Short-term withdrawal of mitogens prior to plating increases neuronal differentiation of human neural precursor cells. by Telma Tiemi Schwindt, Fabiana Louise Motta, Gabriela Filoso Barnabé, Cristina Gonçalves Massant, Alessander de Oliveira Guimarães, Maria Elisa Calcagnotto, Fabio Silva Conceição, João Bosco Pesquero, Stevens Rehen, Luiz E Mello

“…Epidermal growth factor (EGF) and fibroblast growth factor-2 (FGF-2) are used to expand NPC; however, it is not clear if continuous exposure to mitogens may abrogate their subsequent differentiation. …”
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Riboflavin-Induced Disease Resistance Requires the Mitogen-Activated Protein Kinases 3 and 6 in Arabidopsis thaliana. by Shengjun Nie, Huilian Xu

“…Further was suggested that the transcript levels of mitogen-activated protein kinases, MPK3 and MPK6, were primed under riboflavin. …”
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Lack of Mitogen-activated Kinase Phosphatase-5 in Macrophages Protects Ldlr-null Mice against Atherogenesis by Xinbo Zhang, Zhiqiang Zhao, Margaret Baldini, Cheng Zhang, Bo Tao, Lei Zhang, Anton M. Bennett, Jun Yu

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The High Osmolarity Glycerol Mitogen-Activated Protein Kinase regulates glucose catabolite repression in filamentous fungi. by Leandro José de Assis, Lilian Pereira Silva, Li Liu, Kerstin Schmitt, Oliver Valerius, Gerhard H Braus, Laure Nicolas Annick Ries, Gustavo Henrique Goldman

“…An initial screening of a library of 103 non-essential protein kinase (NPK) deletion strains identified several mitogen-activated protein kinases (MAPKs) to be important for carbon catabolite repression (CCR). …”
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RelA and mitogen-activated protein kinase kinase kinases potently enhance lentiviral vector production by Shoji Yamaoka

“…This paper reports that transient co-expression of RelA or several mitogen-activated protein kinase kinase kinases (MAP3Ks) with packaging constructs can potently enhance LV production in HEK293T producer cells. …”
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Towards a comprehensive phylogenetic reconstruction of the evolutionary history of mitogen-activated protein kinases in the plant kingdom by Philipp eJanitza, Kristian Karsten Ullrich, Marcel eQuint

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The Alfalfa (Medicago sativa) TDY1 Gene Encodes a Mitogen-Activated Protein Kinase Homolog by Mark A. Schoenbeck, Deborah A. Samac, Maria Fedorova, Robert G. Gregerson, J. Stephen Gantt, Carroll P. Vance

“…A full-length cDNA clone and the corresponding genomic clone encoding a MAP (mitogen-activated protein) kinase homolog were isolated from alfalfa (Medicago sativa). …”
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Mitogen activated protein kinases (MAPK) and protein phosphatases are involved in Aspergillus fumigatus adhesion and biofilm formation by Adriana Oliveira Manfiolli, Thaila Fernanda dos Reis, Leandro José de Assis, Patrícia Alves de Castro, Lilian Pereira Silva, Juliana I. Hori, Louise A. Walker, Carol A. Munro, Ranjith Rajendran, Gordon Ramage, Gustavo H. Goldman

“…Keywords: Aspergillus fumigatus, Polysaccharide, Extracellular matrix, Biofilm, Mitogen activated protein kinases, Phosphatases…”
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p38 Mitogen-Activated Protein Kinase Mediates Sidestream Cigarette Smoke-Induced Endothelial Permeability by Brad Low, Mei Liang, Jian Fu

“…Sidestream cigarette smoke stimulated the phosphorylation of p38 mitogen-activated protein kinase (MAPK) and myosin light chain (MLC). …”
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αvβ3 Integrin Expression and Mitogenic Effects by Thyroid Hormones in Chronic Lymphocytic Leukemia by Uri Abadi, Avivit Weisz, Dvora Kidron, Aviva Katzav, Aleck Hercbergs, Paul J. Davis, Martin H. Ellis, Osnat Ashur-Fabian

“…We further suggest that the hormones are mitogenic in these cells, presumably via αvβ3-mediated signaling.…”
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Reduction of Cell Surface T-Cell Receptor by Non-Mitogenic CD3 Antibody to Mitigate Murine Lupus by Masashi Morita, Masayuki Mizui, Satoshi Masuyama, George C. Tsokos, Yoshitaka Isaka

“…Collectively, the reduction of surface TCR by non-mitogenic anti-CD3 could sufficiently suppress the development of lupus.…”
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Phosphatase-dependent regulation of epithelial mitogen-activated protein kinase responses to toxin-induced membrane pores. by Jorge L Aguilar, Ritwij Kulkarni, Tara M Randis, Sandeep Soman, Alexander Kikuchi, Yuxin Yin, Adam J Ratner

“…Host cells respond to sublytic concentrations of PFT through conserved intracellular signaling pathways, including activation of mitogen-activated protein kinases (MAPK), which are critical to cell survival. …”
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Phosphorylated p38 mitogen-activated kinase in patients with pemphigus vulgaris: a case–controlled study by Shereen A Sobeih, Marwah A Saleh, Shams M Kholoussi, Eman M El Khateeb, Dina M Kadry

“…The phosphorylated p38 mitogen-activated protein kinase (P38 MAPK) signaling pathway plays a major role in the modulation of immune-mediated inflammatory responses and therefore has been linked with several autoimmune diseases. …”
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In-silico modelling of the mitogen-activated protein kinase (MAPK) pathway in colorectal cancer: mutations and targeted therapy by Sara Sommariva, Silvia Berra, Giorgia Biddau, Giacomo Caviglia, Federico Benvenuto, Michele Piana, Michele Piana

“…The main reason for their effectiveness is in the fact that these networks can be rather naturally encoded as a dynamical system whose asymptotic solution mimics the proteins' concentration profile at equilibrium.Methods and Results: This paper relies on a complex CRN previously designed for modeling colorectal cells in their G1-S transition phase and presents a mathematical method to investigate global and local effects triggered on the network by partial and complete mutations occurring mainly in its mitogen-activated protein kinase (MAPK) pathway. Further, this same approach allowed the in-silico modeling and dosage of a multi-target therapeutic intervention that utilizes MAPK as its molecular target.Discussion: Overall the results shown in this paper demonstrate how the proposed approach can be exploited as a tool for the in-silico comparison and evaluation of different targeted therapies. …”
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Estrogen receptor-alpha 36 mediates mitogenic antiestrogen signaling in ER-negative breast cancer cells. by XinTian Zhang, Ling Ding, LianGuo Kang, Zhao-Yi Wang

“…We found that the effects of both 4-hydoxytamoxifen (4-OHT) and ICI 182, 780 (ICI) exhibited a non-monotonic, or biphasic dose response curve; antiestrogens at low concentrations, elicited a mitogenic signaling pathway to stimulate cell proliferation while at high concentrations, antiestrogens inhibited cell growth. …”
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Deoxynivalenol Induces Inflammation in the Small Intestine of Weaned Rabbits by Activating Mitogen-Activated Protein Kinase Signaling by Pengwei Wang, Libo Huang, Wanying Yang, Quancheng Liu, Fuchang Li, Chunyang Wang

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Correlation between p38 mitogen-activated protein kinase and human telomerase reverse transcriptase in sarcomas by Matsuo Toshihiro, Shimose Shoji, Kubo Tadahiko, Fujimori Jun, Yasunaga Yuji, Sugita Takashi, Ochi Mitsuo

Subjects: “…p38 mitogen-activated protein kinase…”
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Sumoylation of transcription factor Tec1 regulates signaling of mitogen-activated protein kinase pathways in yeast. by Yuqi Wang, Ameair Abu Irqeba, Mihretu Ayalew, Kristina Suntay

“…Tec1 is a transcription factor in the yeast mitogen-activated protein kinase (MAPK) pathway that controls invasive growth. …”
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Emerging Roles of Mitogen-Activated Protein Kinase Signaling Pathways in the Regulation of Fruit Ripening and Postharvest Quality by Juan Jin, Wei Wang, Dingyu Fan, Qing Hao, Wensuo Jia

“…The regulation of these metabolisms is essentially mediated by cellular signal transduction of internal (e.g., hormones) and external cues (i.e., environmental stimuli). Mitogen-activated protein kinase (MAPK) signaling pathways play crucial roles in a diverse array of biological processes, such as plant growth, development and biotic/abiotic responses. …”
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A novel side effect of mitogen-activated protein kinase inhibitor cobimetinib: Acute corneal decompensation by Mahmut Asfuroglu, Yonca Asfuroğlu

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