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17441
Canonical MicroRNA Activity Facilitates but May Be Dispensable for Transcription Factor-Mediated Reprogramming
Published 2015-12-01“…MicroRNAs (miRNAs) are important regulators of reprogramming of somatic cells into induced pluripotent stem cells (iPSCs); however, it is unclear whether miRNAs are required for reprogramming and whether miRNA activity as a whole facilitates reprogramming. …”
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17442
Emerging Role of MicroRNA-30c in Neurological Disorders
Published 2022-12-01“…MicroRNAs (miRNAs or miRs) are a class of small non-coding RNAs that negatively regulate the expression of target genes by interacting with 3′ untranslated regions of target mRNAs to induce mRNA degradation and translational repression. …”
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17443
Developmental conservation of microRNA gene localization at the nuclear periphery.
Published 2019-01-01“…microRNAs are of vital importance for the regulation of the adaptive and innate immune responses, modulating gene expression at the post transcriptional level. …”
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17444
microRNA biomarkers in cystic diseases
Published 2013-07-01“…microRNAs (miRNAs) are small non-coding RNAs that regulategene expression by targeting the 3’-untranslated region of multipletarget genes. …”
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17445
miR-10a regulates proliferation of human cardiomyocyte progenitor cells by targeting GATA6.
Published 2014-01-01“…microRNAs (miRNAs) play essential roles in cardiogenesis. …”
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17446
Pan-cancer characterisation of microRNA with hallmarks of cancer reveals role of microRNA-mediated downregulation of tumour suppressor genes
Published 2018“…microRNAs are key regulators of the human transcriptome across a number of diverse biological processes, such as development, aging and cancer, where particular miRNAs have been identified as tumour suppressive and oncogenic. …”
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17447
Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors
Published 2018“…microRNAs are key regulators of the human transcriptome across a number of diverse biological processes, such as development, aging and cancer, where particular miRNAs have been identified as tumour suppressive and oncogenic. …”
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17448
Primary microRNA transcripts are processed co-transcriptionally.
Published 2008“…microRNAs (miRNAs) are generated from long primary (pri-) RNA polymerase II (Pol II)-derived transcripts by two RNase III processing reactions: Drosha cleavage of nuclear pri-miRNAs and Dicer cleavage of cytoplasmic pre-miRNAs. …”
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17449
Pattern recognition receptor mediated downregulation of microRNA-650 fine-tunes MxA expression in dendritic cells infected with Influenza A virus
Published 2016“…MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression, which have been shown to fine-tune innate immune responses downstream of pattern recognition receptor (PRR) signaling. …”
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17450
Primary microRNA transcripts are processed co-transcriptionally.
Published 2008“…microRNAs (miRNAs) are generated from long primary (pri-) RNA polymerase II (Pol II)-derived transcripts by two RNase III processing reactions: Drosha cleavage of nuclear pri-miRNAs and Dicer cleavage of cytoplasmic pre-miRNAs. …”
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17451
Dicer is selectively important for the earliest stages of erythroid development.
Published 2012“…MicroRNAs (miRs) are involved in many aspects of normal and malignant hematopoiesis, including hematopoietic stem cell (HSC) self-renewal, proliferation, and terminal differentiation. …”
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17452
Potential Biomarkers of miR-371–373 Gene Cluster in Tumorigenesis
Published 2021-09-01“…microRNAs (miRNAs) are small non-coding RNA transcripts (20–24 nucleotides) that bind to their complementary sequences in the 3′-untranslated regions (3′-UTR) of targeted genes to negatively or positively regulate their expression. miRNAs affect the expression of genes in cells, thereby contributing to several important biological processes, including tumorigenesis. …”
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17453
miR-203 Acts as a Tumor Suppressor Gene in Osteosarcoma by Regulating RAB22A.
Published 2015-01-01“…microRNAs (miRNAs), small noncoding RNAs of 19-25 nt, play an important roles in the pathological processes of tumorigenesis. …”
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17454
The Role and Mechanism of microRNA-1224 in Human Cancer
Published 2022-04-01“…microRNAs (miRNAs) are a type of small endogenous non-coding RNAs composed of 20-22 nucleotides, which can regulate the expression of a gene by targeting 3’ untranslated region (3’-UTR) of mRNA. …”
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17455
Recent Advances in miRNA Delivery Systems
Published 2021-01-01“…MicroRNAs (miRNAs) represent a family of short non-coding regulatory RNA molecules that are produced in a tissue and time-specific manner to orchestrate gene expression post-transcription. …”
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17456
Conserved expression patterns predict microRNA targets.
Published 2009-09-01“…microRNAs (miRNAs) are major regulators of gene expression and thereby modulate many biological processes. …”
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17457
miRNAs: Potential as Biomarkers and Therapeutic Targets for Cancer
Published 2023-06-01“…MicroRNAs (miRNAs) are single-stranded, non-coding RNA molecules that regulate gene expression post-transcriptionally by binding to messenger RNAs. miRNAs are important regulators of gene expression, and their dysregulation is implicated in many human and canine diseases. …”
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17458
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER
Published 2014“…MicroRNAs are small regulatory RNAs that post transcriptionally control gene expression. …”
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17459
Advancing GCT Management: A Review of miR-371a-3p and Other miRNAs in Comparison to Traditional Serum Tumor Markers
Published 2024-03-01“…MicroRNAs, short non-protein coding RNAs, are overexpressed in GCTs. …”
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17460
miRacle of microRNA-Driven Cancer Nanotherapeutics
Published 2022-08-01“…MicroRNAs (miRNAs) are non-protein-coding RNA molecules 20–25 nucleotides in length that can suppress the expression of genes involved in numerous physiological processes in cells. …”
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