LncRNA BC promotes lung adenocarcinoma progression by modulating IMPAD1 alternative splicing by Qi Wen Chen, Qian Qian Cai, Ying Yang, Shu Dong, Yuan Yuan Liu, Zhong Yi Chen, Chun Lan Kang, Bing Qi, Yi Wei Dong, Wei Wu, Li Ping Zhuang, Ye Hua Shen, Zhi Qiang Meng, Xing Zhong Wu

“…Materials & Methods: Microarrays were used to screen a comprehensive set of lncRNAs with differential expression profiles in lung cancer cells. …”
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Cladribine and ocrelizumab induce differential miRNA profiles in peripheral blood mononucleated cells from relapsing–remitting multiple sclerosis patients by Ivan Arisi, Ivan Arisi, Leonardo Malimpensa, Valeria Manzini, Rossella Brandi, Tommaso Gosetti di Sturmeck, Chiara D’Amelio, Sebastiano Crisafulli, Gina Ferrazzano, Daniele Belvisi, Daniele Belvisi, Francesca Malerba, Rita Florio, Esterina Pascale, Hermona Soreq, Marco Salvetti, Marco Salvetti, Antonino Cattaneo, Antonino Cattaneo, Mara D’Onofrio, Antonella Conte, Antonella Conte

“…A total of 15 age- and sex-matched healthy control subjects (9 F and 6 M, age 36.3 ± 3.0) were also selected. By using Agilent microarrays, we analyzed miRNA profiles from peripheral blood mononuclear cells (PBMC). miRNA–target networks were obtained by miRTargetLink, and Pearson’s correlation served to estimate the association between miRNAs and outcome clinical features.ResultsFirst, the miRNA profiles of pre-CLA or pre-OCRE RRMS patients compared to healthy controls identified modulated miRNA patterns (40 and seven miRNAs, respectively). …”
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High Expression of Solute Carrier Family 2 Member 1 (SLC2A1) in Cancer Cells Is an Independent Unfavorable Prognostic Factor in Pediatric Malignant Peripheral Nerve Sheath Tumor by Malgorzata A. Krawczyk, Michal Kunc, Malgorzata Styczewska, Anna Gabrych, Gabrielle Karpinsky, Ewa Izycka-Swieszewska, Ewa Bien

“…Therefore, we investigated the prognostic significance of markers of tumor hypoxia and systemic inflammation in 26 pediatric malignant peripheral nerve sheath tumors (MPNST). Tumor tissue microarrays were stained for hypoxia-inducible factor-1α (HIF1A), solute carrier family 2 member 1 (SLC2A1, also known as glucose transporter 1 (GLUT1)), carbonic anhydrase 9 (CA9), and vascular endothelial growth factor A (VEGFA) and classified into low- or high-expression groups. …”
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Atherosclerotic Plaque Fissuration and Clinical Outcomes in Pre-Diabetics vs. Normoglycemics Patients Affected by Asymptomatic Significant Carotid Artery Stenosis at 2 Years of Fol... by Celestino Sardu, Pietro Modugno, Gaetano Castellano, Lucia Scisciola, Michelangela Barbieri, Lella Petrella, Mara Fanelli, Gabriella Macchia, Eugenio Caradonna, Massimo Massetti, Giuseppe Paolisso, Raffaele Marfella

“…The miRs’ expression profiles of circulating exosomes were determined at baseline and at 2 years of follow-up by Affymetrix microarrays from the patients’ plasma samples from any study cohort. …”
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FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer by Zhiyuan Zhou, Bin Zhang, Yue Deng, Suke Deng, Jie Li, Wenwen Wei, Yijun Wang, Jiacheng Wang, Zishan Feng, Mengjie Che, Xiao Yang, Jingshu Meng, Yan Li, Yan Hu, Yajie Sun, Lu Wen, Fang Huang, Yuhan Sheng, Chao Wan, Kunyu Yang

“…Mice models and tissue microarrays were used to verify the effects in vivo. …”
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Spatial Metrics of Interaction between CD163-Positive Macrophages and Cancer Cells and Progression-Free Survival in Chemo-Treated Breast Cancer by Brenton A. Maisel, Misung Yi, Amy R. Peck, Yunguang Sun, Jeffrey A. Hooke, Albert J. Kovatich, Craig D. Shriver, Hai Hu, Marja T. Nevalainen, Takemi Tanaka, Nicole Simone, Li Lily Wang, Hallgeir Rui, Inna Chervoneva

“…Immunofluorescence histo-cytometry of CD<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mn>163</mn><mo>+</mo></msup></semantics></math></inline-formula> TAMs was performed retrospectively on tumor microarrays of 443 cases of invasive breast cancer from patients who subsequently received adjuvant chemotherapy. …”
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EZH2-H3K27me3-mediated silencing of mir-139-5p inhibits cellular senescence in hepatocellular carcinoma by activating TOP2A by Ke Wang, Xunliang Jiang, Yu Jiang, Jun Liu, Yongtao Du, Zecheng Zhang, Yunlong Li, Xinhui Zhao, Jipeng Li, Rui Zhang

“…In addition, tissue microarrays were used to analyze the expression patterns and correlations among EZH2, TOP2A, and miR-139-5p expression in HCC. …”
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Prognostic Significance of Estrogen Receptor Alpha in Oral Squamous Cell Carcinoma by Christian Doll, Carolin Bestendonk, Kilian Kreutzer, Konrad Neumann, Anne Pohrt, Irena Trzpis, Steffen Koerdt, Steffen Dommerich, Max Heiland, Jan-Dirk Raguse, Korinna Jöhrens

“…The expression of ERα was evaluated on tissue microarrays by immunohistochemistry in the primary tumor and/or primary lymph node metastases. …”
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The C250T Mutation of <i>TERTp</i> Might Grant a Better Prognosis to Glioblastoma by Exerting Less Biological Effect on Telomeres and Chromosomes Than the C228T Mutation by Teresa Gorria, Carme Crous, Estela Pineda, Ainhoa Hernandez, Marta Domenech, Carolina Sanz, Pedro Jares, Ana María Muñoz-Mármol, Oriol Arpí-Llucía, Bárbara Melendez, Marta Gut, Anna Esteve, Anna Esteve-Codina, Genis Parra, Francesc Alameda, Cristina Carrato, Iban Aldecoa, Mar Mallo, Nuria de la Iglesia, Carmen Balana

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Analyzing the Impact of Oncological Data at Different Time Points and Tumor Biomarkers on Artificial Intelligence Predictions for Five-Year Survival in Esophageal Cancer by Leandra Lukomski, Juan Pisula, Naita Wirsik, Alexander Damanakis, Jin-On Jung, Karl Knipper, Rabi Datta, Wolfgang Schröder, Florian Gebauer, Thomas Schmidt, Alexander Quaas, Katarzyna Bozek, Christiane Bruns, Felix Popp

“…The models were trained using three predefined subsets of the training dataset as follows: (I) the baseline dataset (BL) consisting of pre-, intra-, and postoperative data, including the TNM but excluding tumor biomarkers, (II) clinical data accessible at the time of the initial diagnostic workup (primary staging dataset, PS), and (III) the PS dataset including tumor biomarkers from tissue microarrays (PS + biomarkers), excluding TNM status. …”
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Prognostic Role of Survivin and Macrophage Infiltration Quantified on Protein and mRNA Level in Molecular Subtypes Determined by RT-qPCR of <i>KRT5</i>, <i>KRT20</i>, and <i>ERBB2<... by Thorsten H. Ecke, Adisch Kiani, Thorsten Schlomm, Frank Friedersdorff, Anja Rabien, Klaus Jung, Ergin Kilic, Peter Boström, Minna Tervahartiala, Pekka Taimen, Jan Gleichenhagen, Georg Johnen, Thomas Brüning, Stefan Koch, Jenny Roggisch, Ralph M. Wirtz

“…Materials and Methods: We used tissue microarrays (TMA) from n = 50 patients (38 males, 12 female) with muscle-invasive bladder cancer. …”
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