Multivalency, autoinhibition, and protein disorder in the regulation of interactions of dynein intermediate chain with dynactin and the nuclear distribution protein by Kayla A Jara, Nikolaus M Loening, Patrick N Reardon, Zhen Yu, Prajna Woonnimani, Coban Brooks, Cat H Vesely, Elisar J Barbar

“…Central to the function of this motor protein complex is dynein intermediate chain (IC), which binds the three dimeric dynein light chains at multivalent sites, and dynactin p150Glued and nuclear distribution protein (NudE) at overlapping sites of its intrinsically disordered N-terminal domain. …”
Get full text

TUBB3 and KIF21A in neurodevelopment and disease by Dharmendra Puri, Dharmendra Puri, Dharmendra Puri, Brenda J. Barry, Brenda J. Barry, Brenda J. Barry, Elizabeth C. Engle, Elizabeth C. Engle, Elizabeth C. Engle, Elizabeth C. Engle

“…Lastly, we highlight additional studies that might contribute to our understanding of the relationship between specific tubulin isotypes and specific kinesin motor proteins in health and disease.…”
Get full text

Eg5 UFMylation promotes spindle organization during mitosis by Guangxu Li, Yuanjiang Huang, Wenbo Han, Liyi Wei, Hongjing Huang, Yingbao Zhu, Qiao Xiao, Zujia Wang, Wen Huang, Ranhui Duan

“…In this study, we identified Eg5, a motor protein crucial for mitotic spindle assembly and maintenance, as a novel substrate for UFMylation and identified Lys564 as the crucial UFMylation site. …”
Get full text

Multiple Copies of microRNA Binding Sites in Long 3′UTR Variants Regulate Axonal Translation by Luba Farberov, Ariel Ionescu, Yazeed Zoabi, Guy Shapira, Amjd Ibraheem, Yosi Azan, Eran Perlson, Noam Shomron

“…Finally, we demonstrated that the long 3′UTR mRNA variant of the motor protein Kif5b is enriched explicitly in motor neuron axons and contains multiple sequence repeats for binding miR-129-5p. …”
Get full text

Neonatal Onset of Hemophagocytic Lymphohistiocytosis Due to Prenatal Varicella-Zoster Infection in a Neonate with Griscelli Syndrome Type 2 by Hamideh Nodehi, Mohammad Faranoush, Saba Arshi, Mohammad Nabavi, Mohammad Hasan Bemanian, Sima Shokri, Mohammad Reza Saghafi, Mohammad-Sadegh Fallah, Morteza Fallahpour

“…Although hypopigmentation is common in all variants, neurological involvement or immunodeficiency with varying severity is seen in different types. Molecular motor protein myosin 5 an (MYo5A) [Type1GS], guanosine Triphosphate (GTP) binding protein (RAB27A) [Type2GS], and mutation in human melanophilin (MLPH) [Type 3GS] which is limited to hypopigmentation are reported as the known genetic defects in GS.3 Severe, ineffective, and uncontrolled inflammatory reactions are referred to as the pathogenesis of Hemophagocytic lymphohistiocytosis (HLH). …”
Get full text

MG53 suppresses tumor growth via transcriptional inhibition of KIF11 in pancreatic cancer by Xiao-Liang Wang, Xiangfei He, Tong Gao, Xinyu Zhou, Zobeida Cruz-Monserrate, Allan Tsung, Jianjie Ma, Chuanxi Cai

“…The overexpression of KIF11, a motor protein crucial for cell mitosis regulation, has been linked to the aggressive proliferation of pancreatic cancer cells. …”
Get full text

Characterization and analysis of myosin gene family in the whitefly (<i>Bemisia tabaci</i>) by Kui Wang, Zhifang Yang, Xiaohui Chen, Shunxiao Liu, Xiang Li, Liuhao Wang, Hao Yu, Hongwei Zhang

“…Myosin is an actin-based motor protein that widely exists in muscle tissue and non-muscle tissue, and myosin of a diverse subfamily has obvious differences in structure and cell function. …”
Get full text

Axon-Autonomous Effects of the Amyloid Precursor Protein Intracellular Domain (AICD) on Kinase Signaling and Fast Axonal Transport by Svenja König, Nadine Schmidt, Karin Bechberger, Sarah Morris, Mercedes Priego, Hannah Zaky, Yuyu Song, Jan Pielage, Silke Brunholz, Scott T. Brady, Stefan Kins, Gerardo Morfini

“…Biochemical experiments linked this effect to aberrant activation of selected axonal kinases and heightened phosphorylation of the anterograde motor protein conventional kinesin, consistent with precedents showing phosphorylation-dependent regulation of motors proteins powering FAT. …”
Get full text

Motor properties of Myosin 5c are modulated by tropomyosin isoforms and inhibited by pentabromopseudilin by András Kengyel, András Kengyel, Philip M. Palarz, Jacqueline Krohn, Anja Marquardt, Johannes N. Greve, Robin Heiringhoff, Anne Jörns, Dietmar J. Manstein

“…Myosin 5c (Myo5c) is a motor protein that is produced in epithelial and glandular tissues, where it plays an important role in secretory processes. …”
Get full text

Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells by Suhong Sun, Shuting Li, Zhengnan Luo, Minhui Ren, Shunji He, Guangqin Wang, Zhiyong Liu

“…Previous attempts at regenerating new OHCs from cochlear supporting cells (SCs) have been unsuccessful, notably lacking expression of the key OHC motor protein, Prestin. Thus, regeneration of Prestin+ OHCs represents a barrier to restore auditory function in vivo. …”
Get full text

Filopodia powered by class x myosin promote fusion of mammalian myoblasts by David W Hammers, Cora C Hart, Michael K Matheny, Ernest G Heimsath, Young il Lee, John A Hammer III, Richard E Cheney, H Lee Sweeney

“…We demonstrate that these projections are filopodia generated by class X myosin (Myo10), an unconventional myosin motor protein specialized for filopodia. We further show that Myo10 is highly expressed by differentiating myoblasts, and Myo10 ablation inhibits both filopodia formation and myoblast fusion in vitro. …”
Get full text

KIF5A regulates axonal repair and time-dependent axonal transport of SFPQ granules and mitochondria in human motor neurons by Irune Guerra San Juan, Jessie W. Brunner, Kevin Eggan, Ruud F. Toonen, Matthijs Verhage

“…Mutations in the microtubule-binding motor protein kinesin 5 A (KIF5A) are implicated in several adult-onset motor neuron diseases, including Amyotrophic Lateral Sclerosis, Spastic Paraplegia Type 10 and Charcot-Marie-Tooth Disease Type 2. …”
Get full text

Genetic analysis of the maintenance of neuronal morphology in Drosophila melanogaster by Whited, Jessica LaMae, 1976-

Get full text
Get full text

Molecular Basis for Specific Regulation of Neuronal Kinesin-3 Motors by Doublecortin Family Proteins by Liu, Judy S., Schubert, Christian R., Fu, Xiaoqin, Fourniol, Franck J., Jaiswal, Jyoti K., Houdusse, Anne, Stultz, Collin M., Moores, Carolyn A., Walsh, Christopher A., Schubert, Christian R., Stultz, Collin M.

“…We show that Dcx is essential for the function of Kif1a, a kinesin-3 motor protein that traffics synaptic vesicles. Neurons lacking Dcx and/or its structurally conserved paralogue, doublecortin-like kinase 1 (Dclk1), show impaired Kif1a-mediated transport of Vamp2, a cargo of Kif1a, with decreased run length. …”
Get full text
Get full text

Thermodynamic machine learning through maximum work production by Boyd, Alexander B., Crutchfield, James P., Gu, Mile

“…Adaptive systems—such as a biological organism gaining survival advantage, an autonomous robot executing a functional task, or a motor protein transporting intracellular nutrients—must somehow embody relevant regularities and stochasticity in their environments to take full advantage of thermodynamic resources. …”
Get full text

Evaluation of inner ear damage by mastoid drilling with measurement of serum prestin (SLC26A5) levels by Ayca Baskadem Yilmazer, Onur Tanrısever, Maide Hacer Alagoz, Rasim Yilmazer, Ayse Enise Goker, Belgin Tutar, Yavuz Uyar

“…Objective: The objective of this study is to demonstrate any inner ear injury caused by drilling in mastoid surgery with prestin, outer hair cell motor protein specific to the cochlea. Methods: The patients with chronic otitis media requiring mastoidectomy (n = 21) and myringoplasty (n = 21) were included. …”
Get full text

A hybrid TIM complex mediates protein import into hydrogenosomes of Trichomonas vaginalis by Abhijith Makki, Sami Kereïche, Tien Le, Jitka Kučerová, Petr Rada, Vojtěch Žárský, Ivan Hrdý, Jan Tachezy

Get full text

Modulation of Agrin and RhoA Pathways Ameliorates Movement Defects and Synapse Morphology in MYO9A-Depleted Zebrafish by Emily O’Connor, George Cairns, Sally Spendiff, David Burns, Stefan Hettwer, Armin Mäder, Juliane Müller, Rita Horvath, Clarke Slater, Andreas Roos, Hanns Lochmüller

“…Therefore, this study highlights a role for MYO9A at the NMJ, the first unconventional myosin motor protein associated with a neuromuscular disease, and provides a potential mechanism of action of MYO9A-pathophysiology.…”
Get full text

Cytoplasmic dynein1 intermediate-chain2 regulates cellular trafficking and physiopathological development in Magnaporthe oryzae by Lily Lin, Ibrahim Tijjani, Hengyuan Guo, Qiuli An, Jiaying Cao, Xiaomin Chen, Wende Liu, Zonghua Wang, Justice Norvienyeku

“…Summary: The cytoplasmic dynein 1, a minus end-directed motor protein, is an essential microtubule-based molecular motor that mediates the movement of molecules to intracellular destinations in eukaryotes. …”
Get full text

Structure and biological evaluation of Caenorhabditis elegans CISD-1/mitoNEET, a KLP-17 tail domain homologue, supports attenuation of paraquat-induced oxidative stress through a p... by Jacob R. Boos, Hanna N. Jandrain, Emi Hagiuda, Alexander T. Taguchi, Kazuya Hasegawa, Bailey L. Fedun, Sarah J. Taylor, Sofhia M. Elad, Sarah E. Faber, Takashi Kumasaka, Toshio Iwasaki, Werner J. Geldenhuys

“…The structure of the C. elegans CISD-1/mitoNEET soluble domain refined at 1.70-Å resolution uniquely shows a reversible disulfide linkage at the homo-dimeric interface and also represents the N-terminal tail domain for dimerization of the cognate kinesin motor protein KLP-17 involved in chromosome segregation dynamics and germline development of the nematode. …”
Get full text