Co-Occurrence of Differentiated Thyroid Cancer and Second Primary Malignancy: Correlation with Expression Profiles of Mismatch Repair Protein and Cell Cycle Regulators by Chih-Yi Liu, Ching-Shui Huang, Chi-Cheng Huang, Wei-Chi Ku, Hsing-Yu Shih, Chi-Jung Huang

“…A retrograde cohort was used to develop immunohistochemical expressions of mismatch repair (MMR) proteins and cell-cycle-related markers from tissue microarrays to produce an equation for predicting the occurrence of DPC. …”
Get full text

Characterization and Function of Glycans on the Spike Proteins of SARS-CoV-2 Variants of Concern by Luping Zheng, Ke Wang, Minghai Chen, Fujun Qin, Chuang Yan, Xian-En Zhang

“…In this study, four VOC S proteins—S-Alpha, S-Beta, S-Delta, and S-Omicron—were expressed and purified. Lectin microarrays were performed to characterize their glycosylation patterns. …”
Get full text

CCAAT/Enhancer-Binding Protein Delta (C/EBPδ): A Previously Unrecognized Tumor Suppressor that Limits the Oncogenic Potential of Pancreatic Ductal Adenocarcinoma Cells by Leonie Hartl, JanWillem Duitman, Hella L. Aberson, Kan Chen, Frederike Dijk, Joris J.T.H. Roelofs, Mark P.G. Dings, Gerrit K.J. Hooijer, Pratika Y. Hernanda, Qiunwei Pan, Olivier R. Busch, Marc G.H. Besselink, Ton Boerman, Maikel P. Peppelenbosch, Maarten F. Bijlsma, C. Arnold Spek

“…We determined C/EBPδ expression in biopsies from pancreatic cancer patients using public gene-expression datasets and in-house tissue microarrays. We found that C/EBPδ is highly expressed in healthy pancreatic ductal cells but lost in pancreatic ductal adenocarcinoma. …”
Get full text

MicroRNA Expression Profiling of Peripheral Blood Samples Predicts Resistance to First-line Sunitinib in Advanced Renal Cell Carcinoma Patients by Angelo Gámez-Pozo, Luis M. Antón-Aparicio, Cristina Bayona, Pablo Borrega, María I. Gallegos Sancho, Rocío García-Domínguez, Teresa de Portugal, Manuel Ramos-Vázquez, Ramón Pérez-Carrión, María V. Bolós, Rosario Madero, Iker Sánchez-Navarro, Juan A. Fresno Vara, Enrique Espinosa Arranz

“…Peripheral blood samples were taken before initiation of therapy and 14 days later in patients receiving first-line therapy with sunitinib for advanced RCC. miRNA expression in peripheral blood was assessed using microarrays and L2 boosting was applied to filtered miRNA expression data. …”
Get full text

Partial trisomy 9p and partial monosomy 7p of an infant inherited from maternal balanced translocation: a case report by Rui Li, Chaojie Wang, Zhenhua Zhang, Dongxiao Li, Lifeng Li, Ding Zhao, Zhaojie Xu

“…With the recent clinical application of genomic microarrays in the evaluation of patients with developmental delays and congenital malformations, it has led to the discovery of several new microdeletion and microduplication syndromes. …”
Get full text

Phosphorylation of Pit-1 by cyclin-dependent kinase 5 at serine 126 is associated with cell proliferation and poor prognosis in prolactinomas by Xie Weiyan, Fang Qiuyue, Guo Jing, Gong Lei, Li Chuzhong, Zhang Yazhuo

“…ELISA was used to measure the level of PRL in the supernatant of GH3 cells. Tissue microarrays and immunohistochemistry were used to evaluate the expression of the phosphorylation level of Ser126-Pit-1 (pSer126-Pit-1) in prolactinomas. …”
Get full text

BoBafit: A copy number clustering tool designed to refit and recalibrate the baseline region of tumors’ profiles by G. Mazzocchetti, A. Poletti, V. Solli, E. Borsi, M. Martello, I. Vigliotta, S. Armuzzi, B. Taurisano, E. Zamagni, M. Cavo, C. Terragna

“…Currently, several molecular biology technologies, such as microarrays, NGS and single-cell approaches are used to define the genomic profile of tumor samples. …”
Get full text

Construction and analysis of gene co-expression network in the pathogenic fungus Ustilago maydis by Cinthia V. Soberanes-Gutiérrez, Alfredo Castillo-Jiménez, Ernesto Pérez-Rueda, Edgardo Galán-Vásquez

“…The enormous growth of experimental information obtained using large-scale genomic techniques such as microarrays and RNA sequencing led to the construction of a wide variety of gene co-expression networks in recent years. …”
Get full text

The Correlations between the Intensity of Histopathological Ubiquitin-Specific Protease 11 Staining and Progression of Prostate Cancer by Jae Heon Kim, Hee Jo Yang, Kwang Woo Lee, Jae Joon Park, Chang-Ho Lee, Youn Soo Jeon, Jae Ho Kim, Suyeon Park, Su Jung Song, Ji-Hye Lee, Ahrim Moon, Yon Hee Kim, Yun Seob Song

“…The aim of the current study was to investigate the associations between immunohistochemical USP11 staining intensities and prognostic indicators in individuals with prostate cancer. Methods: Tissue microarrays (TMAs) were performed for human prostate cancer and normal tissue (control) samples. …”
Get full text

Serine/threonine kinase 36 induced epithelial-mesenchymal transition promotes docetaxel resistance in prostate cancer by Tao He, Nan-Xing Li, Zhao-Jun Pan, Zi-Hao Zou, Jie-Chuan Chen, Si-Zhe Yu, Fa Lv, Quan-Cheng Xie, Jun Zou

“…The expression of STK36 in PCa and the correlation with clinicopathological characteristics of PCa patients were analyzed using the data from different databases and tissue microarrays. To investigate the role of STK36 on cell proliferation, invasion, and migration, STK36 was overexpressed and silenced in DU-145 and PC-3 cell lines. …”
Get full text

Results from a Genome-Wide Association Study (GWAS) in Mastocytosis Reveal New Gene Polymorphisms Associated with WHO Subgroups by Bogusław Nedoszytko, Marta Sobalska-Kwapis, Dominik Strapagiel, Magdalena Lange, Aleksandra Górska, Joanne N. G. Oude Elberink, Jasper van Doormaal, Marcin Słomka, Leszek Kalinowski, Marta Gruchała-Niedoszytko, Roman J. Nowicki, Peter Valent, Marek Niedoszytko

“…DNA samples from saliva or blood were genotyped for 551 945 variants using DNA microarrays. The prevalence of certain SNPs was found to vary substantially when comparing patients and healthy controls: rs10838094 of <i>5OR51Q1</i> was less frequently detected in CM and SM patients (OR = 0.2071, <i>p</i> = 2.21 × 10⁻²⁹), rs80138802 in <i>ABCA2</i> (OR = 5.739, <i>p</i> = 1.98 × 10⁻²⁸)<i>,</i> and rs11845537 in <i>OTX2-AS1</i> (rs11845537, OR = 6.587, <i>p</i> = 6.16 × 10⁻¹⁷) were more frequently detected in CM in children and adults. …”
Get full text

MicroRNA-375 restrains the progression of lung squamous cell carcinoma by modulating the ERK pathway via UBE3A-mediated DUSP1 degradation by Junqing Gan, Yu Zhang, Shan Liu, Guannan Mu, Juan Zhao, Wei Jiang, Jiade Li, Qi Li, Yangjiazi Wu, Xinling Wang, Dehai Che, Xiaomei Li, Xiaoyi Huang, Qingwei Meng

“…To unravel its biological roles, especially its specific mechanisms of action in lung squamous cell carcinoma (LUSC), LUSC tissue microarrays and miRNAscope were performed to identify the miR-375 expression. …”
Get full text

Increased STX3 transcript and protein levels were associated with poor prognosis in two independent cohorts of esophageal squamous cell carcinoma patients by Takahiro Shinozuka, Mitsuro Kanda, Yusuke Sato, Dai Shimizu, Chie Tanaka, Shinichi Umeda, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Goro Nakayama, Yasuhiro Kodera

“…STX3 protein levels were investigated in surgically resected ESCC tissues by immunohistochemistry using tissue microarrays in a different cohort of 177 ESCC patients. …”
Get full text

Transcriptomic responses of Saccharum spontaneum roots in response to polyethylene glycol – 6000 stimulated drought stress by Kai-Chao Wu, Kai-Chao Wu, Kai-Chao Wu, Cheng-Mei Huang, Krishan K. Verma, Krishan K. Verma, Krishan K. Verma, Zhi-Nian Deng, Zhi-Nian Deng, Zhi-Nian Deng, Hai-Rong Huang, Hai-Rong Huang, Hai-Rong Huang, Tian Pang, Tian Pang, Tian Pang, Hui-Qing Cao, Hai-Bin Luo, Hai-Bin Luo, Hai-Bin Luo, Sheng-Li Jiang, Lin Xu, Lin Xu, Lin Xu

“…In the present study addresses the transcriptomic analysis of drought stress imposed by polyethylene glycol-6000 (PED-6000; w/v- 25%) on the root tip tissues of S. spontaneum GX83-10. The analysis of microarrays of drought-stressed roots was performed at 0 (CK), 2 (T2), 4 (T4), 8 (T8) and 24 h (T24). …”
Get full text

COMMD1, from the Repair of DNA Double Strand Breaks, to a Novel Anti-Cancer Therapeutic Target by Amila Suraweera, Pascal H. G. Duijf, Christian Jekimovs, Karsten Schrobback, Cheng Liu, Mark N. Adams, Kenneth J. O’Byrne, Derek J. Richard

“…The role of COMMD1 in NSCLC was investigated using bioinformatic analysis, qRT-PCR and immunoblotting of control and NSCLC cells, tissue microarrays, cell viability and cell cycle experiments. …”
Get full text

Discordance of PD-L1 Expression at the Protein and RNA Levels in Early Breast Cancer by Ioannis Zerdes, Vaia Karafousia, Artur Mezheyeuski, Maria Stogiannitsi, Raoul Kuiper, Pablo Moreno Ruiz, George Rassidakis, Jonas Bergh, Thomas Hatschek, Theodoros Foukakis, Alexios Matikas

“…PD-L1 protein and mRNA expression in BC tissue microarrays from two clinical patient cohorts were evaluated (105 patients; cohort 1: untreated; cohort 2: neoadjuvant chemotherapy-treated). …”
Get full text

Identification of cervical cancer stem cells using single-cell transcriptomes of normal cervix, cervical premalignant lesions, and cervical cancerResearch in context by Tao Zhang, Liang Zhuang, Munawaer Muaibati, Dan Wang, Abuduyilimu Abasi, Qing Tong, Ding Ma, Lei Jin, Xiaoyuan Huang

“…Bioinformatic results were validated by multiplex immunohistochemistry (mIHC) in cervical cancer tissue microarrays (TMA) (n = 85). Findings: We identified cervical cancer stem cells and highlighted the functional changes in cervical stem cells during malignant transformation. …”
Get full text

Tumour-Infiltrating Inflammatory Cells in Early Breast Cancer: An Underrated Prognostic and Predictive Factor? by Sören Schnellhardt, Ramona Erber, Maike Büttner-Herold, Marie-Charlotte Rosahl, Oliver J. Ott, Vratislav Strnad, Matthias W. Beckmann, Lillian King, Arndt Hartmann, Rainer Fietkau, Luitpold Distel

“…Immunohistochemistry was used to double-stain two adjoining sets of tissue microarrays from pre-RT (radiotherapy) tumour resection samples for CD1a/CD20 and CD45RO/CD4. …”
Get full text

Abundant copy-number loss of CYCLOPS and STOP genes in gastric adenocarcinoma by Cutcutache, Ioana, Suzuki, Yuka, Lei, Zhengdeng, Deng, Niantao, Zhang, Shenli, Tan, Patrick, Wu, Alice Yingting, McPherson, John Richard, Wong, Wai Keong, Soo, Khee Chee, Chan, Weng Hoong, Ooi, London Lucien, Rozen, Steven G., Welsch, Roy E

“…Methods We used high-density single-nucleotide polymorphism microarrays to determine patterns of copy-number loss and allelic imbalance in 74 gastric adenocarcinomas. …”
Get full text
Get full text

A Novel Small Molecule Activator of Nuclear Receptor SHP Inhibits HCC Cell Migration via Suppressing Ccl2 by Yang, Zhihong, Koehler, Angela Nicole, Wang, Li

“…First, we performed binding assays using small molecule microarrays (SMM) and discovered 5-(diethylsulfamoyl)-3-hydroxynaphthalene-2-carboxylic acid (DSHN) as a novel activator of SHP. …”
Get full text