Status epilepticus and early development: Neuronal injury, neurodegeneration, and their consequences by Kerry Thompson

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Interaction of Neuromelanin with Xenobiotics and Consequences for Neurodegeneration; Promising Experimental Models by Andrea Capucciati, Fabio A. Zucca, Enrico Monzani, Luigi Zecca, Luigi Casella, Tim Hofer

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Cholesterol homeostasis: A key to prevent or slow down neurodegeneration by Laura eAnchisi, Laura eAnchisi, Sandra eDessi, Alessandra ePani, Antonella eMandas

“…Neurodegeneration, a common feature for many brain disorders, has severe consequences on the mental and physical health of an individual. …”
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Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution by Hemberg, Martin, De Jager, Philip L., Ransohoff, Richard M., Mathys, Hansruedi, Adaikkan, Chinnakkaruppan, Gao, Fan, Young, Jennie Zin-Ney, Manet, Elodie, Regev, Aviv, Tsai, Li-Huei

“…Here, using single-cell RNA sequencing, we determined the transcriptome of more than 1,600 individual microglia cells isolated from the hippocampus of a mouse model of severe neurodegeneration with AD-like phenotypes and of control mice at multiple time points during progression of neurodegeneration. …”
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Modelling Neurodegeneration in Saccharomyces Cerevisiae: Why Cook with Baker's Yeast? by Khurana, Vikram, Lindquist, Susan

“…Here, we describe why the budding yeast Saccharomyces cerevisiae has a unique role in the neurodegeneration armamentarium. As the best-understood and most readily analysed eukaryotic organism, S. cerevisiae is delivering mechanistic insights into cell-autonomous mechanisms of neurodegeneration at an interactome-wide scale.…”
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Neurofilament light as a blood biomarker for neurodegeneration in down syndrome by Strydom, Andre, Heslegrave, Amanda, Startin, Carla M., Mok, Kin Y., Hardy, John, Groet, Jurgen, Nizetic, Dean, Zetterberg, Henrik

“…Conclusions NF-L is a biomarker for neurodegeneration in DS with potential for use in future clinical trials to prevent or delay dementia.…”
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Lipid peroxidation in chronic cerebral hypoperfusion- induced neurodegeneration in rats by Saxena, Anil Kumar, Abdul Majeed, Saif Saad, Oothuman, Pakeer, Mustafa Mahmoud, Mohammed Imad Al-Deen

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The deubiquitylase TRABID coordinates sex-specific neurodegeneration in drosophila melanogaster by Xia, J

“…However, sex differences are widely observed in both inflammation as well as neurodegeneration phenotypes. In this study, I investigated sex dimorphism, in ubiquitination at the intersection of inflammation and neurodegeneration. …”

Does interneuronal dysfunction contribute to neurodegeneration in amyotrophic lateral sclerosis? by Turner, M, Kiernan, M

Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration? by Jeffrey R. Liddell

“…This review describes the evidence for Nrf2 activation in each cell type in prominent neurodegenerative diseases and normal aging in human brain and animal models of neurodegeneration, the response to pharmacological and genetic modulation of Nrf2, and clinical trials involving Nrf2-modifying drugs.…”
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BAG6 prevents the aggregation of neurodegeneration-associated fragments of TDP43 by Yasar Arfat T. Kasu, Akshaya Arva, Jess Johnson, Christin Sajan, Jasmin Manzano, Andrew Hennes, Jacy Haynes, Christopher S. Brower

“…Summary: Neurodegeneration is associated with the aggregation of proteins bearing solvent-exposed hydrophobicity as a result of their misfolding and/or proteolytic cleavage. …”
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Aberrant waste disposal in neurodegeneration: why improved sleep could be the solution by Keith A. Wafford

“…With this understanding we can begin to envisage novel therapeutic approaches to the treatment of neurodegeneration, and how reversing sleep impairment in the correct manner may provide a way to slow these processes and improve brain function.…”
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Zfra Inhibits the TRAPPC6AΔ-Initiated Pathway of Neurodegeneration by Yu-Hao Lin, Yao-Hsiang Shih, Ye Vone Yap, Yen-Wei Chen, Hsiang-Lin Kuo, Tsung-Yun Liu, Li-Jin Hsu, Yu-Min Kuo, Nan-Shan Chang

“…When WWOX is downregulated in middle age, aggregation of a protein cascade, including TRAPPC6AΔ (TPC6AΔ), TIAF1, and SH3GLB2, may start to occur, and the event lasts more than 30 years, which results in amyloid precursor protein (APP) degradation, amyloid beta (Aβ) generation, and neurodegeneration, as shown in Alzheimer’s disease (AD). …”
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Stress Responses in Down Syndrome Neurodegeneration: State of the Art and Therapeutic Molecules by Chiara Lanzillotta, Fabio Di Domenico

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Cell-type resolved transcriptomic approaches for dissecting selective vulnerability in neurodegeneration by Caleb A Wood, Nicholas M Tran

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H₂S IN THE NEURODEGENERATION: A «DOUBLE-FACED JANUS» by E. E. Kolesnikova

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Mural Cells: Potential Therapeutic Targets to Bridge Cardiovascular Disease and Neurodegeneration by Alexander Lin, Niridu Jude Peiris, Harkirat Dhaliwal, Maria Hakim, Weizhen Li, Subramaniam Ganesh, Yogambha Ramaswamy, Sanjay Patel, Ashish Misra

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Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration by Salinee Jantrapirom, Luca Lo Piccolo, Masamitsu Yamaguchi

“…Dysfunctional UbL-UbA proteins render cells, particularly neurons, more susceptible to stressors or aging and may cause earlier neurodegeneration. In this review, we summarized the properties and functions of UbL-UbA family members identified to date, with an emphasis on new findings obtained using <i>Drosophila</i> models showing a direct or indirect role in some neurodegenerative diseases.…”
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The α-Ketoglutarate Dehydrogenase Complex as a Hub of Plasticity in Neurodegeneration and Regeneration by Grace E. Hansen, Gary E. Gibson

“…Abnormal glucose metabolism is central to neurodegeneration, and considerable evidence suggests that abnormalities in key enzymes of the tricarboxylic acid (TCA) cycle underlie the metabolic deficits. …”
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Developmental pathways linked to the vulnerability of adult midbrain dopaminergic neurons to neurodegeneration by Nilima Prakash

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