Effect of polypharmacy on plasma bepridil concentration in patients with heart failure: a multicenter retrospective study by Yuki Asai, Hiroki Arihara, Saki Omote, Ena Tanio, Saena Yamashita, Takashi Higuchi, Ei Hashimoto, Momoko Yamada, Hinako Tsuji, Yoshihiro Kondo, Makoto Hayashi, Yoshiaki Yamamoto

Get full text

Longitudinal Analysis of the Microbiome and Metabolome in the 5xfAD Mouse Model of Alzheimer’s Disease by Sage J. B. Dunham, Katelyn A. McNair, Eric D. Adams, Julio Avelar-Barragan, Stefania Forner, Mark Mapstone, Katrine L. Whiteson

Get full text

Astaxanthin Suppresses PM2.5-Induced Neuroinflammation by Regulating Akt Phosphorylation in BV-2 Microglial Cells by Ryeong-Eun Kim, Chan Young Shin, Seol-Heui Han, Kyoung Ja Kwon

“…Recent studies suggest that fine particulate matter of less than 2.5 (PM2.5), common in air pollution, can reach the brain, potentially resulting in the development and acceleration of various neurological disorders including Alzheimer’s disease, Parkinson’s disease, and other forms of dementia, but the underlying pathological mechanisms are not clear. …”
Get full text

Impairment in Functioning and Quality of Life in Patients with Idiopathic Hypersomnia: The Real World Idiopathic Hypersomnia Outcomes Study (ARISE) by Stevens J, Schneider LD, Husain AM, Ito D, Fuller DS, Zee PC, Macfadden W

“…The Real World Idiopathic Hypersomnia Outcomes Study (ARISE) evaluated the daily functioning, relationships, cognition, emotional well-being, and productivity/employment of participants with idiopathic hypersomnia.Patients and Methods: ARISE was a US-based virtual cross-sectional survey comprising multiple patient-reported outcome measures (Functional Outcomes of Sleep Questionnaire, short version [FOSQ-10], Quality of Life in Neurological Disorders [Neuro-QoL] Social Roles and Stigma domains, British Columbia Cognitive Complaints Inventory [BC-CCI], Patient Health Questionnaire [PHQ-9], and the Work Productivity and Activity Impairment Questionnaire: Specific Health Problem [WPAI:SHP]). …”
Get full text

Non-target GC–MS analyses of fecal VOCs in NASH-hepatocellular carcinoma model STAM mice by Mai Kato, Momoka Yamaguchi, Akira Ooka, Ryota Takahashi, Takuji Suzuki, Keita Onoda, Yuko Yoshikawa, Yuta Tsunematsu, Michio Sato, Yasukiyo Yoshioka, Miki Igarashi, Sumio Hayakawa, Kumiko Shoji, Yutaka Shoji, Tomohisa Ishikawa, Kenji Watanabe, Noriyuki Miyoshi

Get full text

Distribution, Ecology, Chemistry and Toxicology of Plant Stinging Hairs by Hans-Jürgen Ensikat, Hannah Wessely, Marianne Engeser, Maximilian Weigend

“…The physiological effects of stinging hairs on humans vary widely between stinging plants and range from a slight itch, skin rash (urticaria), and oedema to sharp pain and even serious neurological disorders such as neuropathy. Numerous studies have attempted to elucidate the chemical basis of the physiological effects. …”
Get full text

Identification of mitochondrial related signature associated with immune microenvironment in Alzheimer’s disease by Yaodan Zhang, Yuyang Miao, Jin Tan, Fanglian Chen, Ping Lei, Qiang Zhang

“…Five hub MitoDEGs associated with neurological disorders were identified by biological function examination. …”
Get full text

Inclusion of calf implants for the correction of lower limb amyotrophy Inclusão de implantes de panturrilha na correção das amiotrofias dos membros inferiores by Thiago de Oliveira Lopes Cavalcanti, Ivo Pitanguy, Luiz Mário Bonfatti Ribeiro, Francisco Felipe Góis de Oliveira

“…In 4 of 5 patients, the desired result was obtained after a single surgical procedure, and no patient developed capsular contracture, compartment syndrome, circulatory disorders, neurological disorders, or infections. CONCLUSIONS: Calf augmentation in patients with lower limb amyotrophy did not correct the associated functional deficit, but resulted in a high level of satisfaction with regard to the esthetic improvement of the limb, thus improving the quality of life of these patients.…”
Get full text

Associations Between Repetitive Negative Thinking and Objective and Subjective Sleep Health in Cognitively Healthy Older Adults by Munns LB, Demnitz-King H, André C, Rehel S, Ourry V, de La Sayette V, Vivien D, Chételat G, Rauchs G, Marchant NL

“…Lydia B Munns,1,2,* Harriet Demnitz-King,1,* Claire André,3 Stéphane Rehel,3 Valentin Ourry,3 Vincent de La Sayette,4 Denis Vivien,3,5 Gaël Chételat,3 Géraldine Rauchs,3,* Natalie L Marchant1,* On behalf of the Medit-Ageing Research Group1Division of Psychiatry, University College London, London, UK; 2Department of Psychology, York University, York, UK; 3Normandie Univ, UNICAEN, INSERM, U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Neuropresage Team, GIP Cyceron, Caen, France; 4Service de Neurologie, CHU de Caen-Normandie, Caen, France; 5Département de Recherche Clinique, CHU Caen-Normandie, Caen, France*These authors contributed equally to this workCorrespondence: Natalie L Marchant, Division of Psychiatry, University College London, London, UK, Email n.marchant@ucl.ac.uk Lydia B Munns, Department of Psychology, York University, York, United Kingdom, Email lydbmunns@gmail.comObjective: Poor sleep and high levels of repetitive negative thinking (RNT), including future-directed (ie, worry) and past-directed (ie, brooding) negative thoughts, have been associated with markers of dementia risk. …”
Get full text

Claudicação na criança Limping in children by Cláudio Santili, Wilson Lino Júnior, Ellen de Oliveira Goiano, Romero Antunes Barreto Lins, Gilberto Waisberg, Susana dos Reis Braga, Miguel Akkari

“…Among infants (1 to 3 years old), diagnosis will most likely be: transitory synovitis, septic arthritis, neurological disorders (mild brain palsy (BP) and muscular dystrophy), congenital hip dislocation (CHD), varus thigh, juvenile rheumatoid arthritis (JRA) and neoplasias (osteoid osteoma, leukemia); in the scholar age group, between 4 and 10 years old, in addition to the diagnoses above, Legg-Calvé-Perthes disease, discoid meniscus, inferior limbs discrepancy and unspecific muscular pain; in adolescents (11 to 15 years old): slipped capital femoral epiphysis, congenital hip dislocation, chondrolysis, overuse syndromes, dissecans osteochondritis, and tarsal coalition. …”
Get full text

Integrating single-nucleus sequence profiling to reveal the transcriptional dynamics of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis by Li-Yuan Fan, Jing Yang, Ruo-Yu Liu, Ying Kong, Guang-Yu Guo, Yu-Ming Xu

“…Additionally, the identification of arctigenin as a potential therapeutic drug for AD, PD, and MS further highlights its potential in treating these neurological disorders. These discoveries lay the groundwork for future research and interventions to enhance our understanding and treatment of AD, PD, and MS.…”
Get full text

A novel framework for in-vivo diffusion tensor distribution MRI of the human brain by Kulam Najmudeen Magdoom, Alexandru V. Avram, Joelle E. Sarlls, Gasbarra Dario, Peter J. Basser

Get full text

Functional-oriented, portable brain–computer interface training for hand motor recovery after stroke: a randomized controlled study by Jianghong Fu, Shugeng Chen, Xiaokang Shu, Yifang Lin, Zewu Jiang, Dongshuai Wei, Jiajia Gao, Jie Jia, Jie Jia, Jie Jia

Get full text

Statin sebagai Protektor Otak pada Cedera Otak Traumatik by Kenanga Marwan, Cindy Elfira Boom, Rovina Ruslami

“…Statin, 3-hydroxy-3-methyglutaryl coenzym-A (HMG CoA) reductase inhibitor is hypolipidemik drug which has pleiotropic effect in cholesterol-independen manner and suggest potential effect in neurologic disorder such as decreased hemostatic and decreased thrombotic effect and cascade coagulation, increased fibrinolytic and anticoagulation cascade, improve endothelial function, increase nitric oxide bioaviability, antioxidan, immunomodulation and anti-inflammatory activity and stabilize plaque atheroslerotic. …”
Get full text

Applied Machine Learning Techniques to Diagnose Voice-Affecting Conditions and Disorders: Systematic Literature Review by Alper Idrisoglu, Ana Luiza Dallora, Peter Anderberg, Johan Sanmartin Berglund

“…ObjectiveThis study aims to summarize a comprehensive view of research on voice-affecting disorders that uses ML techniques for diagnosis and monitoring through voice samples where systematic conditions, nonlaryngeal aerodigestive disorders, and neurological disorders are specifically of interest. …”
Get full text

Oligoclonal IgG bands in the cerebrospinal fluid of portuguese patients with multiple sclerosis: negative results indicate benign disease Bandas oligoclonais da IgG no líquido céfa... by Maria José Sá, Lucinda Sequeira, Maria Edite Rio, Edward J. Thompson

“…Paired CSF/serum samples of 406 patients with neurological disorders were submitted to isoelectric focusing with immunodetection of IgG. …”
Get full text

Associations between cardiometabolic multimorbidity and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact adults: the CABLE study by Qiong-Yao Li, He-Ying Hu, Gao-Wen Zhang, Hao Hu, Ya-Nan Ou, Liang-Yu Huang, An-Yi Wang, Pei-Yang Gao, Li-Yun Ma, Lan Tan, Jin-Tai Yu

Get full text

Improving levodopa delivery: IPX203, a novel extended-release carbidopa-levodopa formulation by Peter LeWitt, Aaron Ellenbogen, Daniel Burdick, Steven Gunzler, Ramon Gil, Rohit Dhall, Ghazal Banisadr, Richard D'Souza

Get full text

Immature functional development of lumbar locomotor networks in adult Irf8−/− mice by Itaru Yazawa, Itaru Yazawa, Yuko Yoshida, Ryusuke Yoshimi, Ryusuke Yoshimi, Keiko Ozato

Get full text

38 Plasma proteomic signature of motoric cognitive risk syndrome by Gabriela T. Gomez, Sanish Sathyan, Jingsha Chen, Myriam Fornage, Pascal Schlosser, Zhongsheng Peng, Jenifer Cordon, Priya Palta, Kevin J. Sullivan, Adrienne Tin, B. Gwen Windham, Rebecca F. Gottesman, Josef Coresh, Nir Barzilai, Sofiya Milman, Joe Verghese, Keenan A. Walker

Get full text