A human induced pluripotent stem cell‐derived cortical neuron human‐on‐a chip system to study Aβ42 and tau‐induced pathophysiological effects on long‐term potentiation by Julbert Caneus, Nesar Akanda, John W. Rumsey, Xiufang Guo, Max Jackson, Christopher J. Long, Frank Sommerhage, Sanya Georgieva, Nicholas M. Kanaan, David Morgan, James J. Hickman

“…Results Impaired information processing was demonstrated by treatment of neuron‐MEA (microelectrode array) systems with the oligomers and brain extracts by reducing the effects of LTP induction. …”
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Assay for evaluation of proarrhythmic effects of herbal products: Case study with 12 Evodia preparations by Bozhidar Baltov, Stanislav Beyl, Igor Baburin, Jakob Reinhardt, Phillip Szkokan, Aleksandra Garifulina, Eugen Timin, Udo Kraushaar, Olivier Potterat, Matthias Hamburger, Philipp Kügler, Steffen Hering

“…Here, we propose a cardiac safety assay for the detection of proarrhythmic effects of plant extracts based on the experimental approaches described in the Comprehensive In vitro Proarrhythmia Assay (CiPA). Microelectrode array studies (MEAs) and voltage sensing optical technique on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) were combined with ionic current measurements in mammalian cell lines, In-silico simulations of cardiac action potentials (APs) and statistic regression analysis. …”
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Optimization of stimulation parameters for epi-retinal implant based on biosafety consideration. by Yijie Lu, Shan Qin, Lei Zhao, Lan Yue, Tianzhun Wu, Bo Qin, Zhen Xu

“…<h4>Methods</h4>We stimulated mouse retina using biphasic pulse waveform generated by chosen electrodes (single or a 3x3 assembly) from multiple microelectrode arrays, recorded their action potentials and performed spike sorting. …”
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A Wireless Electro-Optic Platform for Multimodal Electrophysiology and Optogenetics in Freely Moving Rodents by Guillaume Bilodeau, Gabriel Gagnon-Turcotte, Léonard L. Gagnon, Iason Keramidis, Igor Timofeev, Yves De Koninck, Christian Ethier, Benoit Gosselin, Benoit Gosselin

“…We recorded AP and LFP signals with the platform using a 16-microelectrode array implanted in the primary motor cortex of a Long Evans rat, both in anesthetized and freely moving conditions. …”
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Zinc Oxide Nanoparticles Induce Mitochondrial Biogenesis Impairment and Cardiac Dysfunction in Human iPSC-Derived Cardiomyocytes by Li Y, Li F, Zhang L, Zhang C, Peng H, Lan F, Peng S, Liu C, Guo J

“…Mitochondrial biogenesis was assayed by detection of mtDNA copy number and PGC-1&alpha; pathway. Moreover, microelectrode array techniques were used to investigate cardiac electrophysiological alterations.Results: We demonstrated that ZnO NPs concentration- and time-dependently elicited cytotoxicity in hiPSC-CMs. …”
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Learning populations with hubs govern the initiation and propagation of spontaneous bursts in neuronal networks after learning by Xiaoli Jia, Xiaoli Jia, Wenwei Shao, Wenwei Shao, Nan Hu, Nan Hu, Jianxin Shi, Jianxin Shi, Xiu Fan, Xiu Fan, Chong Chen, Youwei Wang, Youwei Wang, Liqun Chen, Liqun Chen, Huanhuan Qiao, Huanhuan Qiao, Xiaohong Li, Xiaohong Li

“…By combining high-resolution measurement with a 4,096-channel complementary metal-oxide-semiconductor (CMOS) microelectrode array (MEA) and graph theory, we studied how the learning phase influenced the initiation of spontaneous bursts in cultured networks of rat cortical neurons in vitro. …”
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The pseudoenzyme ADPRHL1 affects cardiac function by regulating the ROCK pathway by Lei Tian, Tianwei Guo, Fujian Wu, Rui Bai, Sinan Ai, Hongyue Wang, Yuanxiu Song, Min Zhu, Youxu Jiang, Shuhong Ma, Xiaofeng Zhuang, Shuzhen Guo

“…We employed confocal laser microscopy to detect calcium transients and microelectrode array (MEA) to assess the electrophysiological activity of ADPRHL1 deficiency cardiomyocytes. …”
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Interferon-γ augments GABA release in the developing neocortex via nitric oxide synthase/soluble guanylate cyclase and constrains network activity by Noah Döhne, Alice Falck, Gabriel M. S. Janach, Egor Byvaltcev, Egor Byvaltcev, Ulf Strauss

“…Functionally, IFN-γ-mediated alterations in GABAergic transmission overall constrained early neocortical activity in a partly nitric oxide–dependent manner as revealed by microelectrode array field recordings in brain slices analyzed with a spike-sorting algorithm. …”
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Gene-Edited Human-Induced Pluripotent Stem Cell Lines to Elucidate <i>DAND5</i> Function throughout Cardiac Differentiation by José M. Inácio, Mafalda M. Nunes, Micael Almeida, Fernando Cristo, Rui Anjos, José A. Belo

“…Moreover, parallel cardiac differentiations showed a differential cardiac gene expression profile, with upregulated cardiac progenitor markers in DAND5-KO hiPSC-CMs. Microelectrode array (MEA) measurements demonstrated that DAND5-KO hiPSC-CMs showed prolonged field potential duration and increased spontaneous beating rates. …”
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Apelin Inhibits Angiotensin II-Induced Atrial Fibrosis and Atrial Fibrillation via TGF-β1/Smad2/α-SMA Pathway by Wenkui Lv, Wenkui Lv, Ling Zhang, Ling Zhang, Xinchun Cheng, Hongli Wang, Wen Qin, Xianhui Zhou, Xianhui Zhou, Baopeng Tang, Baopeng Tang

“…Atrial electrophysiological mapping was recorded by a 32-electrode microelectrode array. Blood was collected to measure the levels of Ang II and apelin. …”
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hiPSC-derived GRN-deficient astrocytes delay spiking activity of developing neurons by Christopher Lee, Jonathan Frew, Nicholas L. Weilinger, Stefan Wendt, Wenji Cai, Stefano Sorrentino, Xiujuan Wu, Brian A. MacVicar, Stephanie M. Willerth, Haakon B. Nygaard

“…Here, we utilized human induced pluripotent stem cell (hiPSC)-derived neural tissue carrying a homozygous GRN R493X−/− knock-in mutation to investigate in vitro whether GRN mutant astrocytes have a non-cell autonomous effect on neurons. Using microelectrode array (MEA) analysis, we demonstrate that the development of spiking activity of neurons cultured with GRN R493X−/− astrocytes was significantly delayed compared to cultures with WT astrocytes. …”
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KCNQ1-deficient and KCNQ1-mutant human embryonic stem cell-derived cardiomyocytes for modeling QT prolongation by Yuanxiu Song, Tianwei Guo, Youxu Jiang, Min Zhu, Hongyue Wang, Wenjing Lu, Mengqi Jiang, Man Qi, Feng Lan, Ming Cui

“…In this study, we established a KCNQ1-deficient human cardiomyocyte (CM) model and performed a series of microelectrode array (MEA) detection experiments on KCNQ1-mutant CMs constructed in other studies to explore the pathogenic mechanism of KCNQ1 deletion and mutation and perform drug screening. …”
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Spinal neuromodulation mitigates myocardial ischemia-induced sympathoexcitation by suppressing the intermediolateral nucleus hyperactivity and spinal neural synchrony by Siamak Salavatian, Siamak Salavatian, Yuki Kuwabara, Benjamin Wong, Jonathan R. Fritz, Kimberly Howard-Quijano, Kimberly Howard-Quijano, Robert D. Foreman, J. Andrew Armour, Jeffrey L. Ardell, Aman Mahajan, Aman Mahajan

“…Extracellular in vivo and in situ spinal dorsal horn (DH) and intermediolateral column (IML) neural recordings were performed using a multichannel microelectrode array inserted at the T2-T3 segment of the spinal cord. …”
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Vagus nerve stimulation-induced cognitive enhancement: Hippocampal neuroplasticity in healthy male rats by Laura K. Olsen, Raquel J. Moore, Naomi A. Bechmann, Victoria T. Ethridge, Nathan M. Gargas, Sylvia D. Cunningham, Zhanpeng Kuang, Joshua K. Whicker, Joyce G. Rohan, Candice N. Hatcher-Solis

“…Electrophysiology recordings were collected using a microelectrode array system to assess functional effects on HC slices 90 min after VNS (N = 19). …”
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Unraveling the assembloid: Real-time monitoring of dopaminergic neurites in an inter-organoid pathway connecting midbrain and striatal regions by Alp Ozgun, David J. Lomboni, Amy Aylsworth, Allison Macdonald, William A. Staines, Marzia Martina, Michael G. Schlossmacher, Joseph S. Tauskela, John Woulfe, Fabio Variola

“…In particular, dopaminergic neurons and striatal GABAergic neurons spontaneously form DA connections across a microelectrode array (MEA), specifically integrated for the real-time monitoring of electrophysiological development and stimuli response. …”
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Representation and decoding of bilateral arm motor imagery using unilateral cerebral LFP signals by Jiafan Lin, Jiafan Lin, Dongrong Lai, Dongrong Lai, Zijun Wan, Zijun Wan, Linqing Feng, Junming Zhu, Junming Zhu, Jianmin Zhang, Jianmin Zhang, Yueming Wang, Yueming Wang, Yueming Wang, Kedi Xu, Kedi Xu, Kedi Xu, Kedi Xu

“…Here we examined the representation and decoding of different laterality and regions arm motor imagery in unilateral motor cortex based on local field potentials (LFPs).MethodsThe LFP signals were recorded from a 96-channel Utah microelectrode array implanted in the left primary motor cortex of a paralyzed participant. …”
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International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment by Ksenia Blinova, Qianyu Dang, Daniel Millard, Godfrey Smith, Jennifer Pierson, Liang Guo, Mathew Brock, Hua Rong Lu, Udo Kraushaar, Haoyu Zeng, Hong Shi, Xiaoyu Zhang, Kohei Sawada, Tomoharu Osada, Yasunari Kanda, Yuko Sekino, Li Pang, Tromondae K. Feaster, Ralf Kettenhofen, Norman Stockbridge, David G. Strauss, Gary Gintant

“…Keywords: comprehensive in vitro proarrhythmia assay, CiPA, human-induced pluripotent stem cell-derived cardiomycotes, hiPSC-CM, drug-induced ventricular arrhythmia Torsade de Pointes, microelectrode array, voltage-sensitive dyes…”
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HAND factors regulate cardiac lineage commitment and differentiation from human pluripotent stem cells by Huixin Guo, Chengwen Hang, Bowen Lin, Zheyi Lin, Hui Xiong, Mingshuai Zhang, Renhong Lu, Junyang Liu, Dan Shi, Duanyang Xie, Yi Liu, Dandan Liang, Jian Yang, Yi-Han Chen

“…The expression of specific markers for heart fields and cardiomyocyte subtypes was examined by quantitative PCR, western blot and immunofluorescence staining. Microelectrode array and whole-cell patch clamp were performed to determine the electrophysiological characteristics of differentiated cardiomyocytes. …”
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A Portable Live-Cell Imaging System With an Invert-Upright-Convertible Architecture and a Mini-Bioreactor for Long-Term Simultaneous Cell Imaging, Chemical Sensing, and Electrophys... by Dhanesh Kattipparambil Rajan, Joose Kreutzer, Hannu Valimaki, Mari Pekkanen-Mattila, Antti Ahola, Anne Skogberg, Katriina Aalto-Setala, Heimo Ihalainen, Pasi Kallio, Jukka Lekkala

“…Cell characterization, differentiation, chemical sensing, drug screening, microelectrode-array-electrophysiological recordings, and cell stimulation can be carried out with simultaneous in-situ imaging and analysis. …”
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Postsynaptic structure formation of human iPS cell-derived neurons takes longer than presynaptic formation during neural differentiation in vitro by Kazuyuki Togo, Hayato Fukusumi, Tomoko Shofuda, Hiroshi Ohnishi, Hiroyuki Yamazaki, Mariko Kato Hayashi, Nana Kawasaki, Nobuyuki Takei, Takanobu Nakazawa, Yumiko Saito, Kousuke Baba, Hitoshi Hashimoto, Yuko Sekino, Tomoaki Shirao, Hideki Mochizuki, Yonehiro Kanemura

“…Neurophysiological analysis using a microelectrode array also revealed that no synaptic activity was generated on hiPSC-neurons at 49 days of differentiation. …”
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