An increase in mitochondrial TOM activates apoptosis to drive retinal neurodegeneration by Agalya Periasamy, Naomi Mitchell, Olga Zaytseva, Arjun S. Chahal, Jiamin Zhao, Peter M. Colman, Leonie M. Quinn, Jacqueline M. Gulbis

“…We used Drosophila melanogaster eyes as an in vivo model to investigate the relationship between elevated Tom40 (the Drosophila homologue of hTomm40) expression and neurodegeneration. Here we provide evidence that an overabundance of Tom40 in mitochondria invokes caspase-dependent cell death in a dose-dependent manner, leading to degeneration of the primarily neuronal eye tissue. …”
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Inorganic Nanomaterials versus Polymer-Based Nanoparticles for Overcoming Neurodegeneration by Simona Martano, Valeria De Matteis, Mariafrancesca Cascione, Rosaria Rinaldi

Subjects: “…neurodegeneration…”
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Oxidative Stress and Neurodegeneration: Interconnected Processes in PolyQ Diseases by Ioannis Gkekas, Anna Gioran, Marina Kleopatra Boziki, Nikolaos Grigoriadis, Niki Chondrogianni, Spyros Petrakis

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Anti-Neurodegenerating Activity: Structure–Activity Relationship Analysis of Flavonoids by Gagan Preet, Ahlam Haj Hasan, Piteesha Ramlagan, Shameem Fawdar, Fabien Boulle, Marcel Jaspars

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Emerging Evidences for an Implication of the Neurodegeneration-Associated Protein TAU in Cancer by Stéphanie Papin, Paolo Paganetti

Subjects: “…neurodegeneration…”
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Noradrenergic Hypothesis Linking Neurodegeneration-Based Cognitive Decline and Astroglia by Giampiero Leanza, Rosario Gulino, Robert Zorec, Robert Zorec

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Neuroinflammation in Post-Ischemic Neurodegeneration of the Brain: Friend, Foe, or Both? by Ryszard Pluta, Sławomir Januszewski, Stanisław J. Czuczwar

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Aging, NRF2, and TAU: A Perfect Match for Neurodegeneration? by Mirjam Brackhan, Marina Arribas-Blazquez, Isabel Lastres-Becker

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The Involvement of Polyamines Catabolism in the Crosstalk between Neurons and Astrocytes in Neurodegeneration by Manuela Cervelli, Monica Averna, Laura Vergani, Marco Pedrazzi, Sarah Amato, Cristian Fiorucci, Marianna Nicoletta Rossi, Guido Maura, Paolo Mariottini, Chiara Cervetto, Manuela Marcoli

“…This genetic model would help researchers understand the linkage between polyamine dysregulation and neurodegeneration and unveil the roles of polyamines in the crosstalk between astrocytes and neurons in neuroprotection or neurodegeneration.…”
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NLRP3 and Infections: β-Amyloid in Inflammasome beyond Neurodegeneration by Giulia Sita, Agnese Graziosi, Patrizia Hrelia, Fabiana Morroni

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Calcium handling: a strategy to fight neurodegeneration in Alzheimer’s disease by Livia La Barbera, Elena Spoleti, Marcello D'Amelio

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Antioxidant Capability and Physical Exercise in Neurobiology: A Focus in Neurodegeneration by Giorgia Scarfò, Simona Daniele, Ferdinando Franzoni

“…Neurodegeneration is a complex process controlled by both genetic and environmental factors [...]…”
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Novel approaches to glaucomatous neurodegeneration, based on the integrated stress response by Luciana B. Chiarini, Hilda Petrs-Silva, Rafael Linden

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Proteostasis unbalance in prion diseases: Mechanisms of neurodegeneration and therapeutic targets by Stefano Thellung, Alessandro Corsaro, Irene Dellacasagrande, Mario Nizzari, Martina Zambito, Tullio Florio, Tullio Florio

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Steps in the Pathogenesis of Multiple Sclerosis - I: From Neuroinflammation to Neurodegeneration by Aslı Kurne, Rana Karabudak, Ömer Faruk Aydın

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“Let Food Be Thy Medicine”: Gluten and Potential Role in Neurodegeneration by Aaron Lerner, Carina Benzvi

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Deletion of Wnt10a Is Implicated in Hippocampal Neurodegeneration in Mice by Jia-He Zhang, Takashi Tasaki, Manabu Tsukamoto, Ke-Yong Wang, Kin-ya Kubo, Kagaku Azuma

“…Our findings revealed that the deletion of Wnt10a decreased neurogenesis, impaired synaptic function, and induced hippocampal neuroinflammation, eventually leading to hippocampal neurodegeneration and memory deficit, possibly through the β-catenin signaling pathway, providing a novel insight into preventive approaches for hippocampus-dependent cognitive impairment.…”
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Switch-Like Roles for Polycomb Proteins from Neurodevelopment to Neurodegeneration by Anke Hoffmann, Vincenza Sportelli, Michael Ziller, Dietmar Spengler

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From Obesity to Hippocampal Neurodegeneration: Pathogenesis and Non-Pharmacological Interventions by Thomas Ho-yin Lee, Suk-yu Yau

“…High-caloric diet and physical inactivity predispose individuals to obesity and diabetes, which are risk factors of hippocampal neurodegeneration and cognitive deficits. Along with the adipose-hippocampus crosstalk, chronically inflamed adipose tissue secretes inflammatory cytokine could trigger neuroinflammatory responses in the hippocampus, and in turn, impairs hippocampal neuroplasticity under obese and diabetic conditions. …”
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Endophilin-B regulates autophagy during synapse development and neurodegeneration by Sergio Hernandez-Diaz, Saurav Ghimire, Irene Sanchez-Mirasierra, Carla Montecinos-Oliva, Jef Swerts, Sabine Kuenen, Patrik Verstreken, Sandra-Fausia Soukup

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