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6721
Electrographic Seizures in Neonates with a High Risk of Encephalopathy
Published 2022-05-01“…The increased excitability in the neonatal brain appears to be highly susceptible to seizures after a variety of insults, and seizures may be the first clinical sign of a serious neurologic disorder. Subtle seizures are common in the neonatal period, and abnormal clinical paroxysmal events may raise the suspicion of neonatal seizures. …”
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6722
Beta-Amyloid (Aβ<sub>1-42</sub>) Increases the Expression of NKCC1 in the Mouse Hippocampus
Published 2022-04-01“…Altered expression levels of K-Cl-2 (KCC2) and N-K-Cl-1 (NKCC1), which are cation–chloride cotransporters (CCCs), have been implicated in disrupting GABAergic activity by regulating GABA<sub>A</sub> receptor signaling polarity in several neurological disorders, but these have not yet been explored in AD. …”
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6723
Whole genome sequencing identifies candidate genes for familial essential tremor and reveals biological pathways implicated in essential tremor aetiology
Published 2022-11-01“…Summary: Background: Essential tremor (ET), one of the most common neurological disorders, has a phenotypically heterogeneous presentation characterized by bilateral kinetic tremor of the arms and, in some patients, tremor involving other body regions (e.g., head, voice). …”
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6724
Identification of miRNA–mRNA regulatory network associated with the glutamatergic system in post-traumatic epilepsy rats
Published 2022-12-01“…BackgroundGlutamate is one of the most important excitatory neurotransmitters in the mammalian brain and is involved in a variety of neurological disorders. Increasing evidence also shows that microRNA (miRNA) and mRNA pairs are engaged in a variety of pathophysiological processes. …”
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6725
Comparative effectiveness of decompressive craniectomy versus craniotomy for traumatic acute subdural hematoma (CENTER-TBI): an observational cohort studyResearch in context
Published 2023-09-01“…Patients with severe pre-existing neurological disorders were excluded. In an instrumental variable analysis, we compared outcomes between centres according to treatment preference, measured by the case-mix adjusted proportion DC per centre. …”
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6726
Predicting 2-year neurodevelopmental outcomes in extremely preterm infants using graphical network and machine learning approachesResearch in context
Published 2023-02-01“…Funding: Supported by the National Institute of Neurological Disorders and Stroke U01NS077953 and U01NS077955.…”
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6727
A pilot investigation of differential hydroxymethylation levels in patient-derived neural stem cells implicates altered cortical development in bipolar disorder
Published 2023-04-01“…Environmental factors, such as maternal smoking and childhood trauma, are believed to modulate risk genotypes and contribute to the pathogenesis of BD, suggesting a key role in epigenetic regulation during neurodevelopment. 5-hydroxymethylcytosine (5hmC) is an epigenetic variant of particular interest, as it is highly expressed in the brain and is implicated in neurodevelopment, and psychiatric and neurological disorders.MethodsInduced pluripotent stem cells (iPSCs) were generated from the white blood cells of two adolescent patients with bipolar disorder and their same-sex age-matched unaffected siblings (n = 4). …”
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6728
Analysis of the role of PANoptosis in seizures via integrated bioinformatics analysis and experimental validation
Published 2024-02-01“…In recent studies, PANoptosis, a newly characterized form of cell death, has emerged as a significant contributor to the development of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. …”
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6729
Plasma and cerebrospinal fluid neurofilament light concentrations reflect neuronal damage in systemic lupus Erythematosus
Published 2022-12-01“…Neurofilament light (NfL) concentrations rise in plasma and cerebrospinal fluid (CSF) during neuronal damage in various neurological disorders. In this cross-sectional study, plasma and CSF concentrations of NfL were explored as a marker of neuronal damage in SLE. …”
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6732
Deciphering the role of QPCTL in glioma progression and cancer immunotherapy
Published 2023-03-01Get full text
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6733
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6734
Different effects of cardiometabolic syndrome on brain age in relation to gender and ethnicity
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6735
Emerging metabolic imaging and spectroscopic methods to study neurodegenerative diseases
Published 2022-11-01“…These labile protons are selectively saturated using radiofrequency irradiation, which is subsequently transferred to the bulk water pool, leading to a decrease in the water signal intensity proportional to the concentration of solute molecules, number of labile protons and proton exchange rate.5 CEST offers more than two orders of magnitude higher sensitivity compared to 1H-MRS in detecting metabolites such as glutamate, creatine, myoinositol and mobile peptides.5 While amide proton transfer (APT) imaging has been investigated in various neurological disorders, other CEST imaging techniques such as glutamate-CEST, creatine-CEST have been performed only in pre-clinical or pilot clinical studies related to neurodegenerative diseases. …”
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6738
The problem of osteoporotic fractures of the femur in children with cerebral palsy
Published 2021-12-01“…All patients had neurological disorders, moved with support or in a wheelchair, had contractures of adjacent joints, according to the pattern, type and form of cerebral palsy, had difficulty with proper nutrition, most had comorbidities. …”
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6739
Targeting selenoprotein H in the nucleolus suppresses tumors and metastases by Isovalerylspiramycin I
Published 2022-04-01Get full text
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6740
Plasma Neurofilament Light Chain Levels Are Elevated in Children and Young Adults With Wolfram Syndrome
Published 2022-04-01Get full text
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