Selection of single domain anti-transferrin receptor antibodies for blood-brain barrier transcytosis using a neurotensin based assay and histological assessment of target engagemen... by Shiran Su, Thomas J Esparza, David L Brody

“…The blood-brain barrier (BBB) presents a major obstacle in developing specific diagnostic imaging agents for many neurological disorders. In this study we aimed to generate single domain anti-mouse transferrin receptor antibodies (anti-mTfR VHHs) to mediate BBB transcytosis as components of novel MRI molecular contrast imaging agents. …”
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Effects of Fasting and Feeding on Transcriptional and Posttranscriptional Regulation of Insulin-Degrading Enzyme in Mice by Carlos M. González-Casimiro, Patricia Cámara-Torres, Beatriz Merino, Sergio Diez-Hermano, Tamara Postigo-Casado, Malcolm A. Leissring, Irene Cózar-Castellano, Germán Perdomo

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Serum neurofilament light chain and cognition decline in US elderly: A cross‐sectional study by Xiaodong Liu, Jun Chen, Chen Meng, Lan Zhou, Yong Liu

“…Neurofilament, a potential biomarker for neurological disorders, has gained attention. Our study aims to investigate the relationship between serum neurofilament light (sNfL) levels and cognitive function in elderly individuals in the United States. …”
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RETRACTED ARTICLE: Effect of apoptosis in neural stem cells treated with sevoflurane by Jianlei Qiu, Pengcai Shi, Wude Mao, Yuyi Zhao, Wenshuai Liu, Yuelan Wang

“…But long-time exposure to inhalation anesthetic could cause neurologic disorder, especially nerve degeneration in infant and developing brain. …”
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Mental Health Issue Accelerates Aging Faster than Smoking – Study Rings Alarm for Pakistan where it still remains a Taboo! by Noman Adil, Aruba Jamal, Sumbul Soha

“…The mental health variables tested included Depression, Sleep Issues, Hopelessness, Feeling unhappy, Loneliness, Married, Widowed, and Living in a Rural area. (2) Ageing directly predisposes individuals to diseases like Diabetes Type 2, Cancer, Cardiovascular and Neurological disorders which significantly affect the lifestyle and lifespan of individuals.(3) Talking about mental health is still seen as Taboo in Pakistan, and that’s why people don’t consider consulting about their mental health issues. …”
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Clinical and neuroimaging predictors of the outcome of microsurgical intervention against the background of cerebral aneurysms rupture by Viktoriya A. Kazantseva, Mykola O. Zorin

“…The effectiveness of MI in the case of CA rupture depends on the severity of prognostic criteria of clinical and neurological examination - evaluation by the GCS, neurological disorders, severity of parenchymal hemorrhage, manifestations of CAS on the day of surgery for TCD, the duration of surgery after CA rupture. …”
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Blood-brain barrier disruption defines the extracellular metabolome of live human high-grade gliomas by Cecile Riviere-Cazaux, Lucas P. Carlstrom, Karishma Rajani, Amanda Munoz-Casabella, Masum Rahman, Ali Gharibi-Loron, Desmond A. Brown, Kai J. Miller, Jaclyn J. White, Benjamin T. Himes, Ignacio Jusue-Torres, Samar Ikram, Seth C. Ransom, Renee Hirte, Ju-Hee Oh, William F. Elmquist, Jann N. Sarkaria, Rachael A. Vaubel, Moses Rodriguez, Arthur E. Warrington, Sani H. Kizilbash, Terry C. Burns

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A Stepped Health Services Intervention to Improve Care for Mental and Neurological Diseases: Protocol for a Prospective Cohort Trial by Johannes Pollmanns, Karlheinz Großgarten, Julia K Wolff, Hans-Dieter Nolting, Clarissa Graf, Frank Bergmann, Gereon Nelles

“… BackgroundMental and neurological disorders cause a large proportion of morbidity burden and require adequate health care structures. …”
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New-onset seizures misdiagnosed as psychogenic non-epileptic seizures: a case of paraneoplastic limbic encephalitis with primary testicular cancer by Axel Rivas, Daniel Levine, Cory Nichols, Mckenzie Merritt, Paul Janda, Aroucha Vickers

“…The authors theorize that paraneoplastic neurological disorders stemming from testicular cancer led to the neurological symptoms seen in this case. …”
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Neonatal Seizure Pattern, Outcome, and its Predictors Among Neonates Admitted to NICU of Ayder Comprehensive Specialized Hospital, Mekelle, Tigray, Ethiopia by Weldegerima K, Gebremariam DS, Haftu H, Berhe G, Hadgu A, Mohammedamin MM

“…Kiros Weldegerima,1 Dawit Seyoum Gebremariam,1 Hansa Haftu,1 Gebretsadik Berhe,2 Amanuel Hadgu,1 Mohammed Mustefa Mohammedamin1 1Mekelle University, College of Health Sciences, School of Medicine, Department of Pediatrics and Child Health, Mekelle, Ethiopia; 2Mekelle University, College of Health Sciences, School of Public Health, Department of Epidemiology, Mekelle, EthiopiaCorrespondence: Dawit Seyoum Gebremariam, Mekelle University, College of Health Sciences, School of Medicine, Department of Pediatrics and Child Health, P.O.Box 1871, Mekelle, Ethiopia, Tel +251011731454, Email dgseyoum@yahoo.comBackground: Seizure is the most frequently observed symptom of neurological disorders and an important determinant of outcome during neonatal period. …”
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Legacy lessons from the COVID-19 era to improve trial participation and retention: Views from trial participants, PPIE contributors and trial staff across the NIHR portfolio. by Heather Leggett, Karen Vinall-Collier, Julia Csikar, Sophy Barber, Rachel Carr, Amrit Bhatti, Sue Pavitt

“…<h4>Methods</h4>Interviews and focus groups were undertaken with PPIE contributors, trial participants and trial staff members from NIHR research trials across the UK (November 2020-June 2021) across portfolio specialities: Cancer, Oral and Dental Health, Musculoskeletal Disorders, Cardiovascular Disease, Neurological Disorders, Primary Care, and Conditions associated with susceptibility to Covid-19 (Diabetes, Stroke, Respiratory Disorders). …”
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Bioinformatics analysis of potential common pathogenic mechanism for carotid atherosclerosis and Parkinson’s disease by Quan Wang, Qun Xue

“…BackgroundCerebrovascular disease (CVD) related to atherosclerosis and Parkinson’s disease (PD) are two prevalent neurological disorders. They share common risk factors and frequently occur together. …”
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Single-cell RNA sequencing of CSF reveals neuroprotective RAC1+ NK cells in Parkinson’s disease by Qing Guan, Wei Liu, Ketao Mu, Qi Hu, Jiazhao Xie, Liming Cheng, Xiong Wang

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Six-month therapy of CGRP monoclonal antibodies in real-world clinical practice: an interim analysis of efficacy and safety data by N. V. Vashchenko, A. M. Uzhakhov, M. V. Bogorodskaya, D. Z. Korobkova, Ju. E. Azimova, K. V. Skorobogatykh

“…Migraine is one of the most common disabling neurological disorders. Recently developed monoclonal antibodies to calcitonin gene-related peptide (CGRP) or its receptor are the first targeted medication for preventive therapy of both episodic and chronic migraine. …”
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Dietary oleic acid contributes to the regulation of food intake through the synthesis of intestinal oleoylethanolamide by Miki Igarashi, Miki Igarashi, Miki Igarashi, Kensuke Iwasa, Tetsuhiko Hayakawa, Tsuyoshi Tsuduki, Ikuo Kimura, Ikuo Kimura, Kei Maruyama, Keisuke Yoshikawa

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Electrically Controlled Neurochemical Delivery from Microelectrodes for Focal and Transient Modulation of Cellular Behavior by Chao Tan, Neetu Kushwah, Xinyan Tracy Cui

“…Electrically controlled drug delivery of neurochemicals and biomolecules from conducting polymer microelectrode coatings hold great potentials in dissecting neural circuit or treating neurological disorders with high spatial and temporal resolution. …”
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SURVIVAL RATES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: REGIONAL REGISTRY DATA by R. R. Ismagilova, E. S. Zamanova, A. N. Maksudova

“…The main clinical manifestations of the disease were damages to the musculoskeletal system (n=199 (77%)), skin and mucous membranes (n=168 (66%)), and kidneys (n=155 (61%)), neurological disorders (n=39 (15%)) and serositis (n=83 (32%)). …”
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Seroprevalence of antibodies to Neospora caninum in dogs in the state of Alagoas, Brazil Soroprevalência de anticorpos anti-Neospora caninum em cães no estado de Alagoas, Brasil by Maria Evódia de Sousa, Wagnner José Nascimento Porto, Pedro Paulo Feitosa de Albuquerque, Orestes Luiz de Souza Neto, José Wilton Pinheiro Júnior, Rinaldo Aparecido Mota

“…Results indicate neosporosis must be included in differential diagnosis of dog neurological disorders.<br>Investigou-se a ocorrência de anticorpos anti-Neospora caninum em cães no Estado de Alagoas, Brasil e os fatores de risco associados à infecção. …”
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Assessing whether ad hoc clinician-generated patient questionnaires provide psychometrically valid information by Minji K. Lee, Jeffrey R. Basford, Allen W. Heinemann, Andrea Cheville

“…In exploratory factor analyses (EFA), 11 factors representing depression, respiratory symptoms, musculoskeletal pain, family support, mobility, activities of daily living, alcohol consumption, weight loss, fatigue, neurological disorders, and fear at home were identified. …”
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Modelling accessibility of adult neurology care in Australia, 2020–2034 by Tomas Kalincik, Merrilee Needham, Steve Simpson-Yap, Christian Lueck, Nicholas Child, Federico Frascoli, Charles Malpas, Benjamin Tsang, James Burrell, Lucinda Harrison, Lauren P Giles

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