Blue again: Perturbational effects of antidepressants suggest monoaminergic homeostasis in major depression by Paul eAndrews, Paul eAndrews, Susan eKornstein, Lisa eHalberstadt, Charles eGardner, Michael C Neale

“…According to disorder advocates, neurochemicals like the monoamine neurotransmitters (serotonin, norepinephrine, and dopamine) are dysregulated in major depression. …”
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Small Interfering RNA Specific for N-Methyl-D-Aspartate Receptor 2B Offers Neuroprotection to Dopamine Neurons through Activation of MAP Kinase by Olivia T.W. Ng, L.W. Chen, Y.S. Chan, Ken K.L. Yung

“…Our previous results showed that reduction in expression of N-methyl-D-aspartate receptor 1 (NR1), the key subunit of N-methyl-D-aspartate receptors, by antisense oligos amelio-rated the motor symptoms in the 6-hydroxydopamine (6-OHDA)-lesioned rat, an animal model of Parkinson's disease (PD) [Lai et al.: Neurochem Int 2004;45:11-22]. To further the investigation on the efficacy of gene silencing, small interference RNA (siRNA) specific for the NR2B subunit was designed and administered in the striatum of 6-OHDA-lesioned rats. …”
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Effect of exercise on sleep quality in Parkinson’s disease: a mini review by M. Abdullah Shafiq, Jyotpal Singh, Zain A. Khan, J. Patrick Neary, Holly A. Bardutz

“…Both high and low-intensity aerobic and resistance exercises, along with exercises related to balance and coordination, have been shown to improve some aspects of sleep. Neurochemically, sleeping leads to an increase in toxin clearance, including α-synuclein. …”
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Chronic Methamphetamine Abuse and Brain Deficits Revealed by Neuroimaging by YANG Hongjie;HU Shu;GAO Zhou;JIA Shaowei

“…These modern neuroimaging techniques allow us to observe change in regional cerebral blood flow and glucose metabolism caused by the abuse and dependence of MA under physiological conditions, to investigate the involvement brain regions and nucleus and to detect some certain neurochemicals change by proton MRS. The combination of neuroimaging techniques allow us monitor the brain anatomical structure change and molecular level change, and many of these neural abnormalities were found to be linked with certain addiction related phenotypes, such as cognitive inflexibility, maladaptive decision-making and poor self-control. …”
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Stress and eating: A dual role for bombesin-like peptides by Zul eMerali, Samantha eGraitson, Jennifer Christine Mackay, Pamela eKent

“…The complex interplay between stress-induced anorexia and stress-induced obesity is discussed in terms of the overlapping circuitry and neurochemicals that mediate feeding, stress and reward pathways. …”
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Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model. by Janezic, S, Threlfell, S, Dodson, P, Dowie, M, Taylor, T, Potgieter, D, Parkkinen, L, Senior, S, Anwar, S, Ryan, B, Deltheil, T, Kosillo, P, Cioroch, M, Wagner, K, Ansorge, O, Bannerman, D, Bolam, J, Magill, P, Cragg, S, Wade-Martins, R

“…Aged SNCA-OVX mice exhibit reduced firing of SNc dopamine neurons in vivo measured by juxtacellular recording of neurochemically identified neurons. These progressive changes in vulnerable SNc neurons were observed independently of overt protein aggregation, suggesting neurophysiological changes precede, and are not driven by, aggregate formation. …”

Spinal Excitatory Dynorphinergic Interneurons Contribute to Burn Injury-Induced Nociception Mediated by Phosphorylated Histone 3 at Serine 10 in Rodents by Angelika Varga, Zoltán Mészár, Miklós Sivadó, Tímea Bácskai, Bence Végh, Éva Kókai, István Nagy, Péter Szücs

“…Thus, we showed that neurochemically heterogeneous SDH neurons exhibit the upregulation of p-S10H3 shortly after noxious heat-induced burn injury and consequential tissue damage, and that a dedicated subset of excitatory dynorphinergic neurons is likely a key player in the development of central sensitization via the p-S10H3 mediated pathway.…”
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In Vitro Biofouling Performance of Boron-Doped Diamond Microelectrodes for Serotonin Detection Using Fast-Scan Cyclic Voltammetry by Bhavna Gupta, Mason L. Perillo, James R. Siegenthaler, Isabelle E. Christensen, Matthew P. Welch, Robert Rechenberg, G M Hasan Ul Banna, Davit Galstyan, Michael F. Becker, Wen Li, Erin K. Purcell

“…Fast-scan cyclic voltammetry (FSCV) has enabled the detection of neurochemicals, including serotonin, on a sub-second timescale via the well-established carbon fiber microelectrode (CFME). …”
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Local and global consequences of reward-evoked striatal dopamine release by Li, Nan, Jasanoff, Alan Pradip

“…Striatal dopamine release also potentiates a network of distal responses, which we delineate using neurochemically dependent functional connectivity analyses. …”
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Skin Conductance as a Viable Alternative for Closing the Deep Brain Stimulation Loop in Neuropsychiatric Disorders by Dilranjan S. Wickramasuriya, Md. Rafiul Amin, Rose T. Faghih

“…Markers from local field potentials, neurochemicals, skin conductance, and hormone concentrations have been proposed as a means of closing the loop in Deep Brain Stimulation (DBS) therapy for treating neuropsychiatric and movement disorders. …”
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Pedunculopontine nucleus stimulation: Where are we now and what needs to be done to move the field forward? by Hokuto eMorita, Chris J Hass, Elena eMoro, Atchar eSudhyadhom, Rajeev eKumar, Michael S. Okun

“…Previous limited studies of PPN deep brain stimulation (DBS) in treating gait symptoms have had mixed clinical outcomes, likely reflect targeting variability and the inherent challenges of targeting a small brainstem structure that is both anatomically and neurochemically heterogeneous. Diffusion tractography shows promise for more accurate targeting and standardization of results. …”
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Mecanismos do ciclo sono-vigília Sleep-wake cycle mechanisms by Flávio Alóe, Alexandre Pinto de Azevedo, Rosa Hasan

“…O modelo da interação recíproca também se aplica aos núcleos colinérgicos (células REM-on) e aminérgicos (células REM-off) do tronco cerebral no controle temporal do sono REM-NREM.<br>Neurochemically distinct systems interact regulating sleep and wakefulness. …”
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Tyrosine hydroxylase phosphorylation in catecholaminergic brain regions: a marker of activation following acute hypotension and glucoprivation. by Hanafi A Damanhuri, Peter G R Burke, Lin K Ong, Larisa Bobrovskaya, Phillip W Dickson, Peter R Dunkley, Ann K Goodchild

“…Furthermore, the neurochemicals that delineate these regions, or are utilized in them when responding to these stressors remain undefined. …”
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Human-specific mutations in VMAT1 confer functional changes and multi-directional evolution in the regulation of monoamine circuits by Daiki X. Sato, Yuu Ishii, Tomoaki Nagai, Kazumasa Ohashi, Masakado Kawata

“…Abstract Background Neurochemicals like serotonin and dopamine play crucial roles in human cognitive and emotional functions. …”
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Serotonin, amygdala and fear: assembling the puzzle by Marco eBocchio, Stephen B McHugh, David M Bannerman, Trevor eSharp, Marco eCapogna

“…We propose that a circuit-based approach taking into account the localization of specific 5-HT receptors on neurochemically-defined neurons in the BLA may be essential to decipher the role of 5-HT in emotional behavior. …”
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Nicotinic α4 Receptor-Mediated Cholinergic Influences on Food Intake and Activity Patterns in Hypothalamic Circuits. by Ana P García, Teemu Aitta-aho, Laura Schaaf, Nicholas Heeley, Lena Heuschmid, Yunjing Bai, Francisco J Barrantes, John Apergis-Schoute

“…These results indicate that various neurochemically distinct hypothalamic populations are under the influence of α4β2 nAChRs and that cholinergic inputs to the lateral hypothalamus can affect satiety signals through activation of local α4β2 nAChR-mediated transmission.…”
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Transcranial stimulation of the human primary motor cortices by Bachtiar, VE

“…This method was used to demonstrate the timecourse of tDCS-induced changes in neurochemicals concurrently from both M1s. Anodal stimulation reduced GABA in both the anode-targeted and non-stimulated M1. …”

Cortical and thalamic innervation of the striatum by Doig, N, Natalie Doig

“…The synaptic innervation from cortex and thalamus was then examined in two individual, electrophysiologically characterised, and neurochemically identified cholinergic interneurons. One neuron received input from both cortex and thalamus, whereas the other neuron received input from the thalamus only. …”

An In-vivo 1H-MRS short-echo time technique at 7T: Quantification of metabolites in chronic multiple sclerosis and neuromyelitis optica brain lesions and normal appearing brain tis... by Tackley, G, Kong, Y, Minne, R, Messina, S, Winkler, A, Cavey, A, Everett, R, DeLuca, GC, Weir, A, Craner, M, Tracey, I, Palace, J, Stagg, CJ, Emir, U

“…Magnetic Resonance Spectroscopy (MRS) allows for the non-invasive quantification of neurochemicals and has the potential to differentiate between the pathologically distinct diseases, multiple sclerosis (MS) and AQP4Ab-positive neuromyelitis optica spectrum disorder (AQP4Ab-NMOSD). …”

Mitochondrial reactive oxygen species in mice lacking superoxide dismutase 2: attenuation via antioxidant treatment. by Morten, K, Ackrell, B, Melov, S

“…R., Harry, J., and Melov, S. (2004) J. Neurochem. 88, 657-667). We have used heart mitochondria from sod2 null mice to better understand mitochondrial reactive oxygen species production both in the absence of SOD2 and following in vivo antioxidant treatment. …”