Design, Synthesis, and In Silico Multitarget Pharmacological Simulations of Acid Bioisosteres with a Validated In Vivo Antihyperglycemic Effect by Elix Alberto Domínguez-Mendoza, Yelzyn Galván-Ciprés, Josué Martínez-Miranda, Cristian Miranda-González, Blanca Colín-Lozano, Emanuel Hernández-Núñez, Gloria I. Hernández-Bolio, Oscar Palomino-Hernández, Gabriel Navarrete-Vazquez

Subjects: “…multitarget ligands…”
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Computational polypharmacology comes of age by Giulio eRastelli, Luca ePinzi

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Optimizing the Synthetic Route of Chromone-2-carboxylic Acids: A Step forward to Speed-up the Discovery of Chromone-based Multitarget-directed Ligands by Fernando Cagide, Catarina Oliveira, Joana Reis, Fernanda Borges

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Playing Around the Coumarin Core in the Discovery of Multimodal Compounds Directed at Alzheimer’s-Related Targets: A Recent Literature Overview by Mariagrazia Rullo, Gabriella La Spada, Angela Stefanachi, Eleonora Macchia, Leonardo Pisani, Francesco Leonetti

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LP1 and LP2: Dual-Target MOPr/DOPr Ligands as Drug Candidates for Persistent Pain Relief by Lorella Pasquinucci, Carmela Parenti, Zafiroula Georgoussi, Lorena Reina, Emilia Tomarchio, Rita Turnaturi

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Antinociceptive Efficacy of the µ-Opioid/Nociceptin Peptide-Based Hybrid KGNOP1 in Inflammatory Pain without Rewarding Effects in Mice: An Experimental Assessment and Molecular Doc... by Maria Dumitrascuta, Marcel Bermudez, Olga Trovato, Jolien De Neve, Steven Ballet, Gerhard Wolber, Mariana Spetea

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Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase by Karin Meirer, Daniel Glatzel, Simon Kretschmer, Sandra K. Wittmann, Markus Hartmann, René Blöcher, Carlo Angioni, Gerd Geisslinger, Dieter Steinhilber, Bettina Hofmann, Robert Fürst, Ewgenij Proschak

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Biological Activity Profiles of Multitarget Ligands from X-ray Structures by Christian Feldmann, Jürgen Bajorath

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New derivatives of quinazolinone as an object in the search for substances that exhibit a multi-target effect by A. A. Starikova, A. A. Tsibizova, N. V. Zolotareva, D. V. Merezhkina, A. A. Ozerov, M. A. Samotrueva

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PQM130, a Novel Feruloyl–Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer’s Disease by Fabiana Morroni, Giulia Sita, Agnese Graziosi, Gloria Ravegnini, Raffaella Molteni, Maria Serena Paladini, Kris Simone Tranches Dias, Ariele Faria dos Santos, Claudio Viegas, Ihosvany Camps, Letizia Pruccoli, Andrea Tarozzi, Patrizia Hrelia

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Solid Lipid Nanoparticles as Carriers for the Synthetic Opioid LP2: Characterization and In Vitro Release by Angelo Spadaro, Lorella Pasquinucci, Miriam Lorenti, Ludovica Maria Santagati, Maria Grazia Sarpietro, Rita Turnaturi, Carmela Parenti, Lucia Montenegro

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Chalcones as Potential Ligands for the Treatment of Parkinson’s Disease by Ewelina Królicka, Katarzyna Kieć-Kononowicz, Dorota Łażewska

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