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6281
Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease
Published 2019-05-01“…However, it is difficult to maintain over a lifetime in postmitotic cells such as neurons, in which DNA damage increases with age and is exacerbated by multiple neurological disorders, including Alzheimer’s disease (AD). …”
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6282
Lessons learned from rapid exome sequencing for 575 critically ill patients across the broad spectrum of rare disease
Published 2024-01-01“…These patients presented with a wide spectrum of rare diseases, including but not limited to neurological disorders, severe combined immune deficiency, and cancer.Results: During the study period, there was a significant increase in rES referrals, with a rise from a total of two referrals in Q1-2016 to 10 referrals per week in Q4-2019. …”
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6283
Enhancing Performance and Bit Rates in a Brain–Computer Interface System With Phase-to-Amplitude Cross-Frequency Coupling: Evidences From Traditional c-VEP, Fast c-VEP, and SSVEP D...
Published 2018-05-01“…For that reason, BCI systems are of high clinical value for targeted populations suffering from neurological disorders. In this paper, we present a new processing approach in three publicly available BCI data sets: (a) a well-known multi-class (N = 6) coded-modulated Visual Evoked potential (c-VEP)-based BCI system for able-bodied and disabled subjects; (b) a multi-class (N = 32) c-VEP with slow and fast stimulus representation; and (c) a steady-state Visual Evoked potential (SSVEP) multi-class (N = 5) flickering BCI system. …”
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6284
Genetic deletion of Krüppel-like factor 11 aggravates traumatic brain injury
Published 2022-11-01“…Krüppel-like transcription factor 11 (KLF 11) belongs to the zinc finger family of transcription factors and actively participates in various pathophysiological processes in neurological disorders. Up to now, the role and molecular mechanisms of KLF11 in regulating the pathogenesis of brain trauma is poorly understood. …”
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6285
Angiotensin II Type I Receptor (AT1R): The Gate towards COVID-19-Associated Diseases
Published 2022-03-01“…COVID-19 is well known for generating respiratory symptoms, but because ACE2 is expressed in various body tissues, several extrapulmonary pathologies are also manifested, including neurologic disorders, vasculature and myocardial complications, kidney injury, gastrointestinal symptoms, hepatic injury, hyperglycemia, and dermatologic complications. …”
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6286
Mechanics of morphogenesis in neural development: In vivo, in vitro, and in silico
Published 2023-01-01“…The combination of these approaches can complement each other to unveil fundamental mechanisms of the neural morphogenesis and shed light on the development, prevention, and treatment of neurological disorders.…”
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6287
Safety and therapeutic effects of personalized transcranial direct current stimulation based on electrical field simulation for prolonged disorders of consciousness: study protocol...
Published 2023-06-01“…Adverse events will be recorded during each treatment session.DiscussionFor patients with neurological disorders, tDCS has served as a painless, non-invasive, easily applied, and effective therapy for several decades, and there is some evidence that it can improve the level of consciousness of patients with DOC. …”
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6288
Disease-specific health spending by age, sex, and type of care in Norway: a national health registry study
Published 2023-06-01“…Results The top five aggregate causes of Norwegian health spending in 2019 were mental and substance use disorders (20.7%), neurological disorders (15.4%), cardiovascular diseases (10.1%), diabetes, kidney, and urinary diseases (9.0%), and neoplasms (7.2%). …”
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6289
Potential Epha2 Receptor Blockers Involved in Cerebral Malaria from <i>Taraxacum officinale</i>, <i>Tinospora cordifolia</i>, <i>Rosmarinus officinalis</i> and <i>Ocimum basilicum<...
Published 2022-11-01“…EphA2 receptors have been linked to several neurological disorders and have a vital role in the CM-associated breakdown of the blood–brain barrier. …”
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6290
Assessing walking ability using a robotic gait trainer: opportunities and limitations of assist-as-needed control in spinal cord injury
Published 2023-09-01“…Abstract Background Walking impairments are a common consequence of neurological disorders and are assessed with clinical scores that suffer from several limitations. …”
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6291
Identification of potential biomarkers to predict organ morbidity in COVID-19: A repository based proteomics perspective
Published 2023-09-01“…The potential biomarker candidates that can flag organ systems involved are: (a) Vitamin K-dependent protein S and Antithrombin-III for hematological disorders; (b) Voltage-dependent anion-selective channel protein 1 for neurological disorders; (c) Filamin-A for cardiovascular disorder and, (d) Peptidyl-prolyl cis-trans isomerase A and Peptidyl-prolyl cis-trans isomerase FKBP1A for digestive disorders.…”
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6292
4-(Azolyl)-Benzamidines as a Novel Chemotype for ASIC1a Inhibitors
Published 2024-03-01“…Growing data suggest that ASIC1a channels are a potential therapeutic target for treating a variety of neurological disorders, including stroke, epilepsy and pain. …”
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6293
Peer Mentoring Program for Informal Caregivers of Homebound Individuals With Advanced Parkinson Disease (Share the Care): Protocol for a Single-Center, Crossover Pilot Study
Published 2022-05-01“…Studies in other neurologic disorders, however, have demonstrated the potential for peer mentoring interventions to improve caregiver outcomes. …”
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6294
Multilineage Differentiating Stress Enduring (Muse) Cells: A New Era of Stem Cell-Based Therapy
Published 2023-06-01“…Indeed, Muse cells have the potential to break through the limitations of current cell-based therapies, and many clinical trials have been conducted, applying intravenously administered Muse cells in stroke, myocardial infarction, neurological disorders and acute respiratory distress syndrome (ARDS) related to novel coronavirus (SARS-CoV-2) infection. …”
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6295
Seizures in febrile children with SARS-CoV-2 infection: clinical features, short-term follow-up
Published 2024-04-01“…Nonetheless, patients with COVID-19 who present with seizures and persistent impaired consciousness need to be alerted to serious neurological disorders such as acute necrotizing encephalopathy. …”
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6296
Neuropharmacological Activity of the Acetonic Extract of <i>Malpighia mexicana</i> A. Juss. and Its Phytochemical Profile
Published 2023-10-01“…Mental and neurological disorders are conditions that affect thoughts, emotions, behavior, and relationships. …”
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6297
ATP2B3 Inhibition Alleviates Erastin–Induced Ferroptosis in HT-22 Cells through the P62–KEAP1–NRF2–HO-1 Pathway
Published 2023-05-01“…Ferroptosis participates in the occurrence and development of neurological disorders. Modulating ferroptosis may have therapeutic potential in nervous system diseases. …”
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6298
Porcine Hemagglutinating Encephalomyelitis Virus Co-Opts Multivesicular-Derived Exosomes for Transmission
Published 2023-02-01“…ABSTRACT Porcine hemagglutinating encephalomyelitis virus (PHEV) is a member of the family Coronaviridae, genus Betacoronavirus, and subgenus Embecovirus that causes neurological disorders, vomiting and wasting disease (VWD), or influenza-like illness (ILI) in pigs. …”
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6299
Identification of 6ω-cyclohexyl-2-(phenylamino carbonylmethylthio)pyrimidin-4(3H)-ones targeting the ZIKV NS5 RNA dependent RNA polymerase
Published 2022-10-01“…Zika virus (ZIKV), a mosquito-borne flavivirus, is a global health concern because of its association with severe neurological disorders such as neonatal microcephaly and adult Guillain-Barre syndrome. …”
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6300
A Deep Learning System for Automated Quality Evaluation of Optic Disc Photographs in Neuro-Ophthalmic Disorders
Published 2023-01-01“…The overall accuracy to distinguish among the three classes was 90.6% (95% CI, 89.1–92.1%), suggesting that this DLS could select optimal quality fundus photographs in patients with neuro-ophthalmic and neurological disorders affecting the ONH.…”
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