Genetic Modulation at the Neural Microelectrode Interface: Methods and Applications by Bailey M. Winter, Samuel R. Daniels, Joseph W. Salatino, Erin K. Purcell

“…The use of implanted microelectrode arrays (MEAs), in the brain, has enabled a greater understanding of neural function, and new treatments for neurodegenerative diseases and psychiatric disorders. …”
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Enhancement of cortical network activity in vitro and promotion of GABAergic neurogenesis by stimulation with an electromagnetic field with a 150 MHz carrier wave pulsed with an al... by Alexandra eGramowski-Voss, Hans-Joachim eSchwertle, Anna-Maria ePielka, Luise eSchultz, Luise eSchultz, Anne eSteder, Konstantin eJuegelt, Juergen eAxmann, Wolfgang ePries

“…Applications of electromagnetic fields to brain tissue have been shown to affect cellular properties and their importance for therapies in medicine is recognized.In this study, differentiating murine cortical networks on multiwell microelectrode arrays were repeatedly exposed to an extremely low electromagnetic field (ELEMF) with alternating 10 and 16 Hz frequencies piggy-backed onto a 150 MHz carrier frequency. …”
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Recent Progress on Non-Conventional Microfabricated Probes for the Chronic Recording of Cortical Neural Activity by Chaebin Kim, Joonsoo Jeong, Sung June Kim

“…While various cortical microelectrode arrays have been extensively and successfully demonstrated in animal and clinical studies, there remains room for further improvement of the probe structure, materials, and fabrication technology, particularly for high-fidelity recording in chronic implantation. …”
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In Vitro Cytotoxicity of D18 and Y6 as Potential Organic Photovoltaic Materials for Retinal Prostheses by Ana Cetkovic, Alessandro Bellapianta, Mihai Irimia-Vladu, Jakob Hofinger, Cigdem Yumusak, Andrea Corna, Markus Clark Scharber, Günther Zeck, Niyazi Serdar Sariciftci, Matthias Bolz, Ahmad Salti

“…We also assessed electrophysiological recordings on mouse retinal explants via microelectrode arrays (MEAs) coated with D18/Y6. In contrast to PFN-Br and PDIN, all in vitro experiments show no cytotoxicity of D18 and Y6 alone or as a D18/Y6 mixture. …”
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Scale-invariant neuronal avalanche dynamics and the cut-off in size distributions. by Shan Yu, Andreas Klaus, Hongdian Yang, Dietmar Plenz

“…The local field potential (LFP) was recorded from premotor and prefrontal cortices in two awake macaque monkeys during rest using chronically implanted 96-microelectrode arrays. Negative deflections in the LFP (nLFP) were identified on the full as well as compact sub-regions of the array quantified by the number of electrodes N (10-95), i.e., the window size. …”
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Adult mouse dorsal root ganglia neurons form aberrant glutamatergic connections in dissociated cultures. by F Kemal Bayat, Betul Polat Budak, Esra Nur Yiğit, Gürkan Öztürk, Halil Özcan Gülçür, Albert Güveniş

“…DRG neurons were grown on microelectrode arrays (MEA) to induce stimulus-evoked activity with a modality-free stimulation strategy. …”
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A New Model to Perform Electrophysiological Studies in the Early Embryonic Mouse Heart by Anna Kornblum, Frank Pillekamp, Matthias Matzkies, Bernd Fleischmann, Hendrik Bonnemeier, Heribert Schunkert, Konrad Brockmeier, Jürgen Hescheler, Michael Reppel

“…Methods and Results: For our studies we used substrate-integrated Microelectrode Arrays combined with newly developed stimulation electrodes to perform electrophysiological studies in these hearts. …”
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Conducting polymer wires for intravascular neural recording by Ruddy, Bryan P. (Bryan Paul), 1983-

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L-Type Calcium Channel Inhibition Contributes to the Proarrhythmic Effects of Aconitine in Human Cardiomyocytes. by Jianjun Wu, Xiangchong Wang, Ying Ying Chung, Cai Hong Koh, Zhenfeng Liu, Huicai Guo, Qiang Yuan, Chuan Wang, Suwen Su, Heming Wei

“…Lastly, increased beating frequency, decreased Ca2+ wave and shortened field potential duration were recorded from hiPSC-CMs by microelectrode arrays assay. In summary, our data demonstrated that LTCC inhibition could play a main role in the proarrhythmic action of ACO in human cardiomyocytes.…”
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Slow conduction in mixed cultured strands of primary ventricular cells and stem cell-derived cardiomyocytes by Jan Pavel Kucera, Yann ePrudat, Irene C Marcu, Irene C Marcu, Michela eAzzarito, Nina D Ullrich

“…Murine embryonic SCMs were pooled with fetal ventricular cells and seeded in predefined proportions on microelectrode arrays to form patterned strands of mixed cells. …”
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Stretchable and Transparent Metal Nanowire Microelectrodes for Simultaneous Electrophysiology and Optogenetics Applications by Jinbi Tian, Zexu Lin, Zhiyuan Chen, Sofian N. Obaid, Igor R. Efimov, Luyao Lu

“…The resulting Ag NW interface exhibits a low sheet resistance (R_sh) of 1.52–4.35 Ω sq⁻¹, an advantageous normalized electrochemical impedance of 3.78–6.04 Ω cm², a high optical transparency of 61.3–80.5% at 550 nm and a stretchability of 40%. The microelectrode arrays (MEAs) fabricated with this approach exhibit uniform electrochemical performance across all channels. …”
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Evidence for a critical role of catecholamines for cardiomyocyte lineage commitment in murine embryonic stem cells. by Martin Lehmann, Filomain Nguemo, Vilas Wagh, Kurt Pfannkuche, Jürgen Hescheler, Michael Reppel

“…Proliferation was analyzed by EB cross-section measurements, while functionality of cardiomyocytes was studied by extracellular field potential (FP) measurements using microelectrode arrays (MEAs). To further differentiate between substance-specific effects of reserpine and catecholamine action via α- and β-receptors we proved the involvement of adrenergic receptors by application of unspecific α- and β-receptor antagonists. …”
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Comparative study between radiofrequency-induced and muscimol-induced inhibition of cultured networks of cortical neuron. by Clément E Lemercier, André Garenne, Florence Poulletier de Gannes, Corinne El Khoueiry, Delia Arnaud-Cormos, Philippe Levêque, Isabelle Lagroye, Yann Percherancier, Noëlle Lewis

“…Previous studies have shown that spontaneously active cultured networks of cortical neuron grown planar microelectrode arrays are sensitive to radiofrequency (RF) fields and exhibit an inhibitory response more pronounced as the exposure time and power increase. …”
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Spatiotemporally controlled cardiac conduction block using high-frequency electrical stimulation. by Burak Dura, Gregory T A Kovacs, Laurent Giovangrandi

“…METHODOLOGY/PRINCIPAL FINDINGS: We investigated the effects of broader amplitude and frequency ranges on the inhibitory effects of extracellular AC stimulation on HL-1 cardiomyocytes cultured on microelectrode arrays, using both sinusoidal and square waveforms. …”
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Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity. by Christine M A Prat, Sonja Schmid, Fanny Farrugia, Nicolas Cenac, Gwendal Le Masson, Martin Schwemmle, Daniel Gonzalez-Dunia

“…Finally, activity-dependent modulation of synaptic activity was restored, as assessed by measuring calcium dynamics in response to depolarization and the electrical properties of neuronal networks grown on microelectrode arrays. Therefore, preventing P phosphorylation by PKC abolishes viral interference with neuronal activity in response to stimulation. …”
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Chronic stability of single-channel neurophysiological correlates of gross and fine reaching movements in the rat. by David T Bundy, David J Guggenmos, Maxwell D Murphy, Randolph J Nudo

“…In each animal, two chronic microelectrode arrays were implanted in motor cortex spanning the caudal forelimb area (rodent primary motor cortex) and the rostral forelimb area (rodent premotor cortex). …”
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Contribution of LFP dynamics to single neuron spiking variability in motor cortex during movement execution by Michael Everett Rule, Carlos eVargas-Irwin, John P. Donoghue, Wilson eTruccolo

“…Neural activity was recorded via microelectrode arrays implanted in ventral and dorsal premotor and primary motor cortices of non-human primates performing naturalistic 3-D reaching and grasping actions. …”
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Contribution of GABAergic interneurons to the development of spontaneous activity patterns in cultured neocortical networks by Thomas Baltz, Ana D De Lima, Thomas Voigt

“…Here we present the results of long-term monitoring of spontaneous electrical activity of cultured networks growing on microelectrode arrays and the time course of changes in GABA action using calcium imaging. …”
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Portrait of intense communications within microfluidic neural networks by Victor Dupuit, Anne Briançon-Marjollet, Cécile Delacour

“…Toward that aim, microelectrode arrays have enabled the monitoring of the short- and mid-term evolution of neuron activation over the culture period at specific locations in organized (microfluidic) and random (control) networks. …”
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Utilizing novel TBI-on-a-chip device to link physical impacts to neurodegeneration and decipher primary and secondary injury mechanisms by Edmond A. Rogers, Timothy Beauclair, Andrew Thyen, Riyi Shi

“…In response, we have developed an in vitro pendulum trauma model capable of imparting rapid acceleration injuries to neuronal networks grown on microelectrode arrays within a clinically relevant range of g forces, with real-time electrophysiological and morphological monitoring. …”
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