GPNMB Modulates Autophagy to Enhance Functional Recovery After Spinal Cord Injury in Rats by Xixi Li, Jiakun Xu, Weijie Su, Luoxi Su, Xiangkun Chen, Jia Yang, Xunxun Lin, Lixuan Yang

“…Autophagy, an essential cellular metabolic process, plays a crucial role in neuroprotection and repair after SCI. Glycoprotein non-metastatic melanoma protein B (GPNMB) has been shown to promote neural regeneration and synapse reconstruction, potentially through the facilitation of autophagy. …”
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Comparative efficacy of Chinese herbal injections for treating acute cerebral infarction: a network meta-analysis of randomized controlled trials by Shi Liu, Jia-Rui Wu, Dan Zhang, Kai-Huan Wang, Bing Zhang, Xiao-Meng Zhang, Di Tan, Xiao-Jiao Duan, Ying-Ying Cui, Xin-Kui Liu

“…CHIs combined with aspirin + anticoagulants + dehydrant + neuroprotectant (AADN) are believed to be effective for the treatment of acute cerebral infarction (ACI). …”
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Activation of Nrf2/HO-1 Pathway by Nardochinoid C Inhibits Inflammation and Oxidative Stress in Lipopolysaccharide-Stimulated Macrophages by Jin-Fang Luo, Jin-Fang Luo, Xiu-Yu Shen, Chon Kit Lio, Chon Kit Lio, Yi Dai, Chun-Song Cheng, Chun-Song Cheng, Jian-Xin Liu, Yun-Da Yao, Yun-Da Yao, Yang Yu, Ying Xie, Ying Xie, Pei Luo, Pei Luo, Xin-Sheng Yao, Zhong-Qiu Liu, Hua Zhou, Hua Zhou, Hua Zhou

“…The roots and rhizomes of Nardostachys chinensis have neuroprotection and cardiovascular protection effects. …”
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Inhibition of FOXO3a/BIM signaling pathway contributes to the protective effect of salvianolic acid A against cerebral ischemia/reperfusion injury by Junke Song, Wen Zhang, Jinhua Wang, Haiguang Yang, Qimeng Zhou, Haigang Wang, Li Li, Guanhua Du

“…KEY WORDS: Salvianolic acid A, Ischemia reperfusion, FOXO3a, BIM, Neuroprotection…”
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Intranasal neuropeptide Y1 receptor antagonism improves motor deficits in symptomatic SOD1 ALS mice by Rosemary M. Clark, Courtney M. Clark, Katherine E.A. Lewis, Marcus S. Dyer, Jyoti A. Chuckowree, Joshua A. Hoyle, Catherine A. Blizzard, Tracey C. Dickson

“…Abstract Objective Neuropeptide Y (NPY) is a 36 amino acid peptide widely considered to provide neuroprotection in a range of neurodegenerative diseases. …”
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Restoring mitochondrial cardiolipin homeostasis reduces cell death and promotes recovery after spinal cord injury by Nai-Kui Liu, Ling-Xiao Deng, Miao Wang, Qing-Bo Lu, Chunyan Wang, Xiangbing Wu, Wei Wu, Ying Wang, Wenrui Qu, Qi Han, Yongzhi Xia, Baylen Ravenscraft, Jin-Lian Li, Si-Wei You, Peter Wipf, Xianlin Han, Xiao-Ming Xu

“…Cellular, molecular, and genetic assessments were performed to determine whether CL alterations mediate mitochondrial dysfunction and neuronal death after SCI, and, if so, whether reversing CL alteration leads to neuroprotection after SCI. Using lipidomic analysis, we uncovered CL alterations at an early stage of SCI. …”
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Sodium-Calcium Exchanger 2: A Pivotal Role in Oxaliplatin Induced Peripheral Neurotoxicity and Axonal Damage? by Elisa Ballarini, Alessio Malacrida, Virginia Rodriguez-Menendez, Eleonora Pozzi, Annalisa Canta, Alessia Chiorazzi, Laura Monza, Sara Semperboni, Cristina Meregalli, Valentina Alda Carozzi, Maryamsadat Hashemi, Gabriella Nicolini, Arianna Scuteri, Stephen N. Housley, Guido Cavaletti, Paola Alberti

“…Embryonic rat Dorsal Root Ganglia (DRG) organotypic cultures treated with SEA0400 (SEA), a NCX inhibitor, were used to assess neuroprotection in a <i>proof-of-concept</i> and <i>pilot</i> study to exploit NCX modulation to prevent ADa. …”
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Cyclosporin A-Mediated Activation of Endogenous Neural Precursor Cells Promotes Cognitive Recovery in a Mouse Model of Stroke by Labeeba Nusrat, Jessica M. Livingston-Thomas, Vaakiny Raguthevan, Kelsey Adams, Ilan Vonderwalde, Dale Corbett, Dale Corbett, Cindi M. Morshead, Cindi M. Morshead, Cindi M. Morshead

“…Second, we investigated the effects of acute and chronic CsA treatment on NPC activation, neuroprotection, and tissue damage. Acute CsA administration post-stroke increased the size of the NPC pool. …”
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Comparative Proteomics Unveils LRRFIP1 as a New Player in the DAPK1 Interactome of Neurons Exposed to Oxygen and Glucose Deprivation by Núria DeGregorio-Rocasolano, Verónica Guirao, Jovita Ponce, Marc Melià-Sorolla, Alicia Aliena-Valero, Alexia García-Serran, Juan B. Salom, Antoni Dávalos, Octavi Martí-Sistac, Teresa Gasull

“…The present study identifies novel partners of DAPK1, such as LRRFIP1, which are suitable as targets for neuroprotection.…”
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Protective Effect of Adenosine A2B Receptor Agonist, BAY60-6583, Against Transient Focal Brain Ischemia in Rat by Ilaria Dettori, Lisa Gaviano, Filippo Ugolini, Daniele Lana, Irene Bulli, Giada Magni, Francesca Rossi, Maria Grazia Giovannini, Felicita Pedata

“…During ischemia, adenosine acts as an endogenous neuroprotectant. Few studies have investigated the role of A2B receptor in brain ischemia because of the low potency of adenosine for it and the few selective ligands developed so far. …”
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P-coumaric acid ameliorates Aβ25–35-induced brain damage in mice by modulating gut microbiota and serum metabolites by Bing Cao, Meng-nan Zeng, Feng-xiao Hao, Zhi-you Hao, Zhen-kai Zhang, Xi-wen Liang, Yuan-yuan Wu, Yu-han Zhang, Wei-sheng Feng, Xiao-ke Zheng

“…P-coumaric acid (PCA), a small molecule phenolic acid widely distributed in the plant kingdom, has pharmacological effects such as neuroprotection, but its anti-AD mechanism has not been fully elucidated. …”
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Nepeta Dschuparensis Bornm Extract Moderates COX-2 and IL-1β Proteins in a Rat Model of Cerebral Ischemia by Alireza Mousavi Nia, Taj Pari Kalantaripour, Mohsen Basiri, Farzaneh Vafaee, Majid Asadi-Shekaari, Azam Eslami, Fatemeh Darvish Zadeh

“…This project examined the effects of the NP extract on cyclooxygenase-2 (COX-2) and interleukin-1β (IL-1β) protein levels and its efficacy in neuroprotection in a cerebral ischemia-reperfusion model. …”
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Nuclear translocation of histone deacetylase 4 induces neuronal death in stroke by Hui Yuan, Kyle Denton, Lin Liu, Xue-Jun Li, Sharon Benashski, Louise McCullough, Jun Li

“…When HDAC4 was inhibited, the neuroprotection provided by CaMKIV overexpression was absent during OGD. …”
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Protective Effects of the Chalcone-Based Derivative AN07 on Inflammation-Associated Myotube Atrophy Induced by Lipopolysaccharide by Wei-Yu Fang, Chih-Lung Lin, Wan-Hsuan Chang, Chih-Hsiang Chang, Yun-Cian Huang, Yi-Hong Tsai, Fang-Rong Chang, Yi-Ching Lo

“…Inflammation is a major cause of skeletal muscle atrophy in various diseases. 2-Hydroxy-4′-methoxychalcone (AN07) is a chalcone-based peroxisome-proliferator-activated receptor gamma (PPARγ) agonist with various effects, such as antiatherosclerosis, anti-inflammation, antioxidative stress, and neuroprotection. In this study, we examined the effects of AN07 on protein homeostasis pathway and mitochondrial function in inflammation-associated myotube atrophy induced by lipopolysaccharides (LPS). …”
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NAC and Vitamin D Improve CNS and Plasma Oxidative Stress in Neonatal HIE and Are Associated with Favorable Long-Term Outcomes by Dorothea D Jenkins, Hunter G Moss, Truman R Brown, Milad Yazdani, Sudhin Thayyil, Paolo Montaldo, Maximo Vento, Julia Kuligowski, Carol Wagner, Bruce W Hollis, Donald B Wiest

“…N-acetylcysteine (NAC) and vitamin D provide effective neuroprotection in animal models of severe or inflammation-sensitized hypoxic ischemic encephalopathy (HIE). …”
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Alterations of mesenchymal stromal cells in cerebrospinal fluid: insights from transcriptomics and an ALS clinical trial by Ashley A. Krull, Deborah O. Setter, Tania F. Gendron, Sybil C. L. Hrstka, Michael J. Polzin, Joseph Hart, Amel Dudakovic, Nicolas N. Madigan, Allan B. Dietz, Anthony J. Windebank, Andre J. van Wijnen, Nathan P. Staff

“…Mechanistic understanding of cellular biology in response to the CSF environment may predict the ability of MSCs to promote injury repair or provide neuroprotection in neurodegenerative diseases. Methods In this study, we characterized changes in morphology, metabolism, and gene expression occurring in human adipose-derived MSCs cultured in human (hCSF) or artificial CSF (aCSF) as well as examined relevant protein levels in the CSF of subjects treated with MSCs for amyotrophic lateral sclerosis (ALS). …”
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Brain glucose hypometabolism and hippocampal inflammation in Goto-Kakizaki rats by J.C.O. Borges, V.A.B. Oliveira, T.D.A. Serdan, F.L.R. Silva, C.S. Santos, J.R.B. Pauferro, A.S.F. Ribas, R. Manoel, A.C.G. Pereira, I.S. Correa, J.N.B. Pereira, R.B. Bazotte, A.C. Levada-Pires, T.C. Pithon-Curi, R. Gorjão, R. Curi, S.M. Hirabara, L.N. Masi

“…Neuroinflammation may also disrupt leptin signaling, an adipokine that centrally regulates appetite and energy balance by acting on the hypothalamus and exerting neuroprotection in the hippocampus. The Goto-Kakizaki (GK) rat is a non-obese type 2 diabetes mellitus (T2DM) animal model used to investigate diabetes-associated molecular mechanisms without obesity jeopardizing effects. …”
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Platelets Selectively Regulate the Release of BDNF, But Not That of Its Precursor Protein, proBDNF by Jessica Le Blanc, Jessica Le Blanc, Samuel Fleury, Samuel Fleury, Imane Boukhatem, Imane Boukhatem, Jean-Christophe Bélanger, Jean-Christophe Bélanger, Mélanie Welman, Marie Lordkipanidzé, Marie Lordkipanidzé

“…BackgroundBrain-derived neurotrophic factor (BDNF) plays a role in synaptic plasticity and neuroprotection. BDNF has well-established pro-survival effects, whereas its precursor protein, proBDNF, induces apoptosis. …”
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Clemastine improves hypomyelination in rats with hypoxic–ischemic brain injury by reducing microglia-derived IL-1β via P38 signaling pathway by Di Xie, Xiaoli Ge, Yanli Ma, Jialong Tang, Yang Wang, Yajie Zhu, Chengjin Gao, Shuming Pan

“…Methods A bilateral common carotid artery occlusion (BCCAO) rat model that received continuous intraperitoneal injection (1 mg/kg) for 14 days was employed to elaborate the neuroprotection effects of clemastine. Interleukin-1β (IL-1β), nod-like receptor protein 3 (NLRP3), histamine H1 receptor, and OPC differentiation levels in the corpus callosum were measured. …”
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G Protein-Coupled Estrogen Receptor 1 Knockout Deteriorates MK-801-Induced Learning and Memory Impairment in Mice by Chun Zhang, Chun Zhang, Qiang Liu, Chun-Yang Yu, Feng Wang, Yu Shao, Kui-Sheng Sun, Tao Sun, Juan Liu, Juan Liu

“…The role of estrogen receptors in neuroprotection and cognition has been extensively studied in humans over the past 20 years. …”
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