Whole Exome Sequencing Reveals Novel Candidate Genes in Familial Forms of Glaucomatous Neurodegeneration by Kiran Narta, Manoj Ramesh Teltumbade, Mansi Vishal, Samreen Sadaf, Mohd. Faruq, Hodan Jama, Naushin Waseem, Aparna Rao, Abhijit Sen, Kunal Ray, Arijit Mukhopadhyay

Get full text

Blocking dPerk in the intestine suppresses neurodegeneration in a Drosophila model of Parkinson’s disease by Rebeka Popovic, Amrita Mukherjee, Nuno Santos Leal, Lydia Morris, Yizhou Yu, Samantha H. Y. Loh, L. Miguel Martins

Get full text

Ameliorative Effects of FMRFamide on 3,4-Methylenedioxyl-Methamphetamine /Tramadol-Induced Neurodegeneration in the Hippocampus by Olubunmi Ogunbiyi, Kehinde Adeniji, Leviticus Arietarhire, Patrick Okwute, Daniel Abaneme, Joseph Enya, Oladimeji Soremekun, Adekunle Mofolorunso, Oluwatosin Soyinka, Stephen Adelodun, Sunday Olatunji, Toluwanimi Afolabi, Testimony Ajibade, Afoluwajuwonlo Obaoye, Moyosoluwa Dada, Joshua Owolabi, John Olanrewaju

Subjects: Get full text

Gut–Brain Axis and Neurodegeneration: State-of-the-Art of Meta-Omics Sciences for Microbiota Characterization by Bruno Tilocca, Luisa Pieroni, Alessio Soggiu, Domenico Britti, Luigi Bonizzi, Paola Roncada, Viviana Greco

“…The increasing accumulation of evidence suggest a pivotal role of the composition and activity of the gut microbiota in neurodegeneration. In the present review we aim to provide an overview of the state-of-the-art of meta-omics sciences including metagenomics for the study of microbial genomes and taxa strains, metatranscriptomics for gene expression, metaproteomics and metabolomics to identify and/or quantify microbial proteins and metabolites, respectively. …”
Get full text

BDNF and Pro-BDNF in Amyotrophic Lateral Sclerosis: A New Perspective for Biomarkers of Neurodegeneration by Giulia Riolo, Claudia Ricci, Nicoletta De Angelis, Carlotta Marzocchi, Gisella Guerrera, Giovanna Borsellino, Fabio Giannini, Stefania Battistini

Get full text

RGC-specific ATF4 and/or CHOP deletion rescues glaucomatous neurodegeneration and visual function by Fang Fang, Pingting Liu, Haoliang Huang, Xue Feng, Liang Li, Yang Sun, Randal J. Kaufman, Yang Hu

“…These studies suggest that blocking the neuronal intrinsic ATF4/CHOP axis of ER stress is a promising neuroprotection strategy for neurodegeneration.…”
Get full text

Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration by Juan García-Revilla, Antonio Boza-Serrano, Ana M. Espinosa-Oliva, Manuel Sarmiento Soto, Tomas Deierborg, Rocío Ruiz, Rocío M. de Pablos, Miguel Angel Burguillos, Jose L. Venero

Get full text

AGE-RAGE axis culminates into multiple pathogenic processes: a central road to neurodegeneration by Reshmee Bhattacharya, Mohammad Rizwan Alam, Mohammad Azhar Kamal, Kyung Jin Seo, Laishram Rajendrakumar Singh

Subjects: Get full text

Mitochondrial membrane protein-associated neurodegeneration (MPAN): Two phenotypes—dystonia and spastic paraparesis by Sruthi Kola, Sai S L. Meka, Syed T Fathima, Abdul Wahed, Rukmini M Kandadai, Rupam Borgohain

Get full text

Low-Density Lipoprotein Receptor-Related Protein 8 at the Crossroad between Cancer and Neurodegeneration by Daniela Passarella, Silvia Ciampi, Valentina Di Liberto, Mariachiara Zuccarini, Maurizio Ronci, Alessandro Medoro, Emanuele Foderà, Monica Frinchi, Donatella Mignogna, Claudio Russo, Carola Porcile

“…The present review analyzes the contributions of LDL receptors, specifically of LRP8, in both cancer and neurodegeneration, pointing out that depending on various interactions and peculiar processing, the receptor can contribute to both proliferative and neurodegenerative processes.…”
Get full text

Dopaminergic neurodegeneration in the substantia nigra is associated with olfactory dysfunction in mice models of Parkinson’s disease by Yu Yuan, Xizhen Ma, Xiaoqing Mi, Le Qu, Meiyu Liang, Mengyu Li, Youcui Wang, Ning Song, Junxia Xie

“…Taken together, this study shows a direct relationship between nigral dopaminergic neurodegeneration and olfactory dysfunction in PD models and put forward the understandings that olfactory dysfunction represents the early stage of neurodegeneration in PD progression.…”
Get full text

IL-33 regulates Müller cell-mediated retinal inflammation and neurodegeneration in diabetic retinopathy by Josy Augustine, Sofia Pavlou, Kevin Harkin, Alan W. Stitt, Heping Xu, Mei Chen

Get full text

Comorbid Neurodegeneration in Primary Progressive Aphasia: Clinicopathological Correlations in a Single-Center Study by Robert Rusina, Radoslava Bajtosova, Zsolt Cséfalvay, Jiri Keller, Anna Kavkova, Jaromír Kukal, Radoslav Matej

Get full text

Correction: The db/db Mouse: A Useful Model for the Study of Diabetic Retinal Neurodegeneration.

Get full text

Homozygous mutation in CSF1R causes brain abnormalities, neurodegeneration, and dysosteosclerosis (BANDDOS) by Hossein Daghagh, Haniyeh Rahbar Kafshboran, Yousef Daneshmandpour, Maryam Nasiri Aghdam, Shahrzad Talebian, Jafar Nouri Nojadeh, Hamid Hamzeiy, Saskia Biskup, Ebrahim Sakhinia

“…Mutations in this gene cause hereditary diffuse leukoencephalopathy with spheroids (HDLS) with autosomal dominant inheritance and BANDDOS (Brain Abnormalities, Neurodegeneration, and Dysosteosclerosis) with autosomal recessive inheritance. …”
Get full text

The Many Faces of Post-Ischemic Tau Protein in Brain Neurodegeneration of the Alzheimer’s Disease Type by Ryszard Pluta, Stanisław J. Czuczwar, Sławomir Januszewski, Mirosław Jabłoński

“…Recent data suggest that post-ischemic brain neurodegeneration in humans and animals is associated with the modified tau protein in a manner typical of Alzheimer’s disease neuropathology. …”
Get full text

Parkinson’s Disease, It Takes Guts: The Correlation between Intestinal Microbiome and Cytokine Network with Neurodegeneration by Georgia Xiromerisiou, Chrysoula Marogianni, Anastasia Androutsopoulou, Panagiotis Ntavaroukas, Dimitrios Mysiris, Stamatia Papoutsopoulou

Get full text

Increase in brain glycogen levels ameliorates Huntington's disease phenotype and rescues neurodegeneration in Drosophila by Akanksha Onkar, Deepashree Sheshadri, Anupama Rai, Arjit Kant Gupta, Nitin Gupta, Subramaniam Ganesh

Get full text

A powerful yeast model to investigate the synergistic interaction of α-synuclein and tau in neurodegeneration. by Gianmario Ciaccioli, Ana Martins, Cátia Rodrigues, Helena Vieira, Patrícia Calado

“…Taken together, the strains described in the present study are able to mimic relevant pathogenic features involved in neurodegeneration and are powerful tools to identify potential target genes able to modulate the synergistic pathway driven by ASYN and tau interaction.…”
Get full text

Exploration of the glutamate-mediated retinal excitotoxic damage: a rat model of retinal neurodegeneration by Ling Gao, Qi-Jun Zheng, Li-Qian-Yu Ai, Kai-Jian Chen, Yuan-Guo Zhou, Jian Ye, Wei Liu

Subjects: “…retinal neurodegeneration…”
Get full text