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8501
Mucosal circadian rhythm pathway genes altered by aging and periodontitis
Published 2022-01-01“…Gingival tissue samples were obtained from healthy, diseased, and resolved sites in four groups: young (≤3 years), adolescent (3–7 years), adult (12–26) and aged (18–23 years). Microarrays targeted circadian rhythm (n = 42), inflammation/tissue destruction (n = 11), bone biology (n = 8) and hypoxia pathway (n = 7) genes. …”
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8502
Advancements in Non-Invasive Biological Surface Sampling and Emerging Applications
Published 2019-11-01“…These advancements include various types of passive samplers, hydrogels, and polydimethylsiloxane (PDMS) patches/microarrays, and other wearable extraction devices used mainly in skin sampling, among other novel techniques developed for ocular surface and oral tissue/fluid sampling.…”
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8503
Temporal Gene Expression Kinetics for Human Keratinocytes Exposed to Hyperthermic Stress
Published 2013-04-01“…In order to obtain temporal gene expression kinetics, we exposed HEK cells to a heat stress protocol (44 °C for 40 min) and used messenger RNA (mRNA) microarrays at 0 h, 4 h and 24 h post-exposure. Bioinformatics software was employed to characterize the chief biological processes and canonical pathways associated with these heat stress genes. …”
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8504
Detecting splicing variants in idiopathic pulmonary fibrosis from non-differentially expressed genes.
Published 2013-01-01“…Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease of unknown cause that lacks a proven therapy for altering its high mortality rate. Microarrays have been employed to investigate the pathogenesis of IPF, but are presented mostly at the gene-expression level due to technologic limitations. …”
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8505
TIAM1 acts as an actin organization regulator to control adipose tissue–derived pericyte cell fate
Published 2023-07-01“…In this study, by comparing human adipose tissue– and periosteum-derived pericyte microarrays, we identified T cell lymphoma invasion and metastasis 1 (TIAM1) as a key regulator of cell morphology and differentiation decisions. …”
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8506
Extensible neural network software : applications in gene expression analysis
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Thesis -
8507
Molecular testing for somatic cancer mutations: a survey of current and future testing in UK laboratories.
Published 2008“…Most laboratories predict testing will increase over the next 10 years, particularly for DNA testing using microarrays. Respondents perceived the main barriers to expanding molecular testing were a lack of laboratory funding and scientific evidence and testing not considered an NHS priority. …”
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8508
Dissecting features of epigenetic variants underlying cardiometabolic risk using full-resolution epigenome profiling in regulatory elements
Published 2019“…Sparse profiling of CpG methylation in blood by microarrays has identified epigenetic links to common diseases. …”
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8509
Tumor necrosis factor receptor-associated protein 1(TRAP1) regulates genes involved in cell cycle and metastases.
Published 2010“…After growing the cells for 16h under normoxic or hypoxic conditions, oligonucleotide microarrays were employed to detect differentially expressed genes. …”
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8510
Construction of human activity-based phosphorylation networks.
Published 2013“…Here, we developed a new strategy, called CEASAR, based on functional protein microarrays and bioinformatics to experimentally identify substrates for 289 unique kinases, resulting in 3656 high-quality KSRs. …”
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8511
The number of regulatory T cells in prostate cancer is associated with the androgen receptor and hypoxia-inducible factor (HIF)-2alpha but not HIF-1alpha.
Published 2007“…METHODS: T(R) cells were identified by FOXP3 in tissue microarrays (TMAs) from 146 radical prostatectomies and correlated with clinicopathological tumor parameters and prostatic specific antigen rise (PSA). …”
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8512
Suppressor of cytokine signalling protein SOCS3 expression is increased at sites of acute and chronic inflammation.
Published 2011“…Epitope and GFP tagged SOCS3 fusion proteins were localised predominantly in the nucleus of transfected cells and a validated anti SOCS3 antiserum revealed the expression of SOCS3 in the nucleus and cytoplasm of macrophages, endothelial and epithelial cells in a wide range of normal tissues in tissue microarrays (n = 31 different tissues). Nuclear SOCS3 was only seen in cells expressing a high level of the protein. …”
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8513
The Gray Institute 'open' high-content, fluorescence lifetime microscopes.
Published 2013“…Several automated high-content fluorescence microscope implementations have been constructed with this design framework and optimized for specific applications with multiwell plates and tissue microarrays. In particular, three platforms incorporate time-domain FLIM via time-correlated single photon counting in an automated fashion. …”
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8514
Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome.
Published 2005“…The MECP2 gene encodes a methyl-CpG-binding protein that can act as a transcriptional repressor. Using cDNA microarrays, we found that Mecp2-null animals differentially express several genes that are induced during the stress response by glucocorticoids. …”
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8515
Sex peptide of Drosophila melanogaster males is a global regulator of reproductive processes in females.
Published 2012“…We profiled mRNA responses to SP in adult female abdomen (Abd) and head+thorax (HT) tissues using microarrays at 3 and 6 h following mating. SP elicited a rich, subtle signature of temporally and spatially controlled mRNAs. …”
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8516
Cytoplasmic YAP1‐mediated ESCRT‐III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer
Published 2023-05-01“…YAP1 bound to NEDD4L, and NEDD4L mediated ubiquitination and degradation of YAP1. Breast tissue microarrays revealed that high levels of cytoplasmic YAP1 were beneficial to the survival of breast cancer patients. …”
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8517
Prognostic implication of downregulated exosomal miRNAs in patients with sepsis: a cross-sectional study with bioinformatics analysis
Published 2023-08-01“…Methods Quantitative real-time PCR-based microarrays were used to profile plasma exosomal miRNA expression levels in 135 patients with sepsis and 11 healthy controls from an ongoing prospective registry of critically ill adult patients admitted to the intensive care unit. …”
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8518
Downregulation of lncRNA EPB41L4A-AS1 Mediates Activation of MYD88-Dependent NF-κB Pathway in Diabetes-Related Inflammation
Published 2021-01-01“…In this study, we aimed to reveal the role and molecular mechanism of lncRNA EPB41L4A-AS1 in type 2 diabetic mellitus (T2DM)-related inflammation.Methods: To explore the relationships between the expression of EPB41L4A-AS1 and inflammatory factors in the blood of T2DM patients, we analyzed peripheral blood mononuclear cell (PBMC) expression microarrays of T2DM patients and expression microarrays of PBMC treated with lipopolysaccharide (LPS) from the GEO database. …”
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8519
Genotypic and metabolic phenotype changes in breast cells using gold‐based compound cancer treatment
Published 2018“…Cytotoxicity assay, real‐time cell analysis (RTCA), apoptosis, caspase 3/7 activity assays and cell cycle assays were done followed by phenotypic microarrays and microRNA expression profile experiments. …”
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Thesis -
8520
Derivation of CD8+ T cell infiltration potentiators in non-small-cell lung cancer through tumor microenvironment analysis
Published 2023-07-01“…IHC validation using primary sample tissue microarrays confirmed a pronounced positive association between CD8+ T cell tumor infiltration and the interferon-associated targets, CCL5 and MDA5. …”
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