Mechanisms of serotonergic control in fear-related neural circuits and behaviour by Sengupta, A

“…</p> <p>Finally, a combination of retrograde tracing and immunohistochemistry was applied to analyse the neurochemical identity of DRN neurons that project to the BA. …”

Conditional deletion of neurexins dysregulates neurotransmission from dopamine neurons by Charles Ducrot, Gregory de Carvalho, Benoît Delignat-Lavaud, Constantin VL Delmas, Priyabrata Halder, Nicolas Giguère, Consiglia Pacelli, Sriparna Mukherjee, Marie-Josée Bourque, Martin Parent, Lulu Y Chen, Louis-Eric Trudeau

“…The molecular mechanisms regulating the connectivity of DA neurons and their neurochemical identity are unknown. An emerging literature suggests that neuroligins, trans-synaptic cell adhesion molecules, regulate both DA neuron connectivity and neurotransmission. …”
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Connectivity-Guided Theta Burst Transcranial Magnetic Stimulation Versus Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Moderate to Severe Depression: Magneti... by Stefan Pszczolkowski, William J Cottam, Paul M Briley, Sarina J Iwabuchi, Catherine Kaylor-Hughes, Abdulrhman Shalabi, Ben Babourina-Brooks, Adam Berrington, Shaun Barber, Ana Suazo Di Paola, Andrew Blamire, R Hamish McAllister-Williams, Jehill Parikh, Mohamed Abdelghani, Lars Matthäus, Ralf Hauffe, Peter Liddle, Dorothee P Auer, Richard Morriss

“…ObjectiveThe aims of the imaging arm of the BRIGhTMIND study are to identify functional and neurochemical brain signatures indexing the treatment mechanisms of rTMS and connectivity-guided intermittent theta burst TMS and to identify imaging-based markers predicting response to treatment. …”
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The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio... by Renee A. Rotolo, Vladimir Dragacevic, Predrag Kalaba, Ernst Urban, Martin Zehl, Alexander Roller, Judith Wackerlig, Thierry Langer, Marco Pistis, Maria Antonietta De Luca, Francesca Caria, Rebecca Schwartz, Rose E. Presby, Jen-Hau Yang, Shanna Samels, Merce Correa, Merce Correa, Gert Lubec, John D. Salamone

“…In summary, (S)-CE-123 has the behavioral and neurochemical profile of a compound that can block DA transport, reverse the effort-related effects of tetrabenazine, and increase selection of high-effort progressive ratio responding. …”
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Progression of dopaminergic depletion in a model of MPTP-induced Parkinsonism in non-human primates. An 18F-DOPA and 11C-DTBZ PET study by Javier Blesa, Carlos Juri, María Collantes, Iván Peñuelas, Elena Prieto, Elena Iglesias, Josep Martí-Climent, Javier Arbizu, José L. Zubieta, Mari Cruz Rodríguez-Oroz, David García-García, José A. Richter, Carmen Cavada, José A. Obeso

“…Dopaminergic depletion in the nigrostriatal system is the neurochemical hallmark of Parkinson's disease (PD). Although numerous efforts have been made to determine the evolution of dopaminergic depletion in PD, “in vivo” data concerning the stages of this process are still scarce. …”
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Dysfunctional hippocampal-prefrontal network underlies a multidimensional neuropsychiatric phenotype following early-life seizure by Rafael Naime Ruggiero, Danilo Benette Marques, Matheus Teixeira Rossignoli, Jana Batista De Ross, Tamiris Prizon, Ikaro Jesus Silva Beraldo, Lezio Soares Bueno-Junior, Ludmyla Kandratavicius, Jose Eduardo Peixoto-Santos, Cleiton Lopes-Aguiar, Joao Pereira Leite

“…Here, we performed a multilevel study to investigate behavioral, electrophysiological, histopathological, and neurochemical long-term consequences of early-life Status epilepticus in male rats. …”
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Antipsychotic effect of diosgenin in ketamine-induced murine model of schizophrenia: Involvement of oxidative stress and cholinergic transmission by Benneth Ben-Azu, Olusegun G. Adebayo, Aliance Romain Fokoua, Benjamin Oritsemuelebi, Emmanuel O. Chidebe, Chukwuebuka B. Nwogueze, Lenatababari Kumanwee, God'swill E. Uyere, Micheal T. Emuakpeje

“…A decrease in the levels of antioxidant arsenals exacerbate generation of reactive oxygen/nitrogen species, leading to neurochemical dysfunction, with significant impact on the pathogenesis of psychotic disorders such as schizophrenia. …”
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Neuroimmunological interactions in stroke by M.A. Sotomayor-Sobrino, A. Ochoa-Aguilar, L.A. Méndez-Cuesta, C. Gómez-Acevedo

“…Development: According to clinical evidence, a number of neurochemical changes take place after stroke, including energy depletion, increased free radical synthesis, calcium accumulation, neurotransmitter imbalance, excitotoxicity, and, at a later stage, immune system activation leading to inflammation.Immune response has been shown to be a major factor in disease progression. …”
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Mapping the Architecture of Ferret Brains at Single-Cell Resolution by Ben Long, Ben Long, Tao Jiang, Jianmin Zhang, Jianmin Zhang, Siqi Chen, Siqi Chen, Xueyan Jia, Xiaofeng Xu, Xiaofeng Xu, Qingming Luo, Qingming Luo, Hui Gong, Hui Gong, Hui Gong, Anan Li, Anan Li, Anan Li, Xiangning Li, Xiangning Li, Xiangning Li

“…Using the cytoarchitectonic datasets for adult ferret brain, we identified giant pyramidal neurons in ferret brains and provide the first report of their morphological diversity, neurochemical phenotype, and distribution patterns in the whole brain in three dimensions. …”
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Influence of Repetitive Transcranial Magnetic Stimulation on Human Neurochemistry and Functional Connectivity: A Pilot MRI/MRS Study at 7 T by Heidi Gröhn, Heidi Gröhn, Bernadette T. Gillick, Ivan Tkáč, Petr Bednařík, Petr Bednařík, Daniele Mascali, Dinesh K. Deelchand, Shalom Michaeli, Gregg D. Meekins, Michael J. Leffler-McCabe, Colum D. MacKinnon, Lynn E. Eberly, Silvia Mangia

“…Concentrations of 17 neurochemicals were quantified in left and right motor cortices. …”
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Neuropsychiatric manifestations of COVID-19, potential neurotropic mechanisms, and therapeutic interventions by Ying Han, Kai Yuan, Zhe Wang, Wei-Jian Liu, Zheng-An Lu, Lin Liu, Le Shi, Wei Yan, Jun-Liang Yuan, Jia-Li Li, Jie Shi, Zhong-Chun Liu, Gao-Hua Wang, Thomas Kosten, Yan-Ping Bao, Lin Lu

“…Time-series monitoring of clinical–neurochemical–radiological progress of neuropsychiatric and neuroimmune complications need implementation in individuals exposed to SARS-CoV-2. …”
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Coffee consumption decreases the connectivity of the posterior Default Mode Network (DMN) at rest by Maria Picó-Pérez, Maria Picó-Pérez, Maria Picó-Pérez, Maria Picó-Pérez, Ricardo Magalhães, Ricardo Magalhães, Madalena Esteves, Madalena Esteves, Rita Vieira, Rita Vieira, Rita Vieira, Teresa C. Castanho, Teresa C. Castanho, Teresa C. Castanho, Teresa C. Castanho, Liliana Amorim, Liliana Amorim, Liliana Amorim, Liliana Amorim, Mafalda Sousa, Mafalda Sousa, Mafalda Sousa, Ana Coelho, Ana Coelho, Pedro S. Moreira, Pedro S. Moreira, Pedro S. Moreira, Rodrigo A. Cunha, Nuno Sousa, Nuno Sousa, Nuno Sousa, Nuno Sousa

“…Using functional connectivity approaches to study resting-state fMRI data in a group of habitual coffee drinkers, we herein show that coffee consumption decreased connectivity of the posterior default mode network (DMN) and between the somatosensory/motor networks and the prefrontal cortex, while the connectivity in nodes of the higher visual and the right executive control network (RECN) is increased after drinking coffee; data also show that caffeine intake only replicated the impact of coffee on the posterior DMN, thus disentangling the neurochemical effects of caffeine from the experience of having a coffee.…”
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The effects of prolonged stress exposure on the brain of rats and insights to understand the impact of work-related stress on caregivers by Jean Marc Pujo, Dewi Yunia Fitriani, Dewi Yunia Fitriani, Dewi Yunia Fitriani, Hajer Ben Saad, Marwa Ghariani, Marwa Ghariani, Amel Dghim, Manel Mellouli, Antoine Burin, Remi Mutricy, Stephanie Houcke, Ariane Roujansky, Muchtaruddin Mansyur, Muchtaruddin Mansyur, Muchtaruddin Mansyur, Flaubert Nkontcho, Bertrand de Toffol, Ibtissem Ben Amara, Hatem Kallel, Hatem Kallel

“…Finally, we noticed behavioral changes and a depression-like syndrome in all stressed rats.ConclusionStressful conditions such as the working environment of caregivers can trigger several pathophysiological processes leading to oxidative, neurochemical, and hypothalamic–pituitary–adrenal disorders. …”
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Time course of the effect of status epilepticus induced in the developing rat on γ-amino butyric acid and glutamate cerebellar concentration by D. Hernández-Martínez, L. Rocha, J. Martínez-Quiroz, C. Morgado-Valle, J. Manzo, M.L. López-Meraz

“…Conclusion: The developing rat cerebellum is resistant to both short- and long-term neurochemical changes induced by SE. Resumen: Introducción: El status epilepticus (SE) es un tipo de actividad epiléptica que causa atrofia cerebelar y pérdida de células de Purkinje en humanos y en animales de experimentación. …”
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Combined In Silico, Ex Vivo, and In Vivo Assessment of L-17, a Thiadiazine Derivative with Putative Neuro- and Cardioprotective and Antidepressant Effects by Alexey Sarapultsev, Pavel Vassiliev, Daniil Grinchii, Alexander Kiss, Mojmir Mach, Jana Osacka, Alexandra Balloova, Ruslan Paliokha, Andrey Kochetkov, Larisa Sidorova, Petr Sarapultsev, Oleg Chupakhin, Maxim Rantsev, Alexander Spasov, Eliyahu Dremencov

“…Combined in silico predictions with ex vivo neurochemical and in vivo electrophysiological assessments might be a useful strategy for early assessment of the efficacy and neural mechanism of action of novel CNS drugs.…”
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Imaging Neurochemistry and Brain Structure Tracks Clinical Decline and Mechanisms of ALS in Patients by Ovidiu C. Andronesi, Katharine Nicholson, Kourosh Jafari-Khouzani, Wolfgang Bogner, Jing Wang, Jing Wang, James Chan, Eric A. Macklin, Mark Levine-Weinberg, Christopher Breen, Michael A. Schwarzschild, Merit Cudkowicz, Bruce R. Rosen, Sabrina Paganoni, Sabrina Paganoni, Eva-Maria Ratai

“…We hypothesized that levels of GSH measured by MR spectroscopic imaging (MRSI) in the motor cortex and corticospinal tract are linked to clinical trajectory of ALS patients.Objectives: Investigate the value of GSH imaging to probe clinical decline of ALS patients in combination with other neurochemical and structural parameters.Methods: Twenty-four ALS patients were imaged at 3 T with an advanced MR protocol. …”
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Evaluación temporal del efecto del status epilepticus inducido en la rata en desarrollo en la concentración cerebelar de ácido γ-aminobutírico y glutamato by D. Hernández-Martínez, L. Rocha, J. Martínez-Quiroz, C. Morgado-Valle, J. Manzo, M.L. López-Meraz

“…Conclusion: The developing rat cerebellum is resistant to both short- and long-term neurochemical changes induced by SE. Palabras clave: Status epilepticus, Cerebelo, Ácido γ-aminobutírico, Glutamato, Keywords: Status epilepticus, Cerebellum, γ-amino butyric acid, Glutamate…”
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Effects of dietary tryptophan and phenylalanine–tyrosine depletion on phasic alertness in healthy adults – A pilot study by Patricia Hildebrand, Werner Königschulte, Tilman Jakob Gaber, Sarah Bubenzer-Busch, Katrin Helmbold, Caroline Sarah Biskup, Karl-Josef Langen, Gereon Rudolf Fink, Florian Daniel Zepf

“…The potential underlying neurochemical processes related to phasic alertness should be the subject of further investigations.…”
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Lactobacillus rhamnosus GG and butyrate supplementation in rats with bone cancer reduces mechanical allodynia and increases expression of μ-opioid receptor in the spinal cord by Wenxi Yuan, Wenxi Yuan, Jie Xiao, Jie Xiao, Huabao Liao, Huabao Liao, Zhiyuan Xie, Zhiyuan Xie, Yiran Zhao, Yiran Zhao, Cheng Li, Cheng Li, Keying Zhou, Xue-Jun Song, Xue-Jun Song

“…Mechanical allodynia, bone destruction, fecal microbiota, and neurochemical changes in the primary dorsal root ganglion (DRG) and the spinal dorsal horn (DH) were assessed.ResultsLGG supplementation (109 CFU/rat/day) delayed the production of BCP for 3–4 days and significantly alleviated mechanical allodynia within the first 2 weeks after TCI. …”
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Chronic Methylmercury Intoxication Induces Systemic Inflammation, Behavioral, and Hippocampal Amino Acid Changes in C57BL6J Adult Mice by Tyciane S. Nascimento, Daniel V. Pinto, Ronaldo P. Dias, Ramon S. Raposo, Paulo Iury G. Nunes, Cássia R. Roque, Flávia A. Santos, Geanne M. Andrade, José Lucas Viana, Anne H. Fostier, Alessandra Sussulini, Jacqueline I. Alvarez-Leite, Carlos Fontes-Ribeiro, João O. Malva, Reinaldo B. Oriá

“…Although much is known about MeHg neurotoxic effects, less is known about how chronic MeHg affects hippocampal amino acids and other neurochemical markers in adult mice. In this study, we evaluated the MeHg effects on systemic lipids and inflammation, hippocampal oxidative stress, amino acid levels, neuroinflammation, and behavior in adult male mice. …”
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