Adipokines, adiposity, and bone marrow adipocytes: Dangerous accomplices in multiple myeloma by Morris, E, Edwards, C

“…This review discusses the link between obesity, monoclonal gammopathy of undetermined significance (a benign condition that precedes MM), and myeloma, and the contribution of key adipokines to disease establishment and progression.…”

Unraveling unique features of plasma cell clones in POEMS syndrome with single-cell analysis by Yusuke Isshiki, Motohiko Oshima, Naoya Mimura, Kensuke Kayamori, Yurie Miyamoto-Nagai, Masahide Seki, Yaeko Nakajima-Takagi, Takashi Kanamori, Eisuke Iwamoto, Tomoya Muto, Shokichi Tsukamoto, Yusuke Takeda, Chikako Ohwada, Sonoko Misawa, Jun-ichiro Ikeda, Masashi Sanada, Satoshi Kuwabara, Yutaka Suzuki, Emiko Sakaida, Chiaki Nakaseko, Atsushi Iwama

“…The proportions of POEMS clones in plasma cells were markedly smaller than in patients with multiple myeloma (MM) and patients with monoclonal gammopathy of undetermined significance (MGUS). Single-cell transcriptomes revealed that POEMS clones were CD19+, CD138+, and MHC class IIlo, which allowed for their prospective isolation. …”
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Abnormal IGF-Binding Protein Profile in the Bone Marrow of Multiple Myeloma Patients. by Liesbeth Bieghs, Malene Brohus, Ida B Kristensen, Niels Abildgaard, Martin Bøgsted, Hans E Johnsen, Cheryl A Conover, Elke De Bruyne, Karin Vanderkerken, Michael T Overgaard, Mette Nyegaard

“…Here we measured total IGF1, IGF2, and intact IGFBP levels in blood and bone marrow samples from MM (n = 17), monoclonal gammopathy of undetermined significance (MGUS) (n = 37), and control individuals (n = 15), using ELISA (IGFs) and 125I-IGF1 Western Ligand Blotting (IGFBPs). …”
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Four Cases of the Rare Skin Manifestation: Monoclonal-Proteinemia by JIN Xianghong, XU Junqing, YANG Chen, ZHU Tienan, ZHUANG Junling

“…The skin manifestations of monoclonal(M)-proteinemia are rare and present in patients with monoclonal gammopathy of undetermined significance (MGUS), smoldering plasma cell myeloma (SMM) and multiple myeloma (MM). …”
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Disentangling age, gender, and racial/ethnic disparities in multiple myeloma burden: a modeling study by John H. Huber, Mengmeng Ji, Yi-Hsuan Shih, Mei Wang, Graham Colditz, Su-Hsin Chang

“…Abstract Multiple myeloma (MM) is a hematological malignancy that is consistently preceded by an asymptomatic condition, monoclonal gammopathy of undetermined significance (MGUS). Disparities by age, gender, and race/ethnicity in both MGUS and MM are well-established. …”
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LAMP5 may promote MM progression by activating p38 by Yan Chen, Tao Ma

“…We first found that Lysosome associated membrane protein 5 (LAMP5) expression was sequentially increased in healthy donors (HD), monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM) and newly diagnosed MM (NDMM), relapsed MM (RMM). …”
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New approaches to idiopathic neutropenia in the era of clonal hematopoiesis by Olisaemeka D. Ogbue, Tariq Kewan, Waled S. Bahaj, Carmelo Gurnari, Valeria Visconte, Jaroslaw P. Maciejewski

“…Patients with neutropenia also had hypogammaglobulinemia (6%) and/or monoclonal gammopathy of undetermined significance (5%). NGS application has further broadened the spectrum of causes of CIN by including manifestations of clonal hematopoiesis, present in 12% of cases. …”
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A Synopsis Clonal Hematopoiesis of Indeterminate Potential in Hematology by Maroun Bou Zerdan, Lewis Nasr, Ludovic Saba, Paul Meouchy, Nadine Safi, Sabine Allam, Jenish Bhandari, Chakra P. Chaulagain

“…This new entity is a potential precursor of myeloid diseases, analogous to monoclonal gammopathy of undetermined significance as a potential precursor of multiple myeloma.…”
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Nucleic Acid Biomarkers in Waldenström Macroglobulinemia and IgM-MGUS: Current Insights and Clinical Relevance by Daniela Drandi, Philippe Decruyenaere, Martina Ferrante, Fritz Offner, Jo Vandesompele, Simone Ferrero

“…WM belongs to the spectrum of IgM gammopathies, ranging from asymptomatic IgM monoclonal gammopathy of undetermined significance (IgM-MGUS), through IgM-related disorders and asymptomatic WM to symptomatic WM. …”
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Monoclonal Gammopathy of Undetermined Cardiovascular Significance; Current Evidence and Novel Insights by Anastasios Tentolouris, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou, Ioanna Andreadou, Evangelos Terpos

“…Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant condition characterized by the presence of low levels of a monoclonal protein in the serum and a low percentage of clonal plasma cells in the bone marrow. …”
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Biclonal gammopathy – A single-center experience by Geetha Narayanan, Sugeeth M Thambi, Pranab Karipody Prabhakaran, T M Anoop, Sreejith G Nair

“…Eleven patients had multiple myeloma, one had plasmacytoma, and one had monoclonal gammopathy of undetermined significance (MGUS). Twelve patients had biclonal gammopathy at diagnosis and one developed biclonal gammopathy at relapse. …”
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Role of protein kinases CK1α and CK2 in multiple myeloma: regulation of pivotal survival and stress-managing pathways by Sabrina Manni, Marilena Carrino, Francesco Piazza

“…This cancer can occur de novo (rarely) or it can develop from monoclonal gammopathy of undetermined significance (most of the cases). …”
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Fibrillary glomerulonephritis combined with chronic inflammatory demyelinating polyneuropathy by Woo Kyung Sung, Jin Uk Jeong, Ki Tae Bang, Jong Ho Shin, Ji Hyung Yoo, Nak Min Kim, Jun Hyung Park, Joo Heon Kim

“…He was ultimately diagnosed with monoclonal gammopathy of undetermined significance (MGUS). A renal biopsy specimen showed fibrillary glomerulonephritis (FGN), which was randomly arranged as 12–20 m nonbranching fibrils in the basement membranes. …”
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Dietary intake is associated with risk of multiple myeloma and its precursor disease. by Marianna Thordardottir, Ebba K Lindqvist, Sigrun H Lund, Rene Costello, Debra Burton, Laufey Steingrimsdottir, Neha Korde, Sham Mailankody, Gudny Eiriksdottir, Lenore J Launer, Vilmundur Gudnason, Tamara B Harris, Ola Landgren, Johanna E Torfadottir, Sigurdur Y Kristinsson

“…The etiology of monoclonal gammopathy of undetermined significance (MGUS), the precursor state of multiple myeloma (MM), is mostly unknown and no studies have been conducted on the effect of diet on MGUS or progression from MGUS to MM. …”
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The Role of Tumor Microenvironment in Multiple Myeloma Development and Progression by Almudena García-Ortiz, Yaiza Rodríguez-García, Jessica Encinas, Elena Maroto-Martín, Eva Castellano, Joaquín Teixidó, Joaquín Martínez-López

“…The progression, from the early stages of the disease as monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) to MM and occasionally extramedullary disease, is drastically affected by the tumor microenvironment (TME). …”
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Development and validation of a diagnostic nomogram model for predicting monoclonal gammopathy of renal significance by Yijun Dong, Ge Yan, Yiding Zhang, Yukun Zhou, LiYang Zhu, Jin Shang

“…The study encompassed 347 patients who underwent kidney biopsy, among whom 116 patients (33.4%) were diagnosed with MGRS and 231 (66.6%) with monoclonal gammopathy of undetermined significance. Monoclonal Ig-related amyloidosis (n = 86) and membranous nephropathy (n = 86) was the most common renal pathological type in each group. …”
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Case Report: Monoclonal Gammopathies of Clinical Significance-Associated Myopathy: A Case-Based Review by Hongbin Yu, Du He, Qing Zhang, Bei Cao, Weiping Liu, Yu Wu

“…It mainly includes amyloid light chain (AL) amyloidosis and sporadic late-onset nemaline myopathy with monoclonal gammopathy of undetermined significance. When myopathy manifests as the initial or sole clinical symptom, it can often be delayed or misdiagnosed as other myopathies. …”
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A single-arm, open-label, phase 2 clinical trial evaluating disease response following treatment with BI-505, a human anti-intercellular adhesion molecule-1 monoclonal antibody, in... by Stina Wichert, Gunnar Juliusson, Åsa Johansson, Elisabeth Sonesson, Ingrid Teige, Anna Teige Wickenberg, Björn Frendeus, Magnus Korsgren, Markus Hansson

“…BACKGROUND:Smoldering multiple myeloma (SMM) is an indolent disease stage, considered to represent the transition phase from the premalignant MGUS (Monoclonal Gammopathy of Undetermined Significance) state towards symptomatic multiple myeloma (MM). …”
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HEAVY-CHAIN DISEASES AND MYELOMA-ASSOCIATED FANCONI SYNDROME: AN UPDATE by Roberto Ria, Franco Dammacco, Angelo Vacca

“…These patients may occasionally be diagnosed with a monoclonal gammopathy of undetermined significance (MGUS). Fanconi syndrome, on the other hand, can be primary (inherited) or secondary (acquired). …”
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Targeting the Microenvironment for Treating Multiple Myeloma by Peter Neumeister, Eduard Schulz, Katrin Pansy, Marta Szmyra, Alexander JA Deutsch

“…MM is consistently preceded by an asymptomatic monoclonal gammopathy of undetermined significance, and in the absence of myeloma defining events followed by a stage termed smoldering multiple myeloma (SMM), which finally progresses to active myeloma if signs of organ damage are present. …”
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