Intermittent Theta Burst Stimulation Ameliorates Cognitive Deficit and Attenuates Neuroinflammation via PI3K/Akt/mTOR Signaling Pathway in Alzheimer’s-Like Disease Model by Andjela Stekic, Milica Zeljkovic, Marina Zaric Kontic, Katarina Mihajlovic, Marija Adzic, Ivana Stevanovic, Ivana Stevanovic, Milica Ninkovic, Milica Ninkovic, Ivana Grkovic, Tihomir V. Ilic, Nadezda Nedeljkovic, Milorad Dragic

“…We aimed to evaluate the effect of intermittent theta burst stimulation (iTBS), an rTMS paradigm, on behavioral, neurochemical and molecular level in trimethyltin (TMT)-induced Alzheimer’s-like disease model. …”
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A Baboon Brain Atlas for Magnetic Resonance Imaging and Positron Emission Tomography Image Analysis by Artur Agaronyan, Artur Agaronyan, Raeyan Syed, Ryan Kim, Chao-Hsiung Hsu, Scott A. Love, Jacob M. Hooker, Alicia E. Reid, Paul C. Wang, Paul C. Wang, Nobuyuki Ishibashi, Yeona Kang, Tsang-Wei Tu, Tsang-Wei Tu

“…There is a need to create a brain atlas that combines the anatomical and functional/neurochemical data independently available from MRI and PET. …”
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Neurotransmitter alterations in the anterior cingulate cortex in Crohn's disease patients with abdominal pain: A preliminary MR spectroscopy study by Kun Lv, Wenwen Song, Rui Tang, Zhiyong Pan, Yong Zhang, Yi Xu, Bin Lv, Yihong Fan, Maosheng Xu

“…Conclusion: The neural mechanism of CD patients with abdominal pain in pain processing is tightly associated with neurochemical metabolites. An imbalance in Glu and GABA may play a key role in abdominal pain processing for patients with CD. …”
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Neuroprotective Effect of Morin Hydrate against Attention-Deficit/Hyperactivity Disorder (ADHD) Induced by MSG and/or Protein Malnutrition in Rat Pups: Effect on Oxidative/Monoamin... by Hoda A. Salem, Nehal Elsherbiny, Sharifa Alzahrani, Hanan M. Alshareef, Zakaria Y. Abd Elmageed, Sadeem M. Ajwah, Ahmed M. E. Hamdan, Yahia S. Abdou, Omneya O. Galal, Marwa K. A. El Azazy, Karema Abu-Elfotuh

“…Our results showed that treatment of rats with a combination of MSG + PM-fed exhibited inferior outcomes as evidenced by deteriorated effects on behavioral, neurochemical, and histopathological analyses when compared to rats who had received MSG or PM alone. …”
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Induction of mandibular tremor using electrolytic lesion of the ventrolateral striatum or using subchronic haloperidol therapy in male rats: An electromyographic comparison by G. Herrera-Meza, J. Manzo, M.E. Hernández, M. Miquel, L.I. García

“…Introduction: Tremulous jaw movement (TJMs) in rats can be induced pharmacologically by striatal dopaminergic manipulation or electrolytic lesion of ventrolateral striatum (VLS). This tremor has neurochemical, anatomical and electromyographic (EMG) characteristics similar to those of tremor in Parkinson patients. …”
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Neurobiological Bases of Alcohol Addiction by Ana Matošić, Srđan Marušić, Branka Vidrih, Ana Kovak-Mufić, Lipa Čičin-Šain

“…The characteristic of alcoholism type 1 is avoiding damage (Harm Avoidance, HA) decreased dopamine transmission and increased serotonin transmission, while the significant characteristic of alcoholism type 2 is seeking for excitement (Novelty Seeking, NS), unchanged dopamine transmission and decreased serotonin transmission. These neurochemical differences among alcoholism subtypes represent the basis for a different therapy approach. …”
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Dietary tryptophan depletion in humans using a simplified two amino acid formula – a pilot study by Maike Linden, Katrin Helmbold, Janina Kempf, Shabnam Sippas, Christian Filss, Karl-Josef Langen, Albrecht Eisert, Florian Daniel Zepf

“…Future studies focusing on the effects of the ATDPHE/LEU protocol and its respective control condition on CSF 5-HIAA concentrations, as well as neurochemical studies in rodents, are needed to further validate this newly developed AA mixture before definite conclusions about its usability in ATD-related research in humans, its specificity, and additional effects can be made.…”
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Characterization of Neurons Expressing the Novel Analgesic Drug Target Somatostatin Receptor 4 in Mouse and Human Brains by Angéla Kecskés, Krisztina Pohóczky, Miklós Kecskés, Zoltán V. Varga, Viktória Kormos, Éva Szőke, Nóra Henn-Mike, Máté Fehér, József Kun, Attila Gyenesei, Éva Renner, Miklós Palkovits, Péter Ferdinandy, István M. Ábrahám, Balázs Gaszner, Zsuzsanna Helyes

“…Therefore, our goals were (i) to elucidate the expression pattern of <i>Sstr4</i>/<i>SSTR4</i> mRNA, (ii) to characterize neurochemically, and (iii) electrophysiologically the <i>Sstr4</i>/<i>SSTR4</i>-expressing neuronal populations in the mouse and human brains. …”
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Pharmacological and Behavioral Effects of the Synthetic Cannabinoid AKB48 in Rats by Sabrine Bilel, Micaela Tirri, Raffaella Arfè, Raffaella Arfè, Serena Stopponi, Laura Soverchia, Roberto Ciccocioppo, Paolo Frisoni, Sabina Strano-Rossi, Cristina Miliano, Fabio De-Giorgio, Giovanni Serpelloni, Anna Fantinati, Maria Antonietta De Luca, Margherita Neri, Matteo Marti, Matteo Marti

“…All behavioral and neurochemical effects were fully prevented by the selective CB1 receptor antagonist/inverse agonist AM251. …”
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Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease by Cátia R. Lopes, Joana S. Silva, Joana Santos, Matilde S. Rodrigues, Daniela Madeira, Andreia Oliveira, Ana Moreira-de-Sá, Vanessa S. Lourenço, Francisco Q. Gonçalves, Henrique B. Silva, Ana Patrícia Simões, Anabela P. Rolo, Paula M. Canas, Ângelo R. Tomé, Carlos M. Palmeira, João Pedro Lopes, Rodrigo A. Cunha, Paula Agostinho, Samira G. Ferreira

“…Here, we performed a behavioral, neurophysiological and neurochemical characterization of 9-month-old female APPswe/PS1dE9 (APP/PS1) mice as a model of early AD. …”
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Interaction of 5-HTTLPR and SLE disease status on resting-state brain function by Lihua Ma, Yifan Yang, Shu Li, Bibhuti Upreti, Shuang Liu, Xiangyu Wang, Ru Bai, Yuqi Cheng, Jian Xu

“…The 5-hydroxynyptamine(5-HT) system has the ability to interact with the majority of the neurochemical systems in the central nervous system (CNS), influencing brain function. …”
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Effect of 17β estradiol on hippocampus region of aging female rat brain: Ultrastructural study by Rashmi Jha, Ranjeet Kumar, Priyanka Mishra, Abbas Ali Mahdi, Shivani Pandey, Najma Zaheer Baquer, Sudha Mahajan Cowsik

“…</span><span style="font-family: 'Times New Roman','serif'; font-size: 10pt; mso-bidi-font-size: 9.0pt; mso-fareast-font-family: 'MS Mincho'; mso-ansi-language: EN-US; mso-fareast-language: JA; mso-bidi-language: AR-SA;" lang="EN-US"> This hormone modulates brain development and aging and affects neurochemical systems which are affected in age-related cognitive decline, AD and other neuropsychiatric disorders. …”
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Inducción del temblor mandibular por lesión electrolítica del estriado ventrolateral y por el tratamiento subcrónico con haloperidol en rata macho: un contraste electromiográfico... by G. Herrera-Meza, J. Manzo, M.E. Hernández, M. Miquel, L.I. García

“…Abstract: Introduction: Tremulous jaw movement (TJMs) in rats can be induced pharmacologically by striatal dopaminergic manipulation or electrolytic lesion of ventrolateral striatum (VLS). This tremor has neurochemical, anatomical and electromyographic (EMG) characteristics similar to those of tremor in Parkinson patients. …”
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Molecular imaging of the association between serotonin degeneration and beta-amyloid deposition in mild cognitive impairment by Gwenn S. Smith, Hillary Protas, Hiroto Kuwabara, Alena Savonenko, Najlla Nassery, Neda F. Gould, Michael Kraut, Dimitri Avramopoulos, Daniel Holt, Robert F. Dannals, Ayon Nandi, Yi Su, Eric M. Reiman, Kewei Chen

“…The results support the application of mmPLS to understand the neurochemical changes associated with Aβ deposition in the course of preclinical AD.…”
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Simultaneous quantification of GABA, Glx and GSH in the neonatal human brain using magnetic resonance spectroscopy by Yanez Lopez Maria, Anthony N. Price, Nicolaas A.J. Puts, Emer J. Hughes, Richard A.E. Edden, Grainne M. McAlonan, Tomoki Arichi, Enrico De Vita

“…With this approach we report for the first time simultaneous GABA+, Glx (glutamate + glutamine) and GSH concentrations in the neonatal brain (n = 18) in two distinct regions (thalamus and anterior cingulate cortex (ACC)) using edited MRS at 3T.The improved sensitivity provided by our method allows specific regional neurochemical differences to be identified including: significantly lower Glx and GSH ratios to total creatine in the thalamus compared to the ACC (p < 0.001 for both), and significantly higher GSH levels in the ACC following tissue-correction (p < 0.01). …”
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Cerebrospinal Fluid-Directed rAAV9-rsATP7A Plus Subcutaneous Copper Histidinate Advance Survival and Outcomes in a Menkes Disease Mouse Model by Marie Reine Haddad, Eun-Young Choi, Patricia M. Zerfas, Ling Yi, Diego Martinelli, Patricia Sullivan, David S. Goldstein, Jose A. Centeno, Lauren R. Brinster, Martina Ralle, Stephen G. Kaler

“…The high-dose rAAV9-rsATP7A plus sc copper histidinate-treated mutant mice showed increased brain copper levels, normalized brain neurochemical levels, improvement of brain mitochondrial abnormalities, and normal growth and neurobehavioral outcomes. …”
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Gender Differences in Neurodegeneration, Neuroinflammation and Na+-Ca2+ Exchangers in the Female A53T Transgenic Mouse Model of Parkinson’s Disease by Giulia Costa, Maria Jose Sisalli, Nicola Simola, Nicola Simola, Salvatore Della Notte, Maria Antonietta Casu, Marcello Serra, Annalisa Pinna, Antonio Feliciello, Lucio Annunziato, Antonella Scorziello, Micaela Morelli, Micaela Morelli, Micaela Morelli

“…Since gender is thought to play a role in the etiology of Parkinson’s disease (PD), we characterized neurochemical and behavioral alterations in 12-month-old female A53T transgenic mice. …”
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The association between language-based task-functional magnetic resonance imaging hemodynamics and baseline GABA+ and glutamate–glutamine measured in pre-supplementary motor area:... by Lisa C. Krishnamurthy, Lisa C. Krishnamurthy, Lisa C. Krishnamurthy, Isabella Paredes Spir, Natalie O. Rocha, Natalie O. Rocha, Brian J. Soher, Brian J. Soher, Edward J. Auerbach, Edward J. Auerbach, Bruce A. Crosson, Bruce A. Crosson, Bruce A. Crosson, Venkatagiri Krishnamurthy, Venkatagiri Krishnamurthy, Venkatagiri Krishnamurthy

“…More specifically, using standard BOLD we will first attempt to validate whether previously reported findings for BOLD amplitude and resting neurochemical relationships hold in an aging model. Secondly, we will investigate how our recently established neurosensitized task-BOLD energetics relate to resting GABA+ and Glx, especially accounting for titration of task difficulty. …”
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Low Prefrontal GABA Levels Are Associated With Poor Cognitive Functions in Professional Boxers by Geon Ha Kim, Geon Ha Kim, Ilhyang Kang, Ilhyang Kang, Hyeonseok Jeong, Shinwon Park, Shinwon Park, Haejin Hong, Haejin Hong, Jinsol Kim, Jinsol Kim, Jung Yoon Kim, Jung Yoon Kim, Richard A. E. Edden, Richard A. E. Edden, In Kyoon Lyoo, In Kyoon Lyoo, In Kyoon Lyoo, Sujung Yoon, Sujung Yoon

“…The current findings may suggest that alterations in GABA levels in the PFC may be a potential neurochemical correlate underlying memory dysfunction related to rmTBI.…”
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Gene-Related Cerebellar Neurodegeneration in SCA3/MJD: A Case-Controlled Imaging-Genetic Study by Huirong Peng, Xiaochun Liang, Zhe Long, Zhao Chen, Yuting Shi, Kun Xia, Li Meng, Beisha Tang, Beisha Tang, Beisha Tang, Beisha Tang, Beisha Tang, Beisha Tang, Beisha Tang, Rong Qiu, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang

“…NAA/Cr and NAA/Cho ratio in the middle cerebellar peduncles, dentate nucleus, cerebellar vermis, and thalamus in the SCA3/MJD patients were significantly reduced when compared to that in the normal controls, suggesting neurochemical alterations in cerebellum in the SCA3/MJD patients. …”
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