Electrographic Seizures in Neonates with a High Risk of Encephalopathy by Wan-Hsuan Chen, Oi-Wa Chan, Jainn-Jim Lin, Ming-Chou Chiang, Shao-Hsuan Hsia, Huei-Shyong Wang, En-Pei Lee, Yi-Shan Wang, Cheng-Yen Kuo, Kuang-Lin Lin, on the behalf of the iCNS Group

“…The increased excitability in the neonatal brain appears to be highly susceptible to seizures after a variety of insults, and seizures may be the first clinical sign of a serious neurologic disorder. Subtle seizures are common in the neonatal period, and abnormal clinical paroxysmal events may raise the suspicion of neonatal seizures. …”
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Beta-Amyloid (Aβ_1-42) Increases the Expression of NKCC1 in the Mouse Hippocampus by Patricia Lam, Chitra Vinnakota, Beatriz Calvo-Flores Guzmán, Julia Newland, Katie Peppercorn, Warren P. Tate, Henry J. Waldvogel, Richard L. M. Faull, Andrea Kwakowsky

“…Altered expression levels of K-Cl-2 (KCC2) and N-K-Cl-1 (NKCC1), which are cation–chloride cotransporters (CCCs), have been implicated in disrupting GABAergic activity by regulating GABA_A receptor signaling polarity in several neurological disorders, but these have not yet been explored in AD. …”
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Whole genome sequencing identifies candidate genes for familial essential tremor and reveals biological pathways implicated in essential tremor aetiology by Lorraine N. Clark, Yizhe Gao, Gao T. Wang, Nora Hernandez, Allison Ashley-Koch, Joseph Jankovic, Ruth Ottman, Suzanne M. Leal, Sandra M. Barral Rodriguez, Elan D. Louis

“…Summary: Background: Essential tremor (ET), one of the most common neurological disorders, has a phenotypically heterogeneous presentation characterized by bilateral kinetic tremor of the arms and, in some patients, tremor involving other body regions (e.g., head, voice). …”
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Identification of miRNA–mRNA regulatory network associated with the glutamatergic system in post-traumatic epilepsy rats by Xiaoyuan Zhang, Xiaoyuan Zhang, Yixun Ma, Yixun Ma, Fengjuan Zhou, Fengjuan Zhou, Mengzhou Zhang, Mengzhou Zhang, Dong Zhao, Dong Zhao, Xu Wang, Xu Wang, Tiantong Yang, Tiantong Yang, Jun Ma, Jun Ma

“…BackgroundGlutamate is one of the most important excitatory neurotransmitters in the mammalian brain and is involved in a variety of neurological disorders. Increasing evidence also shows that microRNA (miRNA) and mRNA pairs are engaged in a variety of pathophysiological processes. …”
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Comparative effectiveness of decompressive craniectomy versus craniotomy for traumatic acute subdural hematoma (CENTER-TBI): an observational cohort studyResearch in context by Thomas A. van Essen, Inge A.M. van Erp, Hester F. Lingsma, Dana Pisică, John K. Yue, Ranjit D. Singh, Jeroen T.J.M. van Dijck, Victor Volovici, Alexander Younsi, Angelos Kolias, Lianne D. Peppel, Majanka Heijenbrok-Kal, Gerard M. Ribbers, David K. Menon, Peter J.A. Hutchinson, Geoffrey T. Manley, Bart Depreitere, Ewout W. Steyerberg, Andrew I.R. Maas, Godard C.W. de Ruiter, Wilco C. Peul, Cecilia Åkerlund, Krisztina Amrein, Nada Andelic, Lasse Andreassen, Audny Anke, Anna Antoni, Gérard Audibert, Philippe Azouvi, Maria Luisa Azzolini, Ronald Bartels, Pál Barzó, Romuald Beauvais, Ronny Beer, Bo-Michael Bellander, Antonio Belli, Habib Benali, Maurizio Berardino, Luigi Beretta, Morten Blaabjerg, Peter Bragge, Alexandra Brazinova, Vibeke Brinck, Joanne Brooker, Camilla Brorsson, Andras Buki, Monika Bullinger, Manuel Cabeleira, Alessio Caccioppola, Emiliana Calappi, Maria Rosa Calvi, Peter Cameron, Guillermo Carbayo Lozano, Marco Carbonara, Ana M. Castaño-León, Simona Cavallo, Giorgio Chevallard, Arturo Chieregato, Giuseppe Citerio, Hans Clusmann, Mark Steven Coburn, Jonathan Coles, Jamie D. Cooper, Marta Correia, Amra Čović, Nicola Curry, Endre Czeiter, Marek Czosnyka, Claire Dahyot-Fizelier, Paul Dark, Helen Dawes, Véronique De Keyser, Vincent Degos, Francesco Della Corte, Hugo den Boogert, Bart Depreitere, Đula Đilvesi, Abhishek Dixit, Emma Donoghue, Jens Dreier, Guy-Loup Dulière, Ari Ercole, Patrick Esser, Erzsébet Ezer, Martin Fabricius, Valery L. Feigin, Kelly Foks, Shirin Frisvold, Alex Furmanov, Pablo Gagliardo, Damien Galanaud, Dashiell Gantner, Guoyi Gao, Pradeep George, Alexandre Ghuysen, Lelde Giga, Ben Glocker, Jagoš Golubović, Pedro A. Gomez, Johannes Gratz, Benjamin Gravesteijn, Francesca Grossi, Russell L. Gruen, Deepak Gupta, Juanita A. Haagsma, Iain Haitsma, Raimund Helbok, Eirik Helseth, Lindsay Horton, Jilske Huijben, Peter J. Hutchinson, Bram Jacobs, Stefan Jankowski, Mike Jarrett, Ji-yao Jiang, Faye Johnson, Kelly Jones, Mladen Karan, Angelos G. Kolias, Erwin Kompanje, Daniel Kondziella, Evgenios Kornaropoulos, Lars-Owe Koskinen, Noémi Kovács, Alfonso Lagares, Linda Lanyon, Steven Laureys, Fiona Lecky, Didier Ledoux, Rolf Lefering, Valerie Legrand, Aurelie Lejeune, Leon Levi, Roger Lightfoot, Hester Lingsma, Andrew I.R. Maas, Marc Maegele, Marek Majdan, Alex Manara, Geoffrey Manley, Hugues Maréchal, Costanza Martino, Julia Mattern, Catherine McMahon, Béla Melegh, David Menon, Tomas Menovsky, Ana Mikolic, Benoit Misset, Visakh Muraleedharan, Lynnette Murray, Nandesh Nair, Ancuta Negru, David Nelson, Virginia Newcombe, Daan Nieboer, József Nyirádi, Matej Oresic, Fabrizio Ortolano, Olubukola Otesile, Aarno Palotie, Paul M. Parizel, Jean-François Payen, Natascha Perera, Vincent Perlbarg, Paolo Persona, Wilco Peul, Anna Piippo-Karjalainen, Matti Pirinen, Dana Pisica, Horia Ples, Suzanne Polinder, Inigo Pomposo, Jussi P. Posti, Louis Puybasset, Andreea Rădoi, Arminas Ragauskas, Rahul Raj, Malinka Rambadagalla, Veronika Rehorčíková, Isabel Retel Helmrich, Jonathan Rhodes, Sylvia Richardson, Sophie Richter, Samuli Ripatti, Saulius Rocka, Cecilie Roe, Olav Roise, Jonathan Rosand, Jeffrey Rosenfeld, Christina Rosenlund, Guy Rosenthal, Rolf Rossaint, Sandra Rossi, Daniel Rueckert, Martin Rusnák, Juan Sahuquillo, Oliver Sakowitz, Renan Sanchez-Porras, Janos Sandor, Nadine Schäfer, Silke Schmidt, Herbert Schoechl, Guus Schoonman, Rico Frederik Schou, Elisabeth Schwendenwein, Charlie Sewalt, Toril Skandsen, Peter Smielewski, Abayomi Sorinola, Emmanuel Stamatakis, Simon Stanworth, Ana Kowark, Robert Stevens, William Stewart, Ewout W. Steyerberg, Nino Stocchetti, Nina Sundström, Riikka Takala, Viktória Tamás, Tomas Tamosuitis, Mark Steven Taylor, Braden Te Ao, Olli Tenovuo, Alice Theadom, Matt Thomas, Dick Tibboel, Marjolijn Timmers, Christos Tolias, Tony Trapani, Cristina Maria Tudora, Andreas Unterberg, Peter Vajkoczy, Egils Valeinis, Shirley Vallance, Zoltán Vámos, Mathieu Van der Jagt, Joukje van der Naalt, Gregory Van der Steen, Jeroen T.J.M. van Dijck, Thomas A. van Essen, Wim Van Hecke, Caroline van Heugten, Dominique Van Praag, Ernest Van Veen, Roel van Wijk, Thijs Vande Vyvere, Alessia Vargiolu, Emmanuel Vega, Kimberley Velt, Jan Verheyden, Paul M. Vespa, Anne Vik, Rimantas Vilcinis, Victor Volovici, Nicole von Steinbüchel, Daphne Voormolen, Petar Vulekovic, Kevin K.W. Wang, Eveline Wiegers, Guy Williams, Lindsay Wilson, Stefan Winzeck, Stefan Wolf, Zhihui Yang, Peter Ylén, Alexander Younsi, Frederick A. Zeiler, Agate Ziverte, Tommaso Zoerle

“…Patients with severe pre-existing neurological disorders were excluded. In an instrumental variable analysis, we compared outcomes between centres according to treatment preference, measured by the case-mix adjusted proportion DC per centre. …”
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Predicting 2-year neurodevelopmental outcomes in extremely preterm infants using graphical network and machine learning approachesResearch in context by Sandra E. Juul, Thomas R. Wood, Kendell German, Janessa B. Law, Sarah E. Kolnik, Mihai Puia-Dumitrescu, Ulrike Mietzsch, Semsa Gogcu, Bryan A. Comstock, Sijia Li, Dennis E. Mayock, Patrick J. Heagerty, Rajan Wadhawan, Sherry E. Courtney, Tonya Robinson, Kaashif A. Ahmad, Ellen Bendel-Stenzel, Mariana Baserga, Edmund F. LaGamma, L. Corbin Downey, Raghavendra Rao, Nancy Fahim, Andrea Lampland, Ivan D. Frantz, III, Janine Khan, Michael Weiss, Maureen M. Gilmore, Nishant Srinivasan, Jorge E. Perez, Victor McKay

“…Funding: Supported by the National Institute of Neurological Disorders and Stroke U01NS077953 and U01NS077955.…”
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A pilot investigation of differential hydroxymethylation levels in patient-derived neural stem cells implicates altered cortical development in bipolar disorder by Ashish Kumar, Ashish Kumar, Mark Z. Kos, Donna Roybal, Donna Roybal, Melanie A. Carless, Melanie A. Carless, Melanie A. Carless

“…Environmental factors, such as maternal smoking and childhood trauma, are believed to modulate risk genotypes and contribute to the pathogenesis of BD, suggesting a key role in epigenetic regulation during neurodevelopment. 5-hydroxymethylcytosine (5hmC) is an epigenetic variant of particular interest, as it is highly expressed in the brain and is implicated in neurodevelopment, and psychiatric and neurological disorders.MethodsInduced pluripotent stem cells (iPSCs) were generated from the white blood cells of two adolescent patients with bipolar disorder and their same-sex age-matched unaffected siblings (n = 4). …”
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Analysis of the role of PANoptosis in seizures via integrated bioinformatics analysis and experimental validation by Yueying Liu, Yuanjin Chang, Xiaofan Jiang, Huiya Mei, Yingsi Cao, Dongqin Wu, Ruijin Xie, Wenjun Jiang, Emely Vasquez, Yu Wu, Shunyan Lin, Yachuan Cao

“…In recent studies, PANoptosis, a newly characterized form of cell death, has emerged as a significant contributor to the development of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. …”
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Plasma and cerebrospinal fluid neurofilament light concentrations reflect neuronal damage in systemic lupus Erythematosus by Kristoffer A. Zervides, Shorena Janelidze, Jessika Nystedt, Birgitta Gullstrand, Petra Nilsson, Pia C. Sundgren, Anders A. Bengtsson, Oskar Hansson, Andreas Jönsen

“…Neurofilament light (NfL) concentrations rise in plasma and cerebrospinal fluid (CSF) during neuronal damage in various neurological disorders. In this cross-sectional study, plasma and CSF concentrations of NfL were explored as a marker of neuronal damage in SLE. …”
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Administration of Bifidobacterium animalis subsp. lactis strain BB-12® in healthy children: characterization, functional composition, and metabolism of the gut microbiome by Carlotta Vizioli, Carlotta Vizioli, Rosario Jaime-Lara, Rosario Jaime-Lara, Rosario Jaime-Lara, Scott G. Daniel, Alexis Franks, Ana F. Diallo, Kyle Bittinger, Tina P. Tan, Daniel J. Merenstein, Brianna Brooks, Paule V. Joseph, Paule V. Joseph, Katherine A. Maki

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Comparing the clinical and cost-effectiveness of remote (telehealth and online) cognitive behavioral therapy-based treatments for high-impact chronic pain relative to usual care: s... by Meghan Mayhew, Benjamin H. Balderson, Andrea J. Cook, John F. Dickerson, Charles R. Elder, Alison J. Firemark, Irina V. Haller, Morgan Justice, Francis J. Keefe, Carmit K. McMullen, Maureen C. O’Keeffe-Rosetti, Ashli A. Owen-Smith, Christine Rini, Jennifer L. Schneider, Michael Von Korff, Laura D. Wandner, Lynn L. DeBar

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Deciphering the role of QPCTL in glioma progression and cancer immunotherapy by Yu’e Liu, Shaojuan Lu, Yihong Sun, Fei Wang, Shibo Yu, Xi Chen, Lei-lei Wu, Hui Yang, Hui Yang, Yufeng Shi, Kaijun Zhao

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Comparative Effectiveness of Robot-Assisted Training Versus Enhanced Upper Extremity Therapy on Upper and Lower Extremity for Stroke Survivors: A Multicentre Randomized Controlled... by Yingnan Lin, Qin-ying Li, Qingming Qu, Li Ding, Zhen Chen, Fubiao Huang, Shihong Hu, Wei Deng, Fengxian Guo, Chuankai Wang, Panmo Deng, Li Li, Hao Jin, Cong Gao, Beibei Shu, Jie Jia

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Different effects of cardiometabolic syndrome on brain age in relation to gender and ethnicity by Sung Hoon Kang, Mengting Liu, Gilsoon Park, Sharon Y. Kim, Hyejoo Lee, William Matloff, Lu Zhao, Heejin Yoo, Jun Pyo Kim, Hyemin Jang, Hee Jin Kim, Neda Jahanshad, Kyumgmi Oh, Seong-Beom Koh, Duk L. Na, John Gallacher, Rebecca F. Gottesman, Sang Won Seo, Hosung Kim

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Emerging metabolic imaging and spectroscopic methods to study neurodegenerative diseases by Sanjeev Chawla, Gaurav Verma, Ravi Prakash Reddy Nanga, Suyash Mohan, Harish Poptani

“…These labile protons are selectively saturated using radiofrequency irradiation, which is subsequently transferred to the bulk water pool, leading to a decrease in the water signal intensity proportional to the concentration of solute molecules, number of labile protons and proton exchange rate.5 CEST offers more than two orders of magnitude higher sensitivity compared to 1H-MRS in detecting metabolites such as glutamate, creatine, myoinositol and mobile peptides.5 While amide proton transfer (APT) imaging has been investigated in various neurological disorders, other CEST imaging techniques such as glutamate-CEST, creatine-CEST have been performed only in pre-clinical or pilot clinical studies related to neurodegenerative diseases. …”
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Enhancing Antitumor Efficacy of Heavily Vascularized Tumors by RAMBO Virus through Decreased Tumor Endothelial Cell Activation by Mitra Nair, Maninder Khosla, Yoshihiro Otani, Margaret Yeh, Flora Park, Toshihiko Shimizu, Jin Muk Kang, Chelsea Bolyard, Jun-Ge Yu, Yeshavanth Kumar Banasavadi-Siddegowda, Gonzalo Lopez, Balveen Kaur, Raphael E. Pollock, Tae Jin Lee, Matthew Old, Ji Young Yoo

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Multimodal anatomical mapping of subcortical regions in marmoset monkeys using high-resolution MRI and matched histology with multiple stains by Kadharbatcha S. Saleem, Alexandru V. Avram, Cecil Chern-Chyi Yen, Kulam Najmudeen Magdoom, Vincent Schram, Peter J. Basser

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The problem of osteoporotic fractures of the femur in children with cerebral palsy by M. I. Lyutkevych

“…All patients had neurological disorders, moved with support or in a wheelchair, had contractures of adjacent joints, according to the pattern, type and form of cerebral palsy, had difficulty with proper nutrition, most had comorbidities. …”
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Targeting selenoprotein H in the nucleolus suppresses tumors and metastases by Isovalerylspiramycin I by Jing Cui, Jingcheng Zhou, Weiqing He, Juan Ye, Timothy Westlake, Rogelio Medina, Herui Wang, Bhushan L. Thakur, Juanjuan Liu, Mingyu Xia, Zhonggui He, Fred E. Indig, Aiguo Li, Yan Li, Robert J. Weil, Mirit I. Aladjem, Laiping Zhong, Mark R. Gilbert, Zhengping Zhuang

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Plasma Neurofilament Light Chain Levels Are Elevated in Children and Young Adults With Wolfram Syndrome by Sarah A. Eisenstein, Sarah A. Eisenstein, Raveena S. Boodram, Courtney L. Sutphen, Heather M. Lugar, Brian A. Gordon, Brian A. Gordon, Bess A. Marshall, Bess A. Marshall, Fumihiko Urano, Fumihiko Urano, Fumihiko Urano, Anne M. Fagan, Anne M. Fagan, Anne M. Fagan, Tamara Hershey, Tamara Hershey, Tamara Hershey

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