Multifactorial Microvariability of the Italian Raw Milk Cheese Microbiota and Implication for Current Regulatory Scheme by Federico Fontana, Giulia Longhi, Giulia Alessandri, Gabriele Andrea Lugli, Leonardo Mancabelli, Chiara Tarracchini, Alice Viappiani, Rosaria Anzalone, Marco Ventura, Francesca Turroni, Christian Milani

“…Thus, these results highlighted the need for a profound rethinking of the current PDO designation with a focus on the production site-specific microbial metabolism to understand and guarantee the organoleptic features of the final product recognized as PDO. …”
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F8 gene inversion and duplication cause no obvious hemophilia A phenotype by Shaoying Li, Jianchun He, Liming Chu, Shuai Ren, Wenzhi He, Xiaoyan Ma, Yanchao Wang, Mincong Zhang, Lingyin Kong, Bo Liang, Qing Li

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Dietary Fibre Intake Is Associated with Serum Levels of Uraemic Toxins in Children with Chronic Kidney Disease by Amina El Amouri, Evelien Snauwaert, Aurélie Foulon, Charlotte Vande Moortel, Maria Van Dyck, Koen Van Hoeck, Nathalie Godefroid, Griet Glorieux, Wim Van Biesen, Johan Vande Walle, Ann Raes, Sunny Eloot

“…Imbalanced colonic microbial metabolism plays a pivotal role in generating protein-bound uraemic toxins (PBUTs), which accumulate with deteriorating kidney function and contribute to the uraemic burden of children with chronic kidney disease (CKD). …”
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The metabolic effects of intermittent versus continuous feeding in critically ill patients by D. Wilkinson, I. J. Gallagher, A. McNelly, D. E. Bear, N. Hart, H. E. Montgomery, A. Le Guennec, M. R. Conte, T. Francis, S. D. R. Harridge, P. J. Atherton, Z. A. Puthucheary

“…Logfold decreases in abundance were seen in metabolites related to amino acids (Glutamine − 0.682; Alanine − 0.594), ketone body metabolism (Acetone − 0.64; 3-Hydroxybutyric Acid − 0.632; Acetonacetic Acid − 0.586), fatty acid (carnitine − 0.509) and carbohydrate metabolism ( Maltose − 0.510; Citric Acid − 0.485). 2–3 Butanediol, a by-product of sugar-fermenting microbial metabolism also decreased (− 0.489). No correlation was seen with change in quadriceps muscle mass for any of the 20 metabolites varying with time (all p > 0.05). …”
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Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota by Koji Hosomi, Mayu Saito, Jonguk Park, Haruka Murakami, Naoko Shibata, Masahiro Ando, Takahiro Nagatake, Kana Konishi, Harumi Ohno, Kumpei Tanisawa, Attayeb Mohsen, Yi-An Chen, Hitoshi Kawashima, Yayoi Natsume-Kitatani, Yoshimasa Oka, Hidenori Shimizu, Mari Furuta, Yoko Tojima, Kento Sawane, Azusa Saika, Saki Kondo, Yasunori Yonejima, Haruko Takeyama, Akira Matsutani, Kenji Mizuguchi, Motohiko Miyachi, Jun Kunisawa

“…Here, the authors inversely associate Blautia wexlerae with obesity and type 2 diabetes mellitus in humans and further show that administration of B. wexlerae to mice decrease both high-fat diet–induced obesity and diabetes via modulating gut microbial metabolism.…”
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Reviewing the state of biosensors and lab-on-a- chip technologies: opportunities for extreme environments and space exploration by Stefano Cinti, Stefano Cinti, Stefano Cinti, Sima Singh, Giovanni Covone, Luca Tonietti, Luca Tonietti, Annarita Ricciardelli, Angelina Cordone, Roberta Iacono, Arianna Mazzoli, Marco Moracci, Marco Moracci, Marco Moracci, Marco Moracci, Alessandra Rotundi, Alessandra Rotundi, Donato Giovannelli, Donato Giovannelli, Donato Giovannelli, Donato Giovannelli, Donato Giovannelli, Donato Giovannelli

“…The possibility of evaluating the occurrence of unknown or unexpected species, identifying redox gradients relevant to microbial metabolism, or testing for specific possible biosignatures, will play a key role in the future of space microbiology. …”
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Physicochemical Properties and Microbiome of Vineyard Soils from DOP Ribeiro (NW Spain) Are Influenced by Agricultural Management by Pilar Blanco, Isaac Rodríguez, Victoria Fernández-Fernández, María Ramil, David Castrillo, Marta Acín-Albiac, Irene Adamo, Clara Fernández-Trujillo, Beatriz García-Jiménez, Alberto Acedo, Noemi Calvo-Portela, Andrea Parente-Sendín, Lara Acemel-Míguez, Flora Alonso-Vega

“…Our microbiome analysis demonstrated that transitioning from conventional to organic management significantly improves several BeCrop^® indexes related to key microbial metabolism and soil bio-sustainability. Such a transition does not affect soil alpha diversity, but leads to a higher interconnected microbial network structure. …”
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Th17 cells in primary Sjögren’s syndrome negatively correlate with increased Roseburia and Coprococcus by Xiaohong Xin, Xiaohong Xin, Xiaohong Xin, Qian Wang, Jianbo Qing, Jianbo Qing, Jianbo Qing, Wenzhu Song, Wenzhu Song, Yanni Gui, Xiaofeng Li, Xiaofeng Li, Xiaofeng Li, Yafeng Li, Yafeng Li, Yafeng Li, Yafeng Li

“…Furthermore, the pathways of biosynthesis of secondary metabolites, biosynthesis of amino acids, peptidoglycan biosynthesis and pyrimidine, galactose, pentose, microbial metabolism in diverse environments, glyoxylate and dicarboxylate metabolism are associated with Treg or Th17/Treg.ConclusionsPrimary Sjögren’s syndrome could lead to decreased gut microbial diversity and richness of intestinal flora in patients. …”
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Marked Response in Microbial Community and Metabolism in the Ileum and Cecum of Suckling Piglets After Early Antibiotics Exposure by Miao Yu, Miao Yu, Miao Yu, Chunlong Mu, Chunlong Mu, Chuanjian Zhang, Chuanjian Zhang, Yuxiang Yang, Yuxiang Yang, Yong Su, Yong Su, Weiyun Zhu, Weiyun Zhu

“…The present study aimed to investigate the effects of early antibiotics exposure on gut microbiota and microbial metabolism of suckling piglets. Sixteen litters of suckling piglets were fed a creep feed diet with (Antibiotic) or without (Control) antibiotics from postnatal days 7–23 (n = 8). …”
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Metagenomic Features Characterized with Microbial Iron Oxidoreduction and Mineral Interaction in Southwest Indian Ridge by Ying-Wen Zhong, Peng Zhou, Hong Cheng, Ya-Dong Zhou, Jie Pan, Lin Xu, Meng Li, Chun-Hui Tao, Yue-Hong Wu, Xue-Wei Xu

“…Understanding about how minerals influence microbial metabolism is currently limited given the obstacles in cultivating microorganisms with sulfur or iron oxidoreduction functions. …”
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Multidimensional morphological analysis of live sperm based on multiple-target tracking by Hao Yang, Mengmeng Ma, Xiangfeng Chen, Guowu Chen, Yi Shen, Lijun Zhao, Jianfeng Wang, Feifei Yan, Difeng Huang, Huijie Gao, Hao Jiang, Yuqian Zheng, Yu Wang, Qian Xiao, Ying Chen, Jian Zhou, Jie Shi, Yi Guo, Bo Liang, Xiaoming Teng

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Dynamic fecal microenvironment properties enable predictions and understanding of peripartum blood oxidative status and nonesterified fatty acids in dairy cows by Sen-Lin Zhu, Feng-Fei Gu, Yi-Fan Tang, Xiao-Han Liu, Ming-Hui Jia, Teresa G. Valencak, Jian-Xin Liu, Hui-Zeng Sun

“…ABSTRACT: The transition period in dairy cows is a critical stage and peripartum oxidative status, negative energy balance (NEB), and inflammation are highly prevalent. Fecal microbial metabolism is closely associated with blood oxidative status and nonesterified fatty acids (NEFA) levels. …”
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Main Determinants Affecting the Antiproliferative Activity of Stilbenes and Their Gut Microbiota Metabolites in Colon Cancer Cells: A Structure–Activity Relationship Study by Antonio González-Sarrías, Juan Carlos Espín-Aguilar, Salvador Romero-Reyes, Julio Puigcerver, Mateo Alajarín, José Berná, María Victoria Selma, Juan Carlos Espín

“…However, how this microbial metabolism affects the cancer chemopreventive activity of stilbenes and their microbial metabolites is poorly known. …”
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Exploring the natural products chemical space through a molecular search to discover potential inhibitors that target the hypoxia-inducible factor (HIF) prolyl hydroxylase domain (... by Abrar Mohammad Sayaf, Saif Ullah Khalid, Jawad Ahmed Hameed, Abdulrahman Alshammari, Abbas Khan, Abbas Khan, Anwar Mohammad, Saeed Alghamdi, Dong-Qing Wei, Dong-Qing Wei, Dong-Qing Wei, Dong-Qing Wei, KarKheng Yeoh

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A Novel TetR Family Transcriptional Regulator, CalR3, Negatively Controls Calcimycin Biosynthesis in Streptomyces chartreusis NRRL 3882 by Lixia Gou, Lixia Gou, Lixia Gou, Tiesheng Han, Tiesheng Han, Tiesheng Han, Xiaoxia Wang, Xiaoxia Wang, Xiaoxia Wang, Jingxuan Ge, Jingxuan Ge, Jingxuan Ge, Wenxiu Liu, Wenxiu Liu, Wenxiu Liu, Fen Hu, Fen Hu, Fen Hu, Zhijun Wang

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Combining thermosonication microstress and pineapple peel extract addition to achieve quality and post-acidification control in yogurt fermentation by Xiaohui Zhang, Yuanrong Zheng, Changyu Zhou, Jinxuan Cao, Yifeng Zhang, Zhen Wu, Daodong Pan, Zhendong Cai, Qiang Xia

“…The results of targeted metabolomics indicated the proposed combination strategy significantly modified the microbial metabolism, leading to the delayed utilization of lactose and the inhibited conversion into glucose during post-fermentation, as well as the decreased lactic acid production and a notable shift towards the formation of relatively weak acids such as succinic acid and citric acid. …”
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Geographically Associated Fungus-Bacterium Interactions Contribute to the Formation of Geography-Dependent Flavor during High-Complexity Spontaneous Fermentation by Yuwei Tan, Hai Du, Hongxia Zhang, Chen Fang, Guangyuan Jin, Shuang Chen, Qun Wu, Yan Zhang, Menghui Zhang, Yan Xu

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Circulating miR-1246 Targeting UBE2C, TNNI3, TRAIP, UCHL1 Genes and Key Pathways as a Potential Biomarker for Lung Adenocarcinoma: Integrated Biological Network Analysis by Siyuan Huang, Yong-Kai Wei, Satyavani Kaliamurthi, Yanghui Cao, Asma Sindhoo Nangraj, Xin Sui, Dan Chu, Huan Wang, Dong-Qing Wei, Gilles H. Peslherbe, Gurudeeban Selvaraj, Jiang Shi

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Sensitive and selective phenol sensing in denitrifying Aromatoleum aromaticum EbN1T by Ramona Buschen, Pia Lambertus, Sabine Scheve, Simon Horst, Fei Song, Lars Wöhlbrand, John Neidhardt, Michael Winklhofer, Tristan Wagner, Ralf Rabus

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Multi-omics analysis of oral bacterial biofilm on titanium oxide nanostructure modified implant surface: In vivo sequencing-based pilot study in beagle dogs by Hanyu Sun, Yuki Chan, Xuan Li, Ruogu Xu, Zhengchuan Zhang, Xiucheng Hu, Fan Wu, Feilong Deng, Xiaolin Yu

“…Moreover, the differentially expressed genes (DEGs) were associated with microbial metabolism, protein synthesis and bacterial invasion of epithelial cells. …”
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