Mitogen-Activated Protein Kinase Phosphatases (MKPs) in Fungal Signaling: Conservation, Function, and Regulation by Gema González-Rubio, Teresa Fernández-Acero, Humberto Martín, María Molina

“…Mitogen-activated protein kinases (MAPKs) are key mediators of signaling in fungi, participating in the response to diverse stresses and in developmental processes. …”
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Playing cancer at its own game: activating mitogenic signaling as a paradoxical intervention by Matheus Henrique Dias, René Bernards

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Identification of mitogen-activated protein kinases substrates in Arabidopsis using kinase client assay by Sunghwa Bahk, Nagib Ahsan, Jonguk An, Sun Ho Kim, Zakiyah Ramadany, Jong Chan Hong, Jay J. Thelen, Woo Sik Chung

“…Mitogen-activated protein kinase (MPK) cascades are essential signal transduction components that control a variety of cellular responses in all eukaryotes. …”
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PKCζ-Mitogen-Activated Protein Kinase Signaling Mediates Crotalphine-Induced Antinociception by Bárbara G. de Freitas, Natália G. Hösch, Leandro M. Pereira, Tereza C. Barbosa, Gisele Picolo, Yara Cury, Vanessa O. Zambelli

“…The opioid receptor activation regulates a variety of intracellular signaling, including the mitogen-activated protein kinase (MAPK) pathway. Using primary cultures of sensory neurons, it was demonstrated that crotalphine increases the level of activated ERK1/2 and JNK-MAPKs and this increase is dependent on the activation of protein kinase Cζ (PKCζ). …”
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Identification, Nomenclature, and Evolutionary Relationships of Mitogen-Activated Protein Kinase (MAPK) Genes in Soybean by Sarbottam Piya, Benjamin V. Benson, Senthil Subramanian, Jai S. Rohila, R. Neil Reese, Achal Neupane, Madhav P. Nepal

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Differential p38-dependent signalling in response to cellular stress and mitogenic stimulation in fibroblasts by Faust Dagmar, Schmitt Christina, Oesch Franz, Oesch-Bartlomowicz Barbara, Schreck Ilona, Weiss Carsten, Dietrich Cornelia

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Multi-Target In Silico Prediction of Inhibitors for Mitogen-Activated Protein Kinase-Interacting Kinases by Amit Kumar Halder, M. Natália D. S. Cordeiro

“…The inhibitors of two isoforms of mitogen-activated protein kinase-interacting kinases (i.e., MNK-1 and MNK-2) are implicated in the treatment of a number of diseases including cancer. …”
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p38 Mitogen-Activated Protein Kinase Regulates Vasoconstriction in Spontaneously Hypertensive Rats by Seongchun Kwon, Lian Hua Fang, Bokyung Kim, Tae-Seon Ha, Sang Jin Lee, Hee Yul Ahn

“…We investigated whether p42/p44 mitogen-activated protein kinase (MAPK) and/or p38 MAPK participates in the regulation of vascular smooth muscle contraction by endothelin-1 (ET-1) in Wistar-Kyoto rat (WKY) and spontaneously hypertensive rat (SHR). …”
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Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice by Amada D. Caliz, Hyung-Jin Yoo, Anastassiia Vertii, Ana C. Dolan, Cathy Tournier, Roger J. Davis, John F. Keaney, Shashi Kant

“…Mitogen kinase kinase 4 (MKK4) and mitogen kinase kinase 7 (MKK7) are members of the MAP2K family that can activate downstream mitogen-activated protein kinases (MAPKs). …”
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RAS/Mitogen-Activated Protein Kinase Signaling Pathway in Testicular Germ Cell Tumors by Angelo Onorato, Eugenia Guida, Ambra Colopi, Susanna Dolci, Paola Grimaldi

“…The receptor Tyrosine Kinase (RTK) pathway and the downstream related Mitogen-Activated Protein Kinase (MAPK) cascades are crucial signal transduction pathways that preside over various cellular processes, including proliferation, differentiation, apoptosis, and responses to stressors. …”
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Induction of glucose metabolism in stimulated T lymphocytes is regulated by mitogen-activated protein kinase signaling. by Aimee J Marko, Rebecca A Miller, Alina Kelman, Kenneth A Frauwirth

“…We therefore investigated the role of mitogen-activated protein kinase (MAPK) signaling in the regulation of mouse T cell glucose metabolism. …”
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Mitogen-Activated Protein Kinases (MAPKs) and Enteric Bacterial Pathogens: A Complex Interplay by Ipsita Nandi, Benjamin Aroeti

“…Diverse extracellular and intracellular cues activate mammalian mitogen-activated protein kinases (MAPKs). Canonically, the activation starts at cell surface receptors and continues via intracellular MAPK components, acting in the host cell nucleus as activators of transcriptional programs to regulate various cellular activities, including proinflammatory responses against bacterial pathogens. …”
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Obesity Increases Mitogen-Activated Protein Kinase Phosphatase-3 Levels in the Hypothalamus of Mice by Bárbara de A. Rodrigues, Vitor R. Muñoz, Gabriel K. Kuga, Gabriel K. Kuga, Rafael C. Gaspar, Susana C. B. R. Nakandakari, Barbara M. Crisol, José D. Botezelli, Luciana S. S. Pauli, Adelino S. R. da Silva, Leandro P. de Moura, Leandro P. de Moura, Leandro P. de Moura, Dennys E. Cintra, Dennys E. Cintra, Eduardo R. Ropelle, Eduardo R. Ropelle, Eduardo R. Ropelle, José R. Pauli, José R. Pauli, José R. Pauli

“…Mitogen-activated Protein Kinase Phosphatase 3 (MKP-3) has been involved in the negative regulation of insulin signaling. …”
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Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish by Matthew Gemberling, Ravi Karra, Amy L Dickson, Kenneth D Poss

“…Our findings identify Nrg1 as a potent, induced mitogen for the endogenous adult heart regeneration program.…”
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Systematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analogues. by Tine Glendorf, Louise Knudsen, Carsten E Stidsen, Bo F Hansen, Anne Charlotte Hegelund, Anders R Sørensen, Erica Nishimura, Thomas Kjeldsen

“…BACKGROUND: Insulin analogues comprising acidic amino acid substitutions at position B10 have previously been shown to display increased mitogenic potencies compared to human insulin and the underlying molecular mechanisms have been subject to much scrutiny and debate. …”
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Interferon-γ Mediated Pathways And Mitogen Stimulated Proliferation During And After An Acute Infection by Knoll Miriam, Fuchs Dietmar, Weiss Guenter, Bellmann-Weiler Rosa, Kovrlija Bojana, Kurz Katharina

“…Peripheral blood mononuclear cells (PBMCs) were isolated from the patients’ blood and stimulated with concanavalin A (Con A), phytohemagglutinin (PHA) and pokeweed mitogen (PWM) in vitro proliferation rates were evaluated by ³H-thymidine incorporation and neopterin production and tryptophan degradation were determined in supernatants of mitogen stimulated PBMCs. …”
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The Role of Insulin Glargine and Human Insulin in the Regulation of Thyroid Proliferation Through Mitogenic Signaling by Xiaoli Sheng, Kannan Yao, Anwen Shao, Sheng Tu, Xinxia Zhang, Ting Chen, Dingguo Yao

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Influence of Different Housing Systems on Distribution, Function and Mitogen-Response of Leukocytes in Pregnant Sows by Verena Grün, Sonja Schmucker, Christiane Schalk, Birgit Flauger, Ulrike Weiler, Volker Stefanski

“…Blood samples were taken at four samplings pre partum to evaluate numbers of lymphocyte subpopulations, mitogen-induced lymphocyte proliferation and cytokine-producing T cells. …”
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Differential effects of mitogen-activated protein kinase pathway inhibitors on P-glycoprotein activation by Hirokazu Wakuda, Shino Miyauchi, Kana Maruyama, Satomi Kagota, Kazuki Nakamura, Keizo Umegaki, Shizuo Yamada, Kazumasa Shinozuka

“…The aim of this study was to evaluate the effects of the mitogen-activated protein kinase (MAPK) pathway inhibitors SB203580, CMPD-1, SB239063, SP600125, and FR180204 on the activity of P-glycoprotein (P-gp) and to assess whether the MAPK pathway affects P-gp directly. …”
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Non-glycosylated IGF2 prohormones are more mitogenic than native IGF2 by Pavlo Potalitsyn, Lucie Mrázková, Irena Selicharová, Michaela Tencerová, Michaela Ferenčáková, Martina Chrudinová, Tereza Turnovská, Andrzej Marek Brzozowski, Aleš Marek, Jakub Kaminský, Jiří Jiráček, Lenka Žáková

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