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8201
Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis
Published 2024-01-01“…This regulation was mediated by the deubiquitinating enzyme USP7. Methods A tissue microarray was used to measure the expression of KPNB1 and USP7 in glioma tissues. …”
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8202
Expanding the Molecular Spectrum of <i>ANKRD11</i> Gene Defects in 33 Patients with a Clinical Presentation of KBG Syndrome
Published 2022-05-01“…By using a multi-testing genomic approach, including gene sequencing, Chromosome Microarray Analysis (CMA), and RT-qPCR gene expression assay, we searched for pathogenic alterations in <i>ANKRD11</i>. …”
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8203
The Role of lncRNAs TAPIR-1 and -2 as Diagnostic Markers and Potential Therapeutic Targets in Prostate Cancer
Published 2020-04-01“…We identified two intergenic long non-coding transcripts, located in close genomic proximity, which are highly expressed in PCa. Microarray studies on a larger cohort comprising 155 patients showed a profound diagnostic potential of these transcripts (AUC~0.94), which we designated as tumor associated prostate cancer increased lncRNA (<i>TAPIR-1</i> and <i>-2</i>). …”
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8204
KDM5A mutations identified in autism spectrum disorder using forward genetics
Published 2020-12-01“…To determine if KDM5A mutations cause ASD in humans, we screened whole exome sequencing and microarray data from a clinical cohort. We identified pathogenic KDM5A variants in nine patients with ASD and lack of speech. …”
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8205
Human umbilical cord mesenchymal stem cell-derived extracellular vesicles alleviated silica induced lung inflammation and fibrosis in mice via circPWWP2A/miR-223–3p/NLRP3 axis
Published 2023-02-01“…We found that miR-223–3p was significantly decreased in macrophages and lung tissues of mice after silica treatment, which were consistent with the results of GEO database microarray analysis. Notably, NLRP3 is a target gene downstream of miR-223–3p. …”
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8206
System biology review of multiple sclerosis and discovery of drug targets (ORP-54)
Published 2023-01-01“…Summary: Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammatory-demyelinating events in the central nervous system. will be The aim of this study is to identify the genes and metabolic pathways effective in the disease using microarray data and to create gene interaction networks. …”
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8207
IGF2 mRNA Binding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis
Published 2019-09-01“…In an IMP2-2 transgenic mouse model microarray and qPCR analyses revealed increased expression of liver progenitor cell (LPC) markers Bex1, Prom1, Spp1, and Cdh1 indicating a de-differentiated liver cell phenotype. …”
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8208
Mechano-growth factor E-domain modulates cardiac contractile function through 14-3-3 protein interactomes
Published 2022-11-01“…Fractional shortening analysis also showed a similar trend, but with no significant change in cardiac geometry. Microarray analysis discovered 21 genes (FDR p < 0.01), that were expressed accordant with the opposing effects on contractile function at 4.5 mg/kg/day, with the nuclear receptor subfamily 4 group A member 2 (Nr4a2) identified as a potential target of peptide regulation. …”
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8209
Renal Genetics Clinic: 3-Year Experience in the Cleveland ClinicPlain-Language Summary
Published 2023-02-01“…Genetic testing was recommended in 292 (94.5%) patients including chromosomal microarray (8.9%), single-gene tests (19.5%), multigene panels (77.3%), and exome sequencing (17.5%). 80.5% of patients received insurance coverage for genetic testing. 45% (115/256) of patients had positive results, 25% (64/256) had variants of unknown significance, and 22.3% (57/256) had negative results. 43 distinct monogenic disorders were diagnosed. …”
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8210
Identification and validation of a pyroptosis-related signature in identifying active tuberculosis via a deep learning algorithm
Published 2023-11-01“…The complexities inherent to its diagnosis significantly hamper the initiatives aimed at its control and eventual eradication.MethodologyUtilizing the Gene Expression Omnibus (GEO), we procured two dedicated microarray datasets, labeled GSE39940 and GSE37250. …”
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8211
Impact of COVID-19 Nonpharmaceutical Interventions on Pneumococcal Carriage Prevalence and Density in Vietnam
Published 2023-02-01“…Pneumococci were quantified using lytA quantitative PCR and serotyped by DNA microarray. Overall, capsular, and nonencapsulated pneumococcal carriage and density were assessed in each NPI period compared with the pre-COVID-19 period using unadjusted log-binomial and linear regression. …”
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8212
Prenatal diagnosis of fetal digestive system malformations and pregnancy outcomes at a tertiary referral center in Fujian, China: A retrospective study
Published 2023-11-01“…Genetic etiology was investigated using conventional karyotyping, chromosome microarray analysis (CMA), and whole-exome sequencing (WES). …”
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8213
Low Protein Expression of both <i>ATRX</i> and <i>ZNRF3</i> as Novel Negative Prognostic Markers of Adult Adrenocortical Carcinoma
Published 2021-01-01“…Two pathologists analyzed immuno-stained slides of a tissue microarray. The low protein expression of <i>ATRX</i> and <i>ZNRF3</i> was associated with a decrease in overall survival (OS) (<i>p</i> = 0.045, <i>p</i> = 0.012, respectively). …”
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8214
Analysis of chromosomal structural variations in patients with recurrent spontaneous abortion using optical genome mapping
Published 2023-09-01“…Unfortunately, routine techniques such as karyotyping, fluorescence in situ hybridization (FISH), chromosomal microarray analysis (CMA), and copy number variation sequencing (CNV-seq) cannot detect all types of SVs. …”
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8215
Indirect effects of 13-valent pneumococcal conjugate vaccine on pneumococcal carriage in children hospitalised with acute respiratory infection despite heterogeneous vaccine covera...
Published 2021-06-01“…Pneumococci were detected using lytA quantitative real-time PCR and serotyped using microarray. PCV13 status and village-level PCV13 coverage were determined using written immunisation records. …”
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8216
Characterization of a novel Plasmodium falciparum merozoite surface antigen and potential vaccine target
Published 2023-04-01“…We analyzed IgG and IgM responses against the common variants of ARMA in independent prospective cohort studies in Burkina Faso (N = 228), Kenya (N = 252) and Mali (N = 195) using a custom microarray, Div-KILCHIP.ResultsWe found a marked population structure between parasites from Africa and Asia. …”
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8217
Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2
Published 2021-07-01“…Subsequent cellular and biochemical analyses revealed that DR5 interacted specifically with recombinant FasL–Fc protein, although the strength of this interaction was approximately 60-fold lower than the affinity between TRAIL and DR5. A microarray assay using joint tissues from mice with arthritis implied that the chemokine CX3CL1 may play an important downstream role of the interaction. …”
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8218
SARS-CoV-2 Proteins Bind to Hemoglobin and Its Metabolites
Published 2021-08-01“…Six short sequences in the RBD and 11 in the NTD of the spike were identified by microarray of peptides to interact with Hb and tree motifs in the N protein by in silico analysis to bind with heme. …”
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8219
Elevating CDCA3 Levels Enhances Tyrosine Kinase Inhibitor Sensitivity in TKI-Resistant EGFR Mutant Non-Small-Cell Lung Cancer
Published 2021-09-01“…We demonstrate that in a small-cohort tissue microarray and in vitro LUAD cell line panel, CDCA3 protein levels are elevated in EGFR mutant NSCLC as a result of increased protein stability downstream of receptor tyrosine kinase signalling. …”
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8220
Single-cell RNA and transcriptome sequencing profiles identify immune-associated key genes in the development of diabetic kidney disease
Published 2023-03-01“…ScRNA-seq and transcriptome sequencing were performed here to identify cell types and key genes associated with DKD.MethodsHere, this study conducted the analysis through five microarray datasets of DKD (GSE131882, GSE1009, GSE30528, GSE96804, and GSE104948) from gene expression omnibus (GEO). …”
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