Showing 581 - 600 results of 8,186 for search '"neurodegeneration"', query time: 0.13s Refine Results
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    Prognostic value of complementary biomarkers of neurodegeneration in a mixed memory clinic cohort by Mathias Holsey Gramkow, Le Gjerum, Juha Koikkalainen, Jyrki Lötjönen, Ian Law, Steen Gregers Hasselbalch, Gunhild Waldemar, Kristian Steen Frederiksen

    Published 2020-07-01
    “…Background Biomarkers of neurodegeneration, e.g. MRI brain atrophy and [18F]FDG-PET hypometabolism, are often evaluated in patients suspected of neurodegenerative disease. …”
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    Network diffusion model predicts neurodegeneration in limb-onset Amyotrophic Lateral Sclerosis. by Anjan Bhattarai, Zhaolin Chen, Phyllis Chua, Paul Talman, Susan Mathers, Caron Chapman, James Howe, C M Sarah Lee, Yenni Lie, Govinda R Poudel, Gary F Egan

    Published 2022-01-01
    “…<h4>Objective</h4>Emerging evidences suggest that the trans-neural propagation of phosphorylated 43-kDa transactive response DNA-binding protein (pTDP-43) contributes to neurodegeneration in Amyotrophic Lateral Sclerosis (ALS). …”
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    A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer’s disease by Liviu Aron, Chenxi Qiu, Zhen Kai Ngian, Marianna Liang, Derek Drake, Jaejoon Choi, Marty A. Fernandez, Perle Roche, Emma L. Bunting, Ella K. Lacey, Sara E. Hamplova, Monlan Yuan, Michael S. Wolfe, David A. Bennett, Eunjung A. Lee, Bruce A. Yankner

    Published 2023-11-01
    “…Here we describe an integrated neurodegeneration checkpoint response to early pathological changes that restricts further disease progression and preserves cognitive function. …”
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    Defective phagocytosis leads to neurodegeneration through systemic increased innate immune signaling by Johnny E. Elguero, Guangmei Liu, Katherine Tiemeyer, Shruthi Bandyadka, Heena Gandevia, Lauren Duro, Zhenhao Yan, Kimberly McCall

    Published 2023-10-01
    “…Loss of Draper leads to persistent neuronal cell corpses and age-dependent neurodegeneration. Here we investigate whether the phagocytic defects observed in draper mutants lead to chronic increased immune activation that promotes neurodegeneration. …”
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    Beyond the Primary Infarction: Focus on Mechanisms Related to Secondary Neurodegeneration after Stroke by Lin Kooi Ong

    Published 2022-12-01
    “…Recently, a growing body of evidence has indicated that secondary neurodegeneration after stroke occurs at remote regions of the brain that are connected to the primary infarction site [...]…”
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    <i>CLEC16A</i>—An Emerging Master Regulator of Autoimmunity and Neurodegeneration by Rahul Pandey, Marina Bakay, Hakon Hakonarson

    Published 2023-05-01
    “…As shown in both human and animal modeling studies, CLEC16A hypofunction predisposes to both autoinflammatory phenotype and neurodegeneration. While the two are clearly related, further functional studies are needed to fully understand the mechanisms involved for optimized therapeutic interventions. …”
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