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Hexose-6-phosphate dehydrogenase: a new risk gene for multiple sclerosis.
Published 2010“…This marker is located on chromosome 1p36.22, which is 1 Mb away from the MS-associated kinesin motor protein KIF1B, although linkage disequilibrium was not observed between these two markers. …”
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263
Non-muscle myosin II in disease: mechanisms and therapeutic opportunities
Published 2015-12-01“…The actin motor protein non-muscle myosin II (NMII) acts as a master regulator of cell morphology, with a role in several essential cellular processes, including cell migration and post-synaptic dendritic spine plasticity in neurons. …”
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264
Mathematical Characterization of Protein Sequences Using Patterns as Chemical Group Combinations of Amino Acids.
Published 2016-01-01“…We also check commonality with another motor protein sub-family kinesin, KIF1A. Based on our analysis we find a common block of length 8 aa both in myosin II and KIF1A. …”
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265
Reconstitution of an active human CENP-E motor
Published 2022-03-01“…CENP-E is a large kinesin motor protein which plays pivotal roles in mitosis by facilitating chromosome capture and alignment, and promoting microtubule flux in the spindle. …”
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266
Phosphorylation by Cdk1 increases the binding of Eg5 to microtubules in vitro and in Xenopus egg extract spindles.
Published 2008-01-01“…BACKGROUND:Motor proteins from the kinesin-5 subfamily play an essential role in spindle assembly during cell division of most organisms. …”
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267
Genome-Wide Identification and Expression Analysis of Kinesin Family in Barley (<i>Hordeum vulgare</i>)
Published 2022-12-01“…Kinesin, as a member of the molecular motor protein superfamily, plays an essential function in various plants’ developmental processes. …”
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268
Microtubule motor driven interactions of lipid droplets: Specificities and opportunities
Published 2022-09-01“…There is growing evidence that motor protein driven motion of LDs along microtubules may facilitate such LD-organelle interactions. …”
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269
Acquisition of Rab11 and Rab11-Fip2-A novel strategy for Chlamydia pneumoniae early survival.
Published 2017-08-01“…Additionally, we show that binding to Rab11 and Fip2 recruits the unconventional actin motor protein myosin Vb to the early inclusion and that together they regulate the relocation of the nascent inclusion from the cell periphery to the perinuclear region, its final destination. …”
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270
Mitochondrial transfer from mesenchymal stem cells to neural stem cells protects against the neurotoxic effects of cisplatin
Published 2018-12-01“…Conversely, overexpression of the mitochondrial motor protein Rho-GTPase 1 (Miro1) in MSCs increased mitochondrial transfer and further improved survival of cisplatin-treated NSCs. …”
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271
Photoreceptor Compartment-Specific TULP1 Interactomes
Published 2021-07-01“…We report the identification of: (1) an IS-specific interaction between Tulp1 and the motor protein Kinesin family member 3a (Kif3a), (2) a synaptic-specific interaction between Tulp1 and the scaffold protein Ribeye, and (3) an interaction between Tulp1 and the cytoskeletal protein microtubule-associated protein 1B (MAP1B) in both compartments. …”
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272
Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells.
Published 2009-01-01“…In KIF5B-depleted cells the autophagosomes formed and accumulated in the close proximity to the Golgi apparatus, whereas in the control cells they appeared uniformly distributed in the cytoplasm.Our data identify KIF5B as a cancer relevant lysosomal motor protein with additional functions in autophagosome formation.…”
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273
Myosin V and iNOS expression is enhanced in J774 murine macrophages treated with IFN-gamma
Published 2001-02-01“…Actin-based motor protein requirements and nitric oxide (NO) production are important features of macrophage activity during phagocytosis or microbicidal processes. …”
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274
Outer Hair Cell Lateral Wall Structure Constrains the Mobility of Plasma Membrane Proteins.
Published 2015-09-01“…Previous studies suggest that Slc26a5 continuously diffuses within the membrane, but how can a freely moving motor protein effectively convey forces critical for hearing? …”
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275
Generation of the CRISPR/Cas9-mediated KIF1C knock-out human iPSC line HIHRSi003-A-1
Published 2020-12-01“…Bi-allelic loss-of-function mutations in the gene encoding the motor protein KIF1C are associated with Hereditary Spastic Paraplegia (HSP) type SPG58, a slowly progressive neurodegenerative motoneuron disease. …”
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276
Processivity of dimeric kinesin‐1 molecular motors
Published 2018-08-01“…Kinesin‐1 is a homodimeric motor protein that can move along microtubule filaments by hydrolyzing ATP with a high processivity. …”
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277
Hearing loss and hair cell death in mice given the cholesterol-chelating agent hydroxypropyl-β-cyclodextrin.
Published 2012-01-01“…In many cases, surviving hair cells in the cochlear apex exhibited abnormal punctate distribution of the motor protein prestin, suggesting long term changes to membrane composition and integrity. …”
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278
Cellular model of neuronal atrophy induced by DYNC1I1 deficiency reveals protective roles of RAS-RAF-MEK signaling
Published 2016-08-01“…A variety of abnormalities including motor protein malfunction and mitochondrial dysfunction contribute to the loss of neuronal architecture; however, less is known about the intracellular signaling pathways that can protect against or delay this pathogenic process. …”
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279
The SPF27 homologue Num1 connects splicing and kinesin 1-dependent cytoplasmic trafficking in Ustilago maydis.
Published 2014-01-01“…Among others, Num1 interacts with the motor protein Kin1 in the cytoplasm. Similar phenotypes with respect to filamentous and polar growth, vacuolar morphology, as well as the motility of early endosomes corroborate the genetic interaction between Num1 and Kin1. …”
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280
Notch signaling limits supporting cell plasticity in the hair cell-damaged early postnatal murine cochlea.
Published 2013-01-01“…Lastly, we show that the vast majority of these newly generated hair cell-like cells express the outer hair cell specific motor protein prestin.…”
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