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Selection of single domain anti-transferrin receptor antibodies for blood-brain barrier transcytosis using a neurotensin based assay and histological assessment of target engagemen...
Published 2022-01-01“…The blood-brain barrier (BBB) presents a major obstacle in developing specific diagnostic imaging agents for many neurological disorders. In this study we aimed to generate single domain anti-mouse transferrin receptor antibodies (anti-mTfR VHHs) to mediate BBB transcytosis as components of novel MRI molecular contrast imaging agents. …”
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6382
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6383
Serum neurofilament light chain and cognition decline in US elderly: A cross‐sectional study
Published 2024-01-01“…Neurofilament, a potential biomarker for neurological disorders, has gained attention. Our study aims to investigate the relationship between serum neurofilament light (sNfL) levels and cognitive function in elderly individuals in the United States. …”
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6384
RETRACTED ARTICLE: Effect of apoptosis in neural stem cells treated with sevoflurane
Published 2015-03-01“…But long-time exposure to inhalation anesthetic could cause neurologic disorder, especially nerve degeneration in infant and developing brain. …”
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6385
Mental Health Issue Accelerates Aging Faster than Smoking – Study Rings Alarm for Pakistan where it still remains a Taboo!
Published 2023-09-01“…The mental health variables tested included Depression, Sleep Issues, Hopelessness, Feeling unhappy, Loneliness, Married, Widowed, and Living in a Rural area. (2) Ageing directly predisposes individuals to diseases like Diabetes Type 2, Cancer, Cardiovascular and Neurological disorders which significantly affect the lifestyle and lifespan of individuals.(3) Talking about mental health is still seen as Taboo in Pakistan, and that’s why people don’t consider consulting about their mental health issues. …”
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6386
Clinical and neuroimaging predictors of the outcome of microsurgical intervention against the background of cerebral aneurysms rupture
Published 2024-03-01“…The effectiveness of MI in the case of CA rupture depends on the severity of prognostic criteria of clinical and neurological examination - evaluation by the GCS, neurological disorders, severity of parenchymal hemorrhage, manifestations of CAS on the day of surgery for TCD, the duration of surgery after CA rupture. …”
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6387
Blood-brain barrier disruption defines the extracellular metabolome of live human high-grade gliomas
Published 2023-06-01Get full text
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6388
A Stepped Health Services Intervention to Improve Care for Mental and Neurological Diseases: Protocol for a Prospective Cohort Trial
Published 2023-01-01“… BackgroundMental and neurological disorders cause a large proportion of morbidity burden and require adequate health care structures. …”
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6389
New-onset seizures misdiagnosed as psychogenic non-epileptic seizures: a case of paraneoplastic limbic encephalitis with primary testicular cancer
Published 2024-02-01“…The authors theorize that paraneoplastic neurological disorders stemming from testicular cancer led to the neurological symptoms seen in this case. …”
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6390
Neonatal Seizure Pattern, Outcome, and its Predictors Among Neonates Admitted to NICU of Ayder Comprehensive Specialized Hospital, Mekelle, Tigray, Ethiopia
Published 2023-09-01“…Kiros Weldegerima,1 Dawit Seyoum Gebremariam,1 Hansa Haftu,1 Gebretsadik Berhe,2 Amanuel Hadgu,1 Mohammed Mustefa Mohammedamin1 1Mekelle University, College of Health Sciences, School of Medicine, Department of Pediatrics and Child Health, Mekelle, Ethiopia; 2Mekelle University, College of Health Sciences, School of Public Health, Department of Epidemiology, Mekelle, EthiopiaCorrespondence: Dawit Seyoum Gebremariam, Mekelle University, College of Health Sciences, School of Medicine, Department of Pediatrics and Child Health, P.O.Box 1871, Mekelle, Ethiopia, Tel +251011731454, Email dgseyoum@yahoo.comBackground: Seizure is the most frequently observed symptom of neurological disorders and an important determinant of outcome during neonatal period. …”
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6391
Legacy lessons from the COVID-19 era to improve trial participation and retention: Views from trial participants, PPIE contributors and trial staff across the NIHR portfolio.
Published 2024-01-01“…<h4>Methods</h4>Interviews and focus groups were undertaken with PPIE contributors, trial participants and trial staff members from NIHR research trials across the UK (November 2020-June 2021) across portfolio specialities: Cancer, Oral and Dental Health, Musculoskeletal Disorders, Cardiovascular Disease, Neurological Disorders, Primary Care, and Conditions associated with susceptibility to Covid-19 (Diabetes, Stroke, Respiratory Disorders). …”
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6392
Bioinformatics analysis of potential common pathogenic mechanism for carotid atherosclerosis and Parkinson’s disease
Published 2023-08-01“…BackgroundCerebrovascular disease (CVD) related to atherosclerosis and Parkinson’s disease (PD) are two prevalent neurological disorders. They share common risk factors and frequently occur together. …”
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6393
Single-cell RNA sequencing of CSF reveals neuroprotective RAC1+ NK cells in Parkinson’s disease
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6394
Six-month therapy of CGRP monoclonal antibodies in real-world clinical practice: an interim analysis of efficacy and safety data
Published 2022-01-01“…Migraine is one of the most common disabling neurological disorders. Recently developed monoclonal antibodies to calcitonin gene-related peptide (CGRP) or its receptor are the first targeted medication for preventive therapy of both episodic and chronic migraine. …”
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6395
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6396
Electrically Controlled Neurochemical Delivery from Microelectrodes for Focal and Transient Modulation of Cellular Behavior
Published 2021-09-01“…Electrically controlled drug delivery of neurochemicals and biomolecules from conducting polymer microelectrode coatings hold great potentials in dissecting neural circuit or treating neurological disorders with high spatial and temporal resolution. …”
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6397
SURVIVAL RATES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: REGIONAL REGISTRY DATA
Published 2020-04-01“…The main clinical manifestations of the disease were damages to the musculoskeletal system (n=199 (77%)), skin and mucous membranes (n=168 (66%)), and kidneys (n=155 (61%)), neurological disorders (n=39 (15%)) and serositis (n=83 (32%)). …”
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6398
Seroprevalence of antibodies to Neospora caninum in dogs in the state of Alagoas, Brazil Soroprevalência de anticorpos anti-Neospora caninum em cães no estado de Alagoas, Brasil
Published 2012-09-01“…Results indicate neosporosis must be included in differential diagnosis of dog neurological disorders.<br>Investigou-se a ocorrência de anticorpos anti-Neospora caninum em cães no Estado de Alagoas, Brasil e os fatores de risco associados à infecção. …”
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6399
Assessing whether ad hoc clinician-generated patient questionnaires provide psychometrically valid information
Published 2020-03-01“…In exploratory factor analyses (EFA), 11 factors representing depression, respiratory symptoms, musculoskeletal pain, family support, mobility, activities of daily living, alcohol consumption, weight loss, fatigue, neurological disorders, and fear at home were identified. …”
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Modelling accessibility of adult neurology care in Australia, 2020–2034
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