Neuropeptide Profiles of Mammalian Male Genital Tract: Distribution and Functional Relevance in Reproduction by Jamiu O. Omirinde, Idris A. Azeez

“…This review provides an overview of neuropeptides with respect to their synthesis, release, and mechanism of actions, with emphasis on the locally acting neuropeptides, such as substance P (SP), neuropeptide Y (NPY), vasoactive intestinal peptides (VIP), calcitonin gene-related peptide (CGRP), galanin (GAL), cholecystokinin (CCK), C-terminal flanking peptide of NPY (CPON), peptide histidine isoleucine (PHI), and met- and leu-enkephalins (M-ENK and L-ENK) along the male genital tract (i.e., the spermatic cord, testis, epididymis, ductus deferens, and accessory sex organs) of 14 species of mammals and their marked influence on reproduction. …”
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Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains. by Cornelia J Geerts, Roberta Mancini, Ning Chen, Frank T W Koopmans, Ka Wan Li, August B Smit, Jan R T van Weering, Matthijs Verhage, Alexander J A Groffen

“…Despite the lack of a membrane anchor these puncta co-migrated with synapsin and neuropeptide Y, markers for respectively SVs and DCVs. …”
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Excitatory and Inhibitory Neurons in the Hippocampus Exhibit Molecularly Distinct Large Dense Core Vesicles by Jose Jorge Ramirez-Franco, Francisco Javier Munoz-Cuevas, Rafael Lujan, Sandra Jurado

“…Furthermore, phogrin is highly expressed in CA3 and dentate gyrus interneurons which are both positive for PV and neuropeptide Y. Surprisingly, chromogranin B a canonical large dense core vesicle marker, is excluded from inhibitory cells in the hippocampus but highly expressed in excitatory CA3 pyramidal neurons and dentate gyrus granule cells. …”
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Epilepsy in Dcx knockout mice associated with discrete lamination defects and enhanced excitability in the hippocampus. by Marika Nosten-Bertrand, Caroline Kappeler, Céline Dinocourt, Cécile Denis, Johanne Germain, Françoise Phan Dinh Tuy, Soraya Verstraeten, Chantal Alvarez, Christine Métin, Jamel Chelly, Bruno Giros, Richard Miles, Antoine Depaulis, Fiona Francis

“…We questioned the functional consequences of these defects and report here that Dcx KO mice are hyperactive and exhibit spontaneous convulsive seizures. Changes in neuropeptide Y and calbindin expression, consistent with seizure occurrence, were detected in a large proportion of KO animals, and convulsants, including kainate and pentylenetetrazole, also induced seizures more readily in KO mice. …”
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The impact of antidiabetic treatment on human hypothalamic infundibular neurons and microglia by Martin J.T. Kalsbeek, Samantha E.C. Wolff, Nikita L. Korpel, Susanne E. la Fleur, Johannes A. Romijn, Eric Fliers, Andries Kalsbeek, Dick F. Swaab, Inge Huitinga, Elly M. Hol, Chun-Xia Yi

“…Here, we characterized the proopiomelanocortin (POMC) immunoreactive (-ir) neurons, the neuropeptide-Y–ir (NPY-ir) neurons, the ionized calcium-binding adapter molecule 1–ir (iba1-ir) microglia, and the transmembrane protein 119–ir (TMEM119-ir) microglia in the infundibular nucleus (IFN) of human postmortem hypothalamus of 32 T2DM subjects with different antidiabetic treatments and 17 matched nondiabetic control subjects. …”
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Adrenergic, nitrergic and peptidergic innervation of the urethral muscle in the boar. by Mirosław Lakomy, Krzysztof Czaja, Jerzy Kaleczyc, Waldemar Sienkiewicz

“…Nerve fibres supplying the urethral muscle were found to show NADPH-d activity and they also expressed immunoreactivity to catecholamine synthesising enzymes including tyrosine hydoxylase (TH) and dopamine-beta-hydroxylase (DbetaH) as well as to: vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY). Different subpopulations of the nerve fibres (NADPH-d positive, TH-, DbetaH-, VIP- and NPY-immunoreactive (IR), but also NADPH-d/VIP- and NADPH-d/NPY-IR) were disclosed. …”
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The surging role of Chromogranin A in cardiovascular homeostasis by BRUNO eTOTA, TOMMASO eANGELONE, MARIA CARMELA CERRA

“…Co-stored within the granule together with neuropeptideY, cardiac natriuretic peptide hormones, several prohormones and their proteolytic enzymes, CGA is a multifunctional protein and a major marker of the sympatho-adrenal neuroendocrine activity. …”
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Long-term correction of type 1 and 2 diabetes by central leptin gene therapy independent of effects on appetite and energy expenditure by Masako Nakano, Akihiro Asakawa, Akio Inui

“…Additionally injection of rAVV-LEP into the hypothalamus suppressed the expression of orexigenic neuropeptide Y (NPY) and enhanced anorexigenic pro-opiomelanocortin (POMC) in the arcuate nucleus (ARC) in rats. …”
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Catamenial Epilepsy by Rabia Gökçen GÖZÜBATIK ÇELİK, Çiğdem ÖZKARA

“…Among steroid hormones, while progesterone and neurosteroids are known as anticonvulsants, estrogen, the best known proconvulsant, has been found in recent studies to also have anticonvulsant effects related to Neuropeptide Y. Hormonal (medroxyprogesterone acetate, clomiphene, triptorelin, leuprolide, progesterone, goserelin), non-hormonal (acetazolamide, clobazam, lamotrigine, levetiracetam), and neurosteroidbased therapies (ganaxolone) are used in the treatment of catamenial epilepsy. …”
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Chemosensory and hyperoxia circuits in C. elegans males influence sperm navigational capacity. by Hieu D Hoang, Michael A Miller

“…SRB signaling is necessary and sufficient in these sensory neurons to influence sperm motility parameters. The neuropeptide Y pathway acts together with SRB-13 to antagonize negative effects of the GCY-35 hyperoxia sensor on spermatogenesis. …”
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Comparitive Study of Serum Leptin Levels in Diabetic Obese Patients and Non-Diabetic Obese Individuals by M Afkhami-Ardakani, J Mohiti-Ardakani, H Sedghi

“…Leptin has two type of receptors in Hypothalamus and other tissues including muscles, liver and intestines. Leptin inhibits neuropeptide Y resulting in decreased appetite and on the other hand increases the basic metabolic rate of the body resulting in homeostasis of body energy. …”
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Inflammation and nerve injury induce expression of pancreatitis-associated protein-II in primary sensory neurons by Bao Lan, Wang Qiong, Zhang Fang-Xiong, Yao Jun-Ru, He Shao-Qiu, Zhang Xu

“…Interestingly, PAP-II expression was shifted from small neurons on day 2 to large DRG neurons that expressed neuropeptide Y during the later post-injury days. These results suggest that PAP-II may play potential roles in the modulation of spinal sensory pathways in pathological pain states.…”
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Effects of high affinity leptin antagonist on prolactin receptor deficient male mouse. by Nadège Carré, Gili Solomon, Arieh Gertler, Nadine Binart

“…Prolactin (PRL) induces the expression of orexigenic neuropeptide Y (NPY) in hypothalamic dorsomedial nucleus (DMH) leading to hyperphagia. …”
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Preferential origin and layer destination of GAD65-GFP cortical interneurons. by López-Bendito, G, Sturgess, K, Erdélyi, F, Szabó, G, Molnár, Z, Paulsen, O

“…At P21, GAD65-GFP cells were found predominantly in layers II-III and expressed calretinin and neuropeptide Y. Remarkably, almost all cholecystokinin-positive but very few parvalbumin-positive neurons expressed GFP. …”

Induction of Gonadotropins for Reproductive Control by Elza Ibrahim Auerkari

“…Of the substances that mediate the metabolic condition to the neuronal network regulating GnRH secretion, the role of the neuropeptide Y (NPY) appears instrumental : for healthy mammals less food means more NPY, and accumulated NPY makes food to become sex. …”
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Maternal high fat diets: impacts on offspring obesity and epigenetic hypothalamic programming by Begüm Harmancıoğlu, Seray Kabaran

“…In addition, maternal HFD is associated with changes in the hypothalamic regulation of body weight and energy homeostasis by altering the expression of the leptin receptor, POMC, and neuropeptide Y in the offspring, as well as altering methylation and gene expression of dopamine and opioid-related genes which cause changes in eating behavior. …”
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Molecular analysis of ivy cells of the hippocampal CA1 stratum radiatum using spectral identification of immunofluorophores by Jozsef eSomogyi, Andras eSzabo, Peter eSomogyi, Karri P Lamsa

“…We have used spectral analysis of antibody- or streptavidin conjugated fluorophores to improve recognition of genuine signals in reactions for molecules such as NOS and neuropeptide-Y, when immunolabelling was low in the recorded cell. …”
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Histology and immunofluorescent study of the pancreas in lovebird (Agapornis personatus) by Nader Goodarzi, Ayda Bashiri

“…The pancreas was assessed using histological and immunofluorescent staining to detect insulin, glucagon, somatostatin, pancreatic polypeptide (PP) and neuropeptide Y (NY). Results The exocrine pancreas was composed of pyramidal acinar cells with zymogen granules at the apical cytoplasm. …”
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Neurotransmitters and putative neuromodulators in the gut of Anguilla anguilla (L.). Localizations in the enteric nervous and endocrine systems by A Veggetti, F Mascarello, S Arrighi, G Radaelli, C Domeneghini

“…Histochemical reactions for the demonstration of nicotinamide adenine dinucleotide phosphate, reduced form-(NADPH-)diaphorase and acetylcholinesterese (AChEase) were performed, as well as the immunohistochemical testing of tyrosine hydroxylase, met-enkephalin, substance P, calcitonin gene-related peptide (CGRP), bombesin, vasoactive intestinal peptide (VIP), neuropeptide Y (NPY), somatostatin, cholecystokinin-octapeptide (CCK-8), serotonin, cholineacetyltransferase. …”
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Neuropeptide co-expression in hypothalamic kisspeptin neurons of laboratory animals and the human by Katalin eSkrapits, Beata Agnes Borsay, László eHerczeg, Philippe eCiofi, Zsolt eLiposits, Zsolt eLiposits, Erik eHrabovszky

“…Human KP neurons do not contain neurotensin, cholecystokinin, proopiomelanocortin-derivatives, agouti-related protein, neuropeptide Y, somatostatin or tyrosine hydroxylase (dopamine). …”
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