Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation by Shrivastav, Nidhi, Li, Deyu, Essigmann, John M.

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Harnessing mutagenic homologous recombination for targeted mutagenesis in vivo by TaGTEAM by Finney-Manchester, Shawn Pete, Maheshri, Narendra

“…Here, we describe a method for in vivo-targeted mutagenesis in yeast, targeting glycosylases to embedded arrays for mutagenesis (TaGTEAM). …”
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Harnessing mutagenic homologous recombination for in vivo targeted mutagenesis by TaGTEAM by Finney-Manchester, Shawn P. (Shawn Peter)

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Frameshift Mutagenesis and Microsatellite Instability Induced by Human Alkyladenine DNA Glycosylase by Klapacz, Joanna, Lingaraju, Gondichatnahalli M., Guo, Haiwei H., Shah, Dharini, Moar-Shoshani, Ayelet, Loeb, Lawrence A., Samson, Leona D.

“…Surprisingly, elevated expression of hAAG increases spontaneous frameshift mutagenesis. By random mutagenesis of eight active site residues, we isolated hAAG-Y127I/H136L double mutant that induces even higher rates of frameshift mutation than does the wild-type hAAG; the Y127I mutation accounts for the majority of the hAAG-Y127I/H136L-induced mutator phenotype. …”
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Alteration of coenzyme specificity of alkyl hydroperoxide reductase by site directed mutagenesis by B K Nirmalee Lakshani Goonewardena

“…The gene coding for AhpF product has been successfully modified using site directed mutagenesis and cloned into two vectors pJET and pET30b for long term storage and protein expression respectively. …”
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Simulated mutagenesis to predict the mutational effect on the thermostability of Bacillus circulans xylanase by Abdul Hadi, Muaz, Noorbatcha, Ibrahim Ali, Ismail, Ahmad Faris, Mohd. Salleh, Hamzah

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Site-directed mutagenesis of beta-lactamase I: role of Glu-166. by Leung, Y, Robinson, C, Aplin, RT, Waley, S

Meiotic DNA breaks drive multifaceted mutagenesis in the human germ line. by Hinch, R, Donnelly, P, Hinch, AG

“…We provide evidence that these mechanisms drive mutagenesis in human germ lines and lead to disruption of hundreds of genes genome wide.…”

Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system by Bassett, AR, Tibbit, C, Ponting, CP, Liu, J-L

“…We show that injection of RNA into the Drosophila embryo can induce highly efficient mutagenesis of desired target genes in up to 88% of injected flies. …”

Interactions between residues in staphylococcal alpha-hemolysin revealed by reversion mutagenesis. by Panchal, R, Bayley, H

“…The present study suggests that the key N-terminal residue His-35 operates in conjunction with residues flanking the loop and C-terminal residues in the region 217-228. Hence, reversion mutagenesis extends the linear analysis that has been provided by direct point mutagenesis.…”

DNA Replication and associated repair pathways are involved in the mutagenesis of methylated cytosine by Tomkova, M, McClellan, M, Kriaucionis, S, Schuster-Böckler, P

“…Together, these findings suggest that mis-incorporation of A opposite 5mC during replication of the leading strand might be a contributing factor in the mutagenesis of methylated cytosine.…”

Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system. by Bassett, A, Tibbit, C, Ponting, C, Liu, J

“…We show that injection of RNA into the Drosophila embryo can induce highly efficient mutagenesis of desired target genes in up to 88% of injected flies. …”

Highly Efficient Targeted Mutagenesis of Drosophila with the CRISPR/Cas9 System by Bassett, A, Tibbit, C, Ponting, C, Liu, J

Characterization of the sialic acid-binding site in sialoadhesin by site-directed mutagenesis. by Vinson, M, van der Merwe, P, Kelm, S, May, A, Jones, E, Crocker, P

“…Here we have carried out site-directed mutagenesis in an attempt to identify the binding site of sialoadhesin. …”

A review on microbial mutagenesis through gamma irradiation for agricultural applications by Phua, Choo Kwai Hoe, Abdul Rahim, Khairuddin, Mohd Saud, Halimi

“…Gamma irradiation is widely used in sterilization and mutagenesis, especially for plant breeding and crop protection. …”
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Enhancement of enzymatic properties of T1 lipase by saturation mutagenesis at glutamine 114 by Ab. Wahab, Roswanira

Subjects: “…Mutagenesis…”
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A review on microbial mutagenesis through gamma irradiation for agricultural applications by Choo, Phua Kwai Hoe, Abdul Rahim, Khairuddin, Mohd Saud, Halimi

“…Gamma irradiation is widely used in sterilization and mutagenesis, especially for plant breeding and crop protection. …”
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Genetic characterization of locally isolated yeast strain through mutagenesis study by Tan, Li Lung

“…Mutants of YL3 were generated using UV mutagenesis to establish suitable genetic markers. …”
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Radiation mutagenesis of microbial biofertilizer for functionalities improvement in cucumber and green mustard by Phua, Choo Kwai Hoe

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Rational mutagenesis of cyclodextrin glucanotransferase at the calcium binding regions for enhancement of thermostability by Goh, Poh Hong, Md. Illias, Rosli, Goh, Kian Mau

“…The calcium binding regions that are known for thermostability function were subjected to site-directed mutagenesis in this study. The starting gene-protein is a variant of CGTase Bacillus sp. …”
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