anxiety of children with under-methadone treatment mother. Iranian Journal of Psychiatry and Clinical Psychology, 23(2), 136-147. …”
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