The gut microbiome: a key player in the complexity of amyotrophic lateral sclerosis (ALS) by Sarah L. Boddy, Ilaria Giovannelli, Matilde Sassani, Johnathan Cooper-Knock, Michael P. Snyder, Eran Segal, Eran Elinav, Lynne A. Barker, Pamela J. Shaw, Christopher J. McDermott

“…Moreover, should compelling evidence of upstream neurotoxicity or neuroprotection initiated by gut microbiota emerge, modification of the microbiome will represent a potential new avenue for disease modifying therapies. …”
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Identification of hypoxia-related genes and exploration of their relationship with immune cells in ischemic stroke by Kai Yang, Zhaoqi Zhang, Xiaoju Liu, Tong Wang, Zhicheng Jia, Xin Li, Wei Liu

“…Screening and identifying hypoxia-related genes (HRGs) and therapeutic targets is important for neuroprotection before and during brain recanalization to protect against injury and extend the time window to further improve functional outcomes before pharmacological and mechanical thrombolysis. …”
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Low Trend for VZV-Associated Disease Patients to Visit Neurologists by Xu G, Xu S, Gong W, Dong S, Yu H

“…However, from the perspective of neuroprotection, it is the duty of neurologists to provide more means.Keywords: herpes zoster, zoster-associated pain, neuropathy, electronic health records, visit preferences…”
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Berberine Supplement and Resistance Training May Ameliorate Diazinon Induced Neural Toxicity in Rat Hippocampus Via the Activation of the TrkB and ERK Signaling Pathway by Elham Shakouri, Mohammad Ali Azarbayjani, Seyed Behnamedin Jameie, Maghsoud Peeri, Mona Farhadi

“…Conclusion: Six weeks of resistance training in combination with berberine treatment significantly reduced apoptosis in the hippocampus region of diazinon-intoxicated rats. It seems the neuroprotection effects of berberine and resistance training are mediated by the stimulation of the expression of enzymes responsible for the antioxidant defense within neuronal cells.…”
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Phenobarbital as alternate anticonvulsant for organophosphate‐induced benzodiazepine‐refractory status epilepticus and neuronal injury by Doodipala Samba Reddy, Dheepthi Perumal, Victoria Golub, Andy Habib, Ramkumar Kuruba, Xin Wu

“…Neuropathology findings showed significant neuroprotection in 100 mg/kg cohorts in brain regions associated with SE. …”
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Nigella sativa L. seed extracts promote wound healing progress by activating VEGF and PDGF signaling pathways: An in vitro and in silico study [version 2; peer review: 2 approved,... by Sirilux Poompradub, Chella Perumal Palanisamy, Selvaraj Jayaraman, Phaniendra Alugoju

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GnRh agonists as precipitating components of psychiatric pathology. A case report. by A. Guerrero Medina, J. S. García Eslava, A. C. Martín Rodriguez, L. Martinez Salvador, M. J. Alvarez Alonso, M. Aubareda Magriña

“…Wieck (Curr Top Behav Neurosci 2011;8:173-87), Frokjaer (J Neurosci Res 2020;98(7):1283-1292), Brzezinski-Sinai et al (Front Psychiatry 2020;11:693) reported that this association could be related with the relationship of the hypothalamic-pituitary-gonadal axis, hormonal fluctuation and its relationship with the dopaminergic regulation, a genetic component that would increase the predisposition to trigger psychiatric pathology in patients with greater sensitivity to hormonal fluctuations, and the loss of neuroprotection generated by the decrease of estrogens in the central nervous system. …”
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Protective Effect and Mechanism of Xbp1s Regulating HBP/O-GlcNAcylation through GFAT1 on Brain Injury after SAH by Kefan Wu, Lili Chen, Zhen Qiu, Bo Zhao, Jiabao Hou, Shaoqin Lei, Meng Jiang, Zhongyuan Xia

“…The GFAT1 enzyme regulates the level of O-GlcNAc modification in cells, which could be a potential target for neuroprotection in SAH. Investigating the IRE1/XBP1s/GFAT1 axis could offer a promising avenue for future research. (2) Methods: SAH was induced using a suture to perforate an artery in mice. …”
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Are we creating a new phenotype? Physiological barriers and ethical considerations in the treatment of hereditary transthyretin-amyloidosis by Maike F. Dohrn, Jessica Medina, Karmele R. Olaciregui Dague, Ernst Hund

“…But what effects will unselective CNS TTR knock-down have considering its role in neuroprotection? A potential approach to overcome this second limitiation might be allele-specific targeting, which is, however, still far from clinical trials. …”
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6-Methoxyflavone and Donepezil Behavioral Plus Neurochemical Correlates in Reversing Chronic Ethanol and Withdrawal Induced Cognitive Impairment by Arif M, Rauf K, Rehman NU, Tokhi A, Ikram M, Sewell RD

“…Flavonoids possess antioxidant and anti-inflammatory properties believed to be contributory factors in reversing cognitive decline. 6-Methoxyflavone (6-MOF), a flavonoid occurring naturally in medicinal plants, has been reported to instigate neuroprotection by reversing cisplatin-induced hyperalgesia and allodynia. …”
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Bioassay-Guided Isolation of Anti-Alzheimer Active Components from the Aerial Parts of <i>Hedyotis diffusa</i> and Simultaneous Analysis for Marker Compounds by Jun Hee Park, Wan Kyunn Whang

“…Previous studies have reported that <i>Hedyotis diffusa</i> Willdenow extract shows various biological activities on cerebropathia, such as neuroprotection and short-term memory enhancement. However, there has been a lack of studies on the inhibitory activity on neurodegenerative diseases such as Alzheimer’s disease (AD) through enzyme assays of <i>H. diffusa</i>. …”
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Deltonin Ameliorates Cerebral Ischemia/Reperfusion Injury in Correlation with Modulation of Autophagy and Inflammation by Zhang Y, Tian Z, Wan H, Liu W, Kong F, Ma G

“…Deltonin exerted neuroprotection effect through relieving autophagy activity by regulating PI3K/Akt/mTOR signaling. …”
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The psychotropic effect of vitamin D supplementation on schizophrenia symptoms by Aras Neriman, Yilmaz Hakan, Ucuncu Ozge

“…Vitamin D plays essential roles in the brain in the context of neuroplasticity, neurotransmitter biosynthesis, neuroprotection, and neurotransmission. Vitamin D receptors are demonstrated in most brain regions that are related to schizophrenia. …”
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Mechanisms of tumor necrosis factor-α-induced interleukin-6 synthesis in glioma cells by Dohi Shuji, Iida Hiroki, Yamaguchi Shinobu, Matsushima-Nishiwaki Rie, Tanabe Kumiko, Kozawa Osamu

“…<p>Abstract</p> <p>Background</p> <p>Interleukin (IL)-6 plays a pivotal role in a variety of CNS functions such as the induction and modulation of reactive astrogliosis, pathological inflammatory responses and neuroprotection. Tumor necrosis factor (TNF)-α induces IL-6 release from rat C6 glioma cells through the inhibitory kappa B (IκB)-nuclear factor kappa B (NFκB) pathway, p38 mitogen-activated protein (MAP) kinase and stress-activated protein kinase (SAPK)/c-<it>Jun </it>N-terminal kinase (JNK). …”
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Programming of neurotoxic cofactor CXCL-10 in HIV-1-associated dementia: abrogation of CXCL-10-induced neuro-glial toxicity in vitro by PKC activator by Mehla Rajeev, Bivalkar-Mehla Shalmali, Nagarkatti Mitzi, Chauhan Ashok

“…Bryostatin, a PKC modulator and suppressor of CXCR4, conferred neuroprotection against combined insult with HIV-1 and CXCL10. …”
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Inflammatory monocytes damage the hippocampus during acute picornavirus infection of the brain by Howe Charles L, LaFrance-Corey Reghann G, Sundsbak Rhianna S, LaFrance Stephanie J

“…Depletion of inflammatory monocytes and neutrophils with the Gr1 antibody resulted in hippocampal neuroprotection and preservation of cognitive function. …”
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The potential mechanism of recombinant human erythropoietin treatment in vivo promoting the cognitive function recovery after traumatic brain injury in mice by Tong-heng CHEN, Zi-wei ZHOU, Sheng-jie LI, Ye TIAN, Guo-wei YANG, Shi-zhao WANG, Ming WEI, Ping LEI, Jian-ning ZHANG

“…It is confirmed that recombinant human erythropoietin (rhEPO) plays an important role in neuroprotection after brain injury. This article discusses the potential mechanism of rhEPO therapy that promotes the neurological function recovery after TBI by observing the changes of neutropils and neuronal apoptosis in the brain tissue of mice after fluid percussion injury (FPI). …”
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PasoDoble, a Proposed Dance/Music for People With Parkinson's Disease and Their Caregivers by Lydia Giménez-Llort, Lydia Giménez-Llort, Lidia Castillo-Mariqueo

“…Managing the heterogeneity of Parkinson's disease symptoms and its progressive nature demands strategies targeting the hallmark disrupted neurotransmission but also the comorbid derangements and bolstering neuroprotection and regeneration. Strong efforts are done to find disease-modifying strategies, since slowing disease progression is not enough to hamper its burden and some motor symptoms are resistant to dopamine-replacement therapy. …”
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Bone marrow mesenchymal stem cells and their derived exosomes resolve doxorubicin-induced chemobrain: critical role of their miRNA cargo by Marwa O. El-Derany, Mohamed H. Noureldein

“…Conclusions BMSCs and their derived exosomes offer neuroprotection against DOX-induced chemobrain via genetic and epigenetic abrogation of hippocampal neurodegeneration through modulating Wnt/β-catenin and hedgehog signaling pathways and through reducing inflammatory, apoptotic, and oxidative stress state. …”
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LncRNA KCNQ1OT1 Sponges miR-206 to Ameliorate Neural Injury Induced by Anesthesia via Up-Regulating BDNF by Yao Y, Wang X, Gao J

“…Our study helps to clarify the mechanism by which ketamine exerts its toxicological effects and provides clues for the neuroprotection during anesthesia.Keywords: ketamine, neural injury, lncRNA KCNQ1OT1, miR-206, BDNF…”
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