Mechanism of Electroacupuncture Against Cerebral Ischemia–Reperfusion Injury: Reducing Inflammatory Response and Cell Pyroptosis by Inhibiting NLRP3 and Caspase-1 by Li Cai, Li Cai, Zeng-Yu Yao, Zeng-Yu Yao, Lu Yang, Lu Yang, Xiu-Hong Xu, Meng Luo, Miao-Miao Dong, Guo-Ping Zhou, Guo-Ping Zhou

“…Results showed that EA could reduce the score of neurological deficit, reduce the volume of cerebral infarction and improve the degree of nerve cell injury, and inhibit NLRP3, pro-caspase-1, cleaved caspase-1 p20, pro-IL-1β, cleaved IL-1β, and GSDMD protein expression. …”
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Hypoglossal Nerve Abnormalities as Biomarkers for Central Nervous System Defects in Mouse Lines Producing Embryonically Lethal Offspring by Lukas F. Reissig, Atieh Seyedian Moghaddam, Fabrice Prin, Robert Wilson, Antonella Galli, Catherine Tudor, Jaqueline K. White, Stefan H. Geyer, Timothy J. Mohun, Wolfgang J. Weninger

“…Hypoglossal nerve (HGN) abnormalities (absent, thin, and abnormal topology) and abnormal morphology or topology of head arteries are both frequently associated with the full spectrum of morphological CNS defects, ranging from exencephaly to more subtle defects such as abnormal nerve cell migration. Statistical analysis confirmed that HGN abnormalities (especially those scored absent or thin) indeed showed a significant correlation with CNS defect phenotypes. …”
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Untargeted and Oxylipin-Targeted Metabolomics Study on the Plasma Samples of Primary Open-Angle Glaucoma Patients by Jianming Xu, Changzhen Fu, Yaru Sun, Xin Wen, Chong-Bo Chen, Chukai Huang, Tsz Kin Ng, Qingping Liu, Mingzhi Zhang

“…<b>Conclusions</b>: This study revealed that the metabolites in the arachidonic acid metabolism pathway are differentially abundant, suggesting high IOP may not be the only detrimental factor for optic nerve cell damage in this group of POAG patients. Lipid metabolism instability-mediated alterations in oxylipins and AA pathways may be important in POAG, suggesting that oxidative stress and immune-related inflammation could be valuable directions for future therapeutic strategies.…”
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Multimodal brain imaging effect of “Adjust Zang-fu and Arouse Spirit” electroacupuncture on diabetic cognitive impairment: study protocol of a randomized, sham-controlled pilot tri... by Lin Yao, Mengyuan Li, Shunan Sun, Ming Xu, Shuo Yu, Ziyang Zhang, Liying Zhang, Haizhu Zheng, Zhen Zhong, Shiqi Ma, Haipeng Huang, Hongfeng Wang

“…The pathogenesis of DCI is complex, but brain nerve injury and brain nerve cell apoptosis are important pathological changes. …”
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Parent-of-origin effects on nuclear chromatin organization and behavior in a Drosophila model for Williams–Beuren Syndrome by A. V. Medvedeva, E. V. Tokmatcheva, A. N. Kaminskaya, S. A. Vasileva, E. A. Nikitina, A. V. Zhuravlev, G. A. Zakharov, O. G. Zatsepina, E. V. Savvateeva-Popova

“…Prognosis of neuropsychiatric disorders in progeny requires consideration of individual (1) parent-of-origin effects (POEs) relying on (2) the nerve cell nuclear 3D chromatin architecture and (3) impact of parent-specific miRNAs. …”
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Overexpression of FSP1 Ameliorates ferroptosis via PI3K/ AKT /GSK3β pathway in PC12 cells with Oxygen-Glucose Deprivation/Reoxygenation by Yonghui Wu, Haoyu Shi, Jie Zheng, Yang Yang, Xuejiao Lei, Xiao Qian, Jie Zhu

“…After ischemia and reperfusion (I/R), nerve cell damage is a pathogenic process that involves numerous molecular processes. …”
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Lipostatic Mechanisms Preserving Cerebellar Lipids in MPTP-Treated Mice: Focus on Membrane Microdomains and Lipid-Related Gene Expression by Mario Díaz, Mario Díaz, Ana Canerina Luis-Amaro, Ana Canerina Luis-Amaro, Deiene Rodriguez Barreto, Verónica Casañas-Sánchez, Verónica Casañas-Sánchez, José A. Pérez, José A. Pérez, Raquel Marin, Raquel Marin

“…We conclude that cerebellum is endowed with efficient mechanisms to preserve nerve cell lipid homeostasis, which greatly maintain the stability of membrane microdomains involved in synaptic transmission, signal transduction, and intercellular communication, which together may participate in the compensatory role of the cerebellum in PD symptomatology.…”
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An advanced approach for the electrical responses of discrete fractional-order biophysical neural network models and their dynamical responses by Yu-Ming Chu, Taher Alzahrani, Saima Rashid, Waleed Rashidah, Shafiq ur Rehman, Mohammad Alkhatib

“…We show that a discrete fractional-order activated nerve cell framework incorporating a Caputo-type fractional difference operator can be used to investigate the impacts of complex interactions on the surge-empowering capabilities noticed within our findings. …”
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Effect of ethanolic extract of pod Prosopis farcta plant on neuronal density of anterior horn following sciatic nerve compression in Rats by Tehranipour M (PhD), Mollashahi M (MSc), Javadmoosavi BZ (MSc)

“…Background and Objective: After axotomy or the compersion the nerve, the death of spinal cord nerves cell body occur. Compersion is one of the factors causing the degeneration of the spinal cord cell body. …”
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Reviving Matrix for Nerve Reconstruction in Rabbit Model of Chronic Peripheral Nerve Injury With Massive Loss Defect by Shimon Rochkind, Mara Almog, Sigal Meilin, Zvi Nevo

“…Background and Aims: The aim of this study was to investigate the innovative guiding regenerative gel (GRG) and antigliotic GRG (AGRG) fillings for nerve conduits, prepared with Food and Drug Administration (FDA)-approved agents and expected to provide an alternative to autologous nerve graft and to enable reconnection of massive nerve gaps in a rabbit model of chronic peripheral nerve injury with massive loss defect that simulates the human condition of chronic injury with a large gap.Methods: The components and dosimetry for GRG and AGRG formulations were investigated in vitro on nerve cell culture and in vivo on 10-mm reconstructed sciatic nerves of 72 rats using different concentrations of agents and completed on a rabbit model of delayed (chronic) complete peripheral nerve injury with a 25-mm gap. …”
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Decreased Mitogen Inducible Gene 6 (MIG-6) Associated with Symptom Severity in Children with Autism by AJ Russo

“…Recent research has shown that epidermal growth factor receptor (EGFR) activation is associated with nerve cell development and repair. Mitogen inducible gene 6 (MIG-6) is a 58-kDa non-kinase scaffolding adaptor protein consisting of 462 amino-acids, which has been shown to be a negative feedback regulator of EGFR and Met receptor tyrosine kinase (RTK) signaling. …”
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Headache on the background of coronavirus infection: features of the clinical picture by Daryna Feshchenko, Svitlana Malyk, Mykola Shevnia

“…Determining the possible routes of entry of the pathogen into the nerve cell, establishing the specifics of Covid-associated headache remains an urgent problem in medicine. …”
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Cell-mediated contraction & induced regeneration of the injured peripheral nerve by Soller, Eric C

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Unveiling amyloid-β1–42 interaction with zinc in water and mixed hexafluoroisopropanol solution in Alzheimer’s disease by Ghani, Nur Syafiqah Abdul, Karjiban, Roghayeh Abedi, Basri, Mahiran, Faujan, Nur Hana, Wui, Zhuan Lim

“…The hallmarks associated with this AD are the presence of Aβ plaques between the nerve cell in the brain which leading to synaptic loss in memory. …”
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Neuroprotective Effects of Emodin against Ischemia/Reperfusion Injury through Activating ERK-1/2 Signaling Pathway by Stephen Wan Leung, Jing Huei Lai, John Chung-Che Wu, Yan-Rou Tsai, Yen-Hua Chen, Shuo-Jhen Kang, Yung-Hsiao Chiang, Cheng-Fu Chang, Kai-Yun Chen

“…Furthermore, Emodin alleviated nerve cell injury following ischemia/reperfusion in a rat MCAO model. …”
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Prioritizing genes associated with brain disorders by leveraging enhancer-promoter interactions in diverse neural cells and tissues by Xingzhong Zhao, Liting Song, Anyi Yang, Zichao Zhang, Jinglong Zhang, Yucheng T. Yang, Xing-Ming Zhao

“…Results We found that identified EPIs showed activity specificity and network aggregation in cell and tissue types, and enriched TF binding in neural cells played key roles in synaptic plasticity and nerve cell development, i.e., EGR1 and SOX family. We also discovered that most neurological disorders exhibit heritability enrichment in neural stem cells and astrocytes, while psychiatric disorders and behavioral-cognitive phenotypes exhibit enrichment in neurons. …”
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Polylactic Acid/Polyaniline Nanofibers Subjected to Pre- and Post-Electrospinning Plasma Treatments for Refined Scaffold-Based Nerve Tissue Engineering Applications by Yongjian Guo, Rouba Ghobeira, Sheida Aliakbarshirazi, Rino Morent, Nathalie De Geyter

“…Although mimicking the extracellular matrix geometry, such scaffolds are highly hydrophobic and usually present an inhomogeneous morphology with massive beads that impede nerve cell-material interactions. Therefore, the present study launches an exclusive combinatorial strategy merging successive pre- and post-electrospinning plasma treatments to cope with these issues. …”
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The Expression of GLAST and GLT1 in a Transient Cerebral Ischemia Mongolian Gerbil Model by Shen Y, Lu H, Xu R, Tian H, Xia X, Zhou FH, Wang L, Dong J, Sun L

“…Immunofluorescence staining showed that S100&beta; and TUNEL double-positive cells increased at 12 h in the core region.Conclusion: The results of GLT-1 and GLAST expression in the cortex indicate that their up-regulation was time-dependent and occurred in the acute post-ischemia period, whereas their down-regulation was region-dependent and it is involved in the pathological progress of nerve cell and glial cell death, and has a series of cascade reactions.Keywords: glutamate transporter, forebrain ischemia, astrocyte, neuronal death, Mongolian gerbil &nbsp;…”
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Effect of dorzolamide-timolol fixed combination prophylaxis on intraocular pressure spikes after intravitreal bevacizumab injection by Sehnaz Ozcaliskan, Faruk Ozturk, Pelin Yilmazbas, Ozlem Beyazyildiz

“…The appropiate approach will monitor IOP after intravitreal injection and evaluate the using prophylactic antiglaucomatous drugs before the injection in patients with ganglion nerve cell damage.…”
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Effects of low dose radiation on behavior rhythm of zebrafish (Danio rerio) by Weichao Zhao, Liang Mao, Chuqi He, Dexin Ding, Nan Hu, Xiaohua Song, Dingxin Long

“…The results revealed that 0.1 and 1 Gy radiation could lead to different degrees of telencephalic nerve cell apoptosis and the formation of vacuolar structures. 0.1 and 1 Gy radiation could reduce the hatching rate of zebrafish embryos at 72 hpf and delay embryo hatching. …”
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