Showing 81 - 100 results of 8,186 for search '"neurodegeneration"', query time: 0.10s Refine Results
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    Phenotyping Neurodegeneration in Human iPSCs by Li, Jonathan, Fraenkel, Ernest

    Published 2021
    “…However, many patients with neurodegenerative diseases do not have a known genetic cause. iPSCs offer a way to generate patient-specific models and study pathways of dysfunction in an in vitro setting in order to understand the causes and subtypes of neurodegeneration. Furthermore, iPSC-based models can be used to search for candidate therapeutics using high-throughput screening. …”
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    Inflammation versus neurodegeneration: consequences for treatment. by Palace, J

    Published 2007
    “…Inflammation is assumed to be the main driver of neurodegeneration in multiple sclerosis. However there is evidence that questions this hypothesis: Data from pathological studies and from imaging have shown that neuronal/axonal damage occurs early in lesion formation and at the earliest clinical stage of the disease. …”
    Journal article
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    Drosophila Toll-9 is induced by aging and neurodegeneration to modulate stress signaling and its deficiency exacerbates tau-mediated neurodegeneration by Yasufumi Sakakibara, Risa Yamashiro, Sachie Chikamatsu, Yu Hirota, Yoko Tsubokawa, Risa Nishijima, Kimi Takei, Michiko Sekiya, Koichi M. Iijima

    Published 2023-02-01
    “…Toll-9 expression was also induced by nerve injury but did not affect acute stress response or glial engulfment activity, suggesting Toll-9 may modulate subsequent neurodegeneration. In a fly tauopathy model, Toll-9 deficiency enhanced neurodegeneration and disease-related tau phosphorylation with reduced SAPK activity, and blocking SAPK enhanced tau phosphorylation and neurodegeneration. …”
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