Singular versus combinatory glucose-sensitive signal control of metabolic sensor protein profiles in hypothalamic astrocyte cultures from each sex by Alhamyani Abdulrahman, Napit Prabhat R., Bheemanapally Khaggeswar, Sylvester Paul W., Briski Karen P.

“…Brain metabolic-sensory targets for modulatory glucose-sensitive endocrine and neurochemical signals remain unidentified. A hypothalamic astrocyte primary culture model was here used to investigate whether glucocorticoid receptor (GR) and noradrenergic signals regulate astrocyte glucose (glucose transporter-2 [GLUT2], glucokinase) and/or energy (5′-AMP-activated protein kinase [AMPK]) sensor reactivity to glucoprivation by sex. …”
Get full text

Figural Memory Impairment in Conjunction With Neuropsychiatric Symptoms in IgLON5 Antibody-Associated Autoimmune Encephalitis by Niels Hansen, Sina Hirschel, Winfried Stöcker, Anja Manig, Hannah Sönne Falk, Marielle Ernst, Ruth Vukovich, Inga Zerr, Jens Wiltfang, Jens Wiltfang, Jens Wiltfang, Claudia Bartels

Get full text

Association between ventricular CSF biomarkers and outcome after shunt surgery in idiopathic normal pressure hydrocephalus by Rebecca Grønning, Anna Jeppsson, Per Hellström, Katarina Laurell, Dan Farahmand, Henrik Zetterberg, Kaj Blennow, Carsten Wikkelsø, Mats Tullberg

“…Abstract Introduction The relationship between neurochemical changes and outcome after shunt surgery in idiopathic normal pressure hydrocephalus (iNPH), a treatable dementia and gait disorder, is unclear. …”
Get full text

Enduring, Sexually Dimorphic Impact of In Utero Exposure to Elevated Levels of Glucocorticoids on Midbrain Dopaminergic Populations by Glenda E. Gillies, Kanwar Virdee, Ilse Pienaar, Felwah Al-Zaid, Jeffrey W. Dalley

“…Specifically, using a rodent model of GC exposure in late gestation (approximating human brain development at late second/early third trimester), we demonstrated enduring effects on the shape and volume of the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) (origins of the mesocorticolimbic and nigrostriatal dopaminergic pathways) on the topographical organisation and size of the dopaminergic neuronal populations and astrocytes within these nuclei and on target innervation density and neurochemical markers of dopaminergic transmission (receptors, transporters, basal and amphetamine-stimulated dopamine release at striatal and prefrontal cortical sites) that impact on the adult brain. …”
Get full text

Artificial Intelligence Identified Resilient and Vulnerable Female Rats After Traumatic Stress and Ethanol Exposure: Investigation of Neuropeptide Y Pathway Regulation by Ray R. Denny, Krista L. Connelly, Marco G. Ghilotti, Joseph J. Meissler, Daohai Yu, Toby K. Eisenstein, Toby K. Eisenstein, Ellen M. Unterwald, Ellen M. Unterwald

“…The results of the study show that an artificial intelligence algorithm can identify individual differences in response to traumatic stress which can be used to predict subsequent ethanol drinking, and the NPY pathway is differentially altered following traumatic stress exposure in resilient and vulnerable populations. Understanding neurochemical alterations following traumatic-stress exposure is critical in developing prevention strategies for the vulnerable phenotype and will help further development of novel therapeutic approaches for individuals suffering from PTSD and at risk for alcohol use disorder.…”
Get full text

A Unique Brain Connectome Fingerprint Predates and Predicts Response to Antidepressants by Samaneh Nemati, Teddy J. Akiki, Jeremy Roscoe, Yumeng Ju, Christopher L. Averill, Samar Fouda, Arpan Dutta, Shane McKie, John H. Krystal, J.F. William Deakin, Lynnette A. Averill, Chadi G. Abdallah

“…In an attempt to solve this mystery, rather than studying the acute neurochemical effects of antidepressants, here we propose focusing on the early changes in the brain functional connectome using traditional statistics and machine learning approaches. …”
Get full text

Cortical GABA levels are reduced in young adult binge drinkers: Association with recent alcohol consumption and sex by Ksenija Marinkovic, Austin B. Alderson Myers, Donatello Arienzo, Martin I. Sereno, Graeme F. Mason

“…However, human evidence on the compensatory reduction in GABA signaling is scant. The neurochemical aspect of this mechanistic model was evaluated in the present study with proton magnetic resonance spectroscopy (1H-MRS) which is sensitive to GABA plus macromolecule signal (GABA + ). …”
Get full text

Chronic Exposure to High Fat Diet Affects the Synaptic Transmission That Regulates the Dopamine Release in the Nucleus Accumbens of Adolescent Male Rats by Wladimir Plaza-Briceño, Victoria B. Velásquez, Francisco Silva-Olivares, Karina Ceballo, Ricardo Céspedes, Gonzalo Jorquera, Gonzalo Cruz, Jonathan Martínez-Pinto, Christian Bonansco, Ramón Sotomayor-Zárate

“…Furthermore, NAcc gene expression of inflammasome components is increased by chronic exposure to HFD. At the neurochemical level, DOPAC content and tonic dopamine (DA) release are reduced in NAcc, while phasic DA release is increased in HFD-fed rats. …”
Get full text

A Novel Approach for Investigating Parkinson’s Disease Personality and Its Association With Clinical and Psychological Aspects by Laura Carelli, Federica Solca, Silvia Torre, Jacopo Pasquini, Claudia Morelli, Rita Pezzati, Rita Pezzati, Francesca Mancini, Andrea Ciammola, Vincenzo Silani, Vincenzo Silani, Barbara Poletti

“…ObjectiveA complex relationship between neuropsychiatric symptoms, personality traits and neurochemical changes in patients with Parkinson’s disease (PD) has been highlighted in the past several decades. …”
Get full text

Pharmacological Modulation of Long-Term Potentiation-Like Activity in the Dorsolateral Prefrontal Cortex by Bahar Salavati, Bahar Salavati, Bahar Salavati, Zafiris J. Daskalakis, Zafiris J. Daskalakis, Reza Zomorrodi, Reza Zomorrodi, Reza Zomorrodi, Daniel M. Blumberger, Daniel M. Blumberger, Daniel M. Blumberger, Robert Chen, Bruce G. Pollock, Bruce G. Pollock, Bruce G. Pollock, Tarek K. Rajji, Tarek K. Rajji, Tarek K. Rajji

“…In contrast, baclofen did not significantly suppress PAS-induced LTP compared to placebo.Conclusions: This study provides a novel approach to study DLPFC neuroplasticity and its modulation in patients with brain disorders that are associated with abnormalities in these neurochemical systems. This study was based on a single dose administration of each drug. …”
Get full text

Morphological and functional alterations in the substantia nigra pars compacta of the Mecp2-null mouse by Nicolas Panayotis, Michel Pratte, Ana Borges-Correia, Adeline Ghata, Laurent Villard, Jean-Christophe Roux

“…We found that the amount of activated-Th (pSer40-Th) is slightly reduced at 5 weeks of age in the Mecp2-deficient mouse, but that this amount is affected more importantly by 9 weeks of age. Neurochemical measurements revealed a significant reduction of dopamine content at 5 and 9 weeks of age in the CPu whereas SNpc contents were preserved. …”
Get full text

Mitoapocynin Attenuates Organic Dust Exposure-Induced Neuroinflammation and Sensory-Motor Deficits in a Mouse Model by Nyzil Massey, Denusha Shrestha, Sanjana Mahadev Bhat, Piyush Padhi, Chong Wang, Chong Wang, Locke A. Karriker, Jodi D. Smith, Anumantha G. Kanthasamy, Chandrashekhar Charavaryamath

“…MA treatment also decreased the expression of HMGB1, 3-NT, IBA1, GFAP, and p-Tau, and significantly reversed exposure induced sensory-motor deficits. Neurochemical analysis provided an early indication of depressive behavior. …”
Get full text

Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model by Ting Long, Wei He, Qi Pan, Shanshan Zhang, Dunke Zhang, Guangcheng Qin, Lixue Chen, Jiying Zhou

“…We investigated the effects of a P2X4R inhibitor (5-BDBD) and an agonist (IVM) on NTG-induced hyperalgesia and neurochemical changes as well as on the expression of p-p38-MAPK and BDNF. …”
Get full text

The stress susceptibility factor FKBP51 controls S-ketamine-evoked release of mBDNF in the prefrontal cortex of mice by Elmira Anderzhanova, Kathrin Hafner, Andreas J. Genewsky, Azza Soliman, Max L. Pöhlmann, Mathias V. Schmidt, Robert Blum, Carsten T. Wotjak, Nils C. Gassen

“…By combining optogenetic, neurochemical (KCl-evoked depolarization), and transgenic (conditional BDNF knockout mice) means, we have shown that the increase in extracellular mBDNF in vivo is determined by neuronal activity. …”
Get full text

Erlangen Score as a tool to predict progression from mild cognitive impairment to dementia in Alzheimer’s disease by Inês Baldeiras, Isabel Santana, Maria João Leitão, Daniela Vieira, Diana Duro, Barbara Mroczko, Johannes Kornhuber, Piotr Lewczuk

“…Abstract Background The previously described and validated Erlangen Score (ES) algorithm enables interpretation of the cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease (AD), ordering them on an ordinal scale: from neurochemically normal (ES = 0) through improbable AD (ES = 1), possible AD (ES = 2 or 3), to probable AD (ES = 4). …”
Get full text

Micro-LED Array-Based Photo-Stimulation Devices for Optogenetics in Rat and Macaque Monkey Brains by Yasumi Ohta, Mark Christian Guinto, Takashi Tokuda, Mamiko Kawahara, Makito Haruta, Hironari Takehara, Hiroyuki Tashiro, Kiyotaka Sasagawa, Hirotaka Onoe, Reona Yamaguchi, Yoshinori Koshimizu, Kaoru Isa, Tadashi Isa, Kenta Kobayashi, Yasemin M. Akay, Metin Akay, Jun Ohta

“…Planar and linear micro-LED array devices were designed and fabricated to photo-stimulate the prefrontal cortex (PFC) and ventral tegmental area (VTA) of the brain and induce a neurochemical response. Device operation, optical intensity, and safety were first characterized using rats. …”
Get full text

Central NPFF signalling is critical in the regulation of glucose homeostasis by Lei Zhang, Julia Koller, Gopana Gopalasingam, Yue Qi, Herbert Herzog

“…Using RNAScope double ISH, we investigated the neurochemical identity of NPFF and NPFFR2 neurons in the caudal brainstem, and the expression of receptors for peripheral factors in NPFF neurons. …”
Get full text

Serum levels of glial fibrillary acidic protein in patients with amyotrophic lateral sclerosis by Federico Verde, Ilaria Milone, Alessio Maranzano, Eleonora Colombo, Silvia Torre, Federica Solca, Alberto Doretti, Francesco Gentile, Arianna Manini, Ruggero Bonetti, Silvia Peverelli, Stefano Messina, Luca Maderna, Claudia Morelli, Barbara Poletti, Antonia Ratti, Vincenzo Silani, Nicola Ticozzi

“…Interpretation Our work provides neurochemical evidence of astrocyte involvement in ALS pathophysiology and particularly in the development of extra‐motor manifestations (namely, cognitive – memory – impairment) and respiratory dysfunction. …”
Get full text

Antigliadin Antibodies (AGA IgG) Are Related to Neurochemistry in Schizophrenia by Laura M. Rowland, Haley K. Demyanovich, S. Andrea Wijtenburg, William W. Eaton, Katrina Rodriguez, Frank Gaston, Daniela Cihakova, Monica V. Talor, Fang Liu, Robert R. McMahon, L. Elliot Hong, Deanna L. Kelly

“…Proton magnetic resonance spectroscopy (MRS) is a non-invasive technique that allows the quantification of certain neurochemicals in vivo that may proxy inflammation in the brain such as myoinositol and choline-containing compounds (glycerophosphorylcholine and phosphorylcholine). …”
Get full text

Anandamide Effects in a Streptozotocin-Induced Alzheimer’s Disease-Like Sporadic Dementia in Rats by Daniel Moreira-Silva, Daniel C. Carrettiero, Adriele S. A. Oliveira, Samanta Rodrigues, Joyce dos Santos-Lopes, Paula M. Canas, Rodrigo A. Cunha, Rodrigo A. Cunha, Maria C. Almeida, Tatiana L. Ferreira

“…Altogether, albeit AEA failed to modify some AD-like neurochemical alterations, it partially prevented STZ-induced cognitive impairments, changes in synaptic markers and ventricle enlargement. …”
Get full text