Development of nanodelivery systems for anti-tuberculosis drugs using metal hydroxides nanolayered hosts by Saifullah

“…Therapeutic efficacy of the anti-TB nanocomposites against mycobacteria tuberculosis was found to be much better compared to para amino salicylic acid and isoniazid in their free form. …”
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Silencing essential gene expression in Mycobacterium abscessus during infection by Yves-Marie Boudehen, Yara Tasrini, John Jairo Aguilera-Correa, Matthéo Alcaraz, Laurent Kremer

“…Herein, we generated a Tet-OFF-based system allowing to knock down the expression of mmpL3, encoding the mycolic acid transporter in mycobacteria. Using this conditional mutant, we confirm the essentiality of mmpL3 in planktonic cultures, in biofilms, and during infection in zebrafish embryos. …”
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Comparação de duas técnicas de isolamento do Mycobacterium avium subsp. paratuberculosis em amostras de fezes de ovinos com suspeita clínica de paratuberculose Comparison of two te... by Ana Cláudia Coelho, Maria de Lurdes Pinto, Adosinda Maria Coelho, Jorge Rodrigues

“…Culture of bacteria from faeces and tissues samples constitutes one of the most effective methods of confirming the diagnosis of para-tuberculosis and the only method available to obtain strains of mycobacteria. However, this method is less sensitive and requires months of incubation before colony growth occurs. …”
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Synthesis and Characterization of Novel 2-Acyl-3-trifluoromethylquinoxaline 1,4-Dioxides as Potential Antimicrobial Agents by Galina I. Buravchenko, Dmitry A. Maslov, Md Shah Alam, Natalia E. Grammatikova, Svetlana G. Frolova, Aleksey A. Vatlin, Xirong Tian, Ivan V. Ivanov, Olga B. Bekker, Maxim A. Kryakvin, Olga A. Dontsova, Valery N. Danilenko, Tianyu Zhang, Andrey E. Shchekotikhin

“…Most of the 2-acyl-3-trifluoromethylquinoxaline 1,4-dioxides showed high antibacterial properties against Gram-positive strains, including mycobacteria, and the introduction of a halogen atom in the position 6 of the quinoxaline ring further increased their activity, with <b>13c</b> being the most active compound. …”
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PPE Barcoding Identifies Biclonal Mycobacterium ulcerans Buruli Ulcer, Côte d’Ivoire by B. G. O. Tchan, S. Ngazoa-Kakou, N. Aka, N. K. B. Apia, N. Hammoudi, M. Drancourt, J. Saad

“…PCR-derived tests used to detect M. ulcerans in environmental and clinical samples do not allow one-shot detection, identification, and typing of M. ulcerans among closely related Mycobacterium marinum complex mycobacteria. We established a 385-member M. marinum/M. ulcerans complex whole-genome sequence database by assembling and annotating 341 M. marinum/M. ulcerans complex genomes and added 44 M. marinum/M. ulcerans complex whole-genome sequences already deposited in the NCBI database. …”
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Development of a microfluidic biosensor for the diagnostics and typing of <i>Mycobacterium Tuberculosis</i> by Tatiana V. Mitko, Ruslan I. Shakurov, Fedor V. Shirshikov, Sizova V. Svetlana, Elena V. Alieva, Valery N. Konopsky, Dmitry V. Basmanov, Julia A. Bespyatykh

“…Thus, the development of new methods for diagnostics and typing of mycobacteria, as well as practice implementation of these developments is an urgent direction. …”
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Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole by Martin Juhás, Andrea Bachtíková, Daria Elżbieta Nawrot, Paulína Hatoková, Vinod Sukanth Kumar Pallabothula, Adéla Diepoltová, Ondřej Janďourek, Pavel Bárta, Klára Konečná, Pavla Paterová, Vít Šesták, Jan Zitko

“…In general, oxazole-containing compounds showed high activity against mycobacteria, especially <i>Mycobacterium tuberculosis</i> (best MIC_H37Ra = 3.13 µg/mL), including the multidrug-resistant strains. …”
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Metagenomic insights into the variation of bacterial communities and potential pathogenic bacteria in drinking water treatment and distribution systems by Jiang Ruiming, Li Zihan, Li Qisheng, Liu Yunqi, Zhu Yuning, Chen Zimo, Liu Peng, Jia Shuyu, Ren Hongqiang, Zhang Xu-Xiang

“…Metagenomic analyses revealed the occurrence of 56 species of potential pathogenic bacteria within 17 genera in drinking water, mainly including <italic>Pseudomonas fluorescens</italic> and five mycobacteria species, which were also persistent in tap water samples. …”
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Comparison of Sputum Treated with Power Ultrasound and Routine NALC-NaOH Methods for Mycobacterial Culture: A Prospective Study by Junling Wang, Yan Wang, Xiaojie Ling, Zhenjin Zhang, Yunfeng Deng, Peng Tian

“…Of the 597 samples, 89 (14.91%) sputum samples treated with the NaOH-NALC method were mycobacterial culture positive, including <i>Mycobacterium tuberculosis</i> (<i>M.TB</i>; <i>n</i> = 77, 12.90%) and nontuberculous mycobacteria (NTM; <i>n</i> = 12, 2.01%). One hundred and ten (18.43%) sputum samples treated with the PU method were culture positive, including <i>M.TB</i> (<i>n</i> = 87, 14.57%) and NTM (<i>n</i> = 23, 3.85%). …”
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Differential Immune Responses and Underlying Mechanisms of Metabolic Reprogramming in Smooth and Rough Variants of <i>Mycobacterium peregrinum</i> Infections by Ji Won Lee, Ho Won Kim, A-Reum Yu, Hoe Sun Yoon, Minji Kang, Hwan-Woo Park, Sung Ki Lee, Jake Whang, Jong-Seok Kim

“…<i>Mycobacterium peregrinum</i> (<i>Mpgm</i>) is a rapidly growing mycobacteria that is classified as a nontuberculous mycobacterium (NTM) and is commonly found in environmental sources such as soil, water, and animals. …”
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Vaccination with Alpha-Gal Protects Against Mycobacterial Infection in the Zebrafish Model of Tuberculosis by Iván Pacheco, Marinela Contreras, Margarita Villar, María Angeles Risalde, Pilar Alberdi, Alejandro Cabezas-Cruz, Christian Gortázar, José de la Fuente

“…These mechanisms included B-cell maturation, antibody-mediated opsonization of mycobacteria, Fc-receptor (FcR)-mediated phagocytosis, macrophage response, interference with the α-Gal antagonistic effect of the toll-like receptor 2 (TLR2)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB)-mediated immune response, and upregulation of pro-inflammatory cytokines. …”
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In Vitro, In Vivo and In Silico Assessment of the Antimicrobial and Immunomodulatory Effects of a Water Buffalo Cathelicidin (WBCATH) in Experimental Pulmonary Tuberculosis by Jacqueline Barrios Palacios, Jorge Barrios-Payán, Dulce Mata-Espinosa, Jacqueline V. Lara-Espinosa, Juan Carlos León-Contreras, Gerald H. Lushington, Tonatiuh Melgarejo, Rogelio Hernández-Pando

“…Furthermore, in vivo WBCATH showed decreased bacterial loads in a model of progressive pulmonary TB in BALB/c mice infected with drug-sensitive or MDR mycobacteria. In addition, a synergistic therapeutic effect was observed when first-line antibiotics were administered with WBCATH. …”
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Comparative proteome analysis revealed the differences in response to both Mycobacterium tuberculosis and Mycobacterium bovis infection of bovine alveolar macrophages by Yurong Cai, Weifeng Gao, Weifeng Gao, Pu Wang, Gang Zhang, Xiaoping Wang, Lingling Jiang, Jin Zeng, Jin Zeng, Yujiong Wang, Yujiong Wang, Zhiwei Wu, Zhiwei Wu, Yong Li, Yong Li

“…Moreover, we observed that both types of mycobacteria triggered significant changes in BAM energy metabolism. …”
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ApoE Mimetic Peptide COG1410 Kills <i>Mycobacterium smegmatis</i> via Directly Interfering ClpC’s ATPase Activity by Chun Wang, Yun-Yao Ren, Li-Mei Han, Peng-Cheng Yi, Wei-Xiao Wang, Cai-Yun Zhang, Xiu-Zhen Chen, Ming-Zhe Chi, Apeng Wang, Wei Chen, Chun-Mei Hu

“…This study sheds light on a unique resistance mechanism against AMPs in mycobacteria, highlighting the pivotal role of ClpC in this process. …”
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Exogenously Scavenged and Endogenously Synthesized Heme Are Differentially Utilized by Mycobacterium tuberculosis by Rebecca K. Donegan, Yibo Fu, Jacqueline Copeland, Stanzin Idga, Gabriel Brown, Owen F. Hale, Avishek Mitra, Hui Yang, Harry A. Dailey, Michael Niederweis, Paras Jain, Amit R. Reddi

“…Altogether, our data suggest that mycobacteria utilize heme from endogenous and exogenous sources differently and that targeting heme synthesis may be an effective therapeutic strategy to treat mycobacterial infections. …”
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Fusion Cytokines IL-7-Linker-IL-15 Promote Mycobacterium Tuberculosis Subunit Vaccine to Induce Central Memory like T Cell-Mediated Immunity by Chunxiang Bai, Lijun Zhou, Junxia Tang, Juanjuan He, Jiangyuan Han, Hongxia Niu, Bingdong Zhu

“…This study indicated that rAd-IL-7-Linker-IL-15 improved the TB subunit vaccine’s efficacy by augmenting T_CM like cells and provided long-term protective efficacy against <i>Mycobacteria</i>.…”
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The significance of notch signaling in the regulation of Тreg-lymphocyte differentiation in patients with infiltrative pulmonary tuberculosis by A. E. Sanina, V. A. Serebryakova, O. I. Urazova, A. A. Gadzhiev, Т. E. Kononova

“…Regardless of cultivation conditions, the number of CD4+FoxP3+ cells in patients with drug-resistant mycobacteria exceeded their number in patients with drug-sensitive pulmonary tuberculosis. …”
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Bibliometric Review on New Possibilities of Antimycobacterial Agents: Exploring Siderophore Desferrioxamine’s Applications as an Antimicrobial Agent by Patrícia Vieira de Oliveira, Roseane Lustosa de Santana Lira, Rafael de Abreu Lima, Yasmim Costa Mendes, Antenor Bezerra Martins, Bruna de Oliveira de Melo, Millena Ferreira Goiano, Rivaldo Lira Filho, Flávia Baluz Bezerra de Farias Nunes, Amanda Silva dos Santos Aliança, Wellyson da Cunha Araújo Firmo, Rafael Cardoso Carvalho, Adrielle Zagmignan, Eduardo Martins de Sousa

“…Mycobacteria cause tuberculosis and other serious diseases. …”
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Natural Bioactive Thiazole-Based Peptides from Marine Resources: Structural and Pharmacological Aspects by Rajiv Dahiya, Sunita Dahiya, Neeraj Kumar Fuloria, Suresh Kumar, Rita Mourya, Suresh V. Chennupati, Satish Jankie, Hemendra Gautam, Sunil Singh, Sanjay Kumar Karan, Sandeep Maharaj, Shivkanya Fuloria, Jyoti Shrivastava, Alka Agarwal, Shamjeet Singh, Awadh Kishor, Gunjan Jadon, Ajay Sharma

“…Peptides are distinctive biomacromolecules that demonstrate potential cytotoxicity and diversified bioactivities against a variety of microorganisms including bacteria, mycobacteria, and fungi via their unique mechanisms of action. …”
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ApoE Mimetic Peptide COG1410 Exhibits Strong Additive Interaction with Antibiotics Against Mycobacterium smegmatis by Zhao YY, Wang C, Wang WX, Han LM, Zhang C, Yu JY, Chen W, Hu CM

“…However, whether it is effective to inhibit growth of mycobacteria has not been investigated yet.Methods: The peptide COG1410 was synthesized with conventional solid-phase peptide synthesis and qualified by HPLC and mass spectrometry. …”
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