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8981
Complete Freund’s Adjuvant Induces a Fibroblast-like Synoviocytes (FLS) Metabolic and Migratory Phenotype in Resident Fibroblasts of the Inoculated Footpad at the Earliest Stage of...
Published 2023-03-01“…Wistar rats were injected with Complete Freund’s Adjuvant (CFA) or saline solution in the hind paws’ footpads and euthanized at 24 or 48 h for genetic and histological analyses. Microarrays revealed the differentially expressed genes between the groups. …”
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8982
High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma
Published 2020-03-01“…Thus, we stained tissue microarrays from 133 molecularly confirmed EwS cases and 320 samples from morphological mimics, as well as a series of patient-derived xenograft (PDX) models for BCL11B, GLG1, and CD99, and systematically assessed the immunoreactivity and optimal cut-offs for each marker. …”
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8983
Combined BRCA2 and MAGEC3 Expression Predict Outcome in Advanced Ovarian Cancers
Published 2022-09-01“…Immunohistochemical staining was quantitated on tumor microarrays of human tumor samples obtained from 357 patients with epithelial ovarian cancer to ascertain BRCA2 expression levels. …”
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8984
The Immune Landscape of Colorectal Cancer
Published 2021-11-01“…We sought to provide a detailed overview of the immune landscape of CRC in the largest study to date in terms of patient numbers and in situ analyzed immune cell types. Tissue microarrays from 536 patients were stained using multiplexed immunofluorescence panels, and fifteen immune cell subclasses, representing adaptive and innate immunity, were analyzed. …”
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8985
MALAT1 expression is associated with aggressive behavior in indolent B-cell neoplasms
Published 2023-10-01“…Here, MALAT1 expression was analyzed using RNA-seq, microarrays or qRT-PCR in primary samples from clinico-biological subtypes of chronic lymphocytic leukemia (CLL, n = 266), paired Richter transformation (RT, n = 6) and follicular lymphoma (FL, n = 61). …”
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8986
Restin protein expression in non‐small cell lung cancer
Published 2023-08-01“…Methods Restin expression was analyzed by immunohistochemistry in three tissue microarrays consisting of formalin‐fixed/paraffin‐embedded NSCLC specimens from 113 patients, represented in triplicate. …”
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8987
ARE STEM CELL MARKER EXPRESSION AND CD133 ANALYSIS RELEVANT TO DIFFERENTIATE COLORECTAL CANCER?
Published 2021-03-01“…Methods: A total of 156 patients with UICC stage I-IV adenocarcinomas (n=122) and adenomas (n=34) were analyzed. Tissue microarrays (TMA) from primary tumors and polyps for CD133, c-MYC and AXL expression were performed and analyzed for their significance with clinicopathologic characteristics. …”
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8988
Bezafibrate Reduces Elevated Hepatic Fumarate in Insulin-Deficient Mice
Published 2022-03-01“…In order to identify key molecules and pathways which participate in the beneficial effects of BEZ, we studied plasma, skeletal muscle, white adipose tissue (WAT) and liver samples using non-targeted metabolomics (NMR spectroscopy), targeted metabolomics (mass spectrometry), microarrays and mitochondrial enzyme activity measurements, with a particular focus on the liver. …”
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8989
Expression of Irisin/FNDC5 in Cancer Cells and Stromal Fibroblasts of Non-Small Cell Lung Cancer
Published 2019-10-01“…<i>Material and methods</i>: Tissue microarrays with 729 NSCLC and 140 non-malignant lung tissue (NMLT) were used to perform immunohistochemical reactions. …”
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8990
A PTPmu Biomarker is Associated with Increased Survival in Gliomas
Published 2019-05-01“…In the current study, we evaluated the PTPmu biomarker in tissue microarrays and individual tumor samples of adolescent and young adult (<i>n</i> = 25) and adult (<i>n</i> = 69) glioma populations using a fluorescent histochemical reagent, SBK4-TR, that recognizes the PTPmu biomarker. …”
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8991
High Levels of MFG-E8 Confer a Good Prognosis in Prostate and Renal Cancer Patients
Published 2022-06-01“…Here, we quantified MFG-E8 and CD68/CD206 expression by immunofluorescence staining in tissue microarrays constructed from renal (<i>n</i> = 190) and prostate (<i>n</i> = 274) cancer patient specimens. …”
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8992
Integrative Metabolomic and Transcriptomic Analysis for the Study of Bladder Cancer
Published 2019-05-01“…BC and control tissue samples (n = 44) from the same patients were analyzed by High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance and microarrays techniques. Besides, urinary profiling study (n = 35) was performed in the same patients to identify a metabolomic profile, linked with BC tissue hallmarks, as a potential non-invasive approach for BC diagnosis. …”
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8993
Gene‐by‐gene interactions associated with the risk of conotruncal heart defects
Published 2020-01-01“…The findings were replicated in an independent sample of 86 NBDPS case‐parental triads genotyped by DNA microarrays. The results of two studies were further integrated by a fixed‐effect meta‐analysis. …”
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8994
Amplification of CDK4 and MDM2: a detailed study of a high-risk neuroblastoma subgroup
Published 2022-07-01“…It is therefore relevant to characterize additional alterations that can function as prognostic and/or predictive markers. Using SNP-microarrays, a group of neuroblastoma patients showing amplification of one or multiple 12q loci was identified. …”
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8995
The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target
Published 2021-10-01“…Thus, to evaluate its potential use in diagnostics and therapy, we quantified uPARAP expression by immunohistochemical H-score in formalin-fixed paraffin-embedded bioptic/surgical human tissue samples and tissue microarrays. We detected pronounced upregulation of uPARAP in the three main MM subtypes compared to non-malignant reactive mesothelial proliferations, with higher expression in sarcomatoid and biphasic than in epithelioid MM. …”
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8996
Labyrinthin Expression Is Associated with Poor Prognosis in Patients with Non-Small-Cell Lung Cancer
Published 2023-02-01“…To determine Labyrinthin (LAB) expression in non-small-cell lung cancer (NSCLC), we immunostained and scored for LAB immunohistochemistry (IHC) expression on sections of tissue microarrays (TMAs) prepared from 256 archival tissue blocks of NSCLC. …”
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8997
LAG-3 Expression Predicts Outcome in Stage II Colon Cancer
Published 2021-07-01“…Patients and Methods: Immunohistochemical staining for LAG-3 was performed on tissue microarrays (TMAs) of formalin-fixed paraffin-embedded tissue from 142 stage II colon cancer patients. …”
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8998
Characterization and prognostic impact of ACTBL2-positive tumor-infiltrating leukocytes in epithelial ovarian cancer
Published 2023-12-01“…Comprehensive immunohistochemical analyses of Tissue-Microarrays of 156 ovarian cancer patients revealed, that a tumor infiltration by ACTBL2-positive leukocytes was significantly associated with an improved overall survival (OS) (61.2 vs. 34.4 months; p = 0.006) and was identified as an independent prognostic factor (HR = 0.556; p = 0.038). …”
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8999
Complete Loss of EPCAM Immunoexpression Identifies <i>EPCAM</i> Deletion Carriers in MSH2-Negative Colorectal Neoplasia
Published 2020-09-01“…LS was confirmed in 68 patients, 53 with <i>MSH2</i> mutations and 15 with <i>EPCAM</i> 3′-end deletions. Tissue microarrays were constructed with human normal tissues and their malignant counterparts to assist in the evaluation of EPCAM staining. …”
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9000
Synovial Fluid Derived from Human Knee Osteoarthritis Increases the Viability of Human Adipose-Derived Stem Cells through Upregulation of FOSL1
Published 2023-01-01“…Gene expression profiling of SF-treated ADSCs using DNA microarrays revealed changes in several genes involved in cell survival. …”
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