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9281
Reappraisal of the Role of Alkaline Phosphatase in Hepatocellular Carcinoma
Published 2022-03-01“…The genetic expression in tumor-tissue microarrays and the perioperative serologic changes in ALP have never been studied for their correlation with HCC prognosis. …”
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9282
PHD finger protein 5A promoted lung adenocarcinoma progression via alternative splicing
Published 2019-05-01“…We found that PHF5A was significantly upregulated in NSCLC tumors compared with normal tissues in both TCGA data set and tissue microarrays. Upregulation of PHF5A was negatively correlated to the overall survival (OS) of lung adenocarcinoma (LUAD) patients. …”
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9283
Growth Factor Receptor Expression in Oropharyngeal Squamous Cell Cancer: Her1–4 and c-Met in Conjunction with the Clinical Features and Human Papillomavirus (p16) Status
Published 2020-11-01“…The protein expression of human epidermal growth factor receptor (Her)1–4 and c-Met were retrospectively assessed using semiquantitative immunohistochemistry on tissue microarrays and analyzed for correlations as well as differences in the clinicopathological criteria. …”
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9284
CD86+/CD206+ tumor-associated macrophages predict prognosis of patients with intrahepatic cholangiocarcinoma
Published 2020-01-01“…Methods Immunohistochemical staining of CD68, CD86 and CD206 were performed in tissue microarrays containing 322 patients, who underwent surgical resection and were pathologically diagnosed with ICC. …”
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9285
Pathway-Centric Integrative Analysis Identifies RRM2 as a Prognostic Marker in Breast Cancer Associated with Poor Survival and Tamoxifen Resistance
Published 2014-05-01“…Increased RRM2 expression in tamoxifen-resistant patients was verified using tissue microarrays, whereas the metabolic products of RRM2 were higher in tamoxifen-resistant cells and in xenograft tumors. …”
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9286
The Role of Irisin/FNDC5 Expression and Its Serum Level in Breast Cancer
Published 2023-05-01“…The aim of this study was to examine the levels of EMT markers, such as E-cadherin, N-cadherin, SNAIL, SLUG, and TWIST, and to compare their expression levels with FNDC5/Ir in BC tissues. Tissue microarrays with 541 BC samples were used to perform immunohistochemical reactions. …”
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9287
Impact of Serum γ-Glutamyltransferase on Overall Survival in Men with Metastatic Castration-Resistant Prostate Cancer Treated with Docetaxel
Published 2021-11-01“…Additionally, GGT expression status was immunohistochemically semi-quantified using tissue microarrays. Results: A total of 67 (63%) men died during follow-up periods (median 22.5 months for survivors). …”
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9288
Polymorphisms of <i>CCSER1</i> Gene and Their Correlation with Milk Quality Traits in Gannan Yak (<i>Bos grunniens</i>)
Published 2023-11-01“…We genotyped 172 Gannan yaks using Illumina Yak <i>c</i>GPS 7K liquid microarrays and analyzed the correlation between the three SNPs loci of the <i>CCSER1</i> gene and the milk qualities of Gannan yaks, including milk fat, protein and casein. …”
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9289
Differential recognition of influenza A virus H1N1 neuraminidase by DNA vaccine-induced antibodies in pigs and ferrets
Published 2023-05-01“…Antigenic sites were further identified with linear and conformational peptide microarrays spanning the full NA of A/California/04/2009(H1N1)pdm09. …”
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9290
TUG1 Is a Regulator of AFP and Serves as Prognostic Marker in Non-Hepatitis B Non-Hepatitis C Hepatocellular Carcinoma
Published 2020-01-01“…The expression profiles of long non-coding RNAs (lncRNAs) were compared in microarrays of HepG2-TRα1 cells treated with/without T<sub>3</sub> and HCC specimens. …”
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9291
Epimutation detection in the clinical context: guidelines and a use case from a new Bioconductor package
Published 2023-12-01“…Epimutations are rare alterations of the normal DNA methylation pattern at specific loci, which can lead to rare diseases. Methylation microarrays enable genome-wide epimutation detection, but technical limitations prevent their use in clinical settings: methods applied to rare diseases’ data cannot be easily incorporated to standard analyses pipelines, while epimutation methods implemented in R packages (ramr) have not been validated for rare diseases. …”
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9292
CD8 + T cell infiltration is associated with improved survival and negatively correlates with hypoxia in clear cell ovarian cancer
Published 2023-04-01“…We employed [18F]EF5-PET/CT imaging, transcriptome profiling, and spatially-resolved histological analysis to evaluate relationships between CAIX, CD8, and survival in CCOC. Tissue microarrays (TMAs) were evaluated for 218 cases in the Canadian COEUR study. …”
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9293
Accelerated Partial Breast Irradiation: Macrophage Polarisation Shift Classification Identifies High-Risk Tumours in Early Hormone Receptor-Positive Breast Cancer
Published 2020-02-01“…Patient selection was characterized by HR+, small tumour size and no metastasis. Tissue microarrays from pre-RT resection samples were double stained for CD68/CD163 using immunohistochemistry. …”
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9294
Comprehensive Genetic Analyses of Inherited Peripheral Neuropathies in Japan: Making Early Diagnosis Possible
Published 2022-06-01“…Genetic analyses were performed using DNA microarrays, next-generation sequencing-based gene panel sequencing, whole-exome sequencing, CNV analysis, and <i>RFC1</i> repeat expansion analysis. …”
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9295
Proteomics Characterization of Clear Cell Renal Cell Carcinoma
Published 2023-01-01“…First, we defined 514 proteins showing differential expression between the two subtypes using a significance analysis of microarrays analysis. Proteins overexpressed in CC1 were mainly related to translation and ribosome, while proteins overexpressed in CC2 were mainly related to focal adhesion and membrane. …”
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9296
Epigenetic Regulation of Processes Related to High Level of Fibroblast Growth Factor 21 in Obese Subjects
Published 2021-02-01“…Human DNA Methylation Microarrays were analysed in leukocytes from each group (<i>n</i> = 16). …”
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9297
Evaluation of tumor antigen-specific antibody responses in patients with metastatic triple negative breast cancer treated with cyclophosphamide and pembrolizumab
Published 2023-03-01“…We evaluated tumor antigen-specific antibody responses in patients with metastatic triple negative breast cancer treated with pembrolizumab following low-dose cyclophosphamide therapy using computational linear epitope prediction and custom peptide microarrays. We found that a minority of predicted linear epitopes were associated with antibody signal, and signal was associated with both neoepitopes and self-peptides. …”
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9298
Integrated Tissue and Blood miRNA Expression Profiles Identify Novel Biomarkers for Accurate Non-Invasive Diagnosis of Breast Cancer: Preliminary Results and Future Clinical Implic...
Published 2022-10-01“…By integrating several methods including significance analysis of microarrays, fold change, Pearson’s correlation analysis, <i>t</i> test, and receiver operating characteristic analysis, we developed a decision-tree-based scoring algorithm, called Optimized Scoring Mechanism for Primary Synergy MicroRNAs (O-PSM). …”
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9299
Gene Profiling of a 3D Psoriatic Skin Model Enriched in T Cells: Downregulation of <i>PTPRM</i> Promotes Keratinocyte Proliferation through Excessive ERK1/2 Signaling
Published 2022-09-01“…In this study, we used a tissue-engineered, two-layered (dermis and epidermis) human skin substitute enriched in T cells as a biomaterial to study both the cellular and molecular mechanisms involved in psoriasis’ pathogenesis. Gene profiling on microarrays revealed significant changes in the profile of genes expressed by the psoriatic skin substitutes compared with the healthy ones. …”
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9300
The administration of pirfenidone modifies the expression of JMJD2B in a murine model of NASH
Published 2022-12-01“…Masson's trichrome hematoxylin-eosin staining was performed. Dual-channel microarrays were hybridized to the 22,000-gene version of the Mus musculus genome. …”
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