Emerging evidence for compromised axonal bioenergetics and axoglial metabolic coupling as drivers of neurodegeneration by Bogdan Beirowski

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Early pheromone perception remodels neurodevelopment and accelerates neurodegeneration in adult C. elegans by Jing-Yi Peng, Xuqing Liu, Xian-Ting Zeng, Yue Hao, Jia-Hui Zhang, Qian Li, Xia-Jing Tong

“…However, how chemical cues modulate neurodegeneration remains unclear. Here, we found that in Caenorhabditis elegans, exposure to pheromones in the L1 stage accelerates neurodegeneration in adults. …”
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Measurement of neurodegeneration using a multivariate early frame amyloid PET classifier by Dawn C. Matthews, Ana S. Lukic, Randolph D. Andrews, Miles N. Wernick, Stephen C. Strother, Mark E. Schmidt, for the Alzheimer's Disease Neuroimaging Initiative

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Natural Products Targeting Hsp90 for a Concurrent Strategy in Glioblastoma and Neurodegeneration by Sarmistha Mitra, Raju Dash, Yeasmin Akter Munni, Nusrat Jahan Selsi, Nasrin Akter, Md Nazim Uddin, Kishor Mazumder, Il Soo Moon

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Amyloid-tau-neurodegeneration profiles and longitudinal cognition in sporadic young-onset dementia by Vipin, Ashwati, Koh, Chen Ling, Wong, Benjamin Yi Xin, Zailan, Fatin Zahra, Tan, Jayne Yi, Soo, See Ann, Satish, Vaynii, Kumar, Dilip, Wang, Brian Zhiyang, Ng, Adeline Su Lyn, Chiew, Hui Jin, Ng, Kok Pin, Kandiah, Nagaendran

“…We examined amyloid-tau-neurodegeneration biomarker effects on cognition in a Southeast-Asian cohort of 84 sporadic young-onset dementia (YOD; age-at-onset <65 years) patients. …”
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Insight of brain degenerative protein modifications in the pathology of neurodegeneration and dementia by proteomic profiling by Adav, Sunil Shankar, Sze, Siu Kwan

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Celecoxib as a neuroprotective agent in chronic cerebral hypoperfusion-induced neurodegeneration in rats by Saxena, Anil Kumar, Mohd Noor, Mohd Fadly, A.Talib, Norlelawati

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Neurodegeneration and brain cancer: a longitudinal field study of rest-activity and sleep by Wams, E

“…<p>This thesis investigates rest-activity and sleep profiles in neurodegeneration and brain cancer. Study 1 comprised longitudinal field assessments of rest-activity, sleep and memory in controls and memory-impairment individuals with: subjective memory complaint (SMC), amnestic mild cognitive impairment (aMCI), mild and moderate Alzheimer’s disease (AD). …”

The synthesis of minds and molecules leads to potential therapy for pantothenate kinase-associated neurodegeneration. by Németh, A

A functional misexpression screen uncovers a role for enabled in progressive neurodegeneration by Rezával, C, Berni, J, Gorostiza, E, Werbajh, S, Fagilde, M, Fernández, M, Beckwith, E, Aranovich, E, Sabio Y García, C, Ceriani, M

“…We carried out a misexpression screen to identify genes involved in neurodegeneration examining locomotor behavior in young and aged flies. …”

Concurrent multiple sclerosis and amyotrophic lateral sclerosis: where inflammation and neurodegeneration meet? by Li, G, Esiri, M, Ansorge, O, DeLuca, G

“…The intricate relationship between neuroinflammation and neurodegeneration in these diseases is discussed.…”

Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7. by Tan, J, Vance, K, Varela, M, Sirey, T, Watson, L, Curtis, H, Marinello, M, Alves, S, Steinkraus, B, Cooper, S, Nesterova, T, Brockdorff, N, Fulga, T, Brice, A, Sittler, A, Oliver, P, Wood, M, Ponting, C, Marques, A

“…Our results illustrate how noncoding RNA-mediated feedback regulation of a ubiquitously expressed housekeeping gene may contribute to specific neurodegeneration.…”

Cognitive impairment in bipolar disorder: neurodevelopment or neurodegeneration? An ECNP expert meeting report. by Goodwin, G, Martinez-Aran, A, Glahn, D, Vieta, E

The role of the cdk5 pathway and NMDA receptor phosphorylation in neurodegeneration in hippocampal sclerosis by Falah, M

An association between insulin resistance and neurodegeneration in zebrafish larval model (Danio rerio) by Md Razip, Nurliyana Najwa, Mohd Noor, Suzita, Norazit, Anwar, Nordin, Norshariza, Mohd Sakeh, Nurshafika, Khaza’ai, Huzwah

“…Background: Type 2 diabetes mellitus has recently been identified as a mediator of neurodegeneration. However, the molecular mechanisms have not been clearly elucidated. …”

Understanding the disease mechanisms of cerebellar ataxia through induced pluripotent stem cell models by Wong, M

Subjects: “…neurodegeneration…”

Mitochondrial Membrane Protein-associated Neurodegeneration: Two Adult Cases with Different Clinical Presentation by Şeyma Aykaç, Hanife Karakaya, Burhanettin Uludağ, Hatice Karasoy

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Protocol for the Tallaght University Hospital Institute for Memory and Cognition-Biobank for Research in Ageing and Neurodegeneration by Eimear Connolly, Shane Lyons, Cliona O’Farrelly, Graham Knight, Antoinette O’Connor, Adam H Dyer, Sean P Kennelly, Emily Killeen, Christine Gaffney, Helena Dolphin, Laura Morrison, Gavin Sedgwick, Aoife McFeely, Conal Gallagher, Naomi Davey, Conor Young, Ruth Ennis, Cathy McHale, Jasmine Joseph, Emmet Kelly, Nollaig M Bourke, Aoife Fallon, Sean O’Dowd

“…However, further discovery and validation cohorts are required to clarify the real-world utility of new biomarkers, facilitate research into the development of novel therapies and advance our understanding of the clinical heterogeneity and pathobiology of neurodegenerative diseases.Methods and analysis The Tallaght University Hospital Institute for Memory and Cognition Biobank for Research in Ageing and Neurodegeneration (TIMC-BRAiN) will recruit 1000 individuals over 5 years. …”
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Editorial: Infection, inflammation, and neurodegeneration: A critical path to Alzheimer's disease, Volume II by Roberta Mancuso, Simone Agostini, Denah M. Appelt, Brian J. Balin

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Characterization of Fluid Biomarkers Reveals Lysosome Dysfunction and Neurodegeneration in Neuronopathic MPS II Patients by Akhil Bhalla, Ritesh Ravi, Meng Fang, Annie Arguello, Sonnet S. Davis, Chi-Lu Chiu, Jessica R. Blumenfeld, Hoang N. Nguyen, Timothy K. Earr, Junhua Wang, Giuseppe Astarita, Yuda Zhu, Damian Fiore, Kimberly Scearce-Levie, Dolores Diaz, Heather Cahan, Matthew D. Troyer, Jeffrey M. Harris, Maria L. Escolar

“…We extended the characterization of pathway and neurodegeneration biomarkers to nMPS II patient samples. …”
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