Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as by Han, Xiaoxing, Kempa, Thomas J., Fukumura, Dai, Jain, Rakesh K., Duda, Dan G., Nocera, Daniel G., Lemon, Christopher Michael, Karnas, Elizabeth, Bruns, Oliver Thomas, Bawendi, Moungi G

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Neurotransmitter-Responsive Nanosensors for T2-Weighted Magnetic Resonance Imaging by Hsieh, Vivian, Okada, Satoshi, Wei, He, Garcia Alvarez, Isabel, Barandov, Ali, Alvarado, Santiago Recuenco, Ohlendorf, Robert, Fan, Jingxuan, Ortega, Athena, Jasanoff, Alan Pradip

“…Neurotransmitter-sensitive contrast agents for magnetic resonance imaging (MRI) have recently been used for mapping signaling dynamics in live animal brains, but paramagnetic sensors for T1-weighted MRI are usually effective only at micromolar concentrations that themselves perturb neurochemistry. Here we present an alternative molecular architecture for detecting neurotransmitters, using superparamagnetic iron oxide nanoparticles conjugated to tethered neurotransmitter analogs and engineered neurotransmitter binding proteins. …”
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Resolving multipath interference in time-of-flight imaging via modulation frequency diversity and sparse regularization by Bhandari, Ayush, Kadambi, Achuta, Whyte, Refael, Barsi, Christopher, Feigin, Micha, Dorrington, Adrian, Raskar, Ramesh

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Relationship between the gut microbiome and behaviour at the molecular, organism, population and evolutionary levels by Johnson, KVA

“…Research is revealing the numerous ways that the gut microbiome interacts with the host’s central nervous system, influencing brain development, neurochemistry, emotion and social behaviour. This microbiome–gut–brain axis is bidirectional since the behaviour and emotional state of the host can in turn alter microbiome composition and function. …”

A clinically relevant rodent model of the HIV antiretroviral drug stavudine induced painful peripheral neuropathy by Huang, W, Calvo, M, Karu, K, Olausen, H, Bathgate, G, Okuse, K, Bennett, D, Rice, A

“…Detailed neuropathological response was also examined using neurochemistry, electron microscopy, and proteomics. After 2 intravenous injections of d4T (50 mg/kg, 4 days apart), rats developed hind paw mechanical hypersensitivity, which plateaued at 21 days after initial d4T injection, a time that these animals also had significant changes in thigmotaxis and burrowing behaviours when compared to the controls; reductions in hind paw intraepidermal nerve fibre density and CGRP/IB4 immunoreactivity in L5 spinal dorsal horn, suggesting injury to both the peripheral and central terminals of L5 dorsal root ganglion neurons; and increases in myelinated and unmyelinated axon diameters in the sural nerve, suggesting axonal swelling. …”

Rebound activation of 5-HT neurons following SSRI discontinuation by Collins, HM, Gullino, LS, Ozdemir, D, Lazarenco, C, Sudarikova, Y, Daly, E, Pilar Cuéllar, F, Pinacho, R, Bannerman, DM, Sharp, T

“…Here we determined the effect on 5-HT neurochemistry of discontinuation from the SSRI paroxetine. …”

A clinically relevant rodent model of the HIV antiretroviral drug stavudine induced painful peripheral neuropathy. by Huang, W, Calvo, M, Karu, K, Olausen, H, Bathgate, G, Okuse, K, Bennett, D, Rice, A

“…Detailed neuropathological response was also examined using neurochemistry, electron microscopy, and proteomics. After 2 intravenous injections of d4T (50 mg/kg, 4 days apart), rats developed hind paw mechanical hypersensitivity, which plateaued at 21 days after initial d4T injection, a time that these animals also had significant changes in thigmotaxis and burrowing behaviours when compared to the controls; reductions in hind paw intraepidermal nerve fibre density and CGRP/IB4 immunoreactivity in L5 spinal dorsal horn, suggesting injury to both the peripheral and central terminals of L5 dorsal root ganglion neurons; and increases in myelinated and unmyelinated axon diameters in the sural nerve, suggesting axonal swelling. …”

A five-year observational prospective mono-center study of the efficacy of alemtuzumab in a real-world cohort of patients with multiple sclerosis by Sofia Sandgren, Sofia Sandgren, Lenka Novakova, Lenka Novakova, Anna Nordin, Anna Nordin, Markus Axelsson, Markus Axelsson, Clas Malmeström, Clas Malmeström, Clas Malmeström, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Jan Lycke, Jan Lycke

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Prescreening for European Prevention of Alzheimer Dementia (EPAD) trial-ready cohort: impact of AD risk factors and recruitment settings by Lisa Vermunt, Graciela Muniz-Terrera, Lea ter Meulen, Colin Veal, Kaj Blennow, Archie Campbell, Isabelle Carrié, Julien Delrieu, Karine Fauria, Gema Huesa Rodríguez, Silvia Ingala, Natalie Jenkins, José Luis Molinuevo, Pierre-Jean Ousset, David Porteous, Niels D. Prins, Alina Solomon, Brian D. Tom, Henrik Zetterberg, Marissa Zwan, Craig W. Ritchie, Philip Scheltens, Gerald Luscan, Anthony J. Brookes, Pieter Jelle Visser, for the IMI-EPAD collaborators

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Interleukin 10 and Heart Fatty Acid-Binding Protein as Early Outcome Predictors in Patients With Traumatic Brain Injury by Linnéa Lagerstedt, Leire Azurmendi, Olli Tenovuo, Olli Tenovuo, Ari J. Katila, Riikka S. K. Takala, Kaj Blennow, Virginia F. J. Newcombe, Henna-Riikka Maanpää, Henna-Riikka Maanpää, Henna-Riikka Maanpää, Jussi Tallus, Iftakher Hossain, Iftakher Hossain, Iftakher Hossain, Mark van Gils, David K. Menon, Peter J. Hutchinson, Peter J. Hutchinson, Peter J. Hutchinson, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Jussi P. Posti, Jussi P. Posti, Jussi P. Posti, Jean-Charles Sanchez

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The effects of mango leaf extract during adolescence and adulthood in a rat model of schizophrenia by Jose Antonio Garcia-Partida, Jose Antonio Garcia-Partida, Sonia Torres-Sanchez, Sonia Torres-Sanchez, Sonia Torres-Sanchez, Karina MacDowell, Karina MacDowell, Maria Teresa Fernández-Ponce, Lourdes Casas, Casimiro Mantell, María Luisa Soto-Montenegro, María Luisa Soto-Montenegro, María Luisa Soto-Montenegro, Diego Romero-Miguel, Diego Romero-Miguel, Nicolás Lamanna-Rama, Nicolás Lamanna-Rama, Juan Carlos Leza, Juan Carlos Leza, Manuel Desco, Manuel Desco, Manuel Desco, Manuel Desco, Esther Berrocoso, Esther Berrocoso, Esther Berrocoso

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Heme Biosynthesis Factors and 5-ALA Induced Fluorescence: Analysis of mRNA and Protein Expression in Fluorescing and Non-fluorescing Gliomas by Mario Mischkulnig, Mario Mischkulnig, Thomas Roetzer-Pejrimovsky, Thomas Roetzer-Pejrimovsky, Daniela Lötsch-Gojo, Daniela Lötsch-Gojo, Nina Kastner, Katharina Bruckner, Romana Prihoda, Romana Prihoda, Alexandra Lang, Alexandra Lang, Mauricio Martinez-Moreno, Julia Furtner, Julia Furtner, Anna Berghoff, Anna Berghoff, Adelheid Woehrer, Adelheid Woehrer, Walter Berger, Georg Widhalm, Georg Widhalm, Barbara Kiesel, Barbara Kiesel

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Gene expression and locomotor recovery in adult rats with spinal cord injury and plasma-synthesized polypyrrole/iodine application combined with a mixed rehabilitation scheme by Angélica Coyoy-Salgado, Angélica Coyoy-Salgado, Carlos Orozco-Barrios, Carlos Orozco-Barrios, Stephanie Sánchez-Torres, Stephanie Sánchez-Torres, María Guadalupe Olayo, Guillermo Jesus Cruz, Juan Morales-Corona, Roberto Olayo, Araceli Diaz-Ruiz, Camilo Ríos, Laura Alvarez-Mejia, Laura Alvarez-Mejia, Rodrigo Mondragón-Lozano, Rodrigo Mondragón-Lozano, Axayacatl Morales-Guadarrama, Axayacatl Morales-Guadarrama, Ana Lucía Alonso-García, Omar Fabela-Sánchez, Hermelinda Salgado-Ceballos, Hermelinda Salgado-Ceballos

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Serum markers glial fibrillary acidic protein and neurofilament light for prognosis and monitoring in cognitively normal older people: a prospective memory clinic-based cohort stud... by Inge M W Verberk, MSc, Malika B Laarhuis, MSc, Karlijn A van den Bosch, MSc, Jarith L Ebenau, MD, Mardou van Leeuwenstijn, Niels D Prins, MD, Philip Scheltens, ProfMD, Charlotte E Teunissen, ProfPhD, Wiesje M van der Flier, ProfPhD

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High-resolution metabolic imaging of high-grade gliomas using 7T-CRT-FID-MRSI by Gilbert Hangel, Cornelius Cadrien, Philipp Lazen, Julia Furtner, Alexandra Lipka, Eva Hečková, Lukas Hingerl, Stanislav Motyka, Stephan Gruber, Bernhard Strasser, Barbara Kiesel, Mario Mischkulnig, Matthias Preusser, Thomas Roetzer, Adelheid Wöhrer, Georg Widhalm, Karl Rössler, Siegfried Trattnig, Wolfgang Bogner

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The specialized pro-resolving lipid mediator Protectin D1 affects macrophages differentiation and activity in Adult-onset Still’s disease and COVID-19, two hyperinflammatory diseas... by Luca Navarini, Luca Navarini, Marta Vomero, Damiano Currado, Damiano Currado, Onorina Berardicurti, Onorina Berardicurti, Alice Biaggi, Annalisa Marino, Pietro Bearzi, Erika Corberi, Amelia Rigon, Luisa Arcarese, Alessandro Leuti, Alessandro Leuti, Marina Fava, Marina Fava, Marta Fogolari, Marta Fogolari, Alessia Mattei, Piero Ruscitti, Ilenia Di Cola, Federica Sambuco, Francesco Travaglino, Silvia Angeletti, Silvia Angeletti, Francesco Ursini, Francesco Ursini, Erminia Mariani, Erminia Mariani, Paola Cipriani, Felice Eugenio Agrò, Felice Eugenio Agrò, Annamaria Iagnocco, Raffaele Antonelli Incalzi, Raffaele Antonelli Incalzi, Mauro Maccarrone, Mauro Maccarrone, Roberto Giacomelli, Roberto Giacomelli

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Glycogen synthase kinase-3β inhibition in the medial prefrontal cortex mediates paradoxical amphetamine action in a mouse model of ADHD by Yi-Chun eYen, Nils C. Gassen, Andreas eZellner, Theo eRein, Rainer eLandgraf, Carsten T. Wotjak, Elmira eAnderzhanova

“…We combined behavioral pharmacology, neurochemistry and molecular analyses to identify mechanisms underlying the paradoxical calming effect of amphetamine in low trait anxiety behavior (LAB) mice, a novel multigenetic animal model of ADHD. …”
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Structural Variation of Chondroitin Sulfate Chains Contributes to the Molecular Heterogeneity of Perineuronal Nets by Shinji Miyata, Satomi Nadanaka, Michihiro Igarashi, Hiroshi Kitagawa

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Racemization in Post-Translational Modifications Relevance to Protein Aging, Aggregation and Neurodegeneration: Tip of the Iceberg by Victor V. Dyakin, Thomas M. Wisniewski, Abel Lajtha

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Is retinal vasculature a biomarker in amyloid proven Alzheimer's disease? by Jurre denHaan, Jacoba A. van deKreeke, Bart N. vanBerckel, Frederik Barkhof, Charlotte E. Teunissen, Philip Scheltens, Frank D. Verbraak, Femke H. Bouwman

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