Involvement of the Catecholamine Pathway in Glioblastoma Development by Zoltán Kraboth, Bela Kajtár, Bence Gálik, Attila Gyenesei, Attila Miseta, Bernadette Kalman

“…In this follow-up study, we quantitated the expression levels of four selected catecholamine pathway markers (alpha 1D adrenergic receptor—ADRA1D; adrenergic beta receptor kinase 1 or G protein-coupled receptor kinase 2—ADRBK1/GRK2; dopamine receptor D2—DRD2; and synaptic vesicle monoamine transporter—SLC18A2) by immunohistochemistry, and compared the histological scores with the methylation levels within the promoters + genes of these markers in 21 pairs of sequential GBM and in controls. …”
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Upregulated DNA Damage-Linked Biomarkers in Parkinson's Disease Model Mice by Fei Zeng, Karsten Parker, Yanqiang Zhan, Matthew Miller, Meng-Yang Zhu

“…In the present study, multiple measurement methods were applied to examine the expression of DNA damage markers in the brain of the vesicular monoamine transporter 2 transgenic mice (VMAT2 Lo), a PD animal model. …”
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Organic cation transporter 2 contributes to SSRI antidepressant efficacy by controlling tryptophan availability in the brain by Alejandro Orrico-Sanchez, Bruno P. Guiard, Stella Manta, Jacques Callebert, Jean-Marie Launay, Franck Louis, Antoine Paccard, Carole Gruszczynski, Catalina Betancur, Vincent Vialou, Sophie Gautron

“…In the present preclinical study, we demonstrate that organic cation transporter 2 (OCT2), an atypical monoamine transporter, contributes to the effects of SSRI by regulating the routing of the essential amino acid tryptophan to the brain. …”
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Historical developments, hotspots, and trends in tardive dyskinesia research: a scientometric analysis of 54 years of publications by Anuradha Baminiwatta, Christoph U. Correll, Christoph U. Correll, Christoph U. Correll

“…More recent clusters include serotonergic receptors, dopamine-supersensitivity psychosis, primary motor abnormalities of schizophrenia, epidemiology/meta-analyses, and advances in TD treatment, particularly vesicular monoamine transporter-2 inhibitors since 2017.ConclusionThis scientometric review visualized the evolution of scientific knowledge on TD over more than five decades. …”
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α-Synuclein Overexpression Increases Dopamine D2/3 Receptor Binding and Immune Activation in a Model of Early Parkinson’s Disease by Kathrine Stokholm, Majken Borup Thomsen, Jenny-Ann Phan, Line K. Møller, Cecilie Bay-Richter, Søren H. Christiansen, David P. D. Woldbye, Marina Romero-Ramos, Anne M. Landau

“…We performed: (1) in situ hybridization of nigral tyrosine hydroxylase mRNA, (2) HPLC of striatal dopamine content, and (3) autoradiography with [³H]raclopride, [³H]DTBZ, [³H]GBR12935, [³H]PK11195, and [³H]UCB-J to measure binding at D2/3 receptors, vesicular monoamine transporter 2, dopamine transporters, mitochondrial translocator protein, and SV2A, respectively. rAAV-α-synuclein induced motor asymmetry and reduced tyrosine hydroxylase mRNA and dopamine content in ipsilateral brain regions. …”
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Synapsin III Regulates Dopaminergic Neuron Development in Vertebrates by Gaia Faustini, Francesca Longhena, Alessia Muscò, Federica Bono, Edoardo Parrella, Luca La Via, Alessandro Barbon, Marina Pizzi, Franco Onofri, Fabio Benfenati, Cristina Missale, Maurizio Memo, Daniela Zizioli, Arianna Bellucci

“…Polymorphisms in the Synapsin III (Syn III) gene can associate with ADHD onset and even affect the therapeutic response to the gold standard ADHD medication, methylphenidate (MPH), a monoamine transporter inhibitor whose efficacy appears related with the stimulation of brain-derived neurotrophic factor (BDNF). …”
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Neuroprotective effects of osmotin in Parkinson’s disease-associated pathology via the AdipoR1/MAPK/AMPK/mTOR signaling pathways by Jun Sung Park, Kyonghwan Choe, Hyeon Jin Lee, Tae Ju Park, Myeong Ok Kim

“…Results Based on our study, osmotin mitigated MPTP- and α-synuclein-induced motor dysfunction by upregulating the nuclear receptor-related 1 protein (Nurr1) transcription factor and its downstream markers tyrosine hydroxylase (TH), dopamine transporter (DAT), and vesicular monoamine transporter 2 (VMAT2). From a pathological perspective, osmotin ameliorated neuronal cell death and neuroinflammation by regulating the mitogen-activated protein kinase (MAPK) signaling pathway. …”
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Immunization Effects of a Novel α-Synuclein-Based Peptide Epitope Vaccine in Parkinson’s Disease-Associated Pathology by Jun Sung Park, Riaz Ahmad, Kyonghwan Choe, Min Hwa Kang, Tae Ju Park, Myeong Ok Kim

“…Furthermore, vaccinated groups, especially OVA and KLH groups, showed decrease in α-syn levels and increased dopamine-related markers, i.e., tyrosine hydroxylase (TH), vesicle monoamine transporter 2 (VMAT2), and dopamine transporter (DAT), and autophagy activities in the striatum and SNpc. …”
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PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III by Hye Yun Kim, Jieun Lee, Hyun-Jin Kim, Byeong Eun Lee, Jaewook Jeong, Eun Jeong Cho, Hyun-Jun Jang, Kyeong Jin Shin, Min Ji Kim, Young Chan Chae, Seung Eun Lee, Kyungjae Myung, Ja-Hyun Baik, Pann-Ghill Suh, Jae-Ick Kim

“…The enhancement of dopamine release was accompanied by increased colocalization of vesicular monoamine transporter 2 (VMAT2) at dopaminergic axon terminals. …”
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Differential Serotonin Uptake Mechanisms at the Human Maternal–Fetal Interface by Petra Baković, Maja Kesić, Maja Perić, Ivona Bečeheli, Marina Horvatiček, Meekha George, Lipa Čičin-Šain, Gernot Desoye, Christian Wadsack, Ute Panzenboeck, Jasminka Štefulj

“…Consistent with this, <i>SERT</i> mRNAs were abundant in term trophoblasts but sparse in feto-placental endothelial cells, whereas the opposite was found for the low-affinity plasma membrane monoamine transporter (<i>PMAT</i>) mRNAs. Organic cation transporter (<i>OCT</i>) <i>1</i>, <i>2,</i> and <i>3</i> mRNAs were absent or sparse in both cell types. …”
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O-Cyclic Phytosphingosine-1-Phosphate Protects against Motor Dysfunctions and Glial Cell Mediated Neuroinflammation in the Parkinson’s Disease Mouse Models by Hyeon Jin Lee, Kyonghwan Choe, Jun Sung Park, Amjad Khan, Min Woo Kim, Tae Ju Park, Myeong Ok Kim

“…In addition, administration of cPS1P restored dopamine-related proteins such as tyrosine hydroxylase (TH), vesicular monoamine transporter 2 (VMAT2), and dopamine transporter (DAT). …”
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GABA_A Receptor Benzodiazepine Binding Sites and Motor Impairments in Parkinson’s Disease by Nicolaas I. Bohnen, Jaimie Barr, Robert Vangel, Stiven Roytman, Rebecca Paalanen, Kirk A. Frey, Peter J. H. Scott, Prabesh Kanel

“…Methods: A total of 11 Patients with PD (males; mean age 69.0 ± 4.6 years; Hoehn and Yahr stages 2–3) underwent [¹¹C]flumazenil GABA_AR benzodiazepine binding site and [¹¹C]dihydrotetrabenazine vesicular monoamine transporter type-2 (VMAT2) PET imaging and clinical assessment. …”
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Dopaminergic cell protection and alleviation of neuropsychiatric disease symptoms by VMAT2 expression through the class I HDAC inhibitor TC‐H 106 by Heejin Lee, Hye‐Ji Kim, Dong‐Kyu Choi, Eu n.‐A. Ko, Jae‐Hyeog Choi, Yohan Seo, Sion Lee, Soong‐Hyun Kim, Sejin Jung, Minwoo Kim, Dongwan Kang, Chun‐Young Im, Gi‐Hun Bae, Sung‐Cherl Jung, Oh‐Bin Kwon

“…Abstract The importance of vesicular monoamine transporter 2 (VMAT2) in dopamine regulation, which is considered crucial for neuropsychiatric disorders, is currently being studied. …”
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Effects of latroeggtoxin-VI on dopamine and α-synuclein in PC12 cells and the implications for Parkinson’s disease by Dianmei Yu, Haiyan Wang, Yiwen Zhai, Zhixiang Lei, Minglu Sun, Si Chen, Panfeng Yin, Xianchun Wang

“…At the same time, LETX-VI promoted the transport and release of dopamine through modulating the abundance and/or posttranslational modification of vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DAT). …”
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Heterotypic Stressors Unmask Behavioral Influences of PMAT Deficiency in Mice by Brady L. Weber, Marissa M. Nicodemus, Allianna K. Hite, Isabella R. Spalding, Jasmin N. Beaver, Lauren R. Scrimshaw, Sarah K. Kassis, Julie M. Reichert, Matthew T. Ford, Cameron N. Russell, Elayna M. Hallal, T. Lee Gilman

“…This is when polyspecific transporters like plasma membrane monoamine transporter (PMAT, <i>Slc29a4</i>) are hypothesized to contribute most to monoaminergic signaling regulation. …”
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The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice by Vladimir M. Pogorelov, Ramona M. Rodriguiz, Ramona M. Rodriguiz, Bryan L. Roth, Bryan L. Roth, William C. Wetsel, William C. Wetsel, William C. Wetsel

“…Using vesicular monoamine transporter 2 mice, lisuride reduced immobility times in tail suspension and promoted a preference for sucrose that lasted up to 2 days. …”
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Behavioral and Transcriptomic Changes Following Brain-Specific Loss of Noradrenergic Transmission by Elsa Isingrini, Chloé Guinaudie, Léa Perret, Elisa Guma, Victor Gorgievski, Ian D. Blum, Jessica Colby-Milley, Maryia Bairachnaya, Sébastien Mella, Antoine Adamantidis, Kai-Florian Storch, Bruno Giros

“…To address this question, we used a unique genetic model in which the brain-specific vesicular monoamine transporter-2 (VMAT2) gene expression was removed in NE-positive neurons disabling NE release in the entire brain. …”
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Conditional deletion of neurexins dysregulates neurotransmission from dopamine neurons by Charles Ducrot, Gregory de Carvalho, Benoît Delignat-Lavaud, Constantin VL Delmas, Priyabrata Halder, Nicolas Giguère, Consiglia Pacelli, Sriparna Mukherjee, Marie-Josée Bourque, Martin Parent, Lulu Y Chen, Louis-Eric Trudeau

“…In line with an alteration in DA neurotransmission, decreased levels of the membrane DA transporter (DAT) and increased levels of the vesicular monoamine transporter (VMAT2) were detected in the striatum of DAT::NrxnsKO mice, along with reduced activity-dependent DA release. …”
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Chirality Matters: Fine-Tuning of Novel Monoamine Reuptake Inhibitors Selectivity through Manipulation of Stereochemistry by Predrag Kalaba, Katharina Pacher, Philip John Neill, Vladimir Dragacevic, Martin Zehl, Judith Wackerlig, Michael Kirchhofer, Simone B. Sartori, Hubert Gstach, Shima Kouhnavardi, Anna Fabisikova, Matthias Pillwein, Francisco Monje-Quiroga, Karl Ebner, Alexander Prado-Roller, Nicolas Singewald, Ernst Urban, Thierry Langer, Christian Pifl, Jana Lubec, Johann Jakob Leban, Gert Lubec

“…Furthermore, by generating a large library of compounds with defined absolute configurations, we lay the groundwork for computational chemists to further optimize and rationally design specific monoamine transporter reuptake inhibitors.…”
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Cardiac sympathetic neural signalling in hypertension by Shanks, J

“…A novel fluorescent assay of the monoamine transporter family was used to monitor NET activity within isolated sympathetic cells from three ganglia associated with hypertension. …”