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8361
Signature-tagged mutagenesis: barcoding mutants for genome-wide screens.
Published 2006“…By combining whole-genome microarrays and comprehensive ordered libraries of mutants, high-throughput functional screens can now be achieved on a genomic scale.…”
Journal article -
8362
Understanding non-coding DNA regions in yeast.
Published 2013“…In the present review, we discuss advantages and limitations of recently developed sequencing techniques, such as ESTs, DNA microarrays, RNA-Seq (RNA sequencing), DRS (direct RNA sequencing) and TIF-Seq (transcript isoform sequencing). …”
Journal article -
8363
Altered expression of glycan patterns and glycan-related genes in the medial prefrontal cortex of the valproic acid rat model of autism
Published 2022-12-01“…Following confirmation of reduced sociability and increased self-grooming behaviors in VPA-treated offspring, we analyzed the alterations in the expression profile of glycan patterns and glycan-related genes by lectin microarrays and RNA-seq, respectively. Lectin microarrays detected 14 significantly regulated lectins in VPA rats, with an up-regulation of high-mannose with antennary and down-regulation of Siaα2-3 Gal/GalNAc. …”
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Article -
8364
DOG1 as a novel antibody-drug conjugate target for the treatment of multiple gastrointestinal tumors and liver metastasis
Published 2023-01-01“…The DOG1 expression profile was determined among TCGA samples and tissue microarrays. High levels of DOG1 expression were ubiquitously observed in multiple cancer samples from the alimentary tract determined by TCGA samples and tissue microarrays. …”
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8365
Increases prognostic value of clinical-pathological nomogram in patients with esophageal squamous cell carcinoma
Published 2023-02-01“…Subsequently, the tumor tissues of all patients were prepared into tissue microarrays. AIPATHWELL software was employed to explore tissue microarrays and calculate the tumor-stroma ratio. …”
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8366
Multiple-model machine learning identifies potential functional genes in dilated cardiomyopathy
Published 2023-01-01“…We aim to develop a novel overall normalized sum weight of multiple-model MLs to assess the diagnosing value in DCM.MethodsGene expression data were selected from previously published databases (six sets of eligible microarrays, 386 samples) with eligible criteria. Two sets of microarrays were used as training; the others were studied in the testing sets (ratio 5:1). …”
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8367
An application of the Shapley value to the analysis of co-expression networks
Published 2018-08-01“…An application of the method to the analysis of gene expression data from microarrays is presented, as well as a comparison with classical centrality indices. …”
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Article -
8368
The Critical Role of Pharmacists in the Clinical Delivery of Pharmacogenetics in the U.S
Published 2023-09-01“…Since the rebirth of pharmacogenomics (PGx) in the 1990s and 2000s, with new discoveries of genetic variation underlying adverse drug response and new analytical technologies such as sequencing and microarrays, there has been much interest in the clinical application of PGx testing. …”
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8369
Application of personalised medicine to solid tumours: opportunities and challenges
Published 2012-06-01“…The technological advances in the last few years, such as the development of high resolution DNA microarrays or second generation sequencers, have led to a dramatic increase in the number of ongoing genomic profiling studies. …”
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Article -
8370
Bioinformatics analysis of estrogen-responsive genes
Published 2016“…Identification of estrogen target genes is greatly facilitated by the use of transcriptomic methods, such as RNA-seq and expression microarrays, and chromatin immunoprecipitation with massively parallel sequencing (ChIP-seq). …”
Journal article -
8371
Ovarian Transcriptomic Analysis Reveals Differential Expression Genes Associated with Cell Death Process after Selection for Ovulation Rate in Rabbits
Published 2020-10-01“…A transcriptomic study was performed, using microarrays, in ovarian tissue from females belonging to the selected line and the control line. …”
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Article -
8372
The Innate Immune-Related Genes in Catfish
Published 2012-11-01“…This review summarizes the current understanding of innate immune-related genes in catfish, including pattern recognition receptors, antimicrobial peptides, complements, lectins, cytokines, transferrin and gene expression profiling using microarrays and next generation sequencing technologies. …”
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Article -
8373
Approach to Thrombophilia in Pregnancy—A Narrative Review
Published 2022-05-01“…Genetic testing for thrombophilic gene mutations is evaluated using different methodologies of real-time polymerase chain reaction and DNA microarrays of specific genes. Adapting the general care of the pregnant woman to the particularities caused by thrombophilia is an important component, so screening is preferred to assess the degree of genetic damage that manifests itself as a risk of thrombosis. …”
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8374
Feature selection in bioinformatics
Published 2013“…For example, there are millions of single nucleotide polymorphisms (SNPs) that are genetic variations which determine the dierence between any two unrelated individuals. In microarrays, thousands of genes can be proled in each test. …”
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Conference Paper -
8375
Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression
Published 2018-07-01“…Results SNHG7 expression showed a high fold (SW620/SW480) in CRC microarrays. The CRC patients with high expression of SNHG7 had a significantly poor prognosis. …”
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Article -
8376
Programmed Death Ligand 1 (PD-L1) Expression in Malignant Mesenchymal Tumors
Published 2017-09-01“…Material and Method: Tissue microarrays of 3-4 mm diameter were composed from paraffin blocks of 222 various sarcomas. …”
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8377
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8378
Synergies of Radiomics and Transcriptomics in Lung Cancer Diagnosis: A Pilot Study
Published 2023-02-01“…For each patient, 749 Computed Tomography (CT) radiomic features were extracted and the corresponding transcriptomics data were provided through DNA microarrays. The radiomic features were clustered using the iterative K-means algorithm resulting in 77 homogeneous clusters, represented by meta-radiomic features. …”
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Article -
8379
Identification of the miRNAome in human fracture callus and nonunion tissues
Published 2023-03-01“…Also, miRNAs were isolated and screened using microarrays followed by bioinformatic analyses, including, differential expression, pathways and biological processes, as well as elucidation of target genes. …”
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8380
PD-L1 expression on stromal tumor-infiltrating lymphocytes is a favorable prognostic factor in ovarian serous carcinoma
Published 2019-06-01“…Methods Tissue microarrays were constructed from ovarian epithelial cancer tissues of 248 patients and PD-L1 immunostaining was performed using the SP263 clone. …”
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Article