A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4. by Sankar N Krishna, Chi-Hao Luan, Rama K Mishra, Li Xu, Karl A Scheidt, Wayne F Anderson, Raymond C Bergan

“…If the metastatic movement of PCa cells could be inhibited, then mortality from PCa could be greatly reduced. Mitogen-activated protein kinase kinase 4 (MAP2K4) has previously been shown to activate pro-invasion signaling pathways in human PCa. …”
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Advance on the Role of Mitogen-activated Protein Kinase (MAPK) Signal Pathway in Non-small Cell Lung Cancer by Yuhui ZHOU, Zhen ZHAN, Yuping TANG, Jin’ao DUAN, Xu ZHANG

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Iranian crack induces hepatic injury through mitogen-activated protein kinase pathway in the liver of Wistar rat by Aliasghar Parvaresh Anbar, Tayyebeh Piran, Mehrdad Farhadi, Pouran karimi

“…The expression of tumor necrosis factor-alpha (TNF-α), interleukin 1β (IL-1β), and phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) and c-Jun N-terminal kinase (c-JNK) were assessed by immunoblotting assay. …”
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Identification and Characterization of Mitogen-Activated Protein Kinase (MAPK) Genes in Sunflower (<i>Helianthus annuus</i> L.) by Surendra Neupane, Sarah E. Schweitzer, Achal Neupane, Ethan J. Andersen, Anne Fennell, Ruanbao Zhou, Madhav P. Nepal

“…Mitogen-Activated Protein Kinase (MAPK) genes encode proteins that regulate biotic and abiotic stresses in plants through signaling cascades comprised of three major subfamilies: MAP Kinase (MPK), MAPK Kinase (MKK), and MAPKK Kinase (MKKK). …”
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Mitogen-induced B-cell proliferation activates Chk2-dependent G1/S cell cycle arrest. by Pavel A Nikitin, Alexander M Price, Karyn McFadden, Christopher M Yan, Micah A Luftig

“…However, all three mitogens triggered a DDR-dependent G1/S phase cell cycle arrest preventing B-cell proliferation. …”
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Lactobacillus acidophilus reduces Listeria monocytogenes infection by inhibiting mitogen-activated protein kinase genes in growing rabbits by Heping Zhao, Feike Zhang, Jun Chai, Jianping Wang

“…ABSTRACT We aimed to investigate the effect of Lactobacillus acidophilus ACCC11073 on the growth performance, oxidation, inflammation, and mitogen-activated protein kinase (MAPK) family genes of rabbits infected with Listeria monocytogenes (L. monocytogenes) using antibiotic enrofloxacin hydrochloride (EH) as a reference. …”
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The Level of TWIST1 expression determines the response of colon cancer cells to mitogen-activated protein kinases inhibitors by Tomasz Przybyla, Martyna Wesserling, Monika Sakowicz-Burkiewicz, Izabela Maciejewska, Tadeusz Pawelczyk

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Protective Function of Mitogen‐Activated Protein Kinase Phosphatase 5 in Aging‐ and Diet‐Induced Hepatic Steatosis and Steatohepatitis by Peng Tang, Heng Boon Low, Chin Wen Png, Federico Torta, Jaspal Kaur Kumar, Hwee Ying Lim, Yi Zhou, Henry Yang, Veronique Angeli, Asim Shabbir, E. Shyong Tai, Richard A. Flavell, Chen Dong, Markus R. Wenk, Dan Yock Yang, Yongliang Zhang

“…We previously showed that mice deficient in mitogen‐activated protein kinase (MAPK) phosphatase 5 (MKP5) spontaneously developed insulin resistance and glucose intolerance, which are associated with visceral obesity and adipose tissue inflammation. …”
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Mi-1-Mediated Aphid Resistance Involves Salicylic Acid and Mitogen-Activated Protein Kinase Signaling Cascades by Qi Li, Qi-Guang Xie, Jennifer Smith-Becker, Duroy A. Navarre, Isgouhi Kaloshian

“…Using virus-induced gene silencing, one or more mitogen-activated protein kinase (MAPK) cascades required for Mi-1-mediated aphid resistance were identified. …”
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Hydrogen Sulfide Alleviates Oxidative Damage under Chilling Stress through Mitogen-Activated Protein Kinase in Tomato by Guoxiu Wu, Xuxu Niu, Jiahui Chen, Changjiang Wu, Yang Li, Yanman Li, Dandan Cui, Xueying He, Fan Wang, Shengli Li

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The p38α mitogen-activated protein kinase as a central nervous system drug discovery target by Van Eldik Linda J, de Almeida Lucia, Borders Aaron S, Watterson D Martin

“…A serine/threonine protein kinase, p38α mitogen-activated protein kinase (MAPK), is an established therapeutic target for peripheral inflammatory disorders because of its critical role in regulation of proinflammatory cytokine production. …”

Purification and characterization of a mucin specific mycelial lectin from Aspergillus gorakhpurensis: application for mitogenic and antimicrobial activity. by Ram Sarup Singh, Hemant Preet Kaur, Jatinder Singh

“…MTT assay revealed strong mitogenic potential of A. gorakhpurensis lectin at a concentration upto 150 µg/mL. …”
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Comparison of peptide array substrate phosphorylation of c-Raf and mitogen activated protein kinase kinase kinase 8. by Kaushal Parikh, Sander H Diks, Jurriaan H B Tuynman, Auke Verhaar, Mark Löwenberg, Daan W Hommes, Jos Joore, Akhilesh Pandey, Maikel P Peppelenbosch

“…Employing this technology, we were able to determine the consensus peptide sequences for substrates of both c-Raf and Mitogen Activated Protein Kinase Kinase Kinase 8, two highly homologous kinases with distinct signalling roles in cellular physiology. …”
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Selective Mitogen Activated Protein Kinase Activity Sensors through the Application of Directionally Programmable D Domain Motifs by Peterson, Laura B, Yaffe, Michael B, Imperiali, Barbara

“…There are over 500 protein kinases in the human kinome. Among these, the mitogen activated protein (MAP) kinases are recognized to be central players in key cellular signaling events and are associated with essential processes including growth, proliferation, differentiation, migration, and apoptosis. …”
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Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice by Song, Chun-Qing, Li, Yingxiang, Mou, Haiwei, Moore, Jill, Park, Angela, Pomyen, Yotsawat, Hough, Soren, Kennedy, Zachary, Fischer, Andrew, Yin, Hao, Anderson, Daniel Griffith, Conte, Darryl, Zender, Lars, Wang, Xin Wei, Thorgeirsson, Snorri, Weng, Zhiping, Xue, Wen

“…We validated the observation that RAS signaling, via mitogen-activated protein kinase, contributes to formation of liver tumors in mice. …”
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Role of RUNX2 in mitogen-activated protein kinase (MAPK) mediated cell proliferation of breast cancer cells. by Goh, Xuewei.

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Expression and sequence analysis of the Blumeria graminis mitogen-activated protein kinase genes, mpk1 and mpk2. by Zhang, Z, Gurr, S

“…Mitogen-activated protein (MAP) kinases represent a group of serine/threonine kinases which play a pivotal role in signal transduction processes in eukaryotic cells. …”

Modulation of fibroblast growth factor-2 receptor binding, signaling, and mitogenic activity by heparin-mimicking polysulfonated compounds. by Liekens, S, Leali, D, Neyts, J, Esnouf, R, Rusnati, M, Dell'Era, P, Maudgal, P, De Clercq, E, Presta, M

“…Moreover, the polysulfonates PSS and PAS inhibited FGF-2-induced activation of mitogen-activated protein kinase-1/2, involved in FGF-2 signal transduction. …”

Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade. by Lasa, M, Mahtani, K, Finch, A, Brewer, G, Saklatvala, J, Clark, A

“…A tetracycline-regulated reporter system was used to investigate the regulation of cyclooxygenase 2 (Cox-2) mRNA stability by the mitogen-activated protein kinase (MAPK) p38 signaling cascade. …”

RANTES activates antigen-specific cytotoxic T lymphocytes in a mitogen-like manner through cell surface aggregation. by Appay, V, Dunbar, P, Cerundolo, V, McMichael, A, Czaplewski, L, Rowland-Jones, S

“…These studies suggest that RANTES acted more like a mitogen than an antigen-independent activator.…”