Editorial: Environmental effect on neuroinflammation and neurodegeneration, volume II by Souvarish Sarkar, Srikant Rangaraju, Claudia Espinosa-Garcia, Monica Renee Langley

Subjects: Get full text

Glaucomatous neurodegeneration: An eye on tumor necrosis factor-alpha by Renu Agarwal, Puneet Agarwal

Get full text

SARS-CoV-2, COVID-19 and Neurodegeneration by Lars Tönges, Stephan Klebe

Get full text

The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration by Anna Pisani, Fabiola Paciello, Valeria Del Vecchio, Rita Malesci, Eugenio De Corso, Elena Cantone, Anna Rita Fetoni

“…Finally, we review significant studies highlighting the possibility to target BDNF as a biomarker in early diagnosis of sensory and cognitive neurodegeneration, opening new opportunities to develop effective therapeutic strategies aimed to counteract neurodegeneration.…”
Get full text

Molecular Profiling and Mechanisms of Cerebrovascular Function in Health and Neurodegeneration by Garcia, Francisco J.

“…Furthermore, the presence of a bloodbrain barrier (BBB) provides protection to vulnerable neurons but poses a challenge for drug delivery. In neurodegeneration, BBB breakdown and vascular impairments are hallmarks that precede the onset of disease-specific phenotypes. …”
Get full text

Linking Cell Cycle Reentry and DNA Damage in Neurodegeneration by Kim, Dohoon, Tsai, Li-Huei

Get full text
Get full text

Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration by Tan, Chin Hong, Bonham, Luke W., Fan, Chun Chieh, Mormino, Elizabeth C., Sugrue, Leo P., Broce, Iris J., Hess, Christopher P., Yokoyama, Jennifer S., Rabinovici, Gil D., Miller, Bruce L., Yaffe, Kristine., Schellenberg, Gerard D., Kauppi, Karolina, Holland, Dominic, McEvoy, Linda K., Kukull, Walter A., Tosun, Duygu, Weiner, Michael W., Sperling, Reisa A., Bennett, David A., Hyman, Bradley T., Andreassen, Ole A., Dale, Anders M., Desikan, Rahul S.

“…Beyond APOE, we show that in living subjects, polygenic hazard scores were associated with amyloid deposition and neurodegeneration in susceptible brain regions. Polygenic hazard scores may also be useful for the identification of individuals at the highest risk for developing multi-aetiological dementia.…”
Get full text

Investigating the role of alternative polyadenylation in neuronal differentiation and neurodegeneration by Patel, R

“…Using a combination of molecular biology and bioinformatics approaches, this thesis assesses changes in APA profiles regulated by transcriptional and post-transcriptional APA during neuronal differentiation, in neurodegeneration and in cellular stress. The BE(2)-M17 neuroblastoma cell line was used to model neuronal differentiation. …”

Oxidative stress mediates tau-induced neurodegeneration in Drosophila. by Dias-Santagata, D, Fulga, T, Duttaroy, A, Feany, M

“…We used a Drosophila model of human tauopathies to investigate the role of oxidative stress in neurodegeneration. Genetic and pharmacological manipulation of antioxidant defense mechanisms significantly modified neurodegeneration in our model, suggesting that oxidative stress plays a causal role in neurotoxicity. …”

Peroxisome proliferator-activated receptor-γ cofactors in neurodegeneration by Katsouri, L, Blondrath, K, Sastre, M

“…In this review, we aim to analyze the role of the main regulators of PPARγ in the brain and during neurodegeneration.…”

The periaqueductal grey area and control of blood pressure in neurodegeneration by Sitsapesan, H, Green, A, Aziz, T, Pereira, E

Fibrin(ogen) and neurodegeneration in the progressive multiple sclerosis cortex by Yates, R, Esiri, M, Palace, J, Jacobs, B, Perera, R, De Luca, G

“…The aim of this study was to investigate the extent and distribution of fibrin(ogen) in progressive MS cortex and elucidate its relationship with neurodegeneration. METHODS: A post-mortem cohort of pathologically confirmed MS (n=47) and control (n=10) cases was used. …”

CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer's disease by Delvenne, A, Gobom, J, Schindler, SE, Kate, MT, Reus, LM, Dobricic, V, Tijms, BM, Benzinger, TLS, Cruchaga, C, Teunissen, CE, Ramakers, I, Martinez‐Lage, P, Tainta, M, Vandenberghe, R, Schaeverbeke, J, Engelborghs, S, Roeck, ED, Popp, J, Peyratout, G, Tsolaki, M, Freund‐Levi, Y, Lovestone, S, Streffer, J, Barkhof, F

“…INTRODUCTION: We aimed to unravel the underlying pathophysiology of the neurodegeneration (N) markers neurogranin (Ng), neurofilament light (NfL), and hippocampal volume (HCV), in Alzheimer's disease (AD) using cerebrospinal fluid (CSF) proteomics. …”

The periaqueductal grey area and control of blood pressure in neurodegeneration. by Sitsapesan, H, Green, A, Aziz, T, Pereira, E

An Overview of Culinary and Medicinal Mushrooms in Neurodegeneration and Neurotrauma Research by Wong, Kah Hui, Ng, Chai Chee, Kanagasabapathy, Gowri, Yow, Yoon Yen, Sabaratnam, Vikineswary

Editorial: Exploring the role of exosomes in disease progression and therapeutics in neurodegeneration by Arif Tasleem Jan, Safikur Rahman, Diana K. Sarko, Elrashdy M. Redwan, Elrashdy M. Redwan

Get full text

Glymphatic System Pathology and Neuroinflammation as Two Risk Factors of Neurodegeneration by Stanisław Szlufik, Kamila Kopeć, Stanisław Szleszkowski, Dariusz Koziorowski

Subjects: “…neurodegeneration…”
Get full text

Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation by Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Naoko Kamano, Naoto Watamura, Hiroki Sasaguri, Yuhei Takado, Yoshihiro Yoshihara, Takashi Saito, Takaomi C. Saido

“…Furthermore, GCLC-KO mouse will serve as a useful tool to investigate the molecular mechanisms underlying neurodegeneration and in the development of new treatment strategies to address neurodegenerative diseases.…”
Get full text

Editorial: Rho family GTPases and their effectors in neuronal survival and neurodegeneration by Daniel A. Linseman, Qun Lu

Subjects: Get full text

Neurodegeneration in Multiple Sclerosis: The Role of Nrf2-Dependent Pathways by Paloma P. Maldonado, Coram Guevara, Margrethe A. Olesen, Juan Andres Orellana, Rodrigo A. Quintanilla, Fernando C. Ortiz

“…In this brief review, we discuss the role of mitochondria dysfunction in the progression of MS, focused on the possible role of Nrf2 signaling in orchestrating the impairment of critical cellular and molecular aspects such as reactive oxygen species (ROS) management, under neuroinflammation and neurodegeneration in MS. In this scenario, we propose a new potential downstream signaling of Nrf2 pathway, namely the opening of hemichannels and pannexons. …”
Get full text