Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease by Niraj M. Shanbhag, Mark D. Evans, Wenjie Mao, Alissa L. Nana, William W. Seeley, Anthony Adame, Robert A. Rissman, Eliezer Masliah, Lennart Mucke

“…However, it is difficult to maintain over a lifetime in postmitotic cells such as neurons, in which DNA damage increases with age and is exacerbated by multiple neurological disorders, including Alzheimer’s disease (AD). …”
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Lessons learned from rapid exome sequencing for 575 critically ill patients across the broad spectrum of rare disease by Abderrahim Marouane, Abderrahim Marouane, Kornelia Neveling, Kornelia Neveling, A. Chantal Deden, Simone van den Heuvel, Dimitra Zafeiropoulou, Steven Castelein, Frank van de Veerdonk, David A. Koolen, Annet Simons, Richard Rodenburg, Dineke Westra, Arjen R. Mensenkamp, Nicole de Leeuw, Marjolijn Ligtenberg, Rene Matthijsse, Rolph Pfundt, Erik Jan Kamsteeg, Han G. Brunner, Christian Gilissen, Ilse Feenstra, Willem P. de Boode, Helger G. Yntema, Wendy A. G. van Zelst-Stams, Marcel Nelen, Lisenka E. L. M. Vissers, Lisenka E. L. M. Vissers

“…These patients presented with a wide spectrum of rare diseases, including but not limited to neurological disorders, severe combined immune deficiency, and cancer.Results: During the study period, there was a significant increase in rES referrals, with a rise from a total of two referrals in Q1-2016 to 10 referrals per week in Q4-2019. …”
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Enhancing Performance and Bit Rates in a Brain–Computer Interface System With Phase-to-Amplitude Cross-Frequency Coupling: Evidences From Traditional c-VEP, Fast c-VEP, and SSVEP D... by Stavros I. Dimitriadis, Stavros I. Dimitriadis, Stavros I. Dimitriadis, Stavros I. Dimitriadis, Stavros I. Dimitriadis, Avraam D. Marimpis

“…For that reason, BCI systems are of high clinical value for targeted populations suffering from neurological disorders. In this paper, we present a new processing approach in three publicly available BCI data sets: (a) a well-known multi-class (N = 6) coded-modulated Visual Evoked potential (c-VEP)-based BCI system for able-bodied and disabled subjects; (b) a multi-class (N = 32) c-VEP with slow and fast stimulus representation; and (c) a steady-state Visual Evoked potential (SSVEP) multi-class (N = 5) flickering BCI system. …”
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Genetic deletion of Krüppel-like factor 11 aggravates traumatic brain injury by Chao Zhou, Ping Sun, Milton H. Hamblin, Ke-Jie Yin

“…Krüppel-like transcription factor 11 (KLF 11) belongs to the zinc finger family of transcription factors and actively participates in various pathophysiological processes in neurological disorders. Up to now, the role and molecular mechanisms of KLF11 in regulating the pathogenesis of brain trauma is poorly understood. …”
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Angiotensin II Type I Receptor (AT1R): The Gate towards COVID-19-Associated Diseases by George El-Arif, Shaymaa Khazaal, Antonella Farhat, Julien Harb, Cédric Annweiler, Yingliang Wu, Zhijian Cao, Hervé Kovacic, Ziad Abi Khattar, Ziad Fajloun, Jean-Marc Sabatier

“…COVID-19 is well known for generating respiratory symptoms, but because ACE2 is expressed in various body tissues, several extrapulmonary pathologies are also manifested, including neurologic disorders, vasculature and myocardial complications, kidney injury, gastrointestinal symptoms, hepatic injury, hyperglycemia, and dermatologic complications. …”
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Mechanics of morphogenesis in neural development: In vivo, in vitro, and in silico by Joseph Sutlive, Hamed Seyyedhosseinzadeh, Zheng Ao, Haning Xiu, Sangita Choudhury, Kun Gou, Feng Guo, Zi Chen

“…The combination of these approaches can complement each other to unveil fundamental mechanisms of the neural morphogenesis and shed light on the development, prevention, and treatment of neurological disorders.…”
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Safety and therapeutic effects of personalized transcranial direct current stimulation based on electrical field simulation for prolonged disorders of consciousness: study protocol... by Mi-Jeong Yoon, Hyun Mi Oh, TaeYeong Kim, Soo-Jin Choi, Woo Hee Choi, Hong Soo Jung, Sung Chul Lim, Yeun Jie Yoo, Hye Jung Park, Bo Young Hong, Geun-Young Park, Donghyeon Kim, Tae-Woo Kim, Sun Im, Seong Hoon Lim

“…Adverse events will be recorded during each treatment session.DiscussionFor patients with neurological disorders, tDCS has served as a painless, non-invasive, easily applied, and effective therapy for several decades, and there is some evidence that it can improve the level of consciousness of patients with DOC. …”
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Disease-specific health spending by age, sex, and type of care in Norway: a national health registry study by Jonas Minet Kinge, Joseph L. Dieleman, Øystein Karlstad, Ann Kristin Knudsen, Søren Toksvig Klitkou, Simon I. Hay, Theo Vos, Christopher J. L. Murray, Stein Emil Vollset

“…Results The top five aggregate causes of Norwegian health spending in 2019 were mental and substance use disorders (20.7%), neurological disorders (15.4%), cardiovascular diseases (10.1%), diabetes, kidney, and urinary diseases (9.0%), and neoplasms (7.2%). …”
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Potential Epha2 Receptor Blockers Involved in Cerebral Malaria from <i>Taraxacum officinale</i>, <i>Tinospora cordifolia</i>, <i>Rosmarinus officinalis</i> and <i>Ocimum basilicum<... by Mohd Sayeed Shaikh, Fahadul Islam, Parag P. Gargote, Rutuja R. Gaikwad, Kalpana C. Dhupe, Sharuk L. Khan, Falak A. Siddiqui, Ganesh G. Tapadiya, Syed Sarfaraz Ali, Abhijit Dey, Talha Bin Emran

“…EphA2 receptors have been linked to several neurological disorders and have a vital role in the CM-associated breakdown of the blood–brain barrier. …”
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Assessing walking ability using a robotic gait trainer: opportunities and limitations of assist-as-needed control in spinal cord injury by Serena Maggioni, Lars Lünenburger, Robert Riener, Armin Curt, Marc Bolliger, Alejandro Melendez-Calderon

“…Abstract Background Walking impairments are a common consequence of neurological disorders and are assessed with clinical scores that suffer from several limitations. …”
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Identification of potential biomarkers to predict organ morbidity in COVID-19: A repository based proteomics perspective by Sabyasachi Bandyopadhyay, Madhan Vishal Rajan, Punit Kaur, Gururao Hariprasad

“…The potential biomarker candidates that can flag organ systems involved are: (a) Vitamin K-dependent protein S and Antithrombin-III for hematological disorders; (b) Voltage-dependent anion-selective channel protein 1 for neurological disorders; (c) Filamin-A for cardiovascular disorder and, (d) Peptidyl-prolyl cis-trans isomerase A and Peptidyl-prolyl cis-trans isomerase FKBP1A for digestive disorders.…”
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4-(Azolyl)-Benzamidines as a Novel Chemotype for ASIC1a Inhibitors by Maksym Platonov, Oleksandr Maximyuk, Alexey Rayevsky, Vasyl Hurmach, Olena Iegorova, Vasyl Naumchyk, Elijah Bulgakov, Andrii Cherninskyi, Danil Ozheredov, Serhiy V. Ryabukhin, Oleg Krishtal, Dmytro M. Volochnyuk

“…Growing data suggest that ASIC1a channels are a potential therapeutic target for treating a variety of neurological disorders, including stroke, epilepsy and pain. …”
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Peer Mentoring Program for Informal Caregivers of Homebound Individuals With Advanced Parkinson Disease (Share the Care): Protocol for a Single-Center, Crossover Pilot Study by Jori E Fleisher, Faizan Akram, Jeanette Lee, Ellen C Klostermann, Serena P Hess, Erica Myrick, Melissa Levin, Bichun Ouyang, Jayne Wilkinson, Deborah A Hall, Joshua Chodosh

“…Studies in other neurologic disorders, however, have demonstrated the potential for peer mentoring interventions to improve caregiver outcomes. …”
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Multilineage Differentiating Stress Enduring (Muse) Cells: A New Era of Stem Cell-Based Therapy by Raghad F. Alanazi, Basma S. Alhwity, Raghad M. Almahlawi, Bashayer D. Alatawi, Shatha A. Albalawi, Raneem A. Albalawi, Amaal A. Albalawi, Mohamed S. Abdel-Maksoud, Nehal Elsherbiny

“…Indeed, Muse cells have the potential to break through the limitations of current cell-based therapies, and many clinical trials have been conducted, applying intravenously administered Muse cells in stroke, myocardial infarction, neurological disorders and acute respiratory distress syndrome (ARDS) related to novel coronavirus (SARS-CoV-2) infection. …”
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Seizures in febrile children with SARS-CoV-2 infection: clinical features, short-term follow-up by Jipeng Jiang, Zhengsong Shen, Jie Cao

“…Nonetheless, patients with COVID-19 who present with seizures and persistent impaired consciousness need to be alerted to serious neurological disorders such as acute necrotizing encephalopathy. …”
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Neuropharmacological Activity of the Acetonic Extract of <i>Malpighia mexicana</i> A. Juss. and Its Phytochemical Profile by Dante Avilés-Montes, David Osvaldo Salinas-Sánchez, César Sotelo-Leyva, Alejandro Zamilpa, Franceli Itzel Batalla-Martinez, Rodolfo Abarca-Vargas, Juan Manuel Rivas-González, Óscar Dorado, Rodolfo Figueroa-Brito, Vera L. Petricevich, Dulce Lourdes Morales-Ferra, Manasés González-Cortazar

“…Mental and neurological disorders are conditions that affect thoughts, emotions, behavior, and relationships. …”
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ATP2B3 Inhibition Alleviates Erastin–Induced Ferroptosis in HT-22 Cells through the P62–KEAP1–NRF2–HO-1 Pathway by Shihui Guo, Aiying Zhong, Dongxu Zhang, Jiang Gao, Yingdong Ni, Ruqian Zhao, Wenqiang Ma

“…Ferroptosis participates in the occurrence and development of neurological disorders. Modulating ferroptosis may have therapeutic potential in nervous system diseases. …”
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Porcine Hemagglutinating Encephalomyelitis Virus Co-Opts Multivesicular-Derived Exosomes for Transmission by Zi Li, Shaoqian Mu, Yihan Tian, Junchao Shi, Yungang Lan, Jiyu Guan, Kui Zhao, Feng Gao, Wenqi He

“…ABSTRACT Porcine hemagglutinating encephalomyelitis virus (PHEV) is a member of the family Coronaviridae, genus Betacoronavirus, and subgenus Embecovirus that causes neurological disorders, vomiting and wasting disease (VWD), or influenza-like illness (ILI) in pigs. …”
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Identification of 6ω-cyclohexyl-2-(phenylamino carbonylmethylthio)pyrimidin-4(3H)-ones targeting the ZIKV NS5 RNA dependent RNA polymerase by Guang-Feng Zhou, Guang-Feng Zhou, Cong-Qiang Xie, Jian-Xia Xue, Jian-Xia Xue, Jing-Bo Wang, Yu-Zhuo Yang, Chang-Bo Zheng, Rong-Hua Luo, Ren-Hua Yang, Wen Chen, Liu-Meng Yang, Yue-Ping Wang, Hong-Bin Zhang, Yan-Ping He, Yong-Tang Zheng

“…Zika virus (ZIKV), a mosquito-borne flavivirus, is a global health concern because of its association with severe neurological disorders such as neonatal microcephaly and adult Guillain-Barre syndrome. …”
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A Deep Learning System for Automated Quality Evaluation of Optic Disc Photographs in Neuro-Ophthalmic Disorders by Ebenezer Chan, Zhiqun Tang, Raymond P. Najjar, Arun Narayanaswamy, Kanchalika Sathianvichitr, Nancy J. Newman, Valérie Biousse, Dan Milea, for the BONSAI Group

“…The overall accuracy to distinguish among the three classes was 90.6% (95% CI, 89.1–92.1%), suggesting that this DLS could select optimal quality fundus photographs in patients with neuro-ophthalmic and neurological disorders affecting the ONH.…”
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