-
8601
SYNZIP Protein Interaction Toolbox: in Vitro and in Vivo Specifications of Heterospecific Coiled-Coil Interaction Domains
Published 2012“…In a yeast two-hybrid screen, >85% of 253 comparable interactions were consistent with prior in vitro measurements made using coiled-coil microarrays. In a yeast-signaling assay controlled by coiled-coil mediated scaffolding, 12 SYNZIP pairs were successfully used to down-regulate the expression of a reporter gene following treatment with α-factor. …”
Get full text
Get full text
Article -
8602
Collagen type V alpha 2 promotes the development of gastric cancer via M2 macrophage polarization
Published 2023-01-01“…There were 65 overlapping differentially expressed genes (DEGs) identified from three microarrays. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway were carried out for the key functions and pathways enriched in the DEGs. …”
Get full text
Article -
8603
New insights about the evaluation of human sperm quality: the aromatase example.
Published 2010-01-01“…The selection of representative transcripts of normal spermatozoa remains complex because a differential expression (increased, decreased or not modified levels) of specific transcripts has been revealed between immotile and motile sperm fractions issued from normozoospermic donors. Microarrays tests or real-time quantitative PCR could be helpful for the identification of factors involved in the male infertility. …”
Get full text
Article -
8604
A comprehensive collection of experimentally validated primers for Polymerase Chain Reaction quantitation of murine transcript abundance
Published 2008-12-01“…This feature is increasingly attractive for confirming and/or making more precise data trends observed from experiments performed with DNA microarrays.</p>…”
Get full text
Article -
8605
Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival
Published 2010-06-01“…</p> <p>Methods</p> <p>In this study, the prognostic impact of AR expression was investigated using immunohistochemistry in tissue microarrays from 154 incident cases of epithelial ovarian cancer (EOC) in the prospective, population-based cohorts Malmö Diet and Cancer Study and Malmö Preventive Project. …”
Get full text
Article -
8606
The Analysis of the Human Megakaryocyte and Platelet Coding Transcriptome in Healthy and Diseased Subjects
Published 2022-07-01“…The platelet transcriptome is highly dynamic and has been extensively studied using microarrays and, more recently, RNA sequencing (RNA-seq) in relation to diverse conditions (inflammation, obesity, cancer, pathogens and others). …”
Get full text
Article -
8607
Rational Design of Porous Poly(ethylene glycol) Films as a Matrix for ssDNA Immobilization and Hybridization
Published 2022-08-01“…The respective strategy can be applied to the fabrication of DNA microarrays and DNA sensors. As a suitable transduction technique, requiring no ssDNA labeling and showing high sensitivity in the PEG-ssDNA case, electrochemical impedance spectroscopy is suggested.…”
Get full text
Article -
8608
Potential Use of Multiple Antisense Oligonucleotide Analogs for Cancer Prevention and Therapy
Published 2024-03-01“…In an alternative approach, genetic analysis of cancer cells using microarrays have shown that cassettes of genes are up- and down-regulated compared to normal tissue. …”
Get full text
Article -
8609
Laser ablation-based one-step generation and bio-functionalization of gold nanoparticles conjugated with aptamers
Published 2010-08-01“…Successful detection of PSMA in human prostate cancer tissue was achieved utilizing tissue microarrays.</p> <p>Conclusions</p> <p>In comparison to the conventional generation of bio-conjugated gold nanoparticles using chemical synthesis and subsequent bio-functionalization, the laser-ablation-based <it>in situ </it>conjugation is a rapid, one-step production method. …”
Get full text
Article -
8610
Accelerating the excisional wound closure by using the patterned microstructural nanofibrous mats/gentamicin-loaded hydrogel composite scaffold
Published 2022-12-01“…Inspired by the extracellular matrix (ECM), the surface of nanofibre top layer was patterned with triangular microarrays using micro-moulding approach to reflect the multidimensional structure of ECM. …”
Get full text
Article -
8611
Nutritional Niches of Cancer Therapy-Induced Senescent Cells
Published 2022-09-01“…We used a panel of mechanistically-diverse TIS triggers (i.e., bleomycin, doxorubicin, alisertib, and palbociclib) and Biolog Phenotype MicroArrays to identify (among 190 different carbon and nitrogen sources) candidate metabolites that support the survival of TIS cells in limiting nutrient conditions. …”
Get full text
Article -
8612
AQP9 expression in glioblastoma multiforme tumors is limited to a small population of astrocytic cells and CD15(+)/CalB(+) leukocytes.
Published 2013-01-01“…In this study, we have examined microarrays to corroborate AQP9 mRNA expression in glioma. …”
Get full text
Article -
8613
Analysis of DNA variations in <it>GSTA</it> and <it>GSTM</it> gene clusters based on the results of genome-wide data from three Russian populations taken as an example
Published 2012-10-01“…<p>Abstract</p> <p>Background</p> <p>Extensive genome-wide analyses of many human populations, using microarrays containing hundreds of thousands of single-nucleotide polymorphisms, have provided us with abundant information about global genomic diversity. …”
Get full text
Article -
8614
RCH1, a Locus in Arabidopsis That Confers Resistance to the Hemibiotrophic Fungal Pathogen Colletotrichum higginsianum
Published 2004-07-01“…Expression analyses with cDNA microarrays indicated that the defense reaction depends primarily on the jasmonic acid- and ethylene-dependent signaling pathways and, to a lesser extent, on the salicylate-dependent pathway. …”
Get full text
Article -
8615
Disruption of Two Defensive Signaling Pathways by a Viral RNA Silencing Suppressor
Published 2010-07-01“…The Cucumber mosaic virus (CMV) 2b counter-defense protein disrupts plant antiviral mechanisms mediated by RNA silencing and salicylic acid (SA). We used microarrays to investigate defensive gene expression in 2b-transgenic Arabidopsis thaliana plants. …”
Get full text
Article -
8616
Low-risk susceptibility alleles in 40 human breast cancer cell lines
Published 2009-07-01“…We have analyzed expression of the four genes that are located nearby the low-risk SNPs, by using real-time RT-PCR and Human Exon microarrays.</p> <p>Results</p> <p>The SNP genotypes and additional phenotypic data on the breast cancer cell lines are presented. …”
Get full text
Article -
8617
Lack of the delta subunit of RNA polymerase increases virulence related traits of Streptococcus mutans.
Published 2011-01-01“…The analysis of 1248 physiological traits using phenotype microarrays showed that the ΔrpoE mutant metabolized a wider spectrum of carbon sources than the wild type and had acquired resistance to antibiotics and inhibitory compounds with various modes of action. …”
Get full text
Article -
8618
Correlation between EGFR amplification and the expression of microRNA-200c in primary glioblastoma multiforme.
Published 2014-01-01“…We have evaluated whole-genome miRNA expression profiling associated with different EGFR amplification patterns, studied by fluorescence in situ hybridization in tissue microarrays, of 30 cases of primary glioblastoma multiforme, whose clinicopathological and immunohistochemical features have also been analyzed. …”
Get full text
Article -
8619
A Population Proportion approach for ranking differentially expressed genes
Published 2008-09-01“…<p>Abstract</p> <p>Background</p> <p>DNA microarrays are used to investigate differences in gene expression between two or more classes of samples. …”
Get full text
Article -
8620
Machine Learning Methods for Cancer Classification Using Gene Expression Data: A Review
Published 2023-01-01“…Deoxyribonucleic acid (DNA) microarrays and ribonucleic acid (RNA)-sequencing methods for gene expression data allow quantifying the expression levels of genes and produce valuable data for computational analysis. …”
Get full text
Article