Memantine Derivatives as Multitarget Agents in Alzheimer’s Disease by Giambattista Marotta, Filippo Basagni, Michela Rosini, Anna Minarini

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The Use of Zidovudine Pharmacophore in Multi-Target-Directed Ligands for AIDS Therapy by Maria da Conceição Avelino Dias Bianco, Debora Inacio Leite, Frederico Silva Castelo Branco, Nubia Boechat, Elisa Uliassi, Maria Laura Bolognesi, Monica Macedo Bastos

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From the “One-Molecule, One-Target, One-Disease” Concept towards Looking for Multi-Target Therapeutics for Treating Non-Polio Enterovirus (NPEV) Infections by Hugo Roux, Franck Touret, Pascal Rathelot, Patrice Vanelle, Manon Roche

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Editorial: Pharmacoinformatics: new developments and challenges in drug design by David Ramírez, Rafael Peláez, Rafael Peláez, Rafael Peláez, Carlos F. Lagos, Carlos F. Lagos, José L. Medina-Franco

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Multi-target Natural and Nature-Inspired Compounds against Neurodegeneration: A Focus on Dual Cholinesterase and Phosphodiesterase Inhibitors by Giovanni Ribaudo, Maurizio Memo, Alessandra Gianoncelli

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Ajmalicine and Reserpine: Indole Alkaloids as Multi-Target Directed Ligands Towards Factors Implicated in Alzheimer’s Disease by Priya Kashyap, Vivekanandan Kalaiselvan, Robin Kumar, Suresh Kumar

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Guanidines: Synthesis of Novel Histamine H₃R Antagonists with Additional Breast Anticancer Activity and Cholinesterases Inhibitory Effect by Marek Staszewski, Magdalena Iwan, Tobias Werner, Marek Bajda, Justyna Godyń, Gniewomir Latacz, Agnieszka Korga-Plewko, Joanna Kubik, Natalia Szałaj, Holger Stark, Barbara Malawska, Anna Więckowska, Krzysztof Walczyński

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σ₂ Receptor and Its Role in Cancer with Focus on a MultiTarget Directed Ligand (MTDL) Approach by Francesca Serena Abatematteo, Mauro Niso, Enza Lacivita, Carmen Abate

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Delivery of Thyronamines (TAMs) to the Brain: A Preliminary Study by Nicoletta di Leo, Stefania Moscato, Marco Borso', Simona Sestito, Beatrice Polini, Lavinia Bandini, Agostina Grillone, Matteo Battaglini, Alessandro Saba, Letizia Mattii, Gianni Ciofani, Grazia Chiellini

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Endogenous 3-Iodothyronamine (T1AM) and Synthetic Thyronamine-Like Analog SG-2 Act as Novel Pleiotropic Neuroprotective Agents through the Modulation of SIRT6 by Lorenza Bellusci, Massimiliano Runfola, Vittoria Carnicelli, Simona Sestito, Federica Fulceri, Filippo Santucci, Paola Lenzi, Francesco Fornai, Simona Rapposelli, Nicola Origlia, Riccardo Zucchi, Grazia Chiellini

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Design, synthesis and in vitro biological activities of coumarin linked 1,3,4-oxadiazole hybrids as potential multi-target directed anti-Alzheimer agents by Namy George, Bushra Al Sabahi, Majed AbuKhader, Khalid Al Balushi, Md. Jawaid Akhtar, Shah Alam Khan

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Profiling donepezil template into multipotent hybrids with antioxidant properties by Eva Mezeiova, Katarina Spilovska, Eugenie Nepovimova, Lukas Gorecki, Ondrej Soukup, Rafael Dolezal, David Malinak, Jana Janockova, Daniel Jun, Kamil Kuca, Jan Korabecny

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A Novel Multifunctional 5,6-Dimethoxy-Indanone-Chalcone-Carbamate Hybrids Alleviates Cognitive Decline in Alzheimer’s Disease by Dual Inhibition of Acetylcholinesterase and Inflamm... by Chan Liu, Chan Liu, Zhipei Sang, Hong Pan, Hong Pan, Qin Wu, Yu Qiu, Jingshan Shi

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Searching for Multi-Targeting Neurotherapeutics against Alzheimer’s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif by Leonardo Pisani, Roberta Farina, Ramon Soto-Otero, Nunzio Denora, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Estefania Mendez-Alvarez, Cosimo Damiano Altomare, Marco Catto, Angelo Carotti

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Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases by Damien Hédou, Julien Godeau, Nadège Loaëc, Laurent Meijer, Corinne Fruit, Thierry Besson

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Discovery of Novel Tryptanthrin Derivatives with Benzenesulfonamide Substituents as Multi-Target-Directed Ligands for the Treatment of Alzheimer’s Disease by Guoxing Wang, Jiyu Du, Jie Ma, Peipei Liu, Siqi Xing, Jucheng Xia, Shuanghong Dong, Zeng Li

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Novel small molecule-based acetylcholinesterase (AChE) inhibitors: From biological perspective to recent developments by Anjali Sobha, Anand Ganapathy, Sangeetha Mohan, Nithya Madhusoodanan, Alansheeja D. Babysulochana, Kumaran Alaganandan, Sasidhar B. Somappa

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Multi-target directed donepezil-like ligands for Alzheimer's disease by Mercedes eUnzeta, Gerard eEsteban, Irene eBolea, Wieslawa Agnieszka Fogel, RONA R. RAMSAY, Moussa B.H. Youdim, Keith F Tipton, Jose eMarco-Contelles

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Editorial: Multi-target directed ligands for the treatment of cancer by Margherita Brindisi, Sonja M. Kessler, Vinod Kumar, Clemens Zwergel

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4-Phenethyl-1-Propargylpiperidine-Derived Dual Inhibitors of Butyrylcholinesterase and Monoamine Oxidase B by Tjaša Mazej, Damijan Knez, Anže Meden, Stanislav Gobec, Matej Sova

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