Environmental aluminum oxide inducing neurodegeneration in human neurovascular unit with immunity by Yingqi Xue, Minh Tran, Yen N. Diep, Seonghun Shin, Jinkee Lee, Hansang Cho, You Jung Kang

“…Here, we employed our AlNP-treated hNVUI model to investigate the underlying mechanism of AlNP-driven neurodegeneration. First, we validated the penetration of AlNP across a blood–brain barrier (BBB) compartment and found AlNP-derived endothelial cellular senescence through the p16 and p53/p21 pathways. …”
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Role of Mesenchymal Stem Cells in Counteracting Oxidative Stress—Related Neurodegeneration by Cristina Angeloni, Martina Gatti, Cecilia Prata, Silvana Hrelia, Tullia Maraldi

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Diet, Microbiota and Brain Health: Unraveling the Network Intersecting Metabolism and Neurodegeneration by Francesco Gentile, Pietro Emiliano Doneddu, Nilo Riva, Eduardo Nobile-Orazio, Angelo Quattrini

“…Here, we present a comprehensive review of the impact of metabolism, diet and microbiota in neurodegeneration, by affecting simultaneously several aspects of health regarding energy metabolism, immune system and neuronal function. …”
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Astrogliosis and sexually dimorphic neurodegeneration and microgliosis in the olfactory bulb in Parkinson’s disease by Alicia Flores-Cuadrado, Daniel Saiz-Sanchez, Alicia Mohedano-Moriano, Elena Lamas-Cenjor, Victor Leon-Olmo, Alino Martinez-Marcos, Isabel Ubeda-Bañon

“…When analyzed per sex, neurodegeneration and microgliosis differences are only present in men. …”
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Editorial: Cannabinoids in neuroinflammation, neurodegeneration and pain: Focus on non-neuronal cells by Haley A. Vecchiarelli, Valerie Joers, Malú Gámez Tansey, Malú Gámez Tansey, Katarzyna Starowicz

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CLIC1 Protein Accumulates in Circulating Monocyte Membrane during Neurodegeneration by Valentina Carlini, Ivan Verduci, Francesca Cianci, Gaetano Cannavale, Chiara Fenoglio, Daniela Galimberti, Michele Mazzanti

Subjects: “…neurodegeneration…”
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S-nitrosation of proteins relevant to Alzheimer’s disease during early stages of neurodegeneration by Bhat, Vadiraja B., Seneviratne, Uthpala Indrajith, Nott, Alexander, Kodihalli, Ravindra, Wishnok, John S, Tsai, Li-Huei, Tannenbaum, Steven R

“…SNOTRAP identified 313 endogenous SNO-sites in 251 proteins in the mouse brain, of which 135 SNO-proteins were detected only during neurodegeneration. S-nitrosation in the brain shows regional differences and becomes elevated during early stages of neurodegeneration in the CK-p25 mouse. …”
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S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration by Bhat, Vadiraja B., Seneviratnea, Uthpala, Nott, Alexi, Ravindra, Kodihalli C., Wishnok, John S, Tsai, Li-Huei, Tannenbaum, Steven R

“…SNOTRAP identified 313 endogenous SNO-sites in 251 proteins in the mouse brain, of which 135 SNO-proteins were detected only during neurodegeneration. S-nitrosation in the brain shows regional differences and becomes elevated during early stages of neurodegeneration in the CK-p25 mouse. …”
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Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma by Chen, Huihui, Cho, Kin-Sang, Vu, T. H. Khanh, Chen, Guochun, Mathew, Rose, McHam, M. Lisa, Fazelat, Ahad, Lashkari, Kameran, AU, Ngan Pan Bennett, TSE, Joyce Ka Yu, Li, Yingqian, Yu, Honghua, Yang, Lanbo, Stein-Streilein, Joan, Ma, Chi Him Eddie, Woolf, Clifford J., Jager, Martine J., Chen, Jianzhu, Chen, Dong F., Shen, Chase, Kaur, Mandeep, Fox, James G, Whary, Mark T.

“…Furthermore, retina-infiltrating T cells cross-react with human and bacterial HSPs; mice raised in the absence of commensal microflora do not develop glaucomatous T-cell responses or the associated neurodegeneration. These results provide compelling evidence that glaucomatous neurodegeneration is mediated in part by T cells that are pre-sensitized by exposure to commensal microflora.…”
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Phosphoproteomics identifies microglial Siglec‐F inflammatory response during neurodegeneration by Morshed, Nader, Ralvenius, William, Nott, Alexander, Watson, Lauren Ashley, Rodriguez, Felicia H, Akay, Leyla Anne, Joughin, Brian Alan, Pao, Ping-Chieh, Penney, Jay, LaRocque, Lauren, Mastroeni, Diego, Tsai, Li‐Huei, White, Forest M.

“…Collectively, our results point to an important role for mouse Siglec-F and human Siglec-8 in regulating microglial activation during neurodegeneration.…”
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Walking the high wire: How neurons maintain stability in the crossline of neurodegeneration by Victor, Matheus B, Tsai, Li-Huei

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MED13 and glycolysis are conserved modifiers of α-synuclein-associated neurodegeneration by Ren, Mengda, Yang, Ying, Heng, Kelsey Hwee Yee, Ng, Lu Yi, Chong, Claris Yuin-Yi, Ng, Yan Ting, Gorur-Shandilya, Srinivas, Lee, Rachel Min Qi, Lim, Kah Leong, Zhang, Jing, Koh, Tong-Wey

“…The resulting neurodegeneration can be suppressed by overexpressing a glycolytic enzyme or treatment with deferoxamine, suggesting that compensatory glycolysis is neuroprotective. …”
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Assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats by Saxena, Anil Kumar, Abdul Majeed, Saif Saad, Oothuman, Pakeer, Gurtu, Sunil

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Analysis of novel pathways in neurodegeneration using mouse and fly model organisms by Paton, L

“…Histological analysis of the brain revealed for the first time progressive neurodegeneration in the cerebellum with severe Purkinje cell loss. …”

Mouse models of neurodegeneration: Know your question, know your mouse by Fisher, E, Bannerman, D

Braiding Braak and Braak: staging patterns and model selection in network neurodegeneration by Putra, P, Thompson, TB, Chaggar, P, Goriely, A

Oxr1 is essential for protection against oxidative stress-induced neurodegeneration. by Oliver, P, Finelli, M, Edwards, B, Bitoun, E, Butts, D, Becker, E, Cheeseman, M, Davies, K, Davies, B

“…Oxidative stress is a common etiological feature of neurological disorders, although the pathways that govern defence against reactive oxygen species (ROS) in neurodegeneration remain unclear. We have identified the role of oxidation resistance 1 (Oxr1) as a vital protein that controls the sensitivity of neuronal cells to oxidative stress; mice lacking Oxr1 display cerebellar neurodegeneration, and neurons are less susceptible to exogenous stress when the gene is over-expressed. …”

Dihydrolipoamide acetyltransferase deficiency in cases of atypical pantothenate kinase associated neurodegeneration by MeWilliam, C, Brown, R, MeWilliam, R, Ridout, C, Tolmie, J, Brown, G

Developing neuroimaging biomarkers for neurodegeneration and ageing using machine learning methods by Arya, Z

“…</p> <br/> <p>Ageing is strongly linked with neurodegeneration. Hence, the second method is an errors-in-variables model for estimating the brain age of individuals. …”

Neurodegeneration in drop-dead mutant drosophila melanogaster is associated with the respiratory system but not with Hypoxia. by Christine Lynn Sansone, Edward M Blumenthal

“…Mutations in the gene drop-dead (drd) cause diverse phenotypes in adult Drosophila melanogaster including early lethality, neurodegeneration, tracheal defects, gut dysfunction, reduced body mass, and female sterility. …”
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