Electrical Input Filters of Ganglion Cells in Wild Type and Degenerating rd10 Mouse Retina as a Template for Selective Electrical Stimulation by Hamed Shabani, Eberhart Zrenner, Daniel L. Rathbun, Zohreh Hosseinzadeh

“…Ganglion cell spike trains were recorded during stimulation using a 60-channel microelectrode array. Hierarchical clustering divided the recorded RGC populations according to their visual and electrical response patterns. …”
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Controlled placement of multiple CNS cell populations to create complex neuronal cultures. by D Soscia, A Belle, N Fischer, H Enright, A Sales, J Osburn, W Benett, E Mukerjee, K Kulp, S Pannu, E Wheeler

“…This study describes a removable insert that successfully deposits neurons from different brain areas onto discrete regions of a microelectrode array (MEA) surface, achieving a separation distance of 100 μm. …”
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Liquid Crystal Polymer-Based Miniaturized Fully Implantable Deep Brain Stimulator by Seung-Hee Ahn, Chin Su Koh, Minkyung Park, Sang Beom Jun, Jin Woo Chang, Sung June Kim, Hyun Ho Jung, Joonsoo Jeong

“…The system integrates the simulator circuit, the receiver coil, and a 20 mm long depth-type microelectrode array in a dome-shaped LCP package that is 13 mm in diameter and 5 mm in height. …”
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Dual-Mode Graphene Field-Effect Transistor Biosensor with Isothermal Nucleic Acid Amplification by Hyo Eun Kim, Ariadna Schuck, Hyeonseek Park, Doo Ryeon Chung, Minhee Kang, Yong-Sang Kim

“…The G-FET biosensor, which has a transparent graphene microelectrode array on a glass substrate, detects LAMP products in less than 30 min using both observable color changes and Dirac point voltage measurements, even in samples with low viral concentrations. …”
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Electrical Characterization and Analysis of Single Cells and Related Applications by Weitao Zhu, Jiaao Wang, Hongzhi Luo, Binwen Luo, Xue Li, Shan Liu, Chenzhong Li

“…Furthermore, it summarizes common single-cell electrical manipulations, such as single-cell amperometry (SCA), electrical impedance sensing (EIS), impedance flow cytometry (IFC), cell-based electrical impedance (CEI), microelectromechanical systems (MEMS), and integrated microelectrode array (IMA). The article also enumerates the application and significance of single-cell electrochemical analysis from the perspectives of CTC liquid biopsy, recombinant adenovirus, tumor cells like lung cancer DTCs (LC-DTCs), and single-cell metabolomics analysis. …”
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Can motor volition be extracted from the spinal cord? by Prasad Abhishek, Sahin Mesut

“…</p> <p>Methods</p> <p>In this work, adult male rats were implanted with a 15-channel microelectrode array (MEA) in the dorsolateral funiculus of the cervical spinal cord to record multi-unit activity from the descending pathways while the animals performed a reach-to-grasp task. …”
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Development path and current status of the NANIVID: a new device for cancer cell studies by Raja, Waseem Khan, Padgen, Michael R., Williams, James K., Gertler, Frank, Wyckoff, Jeffrey B., Condeelis, John S., Castracane, James

“…The device contains a customized hydrogel blend that is loaded with epidermal growth factor (EGF), which diffuses from the outlet to create a chemotactic gradient that can be sustained for many hours in order to attract specific cells to the device. A microelectrode array is under development for quantification of cell collection and will be incorporated into future device generations. …”
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A brain–spine interface alleviating gait deficits after spinal cord injury in primates by Capogrosso, M, Milekovic, T, Borton, D, Wagner, F, Moraud, E, Mignardot, J, Buse, N, Gandar, J, Barraud, Q, Xing, D, Rey, E, Duis, S, Jianzhong, Y, Ko, W, Li, Q, Detemple, P, Denison, T, Micera, S, Bezard, E, Bloch, J, Courtine, G

“…Rhesus monkeys (Macaca mulatta) were implanted with an intracortical microelectrode array in the leg area of the motor cortex and with a spinal cord stimulation system composed of a spatially selective epidural implant and a pulse generator with real-time triggering capabilities. …”

Proarrhythmia risk prediction using human induced pluripotent stem cell-derived cardiomyocytes by Daiju Yamazaki, Takashi Kitaguchi, Masakazu Ishimura, Tomohiko Taniguchi, Atsuhiro Yamanishi, Daisuke Saji, Etsushi Takahashi, Masao Oguchi, Yuta Moriyama, Sanae Maeda, Kaori Miyamoto, Kaoru Morimura, Hiroki Ohnaka, Hiroyuki Tashibu, Yuko Sekino, Norimasa Miyamoto, Yasunari Kanda

“…Keywords: Early afterdepolarization, hiPSC-CMs, Microelectrode array, Proarrhythmia, Safety assessment…”
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Selective stimulation of the ferret abdominal vagus nerve with multi-contact nerve cuff electrodes by Jonathan A. Shulgach, Dylan W. Beam, Ameya C. Nanivadekar, Derek M. Miller, Stephanie Fulton, Michael Sciullo, John Ogren, Liane Wong, Bryan L. McLaughlin, Bill J. Yates, Charles C. Horn, Lee E. Fisher

“…Four-contact nerve cuff electrodes were implanted around the dorsal (N = 3) or ventral (N = 3) abdominal vagus nerve in six ferrets, and the response to stimulation was measured via a 32-channel microelectrode array (MEA) inserted into the left or right nodose ganglion. …”
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Microfluidic Bi-Layer Platform to Study Functional Interaction between Co-Cultured Neural Networks with Unidirectional Synaptic Connectivity by Yana Pigareva, Arseniy Gladkov, Vladimir Kolpakov, Anton Bukatin, Sergei Li, Victor B. Kazantsev, Irina Mukhina, Alexey Pimashkin

“…We utilized cultures of hippocampal neurons grown in a two-chamber microfluidic chip combined with a microelectrode array. The asymmetric configuration of the microchannels between the chambers ensured the growth of axons predominantly in one direction from the Source chamber to the Target chamber, forming two neuronal networks with unidirectional synaptic connectivity. …”
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Impact of Stress on Gamma Oscillations in the Rat Nucleus Accumbens During Spontaneous Social Interaction by Ann Mary Iturra-Mena, Marcelo Aguilar-Rivera, Marcia Arriagada-Solimano, Catherine Pérez-Valenzuela, Pablo Fuentealba, Alexies Dagnino-Subiabre

“…One group of male Sprague-Dawley rats were exposed to chronic social defeat stress (CSDS) while the other group was left undisturbed (control group). Afterward, a microelectrode array was implanted in the NAc of all animals. …”
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Functional engineering of human iPSC‐derived parasympathetic neurons enhances responsiveness to gastrointestinal hormones by Yuka Akagi, Yuzo Takayama, Yuma Nihashi, Azusa Yamashita, Risa Yoshida, Yasuhisa Miyamoto, Yasuyuki S. Kida

“…We generated GI hormone receptor‐expressing neurons (CCKAR, GLP1R, and NPY2R‐neuron) and tested their responsiveness to each ligand using Ca2+ imaging and microelectrode array recording. GI hormone receptor‐expressing neurons (GLP2R and HTR3A) were generated directly by gene induction into iPSC‐derived peripheral nerve progenitors. …”
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Molecular and Cellular Impact of Inflammatory Extracellular Vesicles (EVs) Derived from M1 and M2 Macrophages on Neural Action Potentials by Sarah Vakili, Taha Mohseni Ahooyi, Shadan S. Yarandi, Martina Donadoni, Jay Rappaport, Ilker K. Sariyer

“…In order to investigate the molecular and cellular impacts of macrophages and EVs released from macrophage subtypes on neuronal functions, we used a recently established in vitro M1 and M2 macrophage culture model and isolated and characterized EVs from these macrophage subtypes, treated primary neurons with M1 or M2 EVs, and analyzed the extracellular action potentials of neurons with microelectrode array studies (MEA). Our results introduce evidence on the interfering role of inflammatory EVs released from macrophages in interneuronal signal transmission processes, with implications in the pathogenesis of neuroinflammatory diseases induced by a variety of inflammatory insults.…”
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Differential Effects of Human P301L Tau Expression in Young versus Aged Mice by Holly C. Hunsberger, Sharay E. Setti, Carolyn C. Rudy, Daniel S. Weitzner, Jeremiah C. Pfitzer, Kelli L. McDonald, Hao Hong, Subhrajit Bhattacharya, Vishnu Suppiramaniam, Miranda N. Reed

“…These behavioral changes may be due to enhanced late-stage tau pathology, as evidenced by immunoblotting and exacerbated hippocampal dysregulation of glutamate release and uptake measured by the microelectrode array technique. We additionally observed changes in proteins important for the regulation of glutamate and tau phosphorylation that may mediate these age-related changes. …”
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A Multipurpose CMOS Platform for Nanosensing by Alberto Bonanno, Alessandro Sanginario, Simone L. Marasso, Beatrice Miccoli, Katarzyna Bejtka, Simone Benetto, Danilo Demarchi

“…The NW assembly process is driven by an array of on-chip dielectrophoresis (DEP) generators, enabling a custom layout of different nanosensors on the same microelectrode array. The electrical properties of each assembled NW are singularly sensed through an in situ CMOS read-out circuit (ROC) that guarantees a low noise and reliable measurement. …”
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Neuroprotective Potential of L-Glutamate Transporters in Human Induced Pluripotent Stem Cell-Derived Neural Cells against Excitotoxicity by Kanako Takahashi, Yuto Ishibashi, Kaori Chujo, Ikuro Suzuki, Kaoru Sato

“…At 63 days in vitro (DIV), we detected neuronal circuit functions in hiPSC-derived neural cells by a microelectrode array system (MEA). At 63 DIV, exposure to 100 μM L-Glu for 24 h did not affect the viability of neural cells. 100 µM L-Glu in the medium decreased to almost 0 μM in 60 min. …”
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Development and Characterization of PEDOT:PSS/Alginate Soft Microelectrodes for Application in Neuroprosthetics by Laura Ferlauto, Antonio Nunzio D’Angelo, Paola Vagni, Marta Jole Ildelfonsa Airaghi Leccardi, Flavio Maurizio Mor, Estelle Annick Cuttaz, Marc Olivier Heuschkel, Luc Stoppini, Diego Ghezzi

“…In this work, we report the fabrication of a conductive hydrogel-based microelectrode array for neural recording using a hybrid material composed of poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate), and alginate. …”
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Losartan protects human stem cell-derived cardiomyocytes from angiotensin II-induced alcoholic cardiotoxicity by Yuanxiu Song, Hongxia Li, Shuhong Ma, Min Zhu, Wen-jing Lu, Feng Lan, Ming Cui

“…Real-time cell analysis(RTCA) and microelectrode array (MEA) were used to continuously monitor myocardial beating, observe the effects of alcohol on myocardial electrophysiological activity, and clarify the protective effects of the AT1R blocker losartan on ACM. …”
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Investigating the effect of Shenmai injection on cardiac electrophysiology and calcium signaling using human-induced pluripotent stem cell-derived cardiomyocytes by Zhang Zhang, Yuxin Li, Meihui Yan, Tingting Yu, Xin Yuan, Sen Li

“…Aim of the study: We aimed to systemically evaluate the efficacy and investigate the mechanisms of SMI in modulating electrophysiology and calcium (Ca2+) signaling using a microelectrode array (MEA) and a genetically encoded Ca2+ indicator, GCaMP6s, respectively, in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). …”
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